Article
Biochemistry & Molecular Biology
Haibo Zhang, Xiaodan Dong, Haiyu Ji, Juan Yu, Anjun Liu
Summary: In this study, an acid-extracted polysaccharide (GFP-A) was extracted from the fruiting bodies of G. frondosa. The study aimed to simulate the digestion, absorption, and antitumor activities of G. frondosa polysaccharides in the acidic stomach environment. The results showed that GFP-A is a neutral polysaccharide composed of xylose, mannose, and glucose, which effectively inhibited tumor growth and induced apoptosis in S180 tumor cells.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2023)
Article
Chemistry, Multidisciplinary
Jie Geng, Guining Wang, Jiao Guo, Xiao Han, Yunhe Qu, Yifa Zhou, Guihua Tai, Lin Sun, Hairong Cheng
Summary: In this study, mycelia were obtained from Grifola frondosa through liquid fermentation, and then extracted and characterized using methylation and spectroscopic techniques. The results revealed the presence of fucomannogalactans and beta-1,6-glucans in G. frondosa mycelium, providing important structural information for their further development and application.
FRONTIERS IN CHEMISTRY
(2023)
Article
Biochemistry & Molecular Biology
Xiao-li Wang, Le-le Zhang, Ni Chen, Jian Li, Cheng-feng Han, Shuai Wang, Li-min Hao, Shi-ru Jia, Pei-pei Han
Summary: The study proposed a strategy of exogenous addition of quorum sensing molecule farnesol to enhance the production, antioxidant activity, and antitumor activity of Grifola frondosa extracellular polysaccharide (EPS) by liquid fermentation. Different polysaccharides extracted and purified under different conditions showed variances in chemical composition, antioxidant activities, and antitumor activities, with EPS-F-0.2M exhibiting the highest bioactivities.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2021)
Article
Biochemistry & Molecular Biology
Ying-Ying Liang, Xin-Yi Zan, Lei Sun, Xin Fu, Feng-Jie Cui, Ming Tan, Ze-Yu Shao, Wen-Jing Sun
Summary: The study revealed the mechanism of GFUGT88A1 in extending glucan chains, providing a reference for understanding the biosynthesis pathway of mushroom glucans.
PROCESS BIOCHEMISTRY
(2022)
Article
Biotechnology & Applied Microbiology
Li-Hua Jiang, Xiang-Fei Li, Xin-Yi Zan, Xin Fu, Feng-Jie Cui, Hong-An Zhu, Wen-Jing Sun, Ting-Lei Tao
Summary: The study revealed that GFGLS2 plays a major role in mycelial growth and polysaccharide synthesis, with higher efficiency in downregulation compared to GFGLS. Cosilencing GFGLS and GFGLS2 had a synergistic effect, resulting in slower mycelial growth of Grifola frondosa.
APPLIED MICROBIOLOGY AND BIOTECHNOLOGY
(2022)
Article
Materials Science, Paper & Wood
Yi-Cheng Wang, Te-Sheng Lien, Nan-Yin Chen, Tai-Hao Hsu
Summary: Using commercial API-ZYM screening kits, highly active alpha-glucosidase, beta-glucosidase, and beta-N-acetylglucosaminidase were found in Grifola frondosa, with beta-N-acetylglucosaminidase being purified and characterized. The enzyme, named NAG38, had optimal activity at pH 7.0 and 50 degrees C, and was inhibited by several metal ions.
Article
Food Science & Technology
Zehong Chen, Yuxuan Liu, Dan Wang, Niuniu Wu, Kaiping Wang, Yu Zhang
Summary: In this study, sulfated modification was performed on Grifola frondosa polysaccharide (GFP) using the chlorosulfonic acid-pyridine method. The sulfated GFP (S-GFP) exhibited alpha-glucosidase inhibitory activity and changed the conformation of the enzyme. The results suggest that sulfation alters the structure and inhibitory mechanism of polysaccharides.
JOURNAL OF FUNCTIONAL FOODS
(2022)
Review
Food Science & Technology
Jian-Yong Wu, Ka-Chai Siu, Ping Geng
Summary: Grifola frondosa, also known as hen-of-the-woods or maitake, is an edible mushroom with bioactive constituents like polysaccharides, proteins, and small organic molecules, showing antitumor, immunomodulatory, and antioxidant activities. Research suggests that this mushroom may have potential value for nutraceutical and pharmaceutical applications, but further investigation is needed to understand its structure-bioactivity relationship and mechanisms of action.
Article
Food Science & Technology
Weiwei Yang, Juan Wu, Weimin Liu, Zhilu Ai, Yu Cheng, Zhencheng Wei, Hao Zhang, Haile Ma, Fengjie Cui, Cunshan Zhou, Liuqing Yang
Summary: Rice bran and wheat bran, as high-yield but low-utilization agricultural by-products in China, can be used as fermentation substrates for Grifola frondosa strains to produce polysaccharides with remarkable antioxidant and hypolipidemic abilities.
