Article
Nutrition & Dietetics
Muhammad Abaidullah, Shaokai La, Mengqi Liu, Boshuai Liu, Yalei Cui, Zhichang Wang, Hao Sun, Sen Ma, Yinghua Shi
Summary: This study demonstrates the protective effects of polysaccharides from Smilax glabra on intestinal mucosal injury and the regulation of gut flora and innate immune functions. It provides a novel potential treatment for inflammatory bowel disease and sheds light on the symbiotic associations between host immune mechanisms and the gut microbiome.
Article
Plant Sciences
Peerapong Jeeno, Sukit Tongban, Pichamon Yana, Anurak Wongta, Kunrunya Sutan, Sumed Yadoung, Surat Hongsibsong
Summary: Phytochemicals extracted from Smilax glabra and Smilax corbularia were identified and found to have antioxidant and antimicrobial activities. These plants can be potential sources of antioxidants and herbal medicines for treating Gram-positive bacterial infections.
Article
Biochemistry & Molecular Biology
Tingwei Wang, Yongli Ye, Jian Ji, Shuang Zhang, Xingxing Yang, Jiayuan Xu, Jia-Sheng Wang, Zhiyuan Chen, Bangen Xia, Hongfang Shen, Ruowei Xia, Wenqin Shi, Xiulan Sun
Summary: Astilbin consumption has significant anti-obesity and anti-inflammatory effects in high-fat diet mice. It improves gut microbial dysbiosis, enhances intestinal carbohydrate and lipid metabolism, and protects the integrity of the intestinal barrier. Astilbin is a potential prebiotic for the prevention of gut-liver axis damage and metabolic disruption in obese individuals.
Article
Biochemistry & Molecular Biology
Sheng-Nan Yuan, Cai-Yun Feng, Yao Rong, Xu Guo, Ying-Ying Chen, M. Fraga-Corral, Miguel A. Prieto, Xiao-Yue Zhang, Ning-Yang Li, Chao Liu, Jin-Yue Sun
Summary: This study investigated the immunomodulatory potential of nervonic acid (NA) on murine RAW264.7 macrophages. The effects of NA were evaluated through various assays and techniques, including assessment of nitric oxide levels, cytokine secretion, phagocytic activity, reactive oxygen species generation, and NF-κB signaling pathway. The results showed that NA can promote the production of NO, TNF-α, IL-1β, IL-6, and ROS in RAW264.7 cells, and upregulate the expression of iNOS, TNF-α, IL-1β, and IL-6 mRNA. Additionally, NA increased the expression of TLR4 protein and the phosphorylation level of NF-κB in a concentration-dependent manner. In conclusion, NA has immunomodulatory potential by activating the NF-κB signaling pathway through the TLR4 signaling pathway.
JOURNAL OF FOOD BIOCHEMISTRY
(2023)
Article
Biochemistry & Molecular Biology
Nan Ma, Subramanian Palanisamy, Khamphone Yelithao, Natchanok Talapphet, Yutong Zhang, Lee Dae-Hee, Il-Shik Shin, Dong-Jin Lee, SangGuan You
Summary: A water-soluble polysaccharide (GFP) was isolated from Grateloupia filicina and showed immunostimulatory activity on RAW264.7 macrophages by releasing nitric oxide (NO) and various cytokines via NF-κB and MAPK signaling pathways. GFP-1, one of its fractions, highly stimulated the activation of RAW264.7 cells, mainly through TLR-2 and TLR-4 binding receptors.
CHEMICAL BIOLOGY & DRUG DESIGN
(2023)
Article
Biochemistry & Molecular Biology
Yaoguang Huang, Yongli Ye, Deping Xu, Jian Ji, Jiadi Sun, Mengqi Xu, Bangen Xia, Hongfang Shen, Ruowei Xia, Wenqin Shi, Xiulan Sun
Summary: Crude polysaccharides from Smilax glabra were screened and a neutral polysaccharide S1 with anti-inflammatory activity was identified. S1 consisted mainly of rhamnose, arabinose, galactose, glucose, xylose, and mannose and showed inhibitory effects on pro-inflammatory factors.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2023)
Article
Chemistry, Applied
Jing Li, Yingxiu Zhang, Wenfang Jin, Yue Wang, Li Yang, Zhifeng Zhang, Zhigang Yan
Summary: Zein-lecithin-TFSG complex nanoparticles (Z-L-TFSG NPs) were successfully prepared in this study using the anti-solvent coprecipitation technique. These nanoparticles showed superior stability and controlled release characteristics, improved the antioxidant capacity of TFSG in vitro, and enhanced its protective effects against oxidative damage to HepG2 cells.
