Review
Cell Biology
Wai Ki Wong, Bohan Yin, Ching Ying Katherine Lam, Yingying Huang, Jiaxiang Yan, Zhiwu Tan, Siu Hong Dexter Wong
Summary: This article discusses the importance of epigenetic regulation of T-cell function in cancer immunotherapy and how to restore their function by modulating the epigenetic switches of T-cells, providing new therapeutic strategies.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2022)
Review
Immunology
Adolfo B. Frias, Shannon K. Boi, Xin Lan, Ben Youngblood
Summary: The concept of adaptive immunity, based on immunological memory, has paved the way for modern vaccination and immunotherapy. Recent studies have identified epigenetic programs as a molecular mechanism governing T cell subset specification and immunological memory.
IMMUNOLOGICAL REVIEWS
(2021)
Review
Cell Biology
Avik Dutta, Harini Venkataganesh, Paul E. Love
Summary: This review summarizes recent findings on the role of epigenetic regulators in T cell differentiation in both mice and humans. It provides new insights into how dysregulation of these processes can lead to cancer or autoimmune diseases.
Article
Multidisciplinary Sciences
Gerdien Mijnheer, Lisanne Lutter, Michal Mokry, Marlot van der Wal, Rianne Scholman, Veerle Fleskens, Aridaman Pandit, Weiyang Tao, Mark Wekking, Stephin Vervoort, Ceri Roberts, Alessandra Petrelli, Janneke G. C. Peeters, Marthe Knijff, Sytze de Roock, Sebastiaan Vastert, Leonie S. Taams, Jorg van Loosdregt, Femke van Wijk
Summary: The study illustrates the effector characteristics of human Treg cells under inflammatory conditions and their epigenetic influences, indicating that inflammation-derived Treg cells have specific features and are fine-tuned by environmental adaptations.
NATURE COMMUNICATIONS
(2021)
Article
Multidisciplinary Sciences
Kuniyuki Aso, Michihito Kono, Masatoshi Kanda, Yuki Kudo, Kodai Sakiyama, Ryo Hisada, Kohei Karino, Yusho Ueda, Daigo Nakazawa, Yuichiro Fujieda, Masaru Kato, Olga Amengual, Tatsuya Atsumi
Summary: The study reveals that itaconate can alter T cell function and impact the development of autoimmune diseases through modulation of metabolic and epigenetic programs. Itaconate inhibits Th17 cell differentiation and promotes Treg cell differentiation by suppressing glycolysis and oxidative phosphorylation. The metabolic changes induced by itaconate also affect chromatin accessibility, transcription factor binding, and gene expression in Th17 and Treg cell differentiation. Furthermore, the adoptive transfer of itaconate-treated Th17 cells can ameliorate autoimmune encephalomyelitis. These findings suggest that itaconate is a crucial metabolic regulator for Th17/Treg cell balance and can be a potential therapeutic agent for autoimmune diseases.
NATURE COMMUNICATIONS
(2023)
Article
Immunology
Jad N. Kanbar, Shengyun Ma, Eleanor S. Kim, Nadia S. Kurd, Matthew S. Tsai, Tiffani Tysl, Christella E. Widjaja, Abigail E. Limary, Brian Yee, Zhaoren He, Yajing Hao, Xiang-Dong Fu, Gene W. Yeo, Wendy J. Huang, John T. Chang
Summary: The long noncoding RNA Malat1 affects the differentiation of effector and memory CD8(+) T cell subsets by repressing memory-associated genes through an interaction with Ezh2. This study expands our knowledge of the role of long noncoding RNAs in CD8(+) T cell biology.
JOURNAL OF EXPERIMENTAL MEDICINE
(2022)
Review
Oncology
Yusuke Ito, Yuki Kagoya
Summary: Recent advancements in cancer immunotherapy, such as CAR-engineered T cell therapy and immune checkpoint therapy, have significantly improved patient outcomes. Understanding the molecular mechanisms behind T cell functions and regulation through epigenetic factors can further enhance the effectiveness of cancer immunotherapy. Modulating specific epigenetic genes in CAR-T cells can improve their quality and persistence, leading to improved therapeutic outcomes.
