Article
Oncology
Xiaoyan Bai, Xiao Jiang, Yuting Liu, Yiting Wang, Xuewei Jiang, Guang Song, Hongmei Qiu, Qinggao Zhang
Summary: The aberrant expression of KLF9 is frequently found in certain types of cancer and is implicated in cancer initiation and progression. This study demonstrated that KLF9 inhibits breast cancer cell migration and invasion by activating the E-cadherin promoter. KLF9 also suppresses lung metastasis of breast cancer and upregulates E-cadherin expression in breast cancer cells, providing new insights into potential aggressive treatment strategies for breast cancer targeting the KLF9/E-cadherin axis.
AMERICAN JOURNAL OF CANCER RESEARCH
(2021)
Article
Obstetrics & Gynecology
Nora Karsten, Thomas Kolben, Sven Mahner, Susanne Beyer, Sarah Meister, Christina Kuhn, Elisa Schmoeckel, Rachel Wuerstlein, Nadia Harbeck, Nina Ditsch, Udo Jeschke, Klaus Friese, Theresa Maria Kolben
Summary: The study revealed that increased E-Cadherin expression in primary tumor tissue of breast cancer patients is associated with poor prognosis, contrary to previous beliefs that loss of E-Cadherin promotes metastasis and invasiveness.
ARCHIVES OF GYNECOLOGY AND OBSTETRICS
(2022)
Article
Oncology
Jiming Tian, Xiaolei Liang, Dalin Wang, Jinglin Tian, Haiping Liang, Ting Lei, Zeyu Yan, Dan Wu, Xiaoli Liu, Shujuan Liu, Yongxiu Yang
Summary: This study found that TBC1D2 is upregulated in ovarian cancer (OC) and promotes tumor metastasis through E-cadherin degradation. Additionally, miR-373-3p inhibits OC cell invasion by negatively regulating TBC1D2.
FRONTIERS IN ONCOLOGY
(2022)
Article
Multidisciplinary Sciences
Tobias Wijshake, Zhongju Zou, Beibei Chen, Lin Zhong, Guanghua Xiao, Yang Xie, John G. Doench, Lynda Bennett, Beth Levine
Summary: The study revealed previously unrecognized cooperation between Beclin 1 and E-cadherin in mediating tumor suppression in breast cancer cells.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2021)
Article
Oncology
Rania Alaaeldin, Gamal El-Din A. Abuo-Rahma, Qing-Li Zhao, Moustafa Fathy
Summary: The new ciprofloxacin chalcone showed significant inhibitory effects on the proliferation, migration, and colony formation abilities of MCF-7 and MDA-MB-231 breast cancer cell lines. It induced apoptosis and cell cycle arrest, while also regulating the expression of apoptotic and anti-apoptotic factors and inhibiting epithelial-mesenchymal transition.
ANTICANCER RESEARCH
(2021)
Article
Biochemistry & Molecular Biology
Thomas Brock, Elisabeth Boudriot, Anke Klawitter, Marianne Grosser, Trang T. P. Nguyen, Sindy Giebe, Erik Klapproth, Achim Temme, Ali El-Armouche, Georg Breier
Summary: VE-cadherin enhances the adhesion of breast cancer cells to endothelial cells but does not affect their transmigration, indicating that cancer cell adhesion and incorporation are distinct processes governed by different molecular mechanisms.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Oncology
Xiao-Qing Li, Rui Zhang, Hong Lu, Xiao-Min Yue, Yu-Fan Huang
Summary: This study provides mechanistic insights into the generation of an osteogenic premetastatic niche by breast cancer-derived EVs and identifies potential EV-derived diagnostic biomarkers and targets for breast cancer bone metastasis.
Article
Oncology
Qing Li, Zhi-Wei Zhou, Wei Duan, Cheng-Yuan Qian, Shu-Nan Wang, Meng-Sheng Deng, Dan Zi, Jian-Min Wang, Cheng-Yi Mao, Guanbin Song, Dong Wang, Kenneth D. Westover, Cheng-Xiong Xu
Summary: High APE1 expression is associated with lymph node metastasis in cervical cancer and linked to epithelial to mesenchymal transition (EMT). APE1 promotes invasion and metastasis of cervical cancer cells, while inhibiting APE1 may suppress EMT. Targeting APE1 redox function could be a novel strategy for inhibiting cervical cancer metastasis.
JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH
(2021)
Article
Oncology
Meng Luo, Jinfan Li, Qi Yang, Song Xu, Kun Zhang, Jing Chen, Suzhan Zhang, Shu Zheng, Jiaojiao Zhou
Summary: This study identifies N4BP3 as a new regulator that promotes breast cancer metastasis by regulating the ubiquitination and degradation of E-cadherin. It uncovers an unprecedented role for N4BP3 in breast cancer metastasis and elucidates the underlying molecular mechanisms.
Article
Oncology
Alison E. Obr, Joseph J. Bulatowicz, Yun-Juan Chang, Virginia Ciliento, Alexander Lemenze, Krystopher Maingrette, Quan Shang, Emily J. Gallagher, Derek LeRoith, Teresa L. Wood
Summary: The reduction of IGF1R expression is associated with the upregulation of pathways necessary for promoting metastasis in breast cancer. Functional analysis reveals that decreased IGF1R signaling leads to a dysregulation of cadherin expression, resulting in reduced cell adhesion.
FRONTIERS IN ONCOLOGY
(2022)
Article
Cell Biology
Xiaoqing Wan, Jiaxin Hou, Shurong Liu, Yanli Zhang, Wenqing Li, Yanru Zhang, Yi Ding
Summary: Resistance to anthracyclines, such as doxorubicin, is commonly observed in ER alpha-positive breast cancer patients. EMT plays a role in chemotherapy-induced drug resistance, with ER alpha-positive cells showing lower sensitivity to doxorubicin compared to ER alpha-negative cells. The regulation of E-cadherin expression in response to doxorubicin treatment varies depending on ER alpha status, with potential implications for treatment strategies.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Oncology
John Alexander, Odette Mariani, Celine Meaudre, Laetitia Fuhrmann, Hui Xiao, Kalnisha Naidoo, Andrea Gillespie, Ioannis Roxanis, Anne Vincent-Salomon, Syed Haider, Rachael Natrajan
Summary: This study found that invasive lobular breast cancers with heterogeneous E-cadherin expression are composed of different components with a common ancestor. CDH1 gene mutations and loss of E-cadherin protein expression are characteristic of these tumors. Regardless of E-cadherin protein expression, these tumors should be considered part of the spectrum of invasive lobular breast cancers.
Article
Oncology
Rui Chi, Chengcheng Yao, Si Chen, Yunxia Liu, Yanqi He, Jin Zhang, Lesley G. Ellies, Xuefeng Wu, Qian Zhao, Cixiang Zhou, Ying Wang, Haipeng Sun
Summary: The elevated levels of BCAAs can suppress tumor growth and lung metastasis of breast cancer. The expression of BCAA catabolic genes is associated with the long-term outcomes in breast cancer patients.
FRONTIERS IN ONCOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Somayeh Sedaghati Burkhani, Mahdieh Salimi
Summary: The study found that miR-888 is significantly upregulated in breast cancer patients, while E-cadherin expression is downregulated. miR-888 has an inverse correlation with E-cadherin mRNA levels and is significantly increased in nodal involvement and distant metastasis status.
GENETIC TESTING AND MOLECULAR BIOMARKERS
(2022)
Article
Cell Biology
Bo-Wen Liu, Ning Sun, Hui Lin, Xue-Jie Zhou, Hai-Yan Ma, Xin Wang, Xu-Chen Cao, Yue Yu
Summary: This study reveals the role and molecular mechanism of PLD3 and its embedded miR-6796 in breast cancer proliferation, providing important clues and a theoretical foundation for future research and development of therapeutic targets and prognostic markers for breast cancer.
CELL DEATH & DISEASE
(2023)
Review
Biochemistry & Molecular Biology
Rizwana Afroz, E. M. Tanvir, Mousumi Tania, Junjiang Fu, Mohammad Amjad Kamal, Md. Asaduzzaman Khan
Summary: This review article focuses on the role of toll-like receptors (TLRs), particularly TLR4, in breast cancer. TLRs are widely investigated pattern recognition receptors and TLR4 is the most studied TLR, associated with the development of various cancers, including breast cancer. Activation of TLR4 occurs through the binding of its ligand lipopolysaccharide (LPS), leading to gene expression related to cancer cell proliferation, survival, invasion, and metastasis. The role of TLR4 in breast cancer growth, invasion, and metastasis is attracting significant attention in oncology research, with potential for therapeutic applications.
