Review
Immunology
Yanran Li, Qiyuan Yang, Dongjie Cai, Hongrui Guo, Jing Fang, Hengmin Cui, Liping Gou, Junliang Deng, Zhisheng Wang, Zhicai Zuo
Summary: Resistin, initially proposed as a link between obesity and diabetes in mice, is considered a pro-inflammatory molecule expressed in immune cells in humans, playing a regulatory role in chronic inflammatory diseases, metabolic diseases, infectious diseases, and cancers. However, increasing evidence shows that it functions as a host defense peptide with wide-spectrum anti-microbial activity and immune modulation, limited microbial product-induced inflammation.
FRONTIERS IN IMMUNOLOGY
(2021)
Review
Immunology
Prashanta Silwal, In Soo Kim, Eun-Kyeong Jo
Summary: Autophagy plays a crucial role in enhancing the immune responses and controlling inflammation against NTM infections, and holds potential as a therapeutic target for combating NTM infections.
FRONTIERS IN IMMUNOLOGY
(2021)
Review
Immunology
Kellen J. Cavagnero, Richard L. Gallo
Summary: Fibroblasts are stromal cells that produce extracellular matrix and play a role in tissue structure and scar formation. Recent studies have found that they are highly heterogeneous and actively participate in both innate and adaptive immune defense. Detailed analysis of barrier tissues such as skin, gut, and lung shows that some fibroblasts directly sense pathogens and other danger signals, contributing to host defense functions such as antimicrobial activity, white blood cell recruitment, and production of cytokines relevant to inflammation.
FRONTIERS IN IMMUNOLOGY
(2022)
Review
Immunology
Jae-Min Yuk, Eun-Jin Park, In Soo Kim, Eun-Kyeong Jo
Summary: Itaconate is an important immunometabolite with anti-infective and anti-inflammatory properties. Its derivatives and isomers have potential as drugs for inflammation and infection. However, the exact mechanisms of action and the therapeutic potential of Itaconate are not fully understood due to contradictory results and a lack of clinical data. Further research is needed to understand how itaconate exerts its effects and to explore its therapeutic applications.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Biochemical Research Methods
Reese A. Martin, Ann T. Tate
Summary: Genes involved in immune defense resist rapidly evolving parasites and pathogens and are highly represented in the immune system. Pleiotropic signaling genes affect multiple phenotypes and may play a role in the evolution of inducible immunity. Pleiotropy is prevalent in immune signaling networks, and it provides an advantage for host fitness during infection.
PLOS COMPUTATIONAL BIOLOGY
(2023)
Article
Multidisciplinary Sciences
Ernest Y. Lee, Liana C. Chan, Huiyuan Wang, Juelline Lieng, Mandy Hung, Yashes Srinivasan, Jennifer Wang, James A. Waschek, Andrew L. Ferguson, Kuo-Fen Lee, Nannette Y. Yount, Michael R. Yeaman, Gerard C. L. Wong
Summary: This study confirms the antimicrobial role of PACAP and reveals its selective induction in the brain during infection. Through various mechanisms, including disruption of pathogen membrane integrity and activation of cell death pathways, PACAP exhibits antimicrobial activity.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2021)
Review
Immunology
Jin Kyung Kim, Eun-Jin Park, Eun-Kyeong Jo
Summary: Immune metabolic regulation plays a crucial role in the host-pathogen interaction during tuberculosis infection. Metabolites such as itaconate, L-arginine, and L-citrulline are involved in innate immune protection against Mycobacterium tuberculosis, by restricting bacterial growth and enhancing host defense mechanisms.
