Endoplasmic Reticulum Aminopeptidase-1 Functions Regulate Key Aspects of the Innate Immune Response

Activation of human natural killer cells by the novel innate immune modulator recombinant Eimeria antigen

(2013) Charles F. Aylsworth et al.   HUMAN IMMUNOLOGY

Genome-wide association analysis identifies new susceptibility loci for Behçet's disease and epistasis between HLA-B*51 and ERAP1

(2013) Yohei Kirino et al.   NATURE GENETICS

Investigating the genetic association betweenERAP1and spondyloarthritis

(2012) Amir Kadi et al.   ANNALS OF THE RHEUMATIC DISEASES

The putative role of endoplasmic reticulum aminopeptidases in autoimmunity: Insights from genomic-wide association studies

(2012) Alessandra Fierabracci et al.   AUTOIMMUNITY REVIEWS

Role of Endoplasmic Reticulum Aminopeptidases in Health and Disease: from Infection to Cancer

(2012) Loredana Cifaldi et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Vaccines Expressing the Innate Immune Modulator EAT-2 Elicit Potent Effector Memory T Lymphocyte Responses despite Pre-Existing Vaccine Immunity

(2012) Y. A. Aldhamen et al.   JOURNAL OF IMMUNOLOGY

TGF-β is responsible for NK cell immaturity during ontogeny and increased susceptibility to infection during mouse infancy

(2012) Jeffrey P Marcoe et al.   NATURE IMMUNOLOGY

A Functional Variant in ERAP1 Predisposes to Multiple Sclerosis

(2012) Franca Rosa Guerini et al.   PLoS One

MyD88 Associated ROS Generation Is Crucial for Lactobacillus Induced IL-12 Production in Macrophage

(2012) Shintaro Ichikawa et al.   PLoS One

ERAAP modulation: A possible novel strategy for cancer immunotherapy?

(2012) Doriana Fruci et al.   OncoImmunology

The Cell Biology of Phagocytosis

(2011) Ronald S. Flannagan et al.   Annual Review of Pathology-Mechanisms of Disease

Natural Killer Cells Efficiently Reject Lymphoma Silenced for the Endoplasmic Reticulum Aminopeptidase Associated with Antigen Processing

(2011) L. Cifaldi et al.   CANCER RESEARCH

Cytoplasmic DNA innate immune pathways

(2011) Glen N. Barber   IMMUNOLOGICAL REVIEWS

Interaction between ERAP1 and HLA-B27 in ankylosing spondylitis implicates peptide handling in the mechanism for HLA-B27 in disease susceptibility

(2011) David M Evans et al.   NATURE GENETICS

Human cytomegalovirus microRNA miR-US4-1 inhibits CD8+ T cell responses by targeting the aminopeptidase ERAP1

(2011) Sungchul Kim et al.   NATURE IMMUNOLOGY

TRIF Is a Critical Negative Regulator of TLR Agonist Mediated Activation of Dendritic Cells In Vivo

(2011) Sergey S. Seregin et al.   PLoS One

Adenovirus capsid-display of the retro-oriented human complement inhibitor DAF reduces Ad vector-triggered immune responses in vitro and in vivo

(2010) S. S. Seregin et al.   BLOOD

Natural killer cells in human autoimmune diseases

(2010) Nicolas Schleinitz et al.   IMMUNOLOGY

Endoplasmic Reticulum Aminopeptidase Associated with Antigen Processing Defines the Composition and Structure of MHC Class I Peptide Repertoire in Normal and Virus-Infected Cells

(2010) N. Blanchard et al.   JOURNAL OF IMMUNOLOGY

Genome-wide association study of ankylosing spondylitis identifies non-MHC susceptibility loci

(2010) John D Reveille et al.   NATURE GENETICS

A New Adenovirus Based Vaccine Vector Expressing an Eimeria tenella Derived TLR Agonist Improves Cellular Immune Responses to an Antigenic Target

(2010) Daniel M. Appledorn et al.   PLoS One

Improving Adenovirus Based Gene Transfer: Strategies to Accomplish Immune Evasion

(2010) Sergey S. Seregin et al.   Viruses-Basel

Maturation of mouse NK cells is a 4-stage developmental program

(2009) L. Chiossone et al.   BLOOD

Antigen processing and presentation: TAPping into ABC transporters

(2009) Erik Procko et al.   CURRENT OPINION IN IMMUNOLOGY

CR1/2 is an important suppressor of Adenovirus-induced innate immune responses and is required for induction of neutralizing antibodies

(2009) S S Seregin et al.   GENE THERAPY

Investigating the genetic association between ERAP1 and ankylosing spondylitis

(2009) David Harvey et al.   HUMAN MOLECULAR GENETICS

Transient Pretreatment With Glucocorticoid Ablates Innate Toxicity of Systemically Delivered Adenoviral Vectors Without Reducing Efficacy

(2009) Sergey S Seregin et al.   MOLECULAR THERAPY

Wild-type adenoviruses from groups A–F evoke unique innate immune responses, of which HAd3 and SAd23 are partially complement dependent

(2008) D M Appledorn et al.   GENE THERAPY

Analysis of 17 autoimmune disease-associated variants in type 1 diabetes identifies 6q23/TNFAIP3 as a susceptibility locus

(2008) E Y M G Fung et al.   GENES AND IMMUNITY

Invariant NKT cells reduce the immunosuppressive activity of influenza A virus–induced myeloid-derived suppressor cells in mice and humans

(2008) Carmela De Santo et al.   JOURNAL OF CLINICAL INVESTIGATION

Immunodominant, protective response to the parasite Toxoplasma gondii requires antigen processing in the endoplasmic reticulum

(2008) Nicolas Blanchard et al.   NATURE IMMUNOLOGY

Up on the tightrope: natural killer cell activation and inhibition

(2008) Lewis L Lanier   NATURE IMMUNOLOGY

The Internal Sequence of the Peptide-Substrate Determines Its N-Terminus Trimming by ERAP1

(2008) Irini Evnouchidou et al.   PLoS One

Adenovirus vector induced innate immune responses: Impact upon efficacy and toxicity in gene therapy and vaccine applications

(2007) Zachary C. Hartman et al.   VIRUS RESEARCH