Editorial Material
Cell & Tissue Engineering
Marieke Lavaert, Avinash Bhandoola
Summary: Researchers efficiently generate highly functional tumor-fighting T cells by inhibiting EZH1 expression in iPSCs in vitro.
Article
Multidisciplinary Sciences
David M. Schauder, Jian Shen, Yao Chen, Moujtaba Y. Kasmani, Matthew R. Kudek, Robert Burns, Weiguo Cui
Summary: During acute viral infections, CD8 T cells encounter various antigenic and inflammatory signals, leading to differentiation into memory cells or death. Research has shown that memory precursor effector cells maintain open enhancers for key memory genes, with a high enrichment of E2A binding sites. E2A directly regulates the accessibility of enhancers for memory-related genes, increasing the frequency of memory precursor effector cells and accelerating memory cell formation while reducing short-lived effector cells.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2021)
Review
Immunology
Mohammad Heidarian, Thomas S. S. Griffith, Vladimir P. P. Badovinac
Summary: Formation of long-lasting memory lymphocytes is crucial for adaptive immunity and vaccination strategies. Memory CD8 T cells, which are distinct from naive CD8 T cells, display heterogeneity in tissue localization, cytotoxic ability, and proliferative capacity. Sepsis not only reduces the number and function of memory CD8 T cells, but also alters their transcriptional profile and impairs their protective capacity. This review explores different aspects of memory CD8 T cell subsets and the impact of sepsis on their biology.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Immunology
Josephine R. Giles, Sasikanth Manne, Elizabeth Freilich, Derek A. Oldridge, Amy E. Baxter, Sangeeth George, Zeyu Chen, Hua Huang, Lakshmi Chilukuri, Mary Carberry, Lydia Giles, Nan-Ping P. Weng, Regina M. Young, Carl H. June, Lynn M. Schuchter, Ravi K. Amaravadi, Xiaowei Xu, Giorgos C. Karakousis, Tara C. Mitchell, Alexander C. Huang, Junwei Shi, E. John Wherry
Summary: This study generated an epigenetic and transcriptional atlas of T cell differentiation from healthy humans and applied it to explore disease-specific biology. The study identified molecular regulations of gene expression and chromatin accessibility during T cell differentiation and provided insights into disease biology through three research settings. The study also successfully predicted genome-wide cis-regulatory elements and validated the approach for functional annotation of key effector genes, demonstrating the potential of identifying targets for non-coding cellular engineering.
Article
Immunology
Xuyong Chen, Benjamin Sunkel, Meng Wang, Siwen Kang, Tingting Wang, J. N. Rashida Gnanaprakasam, Lingling Liu, Teresa A. Cassel, David A. Scott, Ana M. Munoz-Cabello, Jose Lopez-Barneo, Jun Yang, Andrew N. Lane, Gang Xin, Benjamin Z. Stanton, Teresa W. -M. Fan, Ruoning Wang
Summary: Effective T cell-mediated immune responses require proper allocation of metabolic resources and epigenetic control. Our study revealed that tricarboxylic acid cycle flux fuels biosynthetic processes and controls the ratio of succinate/alpha-ketoglutarate to modulate T cell inflammation. SDH/complex II deficiency in T cells caused proliferation and survival defects when the TCA cycle was truncated, but replenishing the nucleoside pool partially relieved the dependence of T cells on SDH/complex II. SDH deficiency induced a proinflammatory gene signature and promoted T helper 1 and T helper 17 lineage differentiation by increasing succinate/alpha-KG ratio. SDH/complex II plays a role in allocating carbon resources and epigenetic regulation in T cell proliferation and inflammation.
