Article
Critical Care Medicine
Sergei Rey, Vladimir M. Kulabukhov, Alexander Popov, Olga Nikitina, Gennady Berdnikov, Marat Magomedov, Timur Kim, Sergei Masolitin, Olga Ignatenko, Nikolai Krotenko, Anastasia Marysheva, Nikolai Chaus, Leonid Ohinko, Makarii Mendibaev, Anastasia Chumachenko, Vladimir Pisarev
Summary: Extracorporeal hemoperfusion (EHP) with Efferon LPS cartridges effectively improved the course and outcomes of patients with septic shock. EHP led to increased MAP and arterial oxygenation, decreased norepinephrine doses, and improved organ function. However, there were no significant improvements in survival rates at 14 and 28 days. Laboratory tests showed rapid reductions in inflammatory biomarkers only in the Efferon LPS group.
Review
Critical Care Medicine
Kusum Menon, Luregn J. Schlapbach, Samuel Akech, Andrew Argent, Paolo Biban, Enitan D. Carrol, Kathleen Chiotos, Mohammod Jobayer Chisti, Idris V. R. Evans, David P. Inwald, Paul Ishimine, Niranjan Kissoon, Rakesh Lodha, Simon Nadel, Claudio Flauzino Oliveira, Mark Peters, Benham Sadeghirad, Halden F. Scott, Daniela C. de Souza, Pierre Tissieres, R. Scott Watson, Matthew O. Wiens, James L. Wynn, Jerry J. Zimmerman, Lauren R. Sorce
Summary: The study aimed to determine the associations of demographic, clinical, laboratory, organ dysfunction, and illness severity variable values with sepsis, severe sepsis, or septic shock in children with infection, as well as multiple organ dysfunction or death in children with sepsis, severe sepsis, or septic shock. The findings revealed significant associations between multiple markers of organ dysfunction and the outcomes of interest.
CRITICAL CARE MEDICINE
(2022)
Article
Biochemistry & Molecular Biology
Franz-Simon Centner, Jochen J. Schoettler, Kathrin Brohm, Sonani Mindt, Evelyn Jaeger, Bianka Hahn, Tanja Fuderer, Holger A. Lindner, Verena Schneider-Lindner, Joerg Krebs, Michael Neumaier, Manfred Thiel
Summary: A common final pathway of pathogenetic mechanisms in septic organ dysfunction and death is a lack or non-utilization of oxygen. Plasma concentrations of lactate serve as surrogates for the oxygen-deficiency-induced imbalance between energy supply and demand. S-adenosylhomocysteine (SAH) appears to be a better contributor to the prediction of septic organ dysfunction and death than lactate in critically ill patients.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Immunology
Wenfang He, Haiyun Dong, Chenfang Wu, Yanjun Zhong, Jinxiu Li
Summary: Sepsis, characterized by host immune imbalance and organ dysfunction caused by infection, remains a formidable challenge with limited therapeutic options and high mortality rates. Recent studies have highlighted the potential of targeting NLRP3 inflammasome as a therapeutic strategy for sepsis. Activation of the NLRP3 inflammasome complex has been shown to play a critical role in the development and progression of sepsis, while inhibition of its activation can ameliorate the inflammatory response, protect organ function, and improve patient outcomes and survival.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2023)
Review
Biochemistry & Molecular Biology
Alba Montero-Jodra, Miguel Angel de la Fuente, Dino Gobelli, Marta Martin-Fernandez, Jesus Villar, Eduardo Tamayo, Maria Simarro
Summary: Sepsis is the leading cause of infection-related death worldwide, and there is currently no specific treatment available. This review provides an overview of the important role of endothelial cell activation and dysfunction in sepsis development, as well as the involvement of mitochondria as potential targets in experimental models.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE
(2024)
Article
Critical Care Medicine
Alice Blet, Benjamin Deniau, Karine Santos, Dirk P. T. van Lier, Feriel Azibani, Xavier Wittebole, Benjamin G. Chousterman, Etienne Gayat, Oliver Hartmann, Joachim Struck, Andreas Bergmann, Massimo Antonelli, Albertus Beishuizen, Jean-Michel Constantin, Charles Damoisel, Nicolas Deye, Salvatore Di Somma, Thierry Dugernier, Bruno Francois, Stephane Gaudry, Vincent Huberlant, Jean-Baptiste Lascarrou, Gernot Marx, Emmanuelle Mercier, Haikel Oueslati, Peter Pickkers, Romain Sonneville, Matthieu Legrand, Pierre-Francois Laterre, Alexandre Mebazaa
Summary: The study revealed that the levels and rapid changes in cDPP3 upon admission can predict the outcomes of patients with sepsis.
