Article
Biochemistry & Molecular Biology
Nadine de Godoy Torso, Julia Coelho Franca Quintanilha, Maria Aparecida Cursino, Eder de Carvalho Pincinato, Carmen Silvia Passos Lima, Patricia Moriel
Summary: This study aimed to determine the most adequate endogenous normalizer for urinary miRNA relative quantification in head and neck cancer patients treated with cisplatin chemoradiotherapy. RNA-Seq was performed to identify differentially expressed miRNAs between groups with and without cisplatin nephrotoxicity. Four miRNAs were selected as candidate endogenous normalizers and validated by qRT-PCR in a cohort of 49 patients, with hsa-miR-875-5p shown to be an adequate normalizer due to its invariant expression between the two groups.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Editorial Material
Biochemistry & Molecular Biology
Joshua R. Veatch, Stanley R. Riddel
Summary: The study reveals the effectiveness of immune checkpoint blockade on tissue-resident memory T cells in head and neck cancers, as well as the prediction of pathologic tumor regression based on specific CD8(+) T cells in pretreatment blood.
Review
Medicine, General & Internal
Mayur D. Mody, James W. Rocco, Sue S. Yom, Robert Haddad, Nabil F. Saba
Summary: Head and neck cancer is the seventh most common type of cancer worldwide, with the predominant risk factors being tobacco use, alcohol abuse, and oncogenic viruses. Treatment typically involves a multidisciplinary approach with surgery, radiotherapy, and systemic therapy, and is challenging due to site-specific and histology-specific variations.
Review
Health Care Sciences & Services
Enar Jumaniyazova, Anastasiya Lokhonina, Dzhuliia Dzhalilova, Anna Kosyreva, Timur Fatkhudinov
Summary: Head-and-neck cancers, particularly squamous cell carcinomas, are aggressive tumors with low survival rates. The immune system plays a crucial role in the development and progression of these cancers. The interactions between different cell types in the tumor microenvironment shape the structure and function of the tumor, facilitating angiogenesis, proliferation, and metastasis. Understanding these interactions is important for the development of advanced therapies for head-and-neck cancers.
JOURNAL OF PERSONALIZED MEDICINE
(2022)
Article
Plant Sciences
Himanshu Sharma, Alok Sharma, Ruchika Rajput, Sukhjeet Sidhu, Harpal Dhillon, Praveen Chandra Verma, Ashutosh Pandey, Santosh Kumar Upadhyay
Summary: In this study, 29 BOR genes were identified and analyzed for their conserved nature. The role of duplication events and purifying selection in the expansion of the BOR family in wheat was revealed. The study also showed the expression and co-expression patterns of BOR genes under biotic and abiotic stress conditions, as well as their involvement in B stress management.
Editorial Material
Oncology
Joanne Soo, Michael C. Jin, Beth M. Beadle, F. Christopher Holsinger, Andrey Finegersh
Summary: This study reveals that measuring the genetic components of human papillomavirus-related throat cancer after surgery can help predict the effectiveness of treatment.
Article
Oncology
Benjamin A. Kansy, Tim P. Wehrs, Kirsten Bruderek, Yu Si, Sonja Ludwig, Freya Droege, Pia Hasskamp, Uta Henkel, Nina Dominas, Thomas K. Hoffmann, Peter A. Horn, Martin Schuler, Thomas C. Gauler, Monika Lindemann, Stephan Lang, Agnes Bankfalvi, Sven Brandau
Summary: Patients with HPV-related head and neck cancer have poorer outcomes after surgery and radiochemotherapy, possibly due to differences in immune status and immune activity. This study found differences in the frequency and ratio of MDSC and effector T cells between HPV+ and HPV- disease, providing new insights for more personalized immunotherapeutic approaches in the future.
CANCER IMMUNOLOGY IMMUNOTHERAPY
(2023)
Review
Oncology
Niki Gavrielatou, Ioannis Vathiotis, Panagiota Economopoulou, Amanda Psyrri
Summary: Host immunity plays a crucial role in cancer evolution, with a focus on B-cell involvement in head and neck cancer. The immune infiltrated status and immunosuppressive characteristics of the tumor microenvironment are key considerations, as PD-1/PD-L1 checkpoint inhibitors have revolutionized treatment. Further research on B-cell impact and potential biomarkers in cancer immunity is necessary for future therapeutic strategies.