SCIENCE IMMUNOLOGY
(2022)
Article
Oncology
Behnia Akbari, Zahra Hosseini, Pardis Shahabinejad, Saba Ghassemi, Hamid Reza Mirzaei, Roddy S. O'Connor
Summary: This article focuses on the functional impairments of CAR T cells in tumor microenvironments, where tumor cell metabolism and nutrient competition affect the differentiation and function of CAR T cells' progeny. Metabolic intermediates shape the immune response by influencing epigenetic programs.
Review
Cell Biology
Yuanjie Ding, Yuanchun Yao, Xingmu Gong, Qi Zhuo, Jinhua Chen, Miao Tian, Maryam Farzaneh
Summary: JMJD3 is a key histone demethylase that regulates H3K27me3 and plays a crucial role in stem cell fate determination during the process of cell reprogramming.
CELL COMMUNICATION AND SIGNALING
(2021)
Review
Immunology
Arianne C. Richard
Summary: The advent of technologies that can characterize individual cells has revealed extensive diversity between cells of the same subset, including CD8(+) T cells. This review focuses on heterogeneity in CD8(+) T cell responses, particularly the impact of TCR stimulation strength and the mechanisms underlying variation between cells.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Gastroenterology & Hepatology
Weiwu Gao, Zhengcai Jia, Yi Tian, Penghui Yang, Hui Sun, Chenhui Wang, Yi Ding, Mengjie Zhang, Yi Zhang, Di Yang, Zhiqiang Tian, Jian Zhou, Zhihua Ruan, Yuzhang Wu, Bing Ni
Article
Biochemical Research Methods
Weiwu Gao, Binbin Lai, Bing Ni, Keji Zhao
Article
Immunology
Huang Huang, Xiaoping Wu, Dongwei Meng, Yizhou Feng, Lan Zhou, Zhenyu Liu, Shupei Tang, Xueqin Li, Yi Cao, Haiyang He, Zhunyi Xie, Jingbo Zhang, Yongwen Chen, Tingting Zhao, Yuzhang Wu, Xinyuan Zhou
Summary: The study demonstrated that LXR beta deficiency leads to a reduction in single-positive (SP) thymocytes and increased apoptosis, indicating the crucial role of LXR beta in promoting the survival of SP thymocytes. The findings also suggest that LXR beta positively regulates the expression of IL-7R alpha in SP thymocytes, which is essential for their survival.
CELLULAR & MOLECULAR IMMUNOLOGY
(2021)
Article
Infectious Diseases
Bo Diao, Kun Wen, Ji Zhang, Jian Chen, Chao Han, Yongwen Chen, Shufeng Wang, Guohong Deng, Hongwei Zhou, Yuzhang Wu
Summary: The FIC assay for NP antigen testing shows high specificity and relatively high sensitivity in early-phase SARS-CoV-2 diagnosis, according to a study conducted in Wuhan and Chongqing between February 10 and 15, 2020.
CLINICAL MICROBIOLOGY AND INFECTION
(2021)
Article
Endocrinology & Metabolism
Lina Wang, Ping Sun, Yuzhang Wu, Li Wang
Summary: Obesity-induced low-grade chronic inflammation in metabolic tissues is a major factor for various diseases. Tissue-resident macrophages and adaptive CD8(+) T cells play important roles in this process, but further research is needed to understand the mechanisms involved.
Review
Biochemistry & Molecular Biology
Yiwei Zhang, Zhiyuan Wei, Hui Dong, Jian Zhou, Jizhao Yuan, Bing Ni, Yuzhang Wu, Chao Han, Yi Tian
Summary: This review summarizes the role of RNA-binding proteins, microRNAs, and long non-coding RNAs in regulating the fate of Th17 cells, as well as the impact of RNA modifications and nonsense-mediated mRNA decay in Th17 cells. Ongoing research may provide insights into practical applications for regulating mRNA stability in the context of Th17-related autoimmune diseases.