Article
Multidisciplinary Sciences
Ismael Luna-Reyes, Erendira G. Perez-Hernandez, Blanca Delgado-Coello, Miguel Angel Avila-Rodriguez, Jaime Mas-Oliva
Summary: Peptide VSAK shows significant protective effects against the detrimental impact of lipopolysaccharides and systemic inflammatory response syndrome (SIRS), suggesting its potential as a candidate for developing new therapeutic approaches.
SCIENTIFIC REPORTS
(2021)
Review
Medicine, General & Internal
Grazia Maria Virzi, Maria Mattiotti, Massimo de Cal, Claudio Ronco, Monica Zanella, Silvia De Rosa
Summary: Lipopolysaccharide (LPS) is a major component of the cell wall of Gram-negative bacteria and plays a crucial role in the pathogenesis of sepsis. LPS activates the host defense system through Toll-like receptor 4, leading to pro-inflammatory mechanisms. Excessive activation of the immune system by LPS results in an exaggerated inflammatory response and extensive organ injury, contributing to sepsis damage.
Article
Health Care Sciences & Services
Caspar Mewes, Julius Runzheimer, Carolin Boehnke, Benedikt Buettner, Jose Hinz, Michael Quintel, Ashham Mansur
Summary: Despite recent advances in the understanding of sepsis and septic shock, the impact of sex on mortality and organ dysfunction in patients with these conditions remains controversial. This study aimed to investigate this association and found that male septic patients exhibited higher organ dysfunction compared to females.
JOURNAL OF PERSONALIZED MEDICINE
(2023)
Letter
Critical Care Medicine
Navin P. Boeddha, Luregn J. Schlapbach, Idse H. Visser, Nicolaas J. G. Jansen
Summary: This study validated an adapted form of the Pediatric Sepsis Score (aPSS), which can be obtained within 60 minutes of admission to the pediatric intensive care unit (PICU). The aPSS, excluding lactate, accurately predicted mortality in children with invasive infection and sepsis. It can serve as a useful tool for predicting outcomes in these children, especially when lactate measurement is not available within 60 minutes.
JOURNAL OF INTENSIVE CARE
(2022)
Review
Multidisciplinary Sciences
Yulei Gao, Xin Tian, Xiang Zhang, Grace Divine Milebe Nkoua, Fang Chen, Yancun Liu, Yanfen Chai
Summary: This review discusses the role of tissue-resident macrophages (TRMs) in the development and progression of sepsis, as well as the potential of modulating TRMs to attenuate sepsis, septic shock, and sepsis-associated organ dysfunction (SAOD).
Article
Critical Care Medicine
John A. Kellum, Claudio Ronco
Summary: Septic shock, caused by bacterial toxins like endotoxin, is a severe disease that can lead to organ failure. It is important to note that endotoxin may play a role in all types of septic shock, including non-bacterial causes such as COVID-19. Diagnosis relies on measuring endotoxin activity in addition to clinical assessment. Treatment options are limited, with immune modulating therapies and extracorporeal blood purification still being investigated.
Article
Biochemistry & Molecular Biology
Caspar Mewes, Julius Runzheimer, Carolin Boehnke, Benedikt Buettner, Marcus Nemeth, Jose Hinz, Michael Quintel, Ashham Mansur
Summary: This study compared the mortality and sepsis-associated organ dysfunction between patients with sepsis following surgical intervention and those with sepsis without prior surgery. The results showed that non-surgical patients had a higher mortality rate and more severe organ dysfunction compared to surgical patients. These findings have important implications for clinical decision-making, patient management, and resource allocation in sepsis care.
