Article
Microbiology
Wei Zheng, Zhenya Zhu, Jingjing Ying, Gao Long, Bo Chen, Kerong Peng, Fubang Li, Hong Zhao, Mizu Jiang
Summary: H. pylori infection significantly influences gastric microbiota in children with duodenal ulcer, resulting in a lower abundance of multiple taxonomic levels. Children with duodenal ulcer exhibit a dysbiotic microbial community with genotoxic potential, which is distinct from that of children with H. pylori infection.
FRONTIERS IN MICROBIOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Olga Sokolova, Michael Naumann
Summary: Gastric cancer is a major cause of cancer-related deaths globally, and its development is influenced by genetic predisposition, environmental factors, and Helicobacter pylori infection. Matrix metalloproteinases (MMPs) play an active role in the progression of gastric cancer, with bacterial dependence being less significant in later stages.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biotechnology & Applied Microbiology
Jinglei Liu, Fangxu Zhang, Zheming Zhang, Chunning Zheng
Summary: This study found that Everolimus has a pharmacological role in protecting gastric epithelial cells from H.pylori-induced damage. It achieves this by reducing oxidative stress and inhibiting inflammatory response, as well as inhibiting the attachment of monocytes to epithelial cells.
Article
Biochemistry & Molecular Biology
Ji Yeong Yang, Jong-Bae Kim, Pyeongjae Lee, Sa-Hyun Kim
Summary: Evodiamine inhibits the growth of H. pylori by downregulating gene expressions related to replication and transcription machineries of the bacteria. Moreover, evodiamine also suppresses urease expression, leading to reduced translocation of CagA and VacA proteins into AGS cells. Additionally, evodiamine inhibits the activation of signaling proteins induced by H. pylori infection, contributing to reduction of IL-8 production in AGS cells.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Gastroenterology & Hepatology
Xiaohua Hou, Fandong Meng, Jiangbin Wang, Weihong Sha, Cheng-Tang Chiu, Woo Chul Chung, Liqun Gu, Kentarou Kudou, Chui Fung Chong, Shutian Zhang
Summary: This study compared the efficacy and safety of vonoprazan and lansoprazole in non-Japanese Asian patients with duodenal ulcers. The results showed that vonoprazan was non-inferior to lansoprazole in healing duodenal ulcers and achieving H. pylori eradication in these patients.
JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY
(2022)
Review
Immunology
Quynh Anh Nguyen, Leonard Schmitt, Raquel Mejias-Luque, Markus Gerhard
Summary: Helicobacter pylori uses its virulence factors, including the adhesin HopQ, to initiate and regulate the host's inflammatory responses during chronic infection in the human stomach. The interaction between HopQ and human CEACAMs allows the translocation of the CagA protein into host cells through the T4SS. The HopQ-CEACAM interaction plays a crucial role in the adhesion of H. pylori to host cells and modulation of cellular processes.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Jonas Wizenty, Stefanie Muellerke, Marina Kolesnichenko, Julian Heuberger, Manqiang Lin, Anne-Sophie Fischer, Hans-Joachim Mollenkopf, Hilmar Berger, Frank Tacke, Michael Sigal
Summary: Helicobacter pylori is a pathogen that causes chronic gastritis by colonizing the stomach. This study found that Rspo3 signaling through Lgr4 regulates the proliferation of stem cells and induces NF-kappa B activity in proliferating stem cells. The invasion of H. pylori leads to Lgr4-driven NF-kappa B activation, resulting in expansion of the gland base module and chemokine expression in stem cells, leading to gland hyperplasia and neutrophil recruitment.
Review
Oncology
Michelle C. C. Lim, Phatcharida Jantaree, Michael Naumann
Summary: Helicobacter pylori is a pathogenic bacterium that resides in the stomach lining and causes inflammation called type B gastritis. The chronic inflammation induced by H. pylori and other factors may lead to the development of stomach neoplasms and adenocarcinoma. Dysregulation of cellular processes in the stomach lining and microenvironment is a characteristic of H. pylori infection. In this review, we discuss the contradictory role of H. pylori in promoting or suppressing apoptosis in gastric epithelial cells and highlight the key processes in the microenvironment that contribute to apoptosis and gastric carcinogenesis.