Article
Multidisciplinary Sciences
Yi Tian, Chao Han, Zhiyuan Wei, Hui Dong, Xiaohe Shen, Yiqiang Cui, Xiaolan Fu, Zhiqiang Tian, Shufeng Wang, Jian Zhou, Di Yang, Yi Sun, Jizhao Yuan, Bing Ni, Yuzhang Wu
Summary: This study identified a novel enhancer, RORCE2, for the transcription factor RORγt, which interacts with Sox5 to modulate RORγt expression at the promoter level, providing insights into the regulation of Th17 differentiation and functions.
NATURE COMMUNICATIONS
(2021)
Article
Biochemistry & Molecular Biology
Yiwei Zhang, Jian Zhou, Zhiyuan Wei, Hui Dong, Di Yang, Yuanyu Deng, Jiahui Li, Saiyu Shi, Yi Sun, Huimin Lu, Jizhao Yuan, Bing Ni, Yuzhang Wu, Yi Tian, Chao Han
Summary: Dendritic cells play a crucial role in the immune system by regulating defense against pathogens and tolerance to self. This review highlights the significance of mRNA stability regulation in dendritic cells for their function and immune therapy.
Review
Immunology
Hui Sun, Yuzhang Wu, Yi Zhang, Bing Ni
Summary: This study focuses on the production mechanisms of IL-10 in ILCs, the key role of IL-10 in NK and ILC2 cells, and the potential impact of IL-10-producing ILCs in diseases such as infections, allergies, and cancers.
FRONTIERS IN IMMUNOLOGY
(2021)
Review
Cell Biology
Xiaojun Du, Rui Dong, Yuzhang Wu, Bing Ni
Summary: Ferroptosis, a type of programmed cell death, has unique morphological, biochemical, and genetic features. This review discusses the theory, process, and physiological functions of ferroptosis, as well as its pathological effects and underlying mechanisms in various diseases. It also explores the role of ferroptosis in the fibrosis process in different organs.
OXIDATIVE MEDICINE AND CELLULAR LONGEVITY
(2022)
Article
Oncology
Jian Li, Jingyang Yin, Wenhua Li, Huaizhi Wang, Bing Ni
Summary: Different molecular subtypes have been identified in pancreatic adenocarcinoma (PAAD) and cuproptosis is likely involved in tumor progression. However, the cuproptosis-related molecular subtypes and its mediated tumor microenvironment (TME) cell infiltration characteristics are still unclear.
CANCER CELL INTERNATIONAL
(2023)
Article
Biochemistry & Molecular Biology
Yanyan Zhang, Baohua Li, Qiang Bai, Pengcheng Wang, Gang Wei, Zhirong Li, Li Hu, Qin Tian, Jing Zhou, Qizhao Huang, Zhiming Wang, Shuai Yue, Jialin Wu, Liuqing Yang, Xinyuan Zhou, Lubin Jiang, Ting Ni, Lilin Ye, Yuzhang Wu
Summary: The study identified a key lncRNA-Snhg1 in CD8 T cells that promotes memory formation and inhibits effector cell differentiation. Snhg1 interacts with Vps13D and regulates IL-7 signaling to play a crucial role in memory CD8 cell generation. The Snhg1-Vps13D-IL-7R-TCF1 axis is central in memory CD8 establishment and a potential target for enhancing vaccination effects against ongoing pandemics.
SIGNAL TRANSDUCTION AND TARGETED THERAPY
(2021)
Article
Cell Biology
Junfeng Zhang, Hui Sun, Songsong Liu, Wenjie Huang, Jianyou Gu, Zhiping Zhao, Huan Qin, Liwen Luo, Jiali Yang, Yongfei Fang, Jiayun Ge, Bing Ni, Huaizhi Wang
Article
Cell Biology
Junfeng Zhang, Jianyou Gu, Shixiang Guo, Wenjie Huang, Yao Zheng, Xianxing Wang, Tao Zhang, Weibo Zhao, Bing Ni, Yingfang Fan, Huaizhi Wang