Review
Chemistry, Medicinal
Hao Wu, Yu Wang, Bing Zhang, Yao-lei Li, Zhi-xin Ren, Jing-jian Huang, Zhi-qi Zhang, Zhi-jian Lin, Xiao-meng Zhang
Summary: This review examines the medicinal properties and pharmacological effects of Smilax glabra Roxb. The plant contains a variety of chemical components and exhibits a wide range of pharmacological activities. However, current research is limited to crude extracts and active ingredients, lacking sufficient clinical and toxicity studies.
DRUG DESIGN DEVELOPMENT AND THERAPY
(2022)
Article
Chemistry, Organic
Kyohei Nitta, Taiki Kuribara, Kiichiro Totani
Summary: This study revealed the branch specificity of ER alpha-1,2-mannosidases by discriminating different inner glycosides, which can differentiate between the glycoproteins' branches.
ORGANIC & BIOMOLECULAR CHEMISTRY
(2021)
Article
Chemistry, Applied
Yang Xu, Na Zhang, Liangliang Xiong, Dejuan Sun, Zhuangzhuang Chen, Lixia Chen
Summary: A new compound was isolated from the rhizome of Smilax china, along with twelve known compounds for the first time. The structure of the new compound was elucidated based on chemical evidences and spectral data analysis. In addition, the inhibitory effects of the compounds on NO production were tested, and compound 7 showed significant inhibitory effect.
NATURAL PRODUCT RESEARCH
(2023)
Article
Chemistry, Applied
Youjiao Wu, Lili He, Yi Yang, Zhigang Yan, Zhifeng Zhang, Xiaojun Yao, Pei Luo
Summary: Fresh Smilax glabra showed promising anti-inflammatory effect, with astilbin identified as the main bioactive compound responsible for its activity. However, heat processing led to isomerization of astilbin, resulting in decreased anti-inflammatory activity.
Article
Immunology
Ruigang Zhou, Ling Teng, Yongjian Zhu, Chenglong Zhang, Yuhui Yang, Yun Chen
Summary: The study successfully prepared Amomum longiligulare polysaccharides 1 (ALP1) into nanoparticles (ALPP) with optimal preparation conditions of volume ratios and F68 concentration. ALPP demonstrated controlled and sustained release, as well as a better activation effect on macrophages compared to ALP1.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2021)
Article
Plant Sciences
Yan Liu, Qi-Zhang Li, Liu-Ding-Ji Li, Xuan-Wei Zhou
Summary: The study revealed that the intracellular polysaccharides from O. sinensis have immunomodulatory effects on macrophages by regulating the mRNA expression of pro-inflammatory and anti-inflammatory cytokines, activating macrophages, and improving phagocytosis. This effect is mediated through MAPK and PI3K/Akt signaling pathways.
JOURNAL OF ETHNOPHARMACOLOGY
(2021)
Article
Endocrinology & Metabolism
Chenyuan Luo, Yuming Wei, Shuzhen Li, Chunjun Li, Honglai Zheng
Summary: This study found that various solvent extracts from the rhizome of Imperata cylindrica possess antioxidant capacity and anti-inflammatory activity, which may be provoked by suppressing the NF-kappa B and activating the Nrf2. Therefore, the rhizome of Imperata cylindrica has the potential to develop new therapeutic agents for treating inflammatory diseases.
JOURNAL OF BIOLOGICAL REGULATORS AND HOMEOSTATIC AGENTS
(2022)
Article
Biochemistry & Molecular Biology
Lei Zhao, Ziyan Qi, Ling Yi, Jingjing Li, Yadong Cui, Faiz Ur Rehman, Jianhua Yang, Jiangyun Liu, Yali Li, Jian Zhang
Summary: The study revealed that the flavonoid extract from Smilax glabra Roxb. (FSGR) could modulate gut dysbiosis induced by high-fat diet (HFD) in a rat model of fatty liver, suggesting its potential as a prebiotic agent to combat metabolic disorders associated with fatty liver.