Article
Nutrition & Dietetics
Moon-Young Song, Da-Young Lee, Young-Min Han, Eun-Hee Kim
Summary: Research has shown that Korean propolis (KP) has anti-inflammatory effects on gastric mucosal injury caused by Helicobacter pylori infection. KP inhibits the growth of H. pylori and reduces the expression of virulence factors. It also decreases inflammation and pathological damage by suppressing the NF-kappa B signaling pathway. These findings suggest that KP could be a natural supplement for patients with gastric mucosal injury caused by H. pylori infection.
Article
Pharmacology & Pharmacy
Ling Wang, Wen-Qun Li, Fen Liu, Yuan-Jian Li, Jie Du
Summary: This study investigates the variations of xCT activity in the gastric mucosa of patients with Helicobacter pylori (Hp) infection. The results show that patients with Hp infection have reduced xCT expression and lower glutamate concentration in gastric juice. The study also discovers a high expression of microRNAs that negatively regulate xCT expression in Hp-positive patients. The findings suggest that reduced xCT activity may play an important role in gastric ulcers caused by Hp infection and the microRNA/xCT pathway could be a potential treatment target for Hp-infection-related ulcers.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Oncology
Jee Hyun Kang, Suyoung Park, Jinhyung Rho, Eun-Ju Hong, Young-Eun Cho, Young-Suk Won, Hyo-Jung Kwon
Summary: IL-17A promotes gastric carcinogenesis, potentially through the regulation of the IL-17RC/NF-κB/NOX1 pathway. This finding provides a new target for the treatment of gastric cancer.
Article
Multidisciplinary Sciences
Carmen Aguilar, Mindaugas Pauzuolis, Malvika Pompaiah, Ehsan Vafadarnejad, Panagiota Arampatzi, Mara Fischer, Dominik Narres, Mastura Neyazi, Ozge Kayisoglu, Thomas Sell, Nils Bluethgen, Markus Morkel, Armin Wiegering, Christoph-Thomas Germer, Stefan Kircher, Andreas Rosenwald, Antoine-Emmanuel Saliba, Sina Bartfeld
Summary: In this study, it was found that Helicobacter pylori prefers to attach to differentiated cells in the pit region of gastric units. Organoid models were used to validate this phenomenon, and it was discovered that differentiated pit cells with high levels of GKN1, GKN2 and PSCA were more susceptible to H. pylori attachment and CagA translocation. It was also found that attachment was unrelated to the expression of MUC5AC or PSCA, but relied on bacterial chemotaxis towards host cell-released urea, which was proportional to the size of the host cell.
NATURE COMMUNICATIONS
(2022)
Review
Medicine, Research & Experimental
Yi-Chia Lee, Maria Pina Dore, David Y. Graham
Summary: The past 5 years have witnessed significant changes in the testing and treatment of Helicobacter pylori infection. Peptic ulcer has transitioned from a chronic disease to an acute condition, and countries with high incidence of gastric cancer have started implementing population-wide screening and treatment. A proactive approach to testing and treatment, including outreach to family members and high-risk populations, is now recommended. The rise in antimicrobial resistance has led to a decline in treatment success, necessitating a reconsideration of treatment guidelines and adherence to principles of antibiotic usage and antimicrobial stewardship.