CURRENT MEDICINAL CHEMISTRY
(2022)
Article
Multidisciplinary Sciences
Jingliang Cheng, Binghui Song, Jiewen Fu, Xiaoli Zheng, Tao He, Junjiang Fu
Summary: The study utilized 19 autosomal STRs to examine allele frequencies and forensic parameters of the Yi ethnic group in unrelated individuals, which could be valuable for individual identification, paternity testing, and genetic population analyses.
SCIENTIFIC REPORTS
(2021)
Article
Cell Biology
Chunli Wei, Hui Zou, Ting Xiao, Xiaoyan Liu, Qianqian Wang, Jingliang Cheng, Shangyi Fu, Jiangzhou Peng, Xin Xie, Junjiang Fu
Summary: The study demonstrates that TQFL12, a novel derivative of TQ, shows stronger anti-proliferative effects against TNBC cells and lower toxicity in both in vitro and in vivo studies, affecting various aspects of breast cancer development. Additionally, TQFL12 inhibited tumor growth and metastasis in a mouse model, with mechanism research indicating an increase in AMPK/ACC activity.
JOURNAL OF CELLULAR AND MOLECULAR MEDICINE
(2021)
Article
Biochemistry & Molecular Biology
Ju Zhou, Saber Imani, Marzieh Dehghan Shasaltaneh, Shuguang Liu, Tao Lu, Junjiang Fu
Summary: This study evaluated the antitumor effect of thymoquinone, an active component in Nigella sativa, on two PIK3CA hotspot mutations in breast cancer cells and investigated the mechanistic effects of these mutations on the PI3K/Akt1 pathway using molecular dynamics. The findings demonstrated that the mutations reduced the inhibitory effect of Delta Np63 alpha on PIK3CA, leading to enhanced activity of the PI3K downstream signals.
MOLECULAR BIOLOGY REPORTS
(2022)
Article
Oncology
Md. Asaduzzaman Khan, Meiling Zheng, Jiewen Fu, Mousumi Tania, Jun Li, Junjiang Fu
Summary: This study identified IL17RD as a novel target of Thymoquinone (TQ) in triple negative breast cancer (TNBC) cells. TQ treatment inhibited the growth and migration of TNBC cells, and IL17RD overexpression in combination with TQ treatment showed the most effective anti-TNBC effects. Higher expression of IL17RD was associated with longer survival in TNBC patients.
Review
Biochemistry & Molecular Biology
Binghui Song, Shiyi Shen, Shangyi Fu, Junjiang Fu
Summary: HSPA6, a member of the HSP70 family, plays a role in tumorigenesis, tumor progression, and non-tumor-related diseases. Its exact roles and mechanisms are still unclear. This article reviews the structure, expression, function, research progress, and potential role of HSPA6 in cancers and other diseases.
MOLECULAR BIOLOGY REPORTS
(2022)
Review
Chemistry, Medicinal
Ali H. El-Far, Soad K. Al Jaouni, Xiaotao Li, Junjiang Fu
Summary: Glycolysis is a primary energy source for cancer growth and metastasis, and inhibiting glycolysis is an effective cancer control strategy. PKM2, a key glycolytic enzyme, is overexpressed in various cancer types, and natural PKM2 inhibitors have potential therapeutic effects.
PHYTOTHERAPY RESEARCH
(2022)
Article
Biochemistry & Molecular Biology
Jiewen Fu, Shuguang Liu, Qi Tan, Zhiying Liu, Jie Qian, Ting Li, Jiaman Du, Binghui Song, Dabing Li, Lianmei Zhang, Jiayue He, Kan Guo, Baixu Zhou, Hanchun Chen, Shangyi Fu, Xiaoyan Liu, Jingliang Cheng, Tao He, Junjiang Fu
Summary: TMPRSS2 plays important roles in cancer and COVID-19, with high expression associated with poor prognosis in certain cancers and low expression associated with COVID-19 severity. TMPRSS2 mutations are common in prostate cancer and are associated with better survival rates. Small molecules can inhibit TMPRSS2 expression in cancer cells, potentially offering a therapeutic strategy for preventing COVID-19 in cancer patients.
