Review
Chemistry, Medicinal
Yali Niu, Guoheng Zhang, Xiaojia Sun, Shikun He, Guorui Dou
Summary: Oxidative stress caused by imbalanced production of reactive species and reduced antioxidant activity can lead to ocular diseases. Lycium barbarum polysaccharides (LBPs) are complex polysaccharides extracted from the fruit of L. barbarum, which have remarkable antioxidant effects and are relatively safe. Recent research has focused on the antioxidant mechanisms of LBPs and their potential applications in various ocular diseases.
Article
Biochemistry & Molecular Biology
Jianjia Huang, Yuman Bai, Wenting Xie, Rongmei Wang, Wenyue Qiu, Shuilian Zhou, Zhaoxin Tang, Jianzhao Liao, Rongsheng Su
Summary: This study aimed to investigate the protective effect and therapeutic mechanism of Lycium barbarum polysaccharides (LBPs) on acute liver injury induced by carbon tetrachloride (CCl4). The results showed that LBPs could improve CCl4-induced liver structural damage, excessive fibrosis, and reduced mitochondrial density, as well as restore and increase the antioxidant capacity of the liver. In addition, LBPs could enhance mitochondrial respiration, raise tissue ATP levels, and reactivate the respiratory chain complexes, thus mitigating mitochondrial damage. The study confirmed that LBPs had therapeutic effects on acute liver injury by reducing oxidative stress, repairing mitochondrial damage, and regulating metabolic pathways.
JOURNAL OF ZHEJIANG UNIVERSITY-SCIENCE B
(2023)
Article
Biochemistry & Molecular Biology
Lu-Lu Gao, Jia-Min Ma, Yan-Na Fan, Yan-Nan Zhang, Rui Ge, Xiu-Juan Tao, Meng-Wei Zhang, Qing-Han Gao, Jian-Jun Yang
Summary: The combination of LBP and AE shows protective effects on NAFLD by restoring gut microbiota balance, enhancing Bacteroidetes, reducing Proteobacteria, and improving intestinal barrier function. This combination therapy also downregulates inflammatory factors and related indicators of the LPS/TLR4/NF-KB signaling pathway in the liver, suggesting it as a promising treatment for NAFLD.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2021)
Article
Chemistry, Applied
Jixian Zhang, Xue Yang, Tao Ji, Chaoting Wen, Zhiqiang Ye, Xiaofang Liu, Li Liang, Guoyan Liu, Xin Xu
Summary: The study investigated the digestion and absorption properties of Lycium barbarum polysaccharides stabilized selenium nanoparticles (LBP-SeNPs). Results showed that LBP-SeNPs can better maintain the morphology and properties of nano particles during the digestion process, leading to improved selenium bioavailability. The selenium release rate and particle size of SeNPs and LBP-SeNPs changed significantly during digestion, with LBP-SeNPs showing higher stability and absorption efficiency.
Article
Biochemistry & Molecular Biology
Yu-Shan Chen, Yu Zhi Lian, Wen-Chao Chen, Chun-Chao Chang, Alexey A. Tinkov, Anatoly V. Skalny, Jane C. -J. Chao
Summary: This study found that Lycium barbarum polysaccharides and capsaicin can alleviate symptoms in DSS-induced ulcerative colitis rats. They exert their effects by inhibiting oxidative stress, proinflammatory cytokines, and protein expression of TRPV1 and TRPA1.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Food Science & Technology
Feng Lu, Rongrong Zhai, Siyu Ruan, Xue Yang, Evans A. Alenyorege, Yucheng Wang, Yanhua Ding, Haile Ma
Summary: The study found that ultrasound can improve the decoloration process of Lycium barbarum polysaccharides on resins and enhance their dynamic desorption effect. By optimizing conditions, a better desorption effect can be achieved.
LWT-FOOD SCIENCE AND TECHNOLOGY
(2021)
Article
Food Science & Technology
Chao Yang, Hui Xia, Huali Tang, Ligang Yang, Guiju Sun
Summary: This study successfully established a quantitative determination method for Lycium barbarum polysaccharides (LBPs) using fluorescein isothiocyanate (FITC) pre-labeling and investigated their tissue distribution in rats. The results showed that LBPs were mainly absorbed by the small intestine and stomach and excreted through the kidney. These findings contribute to a comprehensive understanding of the biological effects of LBPs.
