Review
Immunology
Timothy N. J. Bullock
Summary: Advances in checkpoint blockade immunotherapies have led to an expansion in methods for promoting T cell access to the tumor microenvironment, with dendritic cells playing a crucial role in the immune response to tumor antigens. The role of CD40 as a master regulator of dendritic cell activation in cancer vaccines and other immune-oncology approaches is highlighted and evaluated.
CELLULAR & MOLECULAR IMMUNOLOGY
(2022)
Article
Immunology
Justin Theophilus Ulrich-Lewis, Kevin E. Draves, Kelsey Roe, Megan A. O'Connor, Edward A. Clark, Deborah Heydenburg Fuller
Summary: This study found that stimulator of interferon genes (STING) plays a critical role within conventional dendritic cells (cDCs) in mediating adaptive immune responses induced by DNA vaccines. STING within cDCs was shown to be responsible for the induction of type I T helper cell responses and Th1-type antibody responses, as well as the development of CD8(+) effector cell responses. These findings provide new insight into the mechanism of DNA vaccine-induced immune responses.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Lisa G. M. Huis In 't Veld, Nataschja Ho, Melisssa Wassink, Martijn H. den Brok, Gosse J. Adema
Summary: Saponin-based adjuvants (SBAs) are a promising new type of adjuvant that can enhance dendritic cell-mediated antigen cross-presentation and activate CD8 + T cells by inducing lipid bodies. The study reveals that SBAs specifically induce the PERK pathway and depend on its activation for dendritic cell cross-presentation. Additionally, the MHCII(lo)CD11b(hi) subset of dendritic cells shows the highest responsiveness to SBAs.
CELLULAR AND MOLECULAR LIFE SCIENCES
(2022)
Review
Immunology
Sara Ness, Shiming Lin, John R. Gordon
Summary: Dendritic cells are antigen-presenting cells that interact with T cells to regulate adaptive immune responses. Under certain conditions, dendritic cells can develop into anti-inflammatory cells, inducing immunologic tolerance. Studies have shown that regulatory dendritic cells induce T cell tolerance by suppressing effector T cells and inducing regulatory T cells.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Chemistry, Multidisciplinary
Xuedan He, Shiqi Zhou, Wei-Chiao Huang, Amal Seffouh, Moustafa T. Mabrouk, M. Thomas Morgan, Joaquin Ortega, Scott Abrams, Jonathan F. Lovell
Summary: A new vaccine adjuvant system was developed to induce strong cellular immune responses against multiple tumor cell lines, demonstrating durable immunity. The system showed the importance of stable particle formation for effective immune response induction and could control local and metastatic disease in a therapeutic setting.
Article
Pharmacology & Pharmacy
Yunkai Yang, Xiaohan Guo, Bo Hu, Peng He, Xiaowu Jiang, Zuohuan Wang, Huaxing Zhu, Lina Hu, Minghua Yu, Meiqing Feng
Summary: The fusion protein SNU containing SecPen and ubiquitin-fused NY-ESO-1 loaded onto dendritic cells can elicit stronger and specific T cell immune responses, resulting in increased cytotoxicity towards MC38(NY-ESO-1) tumor cells.
ACTA PHARMACEUTICA SINICA B
(2021)
Review
Immunology
Sarah I. M. Sutherland, Xinsheng Ju, L. G. Horvath, Georgina J. Clark
Summary: Despite the success of using checkpoint inhibitors to reprim T cells to recognize tumors in certain malignancies, including melanoma, lung, and renal cell carcinoma, many tumors, such as prostate cancer, remain resistant to such treatment. DC-based immunotherapy, such as Sipuleucel-T, has shown improved overall survival in prostate cancer, but further research into DC vaccines has been limited. Understanding the immunosuppressive environment of prostate cancer and developing new vaccine strategies that can overcome this environment is essential for future success in immunotherapy.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Virology
Mengjiao Lv, Ting Yao, Yi Zhang, Siyuan Ma, Jinmei Chen, Zhenghao Tang, Guoqing Zang, Xiaohua Chen
Summary: This study demonstrated that loading TPN onto Dexs (TPN-Dexs) can enhance CD8(+) T cell immune response and inhibit HBV replication in transgenic mice, potentially through the AKT/mTOR pathway to regulate autophagy.