Article
Food Science & Technology
Jixian Zhang, Dongming Liu, Chaoting Wen, Jun Liu, Xin Xu, Guoyan Liu, Juan Kan, Chunlu Qian, Changhai Jin
Summary: This review provides a new and updated overview of the extraction methods, structural diversity, and biological activities of Grifola frondosa polysaccharides (GFPs) and their derivatives. However, the active mechanism of GFPs is still unclear, and other potential effects of GFPs need to be further explored.
TRENDS IN FOOD SCIENCE & TECHNOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Yu Zhang, Niuniu Wu, Jingyi Wang, Zehong Chen, Zhijing Wu, Mengzi Song, Ziming Zheng, Kaiping Wang
Summary: In this study, the gastrointestinal metabolism characteristics and mechanism of Grifola frondosa polysaccharide (GFP) were investigated. The results showed significant distribution of the polysaccharide in the liver and kidneys, and degradation in the stomach and small intestine, followed by excretion through urine. These findings contribute to a better understanding and utilization of the pharmacological activities of GFP.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2023)
Article
Food Science & Technology
Bo Ren, Shixiang Wei, He Huang
Summary: This review summarizes the production, properties, and bioactivities of Grifola frondosa polysaccharides (GFPs) reported in recent years. The biosynthetic pathway of GFPs was speculated, providing ideas for tailoring the structure through gene editing. The possible action or mechanisms of bioactivities are summarized and new perspectives for future studies on GFPs in health foods and pharmaceuticals are proposed.
CURRENT OPINION IN FOOD SCIENCE
(2023)
Article
Microbiology
Teresa Fasciana, Maria Letizia Gargano, Nicola Serra, Elena Galia, Ignazio Arrigo, Maria Rita Tricoli, Orazia Diquattro, Giuseppa Graceffa, Salvatore Vieni, Giuseppe Venturella, Anna Giammanco
Summary: The study found that extracts from albino Grifola frondosa could effectively inhibit the growth of certain bacteria and biofilm production by Staphylococcus aureus, reducing the presence of biofilm. This indicates that albino Grifola frondosa extracts could be utilized as functional food and natural additives for food processing control and safety.
Article
Chemistry, Applied
Qian Wang, Hao Jiang, Hongli Zhang, Weiqiao Lu, Xiao Wang, Wenfeng Xu, Jia Li, Youjing Lv, Guoyun Li, Chao Cai, Guangli Yu
Summary: This study proposes a novel strategy of antibody-beta-glucan conjugates (AGC) to enhance the antitumor immune response to immune checkpoint blockade (ICB) therapy. AGC demonstrated powerful tumor suppression and promoted interaction between tumor cells and dendritic cells (DCs), thereby enhancing immunotherapeutic benefits.
CARBOHYDRATE POLYMERS
(2024)
Article
Nutrition & Dietetics
Farida Tripodi, Ermelinda Falletta, Manuela Leri, Cristina Angeloni, Daniela Beghelli, Laura Giusti, Riccardo Milanesi, Belem Sampaio-Marques, Paula Ludovico, Lorenzo Goppa, Paola Rossi, Elena Savino, Monica Bucciantini, Paola Coccetti
Summary: The aqueous extracts of medicinal mushrooms G. frondosa and H. erinaceus have anti-aging and neuroprotective effects, making them potential functional foods for preventing aging and age-related disorders.
Article
Immunology
Jun Cui, Cheng Chen, Xiao Zhou, Wenju Shan, Yuhong Jian, Panpan Li, Yang Sun, Wei Yi
Summary: Bone marrow mesenchymal stem cells (BMSCs) are a promising therapy for sepsis, but metabolic syndromes threaten their effectiveness. This study investigated the potential of small extracellular vesicles from high-fat diet BMSCs in sepsis-induced liver-heart axis injury.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2024)
Article
Immunology
Binbin Zhu, Angyang Cao, Chunqu Chen, Weijian Zhou, Wenjun Luo, Yu Gui, Qinwen Wang, Zhipeng Xu, Jianhua Wang
Summary: GM6001 alleviates postoperative cognitive deficits and neuroinflammation, preserves blood-brain barrier integrity, and rescues aquaporin-4 mislocalization. MMP-9 inhibition plays a dual role in cognitive protection through direct anti-neuroinflammatory effects and regulation of aquaporin-4 membrane distribution.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2024)
Article
Immunology
Anika Sood, Valencia Fernandes, Kumari Preeti, Shruti Rajan, Dharmendra Kumar Khatri, Shashi Bala Singh
Summary: S1PR2 inhibitor improves cognitive function and skews microglia toward anti-inflammatory phenotype in type 2 diabetic mice, promising to be a potential therapy for neuroinflammation.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2024)
Article
Immunology
Haochun Guo, Ran Yu, Haijun Zhang, Wanpeng Wang
Summary: Radiation therapy is an effective treatment for thoracic malignancies, but it can cause radiation-induced lung injury (RILI), including radiation pneumonitis (RP) and radiation pulmonary fibrosis (RPF). The damage to normal lung cells during radiation treatment leads to a pulmonary inflammatory response, resulting in RP and RPF.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2024)
Article
Immunology
Guanghui Wang, Haotian Zheng, Yunzhi Xiang, Yadong Wang, Kai Wang, Xiaoyang Ren, Jiajun Du