Article
Engineering, Chemical
Mehdi Alboofetileh, Masoud Rezaei, Mehdi Tabarsa, SangGuan You
JOURNAL OF FOOD PROCESS ENGINEERING
(2019)
Article
Biochemistry & Molecular Biology
Mehdi Alboofetileh, Masoud Rezaei, Mehdi Tabarsa, SangGuan You, Francesco Mariatti, Giancarlo Cravotto
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2019)
Article
Biochemistry & Molecular Biology
Utoomporn Surayot, Khamphone Yelithao, Mehdi Tabarsa, Dae-Hee Lee, Subramanian Paianisamy, Narayanasamy Marimuthu Prabhu, Juhun Lee, SangGuan You
PROCESS BIOCHEMISTRY
(2019)
Article
Chemistry, Applied
Mehdi Tabarsa, SangGuan You, Khamphone Yelithao, Subramanian Palanisamy, Narayanasamy Marimuthu Prabhu, Ma Nan
CARBOHYDRATE POLYMERS
(2020)
Article
Biochemistry & Molecular Biology
Maryam Alavi, Mehdi Tabarsa, SangGuan You, Hassan Ahmadi Gavlighi
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2020)
Article
Pharmacology & Pharmacy
Muthushanmugam Manikandakrishnan, Subramanian Palanisamy, Manoharan Vinosha, Baskaran Kalanjiaraja, Sonaimuthu Mohandoss, Ramar Manikandan, Mehdi Tabarsa, SangGuan You, Narayanasamy Marimuthu Prabhu
JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY
(2019)
Article
Biochemistry & Molecular Biology
Mehdi Tabarsa, Elham Hashem Dabaghian, SangGuan You, Khamphone Yelithao, RongAn Cao, Masoud Rezaei, Mehdi Alboofetileh, Seraj Bita
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2020)
Article
Biotechnology & Applied Microbiology
Baskaran Babu, Subramanian Palanisamy, Manoharan Vinosha, Ravichandran Anjali, Ponnuchamy Kumar, Boomi Pandi, Mehdi Tabarsa, SangGuan You, Narayanasamy Marimuthu Prabhu
BIOPROCESS AND BIOSYSTEMS ENGINEERING
(2020)
Article
Chemistry, Applied
Mehdi Tabarsa, Elham Hashem Dabaghian, SangGuan You, Khamphone Yelithao, Subramanian Palanisamy, Narayanasamy Marimuthu Prabhu, Changsheng Li
CARBOHYDRATE POLYMERS
(2020)
Article
Biochemistry & Molecular Biology
Rong-An Cao, RuiXue Ji, Mehdi Tabarsa, Subramanian Palanisamy, Natchanok Talapphet, Khamphone Yelithao, ChangYuan Wang, SangGuan You
JOURNAL OF FOOD BIOCHEMISTRY
(2020)
Article
Biochemistry & Molecular Biology
Manoharan Vinosha, Subramanian Palanisamy, Ravichandran Anjali, Changsheng Li, Khamphone Yelithao, Thangapandi Marudhupandi, Mehdi Tabarsa, SangGuan You, Narayanasamy Marimuthu Prabhu
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2020)
Article
Biochemistry & Molecular Biology
Rong-An Cao, RuiXue Ji, Mehdi Tabarsa, JianQiang Zhang, LingQi Meng, ChengTai Zhang, JiaMiao Zhang, LiDong Wang, Rui Wu, ChangYuan Wang, ChengHao Jin, SangGuan You
Summary: The polysaccharide extracted from A. asphodeloides rhizomes consists of neutral sugars, uronic acids, and sulfate esters, showing stimulating effects on cell production and significant inhibitory effects on cancer cell lines, indicating potential medicinal and functional food applications.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2021)
Article
Microbiology
Utoomporn Surayot, Sutee Wangtueai, SangGuan You, Subramanian Palanisamy, Warawut Krusong, Charles S. Brennan, Francisco J. Barba, Yuthana Phimolsiripol, Phisit Seesuriyachan
Summary: This study aimed to extract and fractionate mucilage polysaccharides from Amanita hemibapha subspecies javanica, which are mainly composed of carbohydrates with minor amounts of proteins and sulphates. The polysaccharides were found to stimulate immune responses through the activation of NF-κB and MAPK pathways, suggesting their potential as functional ingredients in food products.