FOOD SCIENCE AND HUMAN WELLNESS
(2022)
Article
Food Science & Technology
Run-Hui Ma, Xiu-Xiu Zhang, Kiran Thakur, Jian-Guo Zhang, Zhao-Jun Wei
Summary: Lycium genus is recognized as a promising source of novel bioactive compounds with diverse biological activities. Research has mainly focused on the chemical constituents and pharmacological properties of L. barbarum L. berries in traditional medicine. Apart from its medicinal use, L. barbarum L. berries and related food products are regarded as dietary supplements or 'superfoods' due to their significant health potential without explicit toxicity. Through a holistic approach, this study provides recent data on the chemical ingredients, their structural characterization, and emphasizes the extensive in vitro and in vivo health effects of L. barbarum L. berries.
CURRENT OPINION IN FOOD SCIENCE
(2022)
Article
Food Science & Technology
Hui Xia, Chao Yang, Beijia Zhou, Huali Tang, Ligang Yang, Wang Liao, Guiju Sun
Summary: A high-performance gel permeation chromatography fluorescence detection method combined with FITC labeling was established for the microanalysis of LBP, showing slow elimination of LBP from plasma and prolonged retention in the intestine with most of it being excreted in feces.
Article
Chemistry, Applied
Zhendong He, Tianyi Ma, Weiwei Zhang, Erzheng Su, Fuliang Cao, Meigui Huang, Yaosong Wang
Summary: The study showed that composite gels with 0.1% Lycium barbarum polysaccharides exhibited the greatest functional value, while gels with 1% LBP had higher porosity. Whey protein formed different types of gels at varying pH levels, but showed no significant difference in hydration properties.
FOOD HYDROCOLLOIDS
(2021)
Article
Medicine, General & Internal
Jiangbo Song, Lian Liu, Zhiquan Li, Ting Mao, Jianfei Zhang, Lei Zhou, Xin Chen, Yunzhu Shang, Tao Sun, Yuxin Luo, Yu Jiang, Duan Tan, Xiaoling Tong, Fangyin Dai
Summary: This study presents a promising animal model for investigating the pathogenesis of PD and conducting drug screening. Treatment with L-dopa and carbidopa, as well as administration of Lycium barbarum polysaccharide, showed positive effects on motor ability, dopamine level, and oxidative damage in the silkworm PD model.
Article
Oncology
Xiaohui Hu, Le Mu, Lingqin Zhu, Xiaoyu Chang, Lihong Nie, Li Wang, Guanghua Li
Summary: Moderate exercise is beneficial for physical and mental health, but excessive exercise can lead to oxidative stress-related damage. Lycium barbarum polysaccharide (LBP) extracted from wolfberry has been shown to protect the cardiovascular system by decreasing oxidative stress levels and enhancing the Keap1/Nrf2 signaling pathway. In in vitro experiments, LBP also exhibited significant antioxidant and anti-inflammatory effects on endothelial cells.
MOLECULAR MEDICINE REPORTS
(2021)
Article
Nutrition & Dietetics
Doudou Li, Xiaoke Zhang, Yanna Fan, Yannan Zhang, Xiujuan Tao, Jianjun Yang
Summary: The study found that Lycium barbarum polysaccharides (LBPs) can improve glucose homeostasis by reducing duodenal contraction amplitude in prediabetic mice. LBPs also improve gut microbiota composition and short-chain fatty acid levels, particularly acetic acid, which regulates duodenal contraction by binding to receptors on neurons.
Review
Pharmacology & Pharmacy
Zhiyong Xiao, Qi Deng, Wenxia Zhou, Yongxiang Zhang
Summary: Lycium barbarum polysaccharides (LBPs), the most valuable and well-researched component of Lycium barbarum, possess antiaging, antidiabetic, antifibrotic, neuroprotective, and immunomodulation properties. Recent studies have provided insights into the structure-activity relationships, receptor recognition, and gut microbiota modulation of LBPs.