JOURNAL OF MEDICAL VIROLOGY
(2023)
Review
Immunology
Nengqi Lin, Wei Yin, Heather Miller, Maria G. Byazrova, Andres A. Herrada, Kamel Benlagha, Pamela Lee, Fei Guan, Jiahui Lei, Quan Gong, Youqing Yan, Alexander Filatov, Chaohong Liu
Summary: Hepatitis B has become a major health threat worldwide, particularly in developing countries and regions. Infection with hepatitis B virus significantly increases the risk of liver diseases such as cirrhosis and cancer. The immune response against hepatitis B is mainly regulated by CD8+ T cells, which play a key role in fighting viral infections, while regulatory T cells prevent excessive immune response. Additionally, follicular T helper cells have a critical role in B-cell activation, proliferation, differentiation, and the formation of germinal centers. The development of hepatitis B virus is generally associated with immune system disorders or dysfunctions. This review focuses on the important functions and biological processes of regulatory T cells and follicular T helper cells during HBV infection.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Medicine, Research & Experimental
Ting Su, Shurong Zhou, Suling Yang, Nicholas Humble, Fuwu Zhang, Guocan Yu, Paula D. Bos, Furong Cheng, Kristoffer Valerie, Guizhi Zhu
Summary: This study reports a radioimmunotherapy for adult brain cancer that combines radiotherapy, immune checkpoint blockade, and lymph-node-targeting vaccines. The vaccines induced anti-cancer immune responses in mice and enhanced therapeutic efficacy in orthotopic brain cancer mice. However, radioimmunotherapy only showed a trend towards improved efficacy compared to radiotherapy alone.
Review
Immunology
Marta Fortunato, Konstantina Morali, Laura Passeri, Silvia Gregori
Summary: Enhancing regulatory cells to promote immune tolerance is a solution to improve long-term allograft survival in organ transplantation. Cell populations like regulatory T cells and regulatory myeloid cells show promise in restoring tolerance. Efforts in applying regulatory cell-based therapy have shown progress in clinical applications.
FRONTIERS IN IMMUNOLOGY
(2021)
Review
Immunology
Anthony M. Joudi, Carla P. Reyes Flores, Benjamin D. Singer
Summary: FoxP3(+) regulatory T cells play a crucial role in maintaining immune homeostasis, self-tolerance, and resolving inflammation and tissue damage. However, their plasticity in inflammatory microenvironments could lead to loss of function and contribute to inflammatory pathology, presenting a barrier to Treg cell immunotherapy. Understanding the determinants of Treg cell stability and utilizing epigenetic mechanisms could enhance the efficacy and minimize toxicity of Treg cell-based therapeutics.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Oncology
Rishu Takimoto, Takashi Kamigaki, Sachiko Okada, Hiroshi Ibe, Eri Oguma, Shigenori Goto
Summary: A study investigated the efficacy of adjuvant immune-cell therapy combined with other systemic therapies in patients with solid tumors. The results suggested that this treatment strategy could potentially provide a survival benefit, especially in patients with a performance status score of 0.