Review
Critical Care Medicine
Sebastien Preau, Dominique Vodovar, Boris Jung, Steve Lancel, Lara Zafrani, Aurelien Flatres, Mehdi Oualha, Guillaume Voiriot, Youenn Jouan, Jeremie Joffre, Fabrice Huel, Nicolas De Prost, Stein Silva, Eric Azabou, Peter Radermacher
Summary: Organ dysfunction in sepsis is associated with impaired metabolism and mitochondrial dysfunction, which could lead to new diagnostic and therapeutic approaches. These findings may help identify distinct subgroups of sepsis and develop personalized treatment strategies, while also serving as bioenergetic targets for metabolism- and mitochondria-targeted treatments in the future.
ANNALS OF INTENSIVE CARE
(2021)
Article
Critical Care Medicine
Carolina Lorencio Cardenas, Juan Carlos Yebenes, Emili Vela, Montserrat Cleries, Josep Ma Sirvent, Cristina Fuster-Bertolin, Clara Reina, Alejandro Rodriguez, Juan Carlos Ruiz-Rodriguez, Josep Trenado, Elisabeth Esteban Torne
Summary: The incidence of sepsis has been increasing in recent years, but hospital mortality has significantly decreased. In septic patients, all organ failures, except liver failure, have shown a statistically significant reduction in associated mortality.
Article
Medicine, Research & Experimental
Hiroshi Hosoda, Hiroshi Tamura, Isao Nagaoka
INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE
(2015)
Article
Immunology
Zhongshuang Hu, Taisuke Murakami, Kaori Suzuki, Hiroshi Tamura, Johannes Reich, Kyoko Kuwahara-Arai, Toshiaki Iba, Isao Nagaoka
INTERNATIONAL IMMUNOLOGY
(2016)
Article
Immunology
Kaori Suzuki, Taisuke Murakami, Zhongshuang Hu, Hiroshi Tamura, Kyoko Kuwahara-Arai, Toshiaki Iba, Isao Nagaoka
JOURNAL OF IMMUNOLOGY
(2016)
Article
Oncology
Taisuke Murakami, Zhongshuang Hu, Hiroshi Tamura, Isao Nagaoka
MOLECULAR MEDICINE REPORTS
(2016)
Article
Medicine, Research & Experimental
Zhongshuang Hu, Taisuke Murakami, Hiroshi Tamura, Johannes Reich, Kyoko Kuwahara-Arai, Toshiaki Iba, Yoko Tabe, Isao Nagaoka
INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE
(2017)
Article
Biochemical Research Methods
Johannes Reich, Hiroshi Tamura, Isao Nagaoka, Hubert Motschmann
Article
Immunology
Ken-ichiro Inoue, Eiko Koike, Rie Yanagisawa, Hirohisa Takano
IMMUNOPHARMACOLOGY AND IMMUNOTOXICOLOGY
(2009)
Article
Medicine, Research & Experimental
Isao Nagaoka, Kaori Suzuki, Taisuke Murakami, Francois Niyonsaba, Hiroshi Tamura, Mchimasa Hirata
INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE
(2010)
Article
Medicine, Research & Experimental
Hiroshi Hosoda, Hiroshi Tamura, Satoshi Kida, Isao Nagaoka
Article
Multidisciplinary Sciences
Zhongshuang Hu, Taisuke Murakami, Kaori Suzuki, Hiroshi Tamura, Kyoko Kuwahara-Arai, Toshiaki Iba, Isao Nagaoka
Article
Medicine, Research & Experimental
Taisuke Murakami, Kaori Suzuki, Hiroshi Tamura, Isao Nagaoka
EXPERIMENTAL AND THERAPEUTIC MEDICINE
(2011)
Article
Biochemistry & Molecular Biology
Johannes Reich, Felix Alexander Weyer, Hiroshi Tamura, Isao Nagaoka, Hubert Motschmann
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2019)
Review
Biochemistry & Molecular Biology
Isao Nagaoka, Hiroshi Tamura, Johannes Reich
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2020)
Review
Biochemistry & Molecular Biology
Hiroshi Tamura, Johannes Reich, Isao Nagaoka
Summary: The blue blood of the horseshoe crab, containing Limulus amebocyte lysate (LAL), is a valuable resource in the biomedical industry for its role in sensitive bacterial and fungal detection. LAL tests have replaced rabbit pyrogen tests in pharmaceutical quality control and show promise as biomarkers for bacterial sepsis and fungal infections. Further advancements in LAL-based endotoxin and beta-glucan assay techniques may enhance the detection of endotoxin in human blood for improved diagnosis and management of related conditions.