FRONTIERS IN IMMUNOLOGY
(2022)
Review
Immunology
Nighat Perveen, Khalid Muhammad, Sabir Bin Muzaffar, Tean Zaheer, Nayla Munawar, Bojan Gajic, Olivier Andre Sparagano, Uday Kishore, Arve Lee Willingham
Summary: Haematophagous arthropods can carry various pathogens and transmit them to humans and animals, making it important to study their relationship with viruses. Insects have an innate immune system that helps them fight infections. The cellular components of haemolymph, called haemocytes, play a central role in the insect immune system. Mosquitoes and ticks, blood-feeding arthropods, can transmit viral pathogens to their hosts. Despite the arthropod vectors' complex immune response, the viruses can still survive and be transmitted. A multidisciplinary approach is needed to control ectoparasite infestations and prevent vector-borne transmission of viral pathogens to humans and animals.
FRONTIERS IN IMMUNOLOGY
(2023)
Review
Immunology
Aditi Choudhary, Pratibha Madbhagat, M. Sreepadmanabh, Vipin Bhardwaj, Ajit Chande
Summary: Circular RNA (circRNA) is a relatively new member of the non-coding RNA family that plays important roles in regulating gene expression, potential coding, and interactions with proteins and microRNAs. The changes in circRNAs during viral infections can modulate the response to infection, and viruses have been found to encode circRNAs with proviral functions.
FRONTIERS IN IMMUNOLOGY
(2021)
Review
Pharmacology & Pharmacy
Zizheng Li, Ou Qiao, Yuru Wang, Ning Li, Yanhua Gong
Summary: Despite medical advancements, severe trauma remains a critical condition with high mortality. Releases of DAMPs during trauma can lead to immune dysfunction and subsequent sepsis or MODS. Vaccines based on specific pathogen antigens and PAMPs are effective in preventing communicable diseases, while autologous molecule-based vaccines show potential in promoting recovery from non-communicable diseases. Developing vaccines targeting DAMPs could be an effective pre-protective measure for trauma management.
TRENDS IN PHARMACOLOGICAL SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Ernesto M. Martell, Melaine Gonzalez-Garcia, Ludger Staendker, Anselmo J. Otero-Gonzalez
Summary: Host defense peptides (HDPs) have both antimicrobial and immunomodulatory activities, with the latter gaining increased interest in the past 20 years. The immunomodulatory activities are more effective in vivo, offering new therapeutic applications in areas such as anti-infective therapy, chronic inflammatory diseases treatment, novel vaccine adjuvants development, and anticancer immunotherapy.
Review
Immunology
Ioannis Eleftherianos, Ghada Tafesh-Edwards, Amr Mohamed
Summary: Recent studies have shown that insect tissues and organs play a crucial role in the natural infection routes of parasites and microbial pathogens. This article summarizes the different types of parasites that infect insects through distinct routes and examines the relationship between infection routes and insect immune response. The findings suggest that understanding the association between infection routes and insect host defense can help in designing strategies for managing agricultural pests and disease vectors.
IMMUNOLOGY LETTERS
(2022)
Article
Multidisciplinary Sciences
Shengzhang Dong, George Dimopoulos
Summary: Ae. aegypti mosquitoes play a crucial role in transmitting important human viral diseases. The disruption of the siRNA pathway by CRISPR/Cas9-mediated Ago2 knockout impairs the mosquitoes' ability to degrade arbovirus RNA, leading to hyper-infection, cell lysis, tissue damage, and ultimately mosquito death.
NATURE COMMUNICATIONS
(2023)
Article
Multidisciplinary Sciences
M. A. Hanson, L. Grollmus, B. Lemaitre
Summary: Antimicrobial peptides, encoded by the host, play a crucial role in combating pathogens and shaping the microbiome in plants and animals. This study focuses on the Diptericin antimicrobial peptide family of Diptera and reveals the specific roles of DptA and DptB in Drosophila melanogaster, demonstrating how they interact with different bacteria. The findings also highlight the correlation between the presence of DptA- or DptB-like genes and the presence of specific bacteria across Diptera.