Summary: This study identified a T-cell synthetic driver-associated prognostic model that accurately predicted prognosis and effectiveness of immunotherapy in LUAD patients. It also highlighted the role of LDHA in promoting tumor cell proliferation, invasion, and resistance to treatment, as well as its involvement in immune escape within the tumor microenvironment. These findings provide a promising new therapeutic strategy for LUAD.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2024)
Article
Immunology
Bowen Wei, Aihua Wang, Wei Liu, Qingyun Yue, Yihua Fan, Bin Xue, Siwei Wang
Summary: This study systematically analyzed the association between pSS and cuproptosis, established a predictive model based on 5 genes, explored the pathogenic mechanisms and novel therapeutic strategies for pSS, and identified EED, CBL, and NFU1 as potential targets for treatment.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2024)
Article
Immunology
Nusrit Iqbal Andrabi, Aminur R. Sarkar, Syed Assim Haq, Diljeet Kumar, Dilpreet Kour, Diksha Saroch, Sanket Kumar Shukla, Ajay Kumar, Asha Bhagat, Asif Ali, Gurleen Kour, Zabeer Ahmed
Summary: Koenimbine and its novel semi-synthetic derivative 1G demonstrate significant anti-inflammatory effects by downregulating the nuclear factor kappa-B (NF-kappa B) signaling pathway.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2024)
Article
Immunology
Jing-Mei Lu, Xiang Xu, Fumie Aosai, Ming-Yue Zhang, Lian-Xun Piao
Summary: This study found that arctiin can improve allergic acute liver injury caused by T.g.HSP70 by inhibiting TLR4 signaling and reducing the production of inflammatory mediators.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2024)
Article
Immunology
Minxuan Xu, Fang Shi, Yongshen Gao, Shumei Han, Chensuo Huang, Qinsheng Hou, Xiaoweng Wen, Bengshi Wang, Zhenyu Zhu, Lei Zou, Mingxin Xiong, Wei Dong, Jun Tan
Summary: There is a growing body of research highlighting the involvement of metabolic imbalance and the inflammatory response in the advancement of colitis. This study recognizes arabinose as a significant protector of the intestinal mucosal barrier, reducing damage to the intestines. In addition, lower levels of arabinose in the bloodstream are associated with a higher severity of inflammatory bowel disease and colorectal cancer.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2024)
Article
Immunology
Yueqing Han, Haoxin Song, Yanshan Li, Rongxin Li, Ling Chen, Bo Gao, Yijun Chen, Shuzhen Wang
Summary: The combination of tetracycline antibiotics, demeclocycline (D), chlortetracycline (C), and minocycline (M), showed therapeutic potential against liver fibrosis by inhibiting the activation of hepatic stellate cells and the MAPK signaling. This study suggests that tetracyclines may be repurposed for the treatment of liver fibrosis.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2024)
Article
Immunology
Yu Li, Hailing Liu, Danwen Zhao, Danjie Zhang
Summary: Chronic stress can lead to lung injury, with the spleen playing a crucial role. This study found that the spleen contributes to chronic restraint stress-induced lung injury, and splenic CD11b+ cells may be an important factor in this process.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2024)
Article
Immunology
Yingqian Mi, Mengyan Tang, Qiong Wu, Yinan Wang, Qihui Liu, Pei Zhu, Xiaoyang Xue, Yuntong Liu, Xinyu Chai, Yuyang Hou, Dongmei Yan
Summary: BCG therapy can induce macrophage polarization to the M1 type, and NMAAP1 plays a crucial role in this process by regulating glycolysis and HIF-1α expression. This promotes the antitumor effect of macrophages.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2024)
Article
Immunology
Xiaosheng Liu, Tingxia Lv, Xiuxia Li, Jing Xue, Ling Lin, Lianfeng Lu, Xiaodi Li, Yang Yang, Yuanni Wu, Qiang Wei, Wei Cao, Taisheng Li
Summary: LLDT-8 exhibits notable efficacy in alleviating immune activation in both an in vivo animal model and in vitro human cell experiments, suggesting its potential as a drug for managing systemic immune activation associated with SIV/HIV infection.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2024)
Article
Immunology
Honghong Yu, Qi Li, Huimin Zhu, Chang Liu, Weiwei Chen, Lingyun Sun
Summary: The activation of the inflammasome plays a critical role in the pathogenesis of systemic lupus erythematosus (SLE), and mesenchymal stem cells (MSC) have been shown to alleviate SLE by suppressing inflammasome activation. This study found that the NLRP3 inflammasome was activated in macrophages from SLE patients and mice, and its activation correlated with disease activity. After MSC transplantation, the severity of SLE was reduced, and NLRP3 inflammasome activation was inhibited. These findings suggest that MSC suppress inflammasome activation and provide a potential therapeutic target for SLE.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2024)
Article
Immunology
Wei Zhou, Dan Zeng, Shunan Liu, Yunxia Huang, Fenglin Lv, Weikang Zhou
Summary: This study found that inhibiting HDAC3 can protect the skin from atopic dermatitis by activating the Nrf2 transcription to upregulate Nrf2/HO-1 signaling pathway activity.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2024)