ANNUAL REVIEW OF MEDICINE
(2022)
Review
Medicine, General & Internal
Irena Mladenova
Summary: Helicobacter pylori is a pathogenic bacterium that infects approximately 50% of the world population, playing a role in chronic gastritis, ulcers, and gastric cancer. Treatment should be based on local antibiotic use and resistance, while diagnostic methods depend on clinical indications.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Immunology
Tobias Frauenlob, Theresa Neuper, Christof Regl, Veronika Schaepertoens, Michael S. Unger, Anna-Lena Oswald, Hieu-Hoa Dang, Christian G. Huber, Fritz Aberger, Silja Wessler, Jutta Horejs-Hoeck
Summary: Helicobacter pylori infection increases the responsiveness of monocytes to subsequent bacterial stimulation and induces a unique proteomic signature compared to other inflammation-inducing stimuli. This effect is specific to H. pylori and independent of its virulence factors. The increased reactivity of infected monocytes may contribute to ineffective immune responses and disease progression.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Developmental Biology
Meenakshi Maitra, Marie K. Schluterman, Haley A. Nichols, James A. Richardson, Cecilia W. Lo, Deepak Srivastava, Vidu Garg
DEVELOPMENTAL BIOLOGY
(2009)
Article
Biochemistry & Molecular Biology
Meenakshi Maitra, Yongyu Wang, Robert D. Gerard, Carole R. Mendelson, Christine Kim Garcia
JOURNAL OF BIOLOGICAL CHEMISTRY
(2010)
Article
Genetics & Heredity
Meenaksi Chakravorty, Dipanjana Datta De, Abrijit Choudhury, Amal Santra, Susanta Roychoudhury
JOURNAL OF GENETICS
(2008)
Article
Pediatrics
Meenaksh Maitra, Sara N. Koenig, Deepak Srivastava, Vidu Garg
PEDIATRIC RESEARCH
(2010)
Article
Multidisciplinary Sciences
Dipanjana Datta De, Sumana Bhattacharjya, Meenakshi Maitra, Arindam Datta, Abhijit Choudhury, G. K. Dhali, Susanta Roychoudhury
Article
Genetics & Heredity
M Chakravorty, A Ghosh, A Choudhury, A Santra, J Hembrum, S Roychoudhury
Article
Gastroenterology & Hepatology
Shabana Farheen, Sanghamitra Sengupta, Amal Santra, Suparna Pal, Gopal Krishna Dhali, Meenakshi Chakravorty, Partha P. Majumder, Abhijit Chowdhury
WORLD JOURNAL OF GASTROENTEROLOGY
(2006)
Article
Anthropology
M Chakravorty, A Ghosh, A Choudhury, A Santra, J Hembrum, S Roychoudhury
Article
Biochemistry & Molecular Biology
Kun He, Mengyi Xie, Weifeng Hong, Yonghe Li, Yaolin Yin, Xiaojin Gao, Yi He, Yu Chen, Chuan You, Jingdong Li
Summary: Centromere protein L (CENPL) is overexpressed in hepatocellular carcinoma (HCC) and is associated with poor patient prognosis. Upregulation of CENPL promotes tumor proliferation and glycolysis in HCC cells by activating the MEK1/2-ERK1/2 signaling pathway.
INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY
(2024)
Article
Biochemistry & Molecular Biology
Yingzi Wang, Haozhong Huang, Huimin Weng, Chunsen Jia, Bin Liao, Yang Long, Fengxu Yu, Yongmei Nie
Summary: Talin protein plays a crucial role in transmitting mechanical forces by connecting the extracellular matrix to the cytoskeleton. It converts mechanical signals into biochemical signals and serves as diagnostic, therapeutic, and prognostic indicators in diseases.
INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY
(2024)
Review
Biochemistry & Molecular Biology
Hema Saranya Ilamathi, Marc Germain
Summary: Mitochondria are the central metabolic hubs in cells, relying on proteins encoded by nuclear DNA and mitochondrial DNA (mtDNA) for their function. The maintenance and distribution of mtDNA are crucial for proper mitochondrial function and are associated with mitochondrial diseases. mtDNA is organized into nucleoids that dynamically move and interact with each other. The replication and distribution of mtDNA nucleoids are regulated by the complex interplay of mitochondrial dynamics, ER-mitochondria contact sites, and cytoskeletal networks.
INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY
(2024)
Article
Biochemistry & Molecular Biology
K. K. Sruthi, Sirisha Natani, Ramesh Ummanni
Summary: The overexpression of TPD52 is associated with the emergence of neuroendocrine prostate cancer (NEPC). TPD52 activates the NF-kappa B - STAT3 axis to induce neuroendocrine differentiation (NED) of prostate cancer cells. Therapeutic targeting of TPD52 is important for the treatment of prostate cancer.
INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY
(2024)
Article
Biochemistry & Molecular Biology
Cui Li, Feifan Xiang, Yuqi Gong, Yi Fu, Ge Chen, Zhi Wang, Zhong Li, Daiqing Wei
Summary: Our study demonstrates the significant role of tumor-derived microparticles (T-MPs) in osteosarcoma metastasis and immune response. T-MPs promote macrophage polarization and stimulate migration and chemoresistance of osteosarcoma cells, thereby affecting the progression of osteosarcoma.
INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY
(2024)