Review
Immunology
Jianya Peng, Hannah G. G. Federman, Christina M. Hernandez, Mark C. C. Siracusa
Summary: Parasitic helminth infections are a global health issue, causing significant morbidity and economic hardships. Host protective responses to helminths involve the initiation of type 2 inflammation and the involvement of various immune cells. Recent studies have also highlighted the importance of neuro-immune interactions in regulating anti-helminth immunity.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Medicine, Research & Experimental
Hiroshi Hosoda, Hiroshi Tamura, Isao Nagaoka
INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE
(2015)
Article
Immunology
Zhongshuang Hu, Taisuke Murakami, Kaori Suzuki, Hiroshi Tamura, Johannes Reich, Kyoko Kuwahara-Arai, Toshiaki Iba, Isao Nagaoka
INTERNATIONAL IMMUNOLOGY
(2016)
Article
Immunology
Kaori Suzuki, Taisuke Murakami, Zhongshuang Hu, Hiroshi Tamura, Kyoko Kuwahara-Arai, Toshiaki Iba, Isao Nagaoka
JOURNAL OF IMMUNOLOGY
(2016)
Article
Oncology
Taisuke Murakami, Zhongshuang Hu, Hiroshi Tamura, Isao Nagaoka
MOLECULAR MEDICINE REPORTS
(2016)
Article
Medicine, Research & Experimental
Zhongshuang Hu, Taisuke Murakami, Hiroshi Tamura, Johannes Reich, Kyoko Kuwahara-Arai, Toshiaki Iba, Yoko Tabe, Isao Nagaoka
INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE
(2017)
Article
Biochemical Research Methods
Johannes Reich, Hiroshi Tamura, Isao Nagaoka, Hubert Motschmann
Article
Immunology
Kaori Suzuki, Taisuke Murakami, Kyoko Kuwahara-Arai, Hiroshi Tamura, Keiichi Hiramatsu, Isao Nagaoka
INTERNATIONAL IMMUNOLOGY
(2011)
Article
Medicine, Research & Experimental
Daiju Okuda, Shin Yomogida, Kyoko Kuwahara-Arai, Keiichi Hitamatsu, Hiroshi Tamura, Isao Nagaoka
INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE
(2009)
Article
Medicine, Research & Experimental
Isao Nagaoka, Kaori Suzuki, Taisuke Murakami, Francois Niyonsaba, Hiroshi Tamura, Mchimasa Hirata
INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE
(2010)
Article
Medicine, Research & Experimental
Hiroshi Hosoda, Hiroshi Tamura, Satoshi Kida, Isao Nagaoka
Article
Multidisciplinary Sciences
Zhongshuang Hu, Taisuke Murakami, Kaori Suzuki, Hiroshi Tamura, Kyoko Kuwahara-Arai, Toshiaki Iba, Isao Nagaoka
Article
Medicine, Research & Experimental
Taisuke Murakami, Kaori Suzuki, Hiroshi Tamura, Isao Nagaoka
EXPERIMENTAL AND THERAPEUTIC MEDICINE
(2011)
Article
Biochemistry & Molecular Biology
Johannes Reich, Felix Alexander Weyer, Hiroshi Tamura, Isao Nagaoka, Hubert Motschmann
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2019)
Review
Biochemistry & Molecular Biology
Isao Nagaoka, Hiroshi Tamura, Johannes Reich
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2020)
Review
Biochemistry & Molecular Biology
Hiroshi Tamura, Johannes Reich, Isao Nagaoka
Summary: The blue blood of the horseshoe crab, containing Limulus amebocyte lysate (LAL), is a valuable resource in the biomedical industry for its role in sensitive bacterial and fungal detection. LAL tests have replaced rabbit pyrogen tests in pharmaceutical quality control and show promise as biomarkers for bacterial sepsis and fungal infections. Further advancements in LAL-based endotoxin and beta-glucan assay techniques may enhance the detection of endotoxin in human blood for improved diagnosis and management of related conditions.