Article
Microbiology
Utoomporn Surayot, Sutee Wangtueai, Sangguan You, Charin Techapun, Yuthana Phimolsiripol, Noppol Leksawasdi, Warawut Krusong, Francisco J. Barba, Phisit Seesuriyachan
Summary: This study isolated mucilage polysaccharide from Amanita hemibapha subspecies javanica and tested its immune-enhancing properties on RAW264.7 and NK cells. The results showed that the molecular weight of polysaccharide derivatives plays a key role in cell stimulation, with sulphate derivatives significantly influencing NK cell activation.
Article
Biochemistry & Molecular Biology
Avudaiyan Muthamil Selvi, Subramanian Palanisamy, Singaram Jeyanthi, Manoharan Vinosha, Sonaimuthu Mohandoss, Mehdi Tabarsa, SangGuan You, Ethiraj Kannapiran, Narayanasamy Marimuthu Prabhu
PROCESS BIOCHEMISTRY
(2020)
Article
Biochemistry & Molecular Biology
Wei-Han Hui, Yen-Lin Chen, Shu-Wei Chang
Summary: Crosslinking affects the mechanical behavior and tissue metabolism of collagen-based tissues. Aging and diabetes alter the crosslinking type and density, thus changing tissue properties. High-connectivity enzymatic crosslinking and advanced-glycation end-products result in uniform deformation under daily activity, while low-connectivity enzymatic crosslinking does not. High-connectivity model displays more sliding, while AGEs induce instability in structures near the binding sites.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
Article
Biochemistry & Molecular Biology
Yao-Bin Ma, Xiao-Qiu Zhou, Wei-Dan Jiang, Pei Wu, Yang Liu, Shu-Wei Li, Ling Tang, Lu Zhang, Hai-Feng Mi, Lin Feng
Summary: Tea polyphenols (TPs) are an inexpensive feed additive that can protect the gill function of fish against Flavobacterium columnare (F. columnare) through various mechanisms, including suppression of oxidative stress, apoptosis, and inflammation.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
Article
Biochemistry & Molecular Biology
Yan-Jia Guo, Jing-Ru Pang, Yu Zhang, Zhong-Rui Li, Xiao-Lin Zi, Hong-Min Liu, Ning Wang, Li-Juan Zhao, Ya Gao, Bo Wang, Piet Herdewijn, Cheng-Yun Jin, Ying Liu, Yi-Chao Zheng
Summary: This study identifies the conjugation of NEDD8 to LSD1 and its impact on GC cells, revealing the significance of LSD1 neddylation in GC.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
Review
Biochemistry & Molecular Biology
Geum-Jae Jeong, Fazlurrahman Khan, Nazia Tabassum, Young-Mog Kim
Summary: Vibrio species are motile gram-negative bacteria commonly found in aquatic environments. They can adapt to environmental fluctuations and develop protective mechanisms against host immune systems. Different types of sigma and anti-sigma factors play important roles in regulating gene expression and virulence in Vibrio species.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
Article
Biochemistry & Molecular Biology
Zahra Mohammadbagheri, Behrooz Movahedi, Shaghayegh Saeedi, Abbas Rahmati
Summary: In this study, a reusable biobased composite hydrogel was successfully synthesized and used for the removal of Tl(I) from aqueous solutions. The hydrogel exhibited high adsorption capacity and thermal stability, and the adsorption process was found to be thermodynamically spontaneous. The results demonstrated that the hydrogel can be reused multiple times without significant loss of its adsorption capacity.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
Article
Biochemistry & Molecular Biology
Iqra Batool, Muhammad Imran, Ayesha Anwar, Farhan Ahmed Khan, Afrah E. Mohammed, Ashwag Shami, Hafiz Iqbal
Summary: Enzyme immobilization on ZnO/SnO2 and ZnO/SnO2/SA nanocomposites was studied, and the catalytic and biochemical characteristics of the immobilized enzyme were investigated. The results showed that ZnO/SnO2 and ZnO/SnO2/SA nanostructures are suitable carriers for enzyme immobilization.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
Article
Biochemistry & Molecular Biology
Elias Mosaffa, Dhruvi Patel, Nasim Amiri Ramsheh, Rishikumar Indravadan Patel, Atanu Banerjee, Hossein Ghafuri
Summary: In this study, a unique 3D bead structure of adsorbent, composed of bacterial cellulose microfilaments reinforced chitosan adorned with melamine 2D plates, was synthesized for anionic dye removal. The adsorbent showed high specific surface area and abundant functional groups, resulting in exceptional adsorption capacity. The characteristics and optimal conditions of the adsorbent were assessed and analyzed.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
Article
Biochemistry & Molecular Biology