PHARMACOLOGY & THERAPEUTICS
(2022)
Article
Biochemistry & Molecular Biology
Guoyan Liu, Xue Yang, Jixian Zhang, Li Liang, Feng Miao, Tao Ji, Zhiqiang Ye, Meng Chu, Jiaoyan Ren, Xin Xu
Summary: The study demonstrated that Lycium barbarum polysaccharides (LBP), specifically LBP1, can be used as stabilizers and capping agents for uniformly dispersed selenium nanoparticles (SeNPs) with excellent stability. LBP1-decorated SeNPs showed smaller particle size and enhanced fatigue-relieving activity, as indicated by prolonged swimming time and improved biochemical markers.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2021)
Article
Biochemistry & Molecular Biology
Wei-Han Hui, Yen-Lin Chen, Shu-Wei Chang
Summary: Crosslinking affects the mechanical behavior and tissue metabolism of collagen-based tissues. Aging and diabetes alter the crosslinking type and density, thus changing tissue properties. High-connectivity enzymatic crosslinking and advanced-glycation end-products result in uniform deformation under daily activity, while low-connectivity enzymatic crosslinking does not. High-connectivity model displays more sliding, while AGEs induce instability in structures near the binding sites.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
Article
Biochemistry & Molecular Biology
Yao-Bin Ma, Xiao-Qiu Zhou, Wei-Dan Jiang, Pei Wu, Yang Liu, Shu-Wei Li, Ling Tang, Lu Zhang, Hai-Feng Mi, Lin Feng
Summary: Tea polyphenols (TPs) are an inexpensive feed additive that can protect the gill function of fish against Flavobacterium columnare (F. columnare) through various mechanisms, including suppression of oxidative stress, apoptosis, and inflammation.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
Article
Biochemistry & Molecular Biology
Yan-Jia Guo, Jing-Ru Pang, Yu Zhang, Zhong-Rui Li, Xiao-Lin Zi, Hong-Min Liu, Ning Wang, Li-Juan Zhao, Ya Gao, Bo Wang, Piet Herdewijn, Cheng-Yun Jin, Ying Liu, Yi-Chao Zheng
Summary: This study identifies the conjugation of NEDD8 to LSD1 and its impact on GC cells, revealing the significance of LSD1 neddylation in GC.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
Review
Biochemistry & Molecular Biology
Geum-Jae Jeong, Fazlurrahman Khan, Nazia Tabassum, Young-Mog Kim
Summary: Vibrio species are motile gram-negative bacteria commonly found in aquatic environments. They can adapt to environmental fluctuations and develop protective mechanisms against host immune systems. Different types of sigma and anti-sigma factors play important roles in regulating gene expression and virulence in Vibrio species.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
Article
Biochemistry & Molecular Biology
Zahra Mohammadbagheri, Behrooz Movahedi, Shaghayegh Saeedi, Abbas Rahmati
Summary: In this study, a reusable biobased composite hydrogel was successfully synthesized and used for the removal of Tl(I) from aqueous solutions. The hydrogel exhibited high adsorption capacity and thermal stability, and the adsorption process was found to be thermodynamically spontaneous. The results demonstrated that the hydrogel can be reused multiple times without significant loss of its adsorption capacity.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
Article
Biochemistry & Molecular Biology
Iqra Batool, Muhammad Imran, Ayesha Anwar, Farhan Ahmed Khan, Afrah E. Mohammed, Ashwag Shami, Hafiz Iqbal
Summary: Enzyme immobilization on ZnO/SnO2 and ZnO/SnO2/SA nanocomposites was studied, and the catalytic and biochemical characteristics of the immobilized enzyme were investigated. The results showed that ZnO/SnO2 and ZnO/SnO2/SA nanostructures are suitable carriers for enzyme immobilization.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
Article
Biochemistry & Molecular Biology
Elias Mosaffa, Dhruvi Patel, Nasim Amiri Ramsheh, Rishikumar Indravadan Patel, Atanu Banerjee, Hossein Ghafuri
Summary: In this study, a unique 3D bead structure of adsorbent, composed of bacterial cellulose microfilaments reinforced chitosan adorned with melamine 2D plates, was synthesized for anionic dye removal. The adsorbent showed high specific surface area and abundant functional groups, resulting in exceptional adsorption capacity. The characteristics and optimal conditions of the adsorbent were assessed and analyzed.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
Article
Biochemistry & Molecular Biology