Article
Cell Biology
Chunli Wei, Yun Liu, Xiaoyan Liu, Jingliang Cheng, Jiewen Fu, Xiuli Xiao, Robb E. Moses, Xiaotao Li, Junjiang Fu
Summary: This study reveals a new mechanism by which SPOP regulates TWIST1 degradation in breast cancer, suppressing cancer cell migration and invasion. The expression levels of SPOP and TWIST1 are closely associated with the prognosis of breast cancer patients, particularly those with metastatic triple-negative breast cancer.
CELL DEATH DISCOVERY
(2022)
Article
Biochemistry & Molecular Biology
Lisha Yang, Jiewen Fu, Jingliang Cheng, Baixu Zhou, Xiaoyan Liu, Songyot Anuchapreeda, Junjiang Fu
Summary: A novel pathogenic variant in the NF1 gene was identified in a large Chinese pedigree with NF1 disorder, expanding the NF1 mutation spectrum. Additionally, the expression of NF1 showed low tissue specificity in different human tissues, which may impact the phenotypes of multiple organs.
MOLECULAR BIOLOGY REPORTS
(2023)
Article
Biochemistry & Molecular Biology
Jiayue He, Shuguang Liu, Qi Tan, Zhiying Liu, Jiewen Fu, Ting Li, Chunli Wei, Xiaoyan Liu, Zhiqiang Mei, Jingliang Cheng, Kai Wang, Junjiang Fu
Summary: This study evaluated the inhibitory effects of cordycepin, thymoquinone, and N6, N6-dimethyladenosine on ADAM17 in cancer cells and predicted their potential in anti-COVID-19 therapy. The results showed that these compounds suppressed the expression of ADAM17 and had potential against SARS-CoV-2. Pharmacological analysis indicated that ADAM17 might be a target for anti-COVID-19 therapy with these compounds.
Review
Medicine, Legal
Binghui Song, Jie Qian, Junjiang Fu
Summary: Epigenetic markers, particularly non-coding RNAs (ncRNAs) such as miRNA, circRNA, lncRNA, and piRNA, have been extensively studied in forensic medicine due to their unique mode of inheritance. They offer potential strategies and methods for tissue and body fluid identification, cause-of-death analysis, time-related estimation, age estimation, and monozygotic twin identification. This review discusses the research progress, application status, and the value of ncRNAs in forensic practice.
INTERNATIONAL JOURNAL OF LEGAL MEDICINE
(2023)
Article
Biochemistry & Molecular Biology
Ting Li, Qi Tan, Chunli Wei, Hui Zou, Xiaoyan Liu, Zhiqiang Mei, Pengfei Zhang, Jingliang Cheng, Junjiang Fu
Summary: TQFL12, a novel derivative of Thymoquinone (TQ) extracted from Nigella sativa seeds, was found to be more effective in treating TNBC than TQ. Through in vivo experiments, it was discovered that TQFL12 had significantly lower acute toxicity than TQ, possibly through the AMPK signaling pathway.
Article
Genetics & Heredity
Binghui Song, Jiewen Fu, Jie Qian, Lisha Yang, Jingliang Cheng, Junjiang Fu
Summary: This study evaluated 21 autosomal STR loci in 1959 Han-Chinese individuals from Luzhou area and found no substantial linkage disequilibrium among the markers. These loci were in Hardy-Weinberg equilibrium and had high discrimination power and exclusion probability. The results suggest that historical influences, geographical distribution, cultural integration, and economic development may impact the Luzhou Han population and other Chinese populations.
Article
Genetics & Heredity
Jiewen Fu, Binghui Song, Jie Qian, Ting He, Hanchun Chen, Jingliang Cheng, Junjiang Fu
Summary: This study analyzed the Y-STRs genetic data of male individuals from the Han population in Luzhou, demonstrating high polymorphism. Comparisons with 11 other related Han populations revealed close genetic relationships between Luzhou Han people and Han populations in Sichuan, Guangdong, and Hunan, consistent with geographical distribution, historical influence, and economic development. These findings are of great value for forensic applications and population genetics research.