Carolina Gismene, Jorge Enrique Hernandez Gonzalez, Marilia de Freitas Calmon, Andrey Fabricio Ziem Nascimento, Angela Rocio Nino Santisteban, Felipe Antunes Calil, Alana Della Torre da Silva, Paula Rahal, Rejane Maira Goes, Raghuvir Krishnaswamy Arni, Ricardo Barros Mariutti
Summary: Mammaliicoccus sciuri, a bacterium of clinical and veterinary relevance, expresses the virulence factor Exfoliative Toxin C (ExhC), which binds specifically to desmoglein-1 (Dsg1) and plays a role in tissue integrity. This study investigates the necrotic activity of ExhC and identifies a variant lacking necrotic potential but retaining enzymatic activity through mutagenesis experiments and crystal structure determination.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
Article
Biochemistry & Molecular Biology
Bibhas K. Bhunia, Ashutosh Bandyopadhyay, Souradeep Dey, Biman B. Mandal
Summary: Intervertebral disc degeneration is a major cause of chronic low back pain and disability. Researchers have developed a bioactive silk-based hybrid hydrogel system functionalized with decellularized human Wharton's jelly extracellular matrix as bioactive cues. The hydrogels mimic the rheological and mechanical properties of the native nucleus pulposus tissue and support cell viability, proliferation, and tissue maturation.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
Article
Biochemistry & Molecular Biology
Qun Zhang, Yonggan Yan, Zhao Li, Jing Du, Kai Zhang, Liguo Zhang, Ting Wang, Alberto Bianco, Shaohua Ge, Baojin Ma
Summary: A new crosslinking strategy has been devised to construct injectable sodium alginate hydrogels, which can be regulated for injectability and have great potential in biomedical applications.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
Article
Biochemistry & Molecular Biology
Seong Eun Hong, Ji-Soo Lee, Hyeon Gyu Lee
Summary: The potential of multi-layer nanoemulsions for improving the cellular uptake, antioxidant activity, and in vitro bioaccessibility of alpha-tocopherol was examined. The results showed that the multi-layer nanoemulsions significantly enhanced the cellular uptake and antioxidant activity of alpha-tocopherol compared to free coumarin 6. Furthermore, the use of chitosan and dextran sulfate as wall materials in the multi-layer nanoemulsions led to even higher cellular uptake, in vitro bioaccessibility, and antioxidant activity of alpha-tocopherol.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
Article
Biochemistry & Molecular Biology
Jingjing Yu, Yanhui Zhang, Ruoning Zhang, Yanxiang Gao, Like Mao
Summary: High internal phase emulsions (HIPEs) based on beeswax (BW) oleogels and octenyl succinic acid starch (OSA starch) were prepared by a simple one-step method. The results showed that oleogelation improved the stability and encapsulation capability of the HIPEs, which is significant for the development of novel healthy food.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
Review
Biochemistry & Molecular Biology
Bi-Feng Yao, Xiu-Ju Luo, Jun Peng
Summary: The balanced and continuous fission and fusion of mitochondria, regulated by OPA1, are important for maintaining mitochondrial dynamics in cardiovascular disorders. Understanding the role of OPA1 in mitochondrial fusion can provide insights into the pathogenesis of cardiovascular diseases.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
Review
Biochemistry & Molecular Biology
Gokul Paramasivam, Anandhavelu Sanmugam, Vishnu Vardhan Palem, Murugan Sevanan, Ananda Babu Sairam, Nachiappan Nachiappan, Buhyun Youn, Jung Sub Lee, Muthuchamy Nallal, Kang Hyun Park
Summary: Nanomaterials are being used to deliver therapeutic agents in living systems. Different nanotechnological applications such as immunosensors, immune assays, and drug delivery are being implemented using nanotechnology. Genomics plays a crucial role in selecting appropriate drugs for personalized cancer therapy. It helps in analyzing gene and protein expression, disease classification, and designing disease models. Delivering drugs to specific areas using nanoparticles is a challenging issue.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
Article
Biochemistry & Molecular Biology
Jing Li, Wei Wang, Han Wu, Feng Peng, Hui Gao, Ying Guan
Summary: In this study, CMH-based CPF films were prepared and their thermal and barrier properties were successfully regulated. The tensile strength and water vapor barrier property of CPF films were significantly improved, making them promising for food packaging applications.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)