ANTICANCER RESEARCH
(2022)
Article
Biochemistry & Molecular Biology
Mariana P. Pinho, Guilherme A. Lepski, Roberta Rehder, Nadia E. Chauca-Torres, Gabriela C. M. Evangelista, Sarah F. Teixeira, Elizabeth A. Flatow, Jaqueline V. de Oliveira, Carla S. Fogolin, Nataly Peres, Analia Arevalo, Venancio Alves, Jose A. M. Barbuto, Patricia C. Bergami-Santos
Summary: This case study investigated the treatment of glioblastoma in a 25-year-old female patient with a dendritic-tumor cell fusion vaccine. The findings suggest that tumor-specific CD4+ T-cell numbers and phenotype could serve as biomarkers for treatment efficacy.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Immunology
Jaehwan Kim, Ariana Moreno, James G. G. Krueger
Summary: Psoriasis vulgaris is a common inflammatory disease affecting 7.5 million adults in the US, with immunopathogenesis paradigms rapidly evolving due to advancements in technology. Single-cell RNA sequencing technology is now being applied to clinical trials of biologics to test the expansion of regulatory immune cell subsets involved in skin homeostasis.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Immunology
Jun Cui, Cheng Chen, Xiao Zhou, Wenju Shan, Yuhong Jian, Panpan Li, Yang Sun, Wei Yi
Summary: Bone marrow mesenchymal stem cells (BMSCs) are a promising therapy for sepsis, but metabolic syndromes threaten their effectiveness. This study investigated the potential of small extracellular vesicles from high-fat diet BMSCs in sepsis-induced liver-heart axis injury.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2024)
Article
Immunology
Binbin Zhu, Angyang Cao, Chunqu Chen, Weijian Zhou, Wenjun Luo, Yu Gui, Qinwen Wang, Zhipeng Xu, Jianhua Wang
Summary: GM6001 alleviates postoperative cognitive deficits and neuroinflammation, preserves blood-brain barrier integrity, and rescues aquaporin-4 mislocalization. MMP-9 inhibition plays a dual role in cognitive protection through direct anti-neuroinflammatory effects and regulation of aquaporin-4 membrane distribution.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2024)
Article
Immunology
Anika Sood, Valencia Fernandes, Kumari Preeti, Shruti Rajan, Dharmendra Kumar Khatri, Shashi Bala Singh
Summary: S1PR2 inhibitor improves cognitive function and skews microglia toward anti-inflammatory phenotype in type 2 diabetic mice, promising to be a potential therapy for neuroinflammation.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2024)
Article
Immunology
Haochun Guo, Ran Yu, Haijun Zhang, Wanpeng Wang
Summary: Radiation therapy is an effective treatment for thoracic malignancies, but it can cause radiation-induced lung injury (RILI), including radiation pneumonitis (RP) and radiation pulmonary fibrosis (RPF). The damage to normal lung cells during radiation treatment leads to a pulmonary inflammatory response, resulting in RP and RPF.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2024)
Article
Immunology
Guanghui Wang, Haotian Zheng, Yunzhi Xiang, Yadong Wang, Kai Wang, Xiaoyang Ren, Jiajun Du
Summary: This study identified a T-cell synthetic driver-associated prognostic model that accurately predicted prognosis and effectiveness of immunotherapy in LUAD patients. It also highlighted the role of LDHA in promoting tumor cell proliferation, invasion, and resistance to treatment, as well as its involvement in immune escape within the tumor microenvironment. These findings provide a promising new therapeutic strategy for LUAD.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2024)
Article
Immunology
Bowen Wei, Aihua Wang, Wei Liu, Qingyun Yue, Yihua Fan, Bin Xue, Siwei Wang
Summary: This study systematically analyzed the association between pSS and cuproptosis, established a predictive model based on 5 genes, explored the pathogenic mechanisms and novel therapeutic strategies for pSS, and identified EED, CBL, and NFU1 as potential targets for treatment.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2024)
Article
Immunology
Nusrit Iqbal Andrabi, Aminur R. Sarkar, Syed Assim Haq, Diljeet Kumar, Dilpreet Kour, Diksha Saroch, Sanket Kumar Shukla, Ajay Kumar, Asha Bhagat, Asif Ali, Gurleen Kour, Zabeer Ahmed