Carolina Gismene, Jorge Enrique Hernandez Gonzalez, Marilia de Freitas Calmon, Andrey Fabricio Ziem Nascimento, Angela Rocio Nino Santisteban, Felipe Antunes Calil, Alana Della Torre da Silva, Paula Rahal, Rejane Maira Goes, Raghuvir Krishnaswamy Arni, Ricardo Barros Mariutti
Summary: Mammaliicoccus sciuri, a bacterium of clinical and veterinary relevance, expresses the virulence factor Exfoliative Toxin C (ExhC), which binds specifically to desmoglein-1 (Dsg1) and plays a role in tissue integrity. This study investigates the necrotic activity of ExhC and identifies a variant lacking necrotic potential but retaining enzymatic activity through mutagenesis experiments and crystal structure determination.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
Article
Biochemistry & Molecular Biology
Bibhas K. Bhunia, Ashutosh Bandyopadhyay, Souradeep Dey, Biman B. Mandal
Summary: Intervertebral disc degeneration is a major cause of chronic low back pain and disability. Researchers have developed a bioactive silk-based hybrid hydrogel system functionalized with decellularized human Wharton's jelly extracellular matrix as bioactive cues. The hydrogels mimic the rheological and mechanical properties of the native nucleus pulposus tissue and support cell viability, proliferation, and tissue maturation.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
Article
Biochemistry & Molecular Biology
Qun Zhang, Yonggan Yan, Zhao Li, Jing Du, Kai Zhang, Liguo Zhang, Ting Wang, Alberto Bianco, Shaohua Ge, Baojin Ma
Summary: A new crosslinking strategy has been devised to construct injectable sodium alginate hydrogels, which can be regulated for injectability and have great potential in biomedical applications.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
Article
Biochemistry & Molecular Biology
Seong Eun Hong, Ji-Soo Lee, Hyeon Gyu Lee
Summary: The potential of multi-layer nanoemulsions for improving the cellular uptake, antioxidant activity, and in vitro bioaccessibility of alpha-tocopherol was examined. The results showed that the multi-layer nanoemulsions significantly enhanced the cellular uptake and antioxidant activity of alpha-tocopherol compared to free coumarin 6. Furthermore, the use of chitosan and dextran sulfate as wall materials in the multi-layer nanoemulsions led to even higher cellular uptake, in vitro bioaccessibility, and antioxidant activity of alpha-tocopherol.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
Article
Biochemistry & Molecular Biology
Jingjing Yu, Yanhui Zhang, Ruoning Zhang, Yanxiang Gao, Like Mao
Summary: High internal phase emulsions (HIPEs) based on beeswax (BW) oleogels and octenyl succinic acid starch (OSA starch) were prepared by a simple one-step method. The results showed that oleogelation improved the stability and encapsulation capability of the HIPEs, which is significant for the development of novel healthy food.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
Review
Biochemistry & Molecular Biology
Bi-Feng Yao, Xiu-Ju Luo, Jun Peng
Summary: The balanced and continuous fission and fusion of mitochondria, regulated by OPA1, are important for maintaining mitochondrial dynamics in cardiovascular disorders. Understanding the role of OPA1 in mitochondrial fusion can provide insights into the pathogenesis of cardiovascular diseases.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
Review
Biochemistry & Molecular Biology
Gokul Paramasivam, Anandhavelu Sanmugam, Vishnu Vardhan Palem, Murugan Sevanan, Ananda Babu Sairam, Nachiappan Nachiappan, Buhyun Youn, Jung Sub Lee, Muthuchamy Nallal, Kang Hyun Park
Summary: Nanomaterials are being used to deliver therapeutic agents in living systems. Different nanotechnological applications such as immunosensors, immune assays, and drug delivery are being implemented using nanotechnology. Genomics plays a crucial role in selecting appropriate drugs for personalized cancer therapy. It helps in analyzing gene and protein expression, disease classification, and designing disease models. Delivering drugs to specific areas using nanoparticles is a challenging issue.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
Article
Biochemistry & Molecular Biology
Jing Li, Wei Wang, Han Wu, Feng Peng, Hui Gao, Ying Guan
Summary: In this study, CMH-based CPF films were prepared and their thermal and barrier properties were successfully regulated. The tensile strength and water vapor barrier property of CPF films were significantly improved, making them promising for food packaging applications.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)