Article
Oncology
Satoshi Yamada, Kiyoshi Misawa, Masato Mima, Atsushi Imai, Daiki Mochizuki, Taiki Yamada, Daichi Shinmura, Junya Kita, Ryuji Ishikawa, Yuki Yamaguchi, Yuki Misawa, Hideya Kawasaki, Hiroyuki Mineta
Summary: Telomere dysfunction is increasingly recognized as a biological marker in cancer progression. The study found that telomere shortening and low levels of 5-hydroxymethylcytosine and TET expression may contribute to the development of head and neck squamous cell carcinoma (HNSCC).
Article
Oncology
Jacob Gadwa, Thomas E. Bickett, Laurel B. Darragh, Michael William Knitz, Shilpa Bhatia, Miles Piper, Benjamin Van Court, Shiv Bhuvane, Diemmy Nguyen, Varuna Nangia, Emily K. Kleczko, Raphael A. Nemenoff, Sana D. Karam
Summary: Inhibition of complement C3a and C5a signaling in HNSCC accelerates tumor growth and increases regulatory T cell populations. Local C3a and C5a signaling is important for CD4 T cell homeostasis and development into effector phenotypes. Depletion of Tregs reverses tumor growth and combining Treg depletion with C3a and C5a receptor inhibition reduces tumor growth further.
JOURNAL FOR IMMUNOTHERAPY OF CANCER
(2021)
Article
Oncology
David S. Hong, Marcus O. Butler, Russell K. Pachynski, Ryan Sullivan, Partow Kebriaei, Sarah Boross-Harmer, Armin Ghobadi, Matthew J. Frigault, Ecaterina E. Dumbrava, Amy Sauer, Francine Brophy, Jean-Marc Navenot, Svetlana Fayngerts, Zohar Wolchinsky, Robyn Broad, Dzmitry G. Batrakou, Ruoxi Wang, Luisa M. Solis, Dzifa Yawa Duose, Joseph P. Sanderson, Andrew B. Gerry, Diane Marks, Jane Bai, Elliot Norry, Paula M. Fracasso
Summary: ADP-A2M10 is a safe and effective treatment for malignancies, with detectable presence in peripheral blood and tumor tissues, showing potential therapeutic effects for MAGE-A10 positive tumors.
FRONTIERS IN ONCOLOGY
(2022)
Review
Medicine, Research & Experimental
Marcelo Coutinho de Miranda, Mariane Izabella Abreu de Melo, Pricila da Silva Cunha, Jovino Gentilini Junior, Jerusa Araujo Quintao Arantes Faria, Michele Angela Rodrigues, Dawidson Assis Gomes
Summary: Head and neck cancer (HNC) is a common malignancy with high morbidity and mortality rates worldwide. The tumor microenvironment, which includes various cells regulating tumor development, plays a role in cancer progression and treatment response. Understanding the role of individual cells in tumor progression, particularly mesenchymal stromal cells (MSCs), remains a challenge due to the lack of specific markers and similarities with other stromal cells.
BIOMEDICINE & PHARMACOTHERAPY
(2021)
Review
Biochemistry & Molecular Biology
Yong Teng, Lixia Gao, Antti A. Makitie, Ewa Florek, Agata Czarnywojtek, Nabil F. Saba, Alfio Ferlito
Summary: This review discusses the relationship between ferroptosis and head and neck cancer treatment, including its conceptual framework, mechanism, functional aspects, and implications for tumor therapy. In addition, strategies for improving the efficacy of head and neck cancer treatment through modulation of ferroptosis are summarized.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Oncology
Rajdeep Chakraborty, Charbel Darido, Fei Liu, Maciej Maselko, Shoba Ranganathan
Summary: Immune therapies have shown promising results in the treatment of head and neck cancer by boosting the patient's immune system to fight tumor spread. This review highlights recent clinical success in the field of head and neck cancer immunotherapy, including the development of immune checkpoint inhibitors and a human papilloma virus vaccine. The review also emphasizes the importance of understanding basic biology and implementing personalized immunotherapy for better treatment outcomes.
Article
Multidisciplinary Sciences
Christiane S. Eberhardt, Haydn T. Kissick, Mihir R. Patel, Maria A. Cardenas, Nataliya Prokhnevska, Rebecca C. Obeng, Tahseen H. Nasti, Christopher C. Griffith, Se Jin Im, Xu Wang, Dong M. Shin, Mary Carrington, Zhuo G. Chen, John Sidney, Alessandro Sette, Nabil F. Saba, Andreas Wieland, Rafi Ahmed
Summary: The study identified different transcriptional subsets of HPV-specific CD8 T cells in HPV-positive head and neck cancer, highlighting the potential response to PD-1 blockade. Furthermore, the inclusion of E2 and E5 proteins in HPV therapeutic vaccines should be considered to elicit a broader tumor-reactive CD8 T cell response.