Summary: Koenimbine and its novel semi-synthetic derivative 1G demonstrate significant anti-inflammatory effects by downregulating the nuclear factor kappa-B (NF-kappa B) signaling pathway.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2024)
Article
Immunology
Jing-Mei Lu, Xiang Xu, Fumie Aosai, Ming-Yue Zhang, Lian-Xun Piao
Summary: This study found that arctiin can improve allergic acute liver injury caused by T.g.HSP70 by inhibiting TLR4 signaling and reducing the production of inflammatory mediators.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2024)
Article
Immunology
Minxuan Xu, Fang Shi, Yongshen Gao, Shumei Han, Chensuo Huang, Qinsheng Hou, Xiaoweng Wen, Bengshi Wang, Zhenyu Zhu, Lei Zou, Mingxin Xiong, Wei Dong, Jun Tan
Summary: There is a growing body of research highlighting the involvement of metabolic imbalance and the inflammatory response in the advancement of colitis. This study recognizes arabinose as a significant protector of the intestinal mucosal barrier, reducing damage to the intestines. In addition, lower levels of arabinose in the bloodstream are associated with a higher severity of inflammatory bowel disease and colorectal cancer.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2024)
Article
Immunology
Yueqing Han, Haoxin Song, Yanshan Li, Rongxin Li, Ling Chen, Bo Gao, Yijun Chen, Shuzhen Wang
Summary: The combination of tetracycline antibiotics, demeclocycline (D), chlortetracycline (C), and minocycline (M), showed therapeutic potential against liver fibrosis by inhibiting the activation of hepatic stellate cells and the MAPK signaling. This study suggests that tetracyclines may be repurposed for the treatment of liver fibrosis.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2024)
Article
Immunology
Yu Li, Hailing Liu, Danwen Zhao, Danjie Zhang
Summary: Chronic stress can lead to lung injury, with the spleen playing a crucial role. This study found that the spleen contributes to chronic restraint stress-induced lung injury, and splenic CD11b+ cells may be an important factor in this process.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2024)
Article
Immunology
Yingqian Mi, Mengyan Tang, Qiong Wu, Yinan Wang, Qihui Liu, Pei Zhu, Xiaoyang Xue, Yuntong Liu, Xinyu Chai, Yuyang Hou, Dongmei Yan
Summary: BCG therapy can induce macrophage polarization to the M1 type, and NMAAP1 plays a crucial role in this process by regulating glycolysis and HIF-1α expression. This promotes the antitumor effect of macrophages.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2024)
Article
Immunology
Xiaosheng Liu, Tingxia Lv, Xiuxia Li, Jing Xue, Ling Lin, Lianfeng Lu, Xiaodi Li, Yang Yang, Yuanni Wu, Qiang Wei, Wei Cao, Taisheng Li
Summary: LLDT-8 exhibits notable efficacy in alleviating immune activation in both an in vivo animal model and in vitro human cell experiments, suggesting its potential as a drug for managing systemic immune activation associated with SIV/HIV infection.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2024)
Article
Immunology
Honghong Yu, Qi Li, Huimin Zhu, Chang Liu, Weiwei Chen, Lingyun Sun
Summary: The activation of the inflammasome plays a critical role in the pathogenesis of systemic lupus erythematosus (SLE), and mesenchymal stem cells (MSC) have been shown to alleviate SLE by suppressing inflammasome activation. This study found that the NLRP3 inflammasome was activated in macrophages from SLE patients and mice, and its activation correlated with disease activity. After MSC transplantation, the severity of SLE was reduced, and NLRP3 inflammasome activation was inhibited. These findings suggest that MSC suppress inflammasome activation and provide a potential therapeutic target for SLE.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2024)
Article
Immunology
Wei Zhou, Dan Zeng, Shunan Liu, Yunxia Huang, Fenglin Lv, Weikang Zhou
Summary: This study found that inhibiting HDAC3 can protect the skin from atopic dermatitis by activating the Nrf2 transcription to upregulate Nrf2/HO-1 signaling pathway activity.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2024)