Meeting Abstract
Gastroenterology & Hepatology
Zhongren Zhou, Donna Russell, Irina Kalatskaya, Norman E. Marcon, Paul Krzyzanowsk, Maria Cirocco, Virginia Litle, Tony E. Godfrey, Lincoln D. Stein
Meeting Abstract
Gastroenterology & Hepatology
Sayak Ghatak, Amy LaLonde, Tanya Malhotra, Liana Toia, Derick Peterson, Tony E. Godfrey, Joseph Wizorek, Christian Peyre, Carolyn Jones, Eileen Redmond, Jeffrey Peters
Meeting Abstract
Surgery
Matthew R. Egyud, Stefanie S. Saunders, Anand K. Devaiah, Scharukh Jalisi, Tony E. Godfrey
JOURNAL OF THE AMERICAN COLLEGE OF SURGEONS
(2017)
Article
Cardiac & Cardiovascular Systems
Juan A. Munoz-Largacha, Adam C. Gower, Praveen Sridhar, Anita Deshpande, Carl J. O'Hara, Emiko Yamada, Tony E. Godfrey, Hiran C. Fernando, Virginia R. Litle
JOURNAL OF THORACIC AND CARDIOVASCULAR SURGERY
(2017)
Article
Biochemical Research Methods
Anders Stahlberg, Paul M. Krzyzanowski, Matthew Egyud, Stefan Filges, Lincoln Stein, Tony E. Godfrey
Article
Otorhinolaryngology
Matthew Egyud, Praveen Sridhar, Anand Devaiah, Emiko Yamada, Stefanie Saunders, Anders Stahlberg, Stefan Filges, Paul M. Krzyzanowski, Irina Kalatskaya, Wei Jiao, Lincoln D. Stein, Scharukh Jalisi, Tony E. Godfrey
HEAD AND NECK-JOURNAL FOR THE SCIENCES AND SPECIALTIES OF THE HEAD AND NECK
(2019)
Article
Cardiac & Cardiovascular Systems
Matthew Egyud, Mohamedtaki Tejani, Arjun Pennathur, James Luketich, Praveen Sridhar, Emiko Yamada, Anders Stahlberg, Stefan Filges, Paul Krzyzanowski, Jennifer Jackson, Irina Kalatskaya, Wei Jiao, Gradon Nielsen, Zhongren Zhou, Virginia Litle, Lincoln Stein, Tony Godfrey
ANNALS OF THORACIC SURGERY
(2019)
Article
Pathology
Hua-Jun He, Erica V. Stein, Yves Konigshofer, Thomas Forbes, Farol L. Tomson, Russell Garlick, Emiko Yamada, Tony Godfrey, Toshiya Abe, Koji Tamura, Michael Borges, Michael Goggins, Sandra Elmore, Margaret L. Gulley, Jessica L. Larson, Lando Ringel, Brian C. Haynes, Chris Karlovich, P. Mickey Williams, Aaron Garnett, Anders Stahlberg, Stefan Filges, Lynn Sorbara, Mathew R. Young, Sudhir Srivastava, Kenneth D. Cole
JOURNAL OF MOLECULAR DIAGNOSTICS
(2019)
Article
Surgery
Arjun Pennathur, Tony E. Godfrey, James D. Luketich
SURGICAL CLINICS OF NORTH AMERICA
(2019)
Article
Multidisciplinary Sciences
Stefan Filges, Emiko Yamada, Anders Stahlberg, Tony E. Godfrey
SCIENTIFIC REPORTS
(2019)
Meeting Abstract
Oncology
R. Garlick, Y. Konigshofer, M. Butler, M. Egyud, A. Stahlberg, T. Godfrey
CLINICAL & EXPERIMENTAL METASTASIS
(2018)
Article
Gastroenterology & Hepatology
Chunhong Pang, Amy LaLonde, Tony E. Godfrey, Jianwen Que, Jun Sun, Tong Tong Wu, Zhongren Zhou
CLINICAL AND EXPERIMENTAL GASTROENTEROLOGY
(2017)
Meeting Abstract
Oncology
Stefanie S. Saunders, Matthew Egyud, Anand Devaiah, Scharukh Jalisi, Tony Godfrey
CLINICAL CANCER RESEARCH
(2017)
Meeting Abstract
Pathology
Y. Konigshofer, M. Egyud, T. Godfrey, B. Anekella, H. Safran, J. Wands, R. Garlick
JOURNAL OF MOLECULAR DIAGNOSTICS
(2017)
Meeting Abstract
Oncology
Matthew Egyud, Jennifer Jackson, Emiko Yamada, Anders Stahlberg, Paul Krzyzanowski, Virginia Litle, Lincoln Stein, Tony Godfrey