Article
Chemistry, Multidisciplinary
Ahmed M. Mansour, Nourhan M. Ibrahim, Ahmad M. Farag, Mahmoud T. Abo-Elfadl
Summary: In this study, two Re(I) complexes were synthesized and their solvatochromic characteristics were examined. The study found that both complexes exhibited autofluorescence emission inside cells and showed increased apoptotic changes in specific cell lines.
Article
Chemistry, Inorganic & Nuclear
Lorenzo Biancalana, Gianluca Ciancaleoni, Stefano Zacchini, Guido Pampaloni, Fabio Marchetti
Summary: The study demonstrates the reaction mechanism of [Fe2Cp2(CO)4] with a series of isocyanides, as well as the structure and characteristics of the products formed. The coordination mode of the isocyanide is minimally influenced by the environment, but partial isocyanide migration may occur upon heating.
INORGANICA CHIMICA ACTA
(2021)
Article
Chemistry, Multidisciplinary
Elena S. Osipova, Ekaterina S. Gulyaeva, Nikolay Kireev, Sergey A. Kovalenko, Christian Bijani, Yves Canac, Dmitry A. Valyaev, Oleg A. Filippov, Natalia Belkova, Elena S. Shubina
Summary: Low-temperature IR and NMR studies combined with DFT calculations revealed the mechanistic complexity of reactions between Mn(i) complex fac-[(dppm)Mn(CO)(3)H] and Lewis acids, involving the formation of mer-[(dppm)Mn(CO)(3)HMIDLINE HORIZONTAL ELLIPSISLA] and unusual dearomatization of the Ph3C+ cation upon hydride transfer.
CHEMICAL COMMUNICATIONS
(2022)
Article
Biochemistry & Molecular Biology
Olga Kuzmycz, Aleksandra Kowalczyk, Pawel Staczek
Summary: The study found that rhenium derivatives of NSAIDs have higher cytotoxic activity against endometrial cancer cells compared to original NSAIDs. These derivatives inhibit cell proliferation and increase mitochondrial ROS levels. This suggests a high potential for rhenium derivatives as a new treatment for endometrial cancer.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Chemistry, Inorganic & Nuclear
Danira A. Habashy, Rabaa M. Khaled, Amr Y. Ahmed, Krzysztof Radacki, Salma K. Ahmed, Engy K. Tharwat, Hana Magdy, Alaa Zeinhom, Ahmed M. Mansour
Summary: The cytotoxicity of two tricarbonyl Mn(I) complexes towards triple negative breast cancer was reported, with compound B showing dose-dependent cytotoxicity and a significant reduction in cell viability when co-treated with paclitaxel.
DALTON TRANSACTIONS
(2022)
Article
Chemistry, Inorganic & Nuclear
Mahmoud T. Abo-Elfadl, Ahmed M. Mansour
Summary: Complex 4 decorated with benzimidazole moiety was found to be harmless to normal mice splenocytes. Fluorescence microscopy revealed that complex 2 exhibited the highest levels of apoptotic and necrotic alterations in the MCF-7 cell line.
INORGANICA CHIMICA ACTA
(2023)
Article
Chemistry, Applied
Jinzhong Guo, Zhuming Guo, Zhiyin Xiao, Jing Jin, Xiuqin Yang, Yi He, Xiaoming Liu
Summary: Four new monoiron (II) tricarbonyl complexes with amine bound have been reported, and their structural confirmation and reaction behavior have been studied. The complexes are relatively stable in DMSO and do not affect the cell viability of RT112 cells.
APPLIED ORGANOMETALLIC CHEMISTRY
(2021)
Review
Chemistry, Inorganic & Nuclear
Kevin Magra, Antonio Frances-Monerris, Cristina Cebrian, Antonio Monari, Stefan Haacke, Philippe C. Gros
Summary: Iron complexes show promise as sustainable molecular photoactive materials alternative to precious metals. This review focuses on recent research on bidentate Fe(II) complexes with N-heterocyclic carbene ligands, discussing their potential for energy conversion and photocatalysis applications, design strategies, and current challenges in the field.
EUROPEAN JOURNAL OF INORGANIC CHEMISTRY
(2022)
Article
Chemistry, Inorganic & Nuclear
Margaret W. Ndinguri, Carrie A. Black, Anna L. Gosser, Sara Reitz, Cody Sutphin, Frank R. Fronczek, Lindsay E. Cormier
Summary: The research aims to develop new rhenium complexes for use in radiometal complexes or for conjugation with biomolecules to create targeted radiolabelled biopharmaceuticals. The study focused on designing and synthesizing water-soluble rhenium complexes, and characterizing their metal binding to biomolecules using various analytical techniques.
INORGANICA CHIMICA ACTA
(2021)
Article
Chemistry, Inorganic & Nuclear
Rabaa M. Khaled, Danira A. Habashy, Amr Y. Ahmed, Omneya S. Ismael, Sara S. Ibrahim, Mennattallah Abdelfatah, Krzysztof Radacki, Ahmed M. Mansour
Summary: This study describes the properties and applications of two water-soluble complexes based on fac-Mn(CO)3, which have potential CO releasing properties, solvatochromism features, and cytotoxicity against malignant cell lines. Functionalized compound B releases CO faster in water compared to compound A, suggesting the role of the methyl group in regulating the CO release kinetics, and the solvent also affects the CO release kinetics of Mn(I) carbon monoxide releasing molecules.
Article
Chemistry, Inorganic & Nuclear
Laura Rotundo, Shahbaz Ahmad, Chiara Cappuccino, Dmitry E. Polyansky, Mehmed Z. Ertem, Gerald F. Manbeck
Summary: A dicationic Re bipyridine-type complex has been synthesized and studied for its electrochemical behavior under Ar and CO2. The presence of tetra-alkylammonium cations shifts the electrocatalytic potential for CO2 reduction. Cyclic voltammetry, infrared spectroelectrochemistry, and theoretical calculations were used to analyze the electrochemical mechanisms in different solvents and in the presence of weak acids.
INORGANIC CHEMISTRY
(2023)
Article
Chemistry, Physical
Ronaldo C. Amaral, Lais S. Matos, Neyde Y. Murakami Iha
Summary: The photochemical and photophysical behaviors of fac-[Re(CO)3(R2bpy)(trans-bpe)]+ complexes were studied, showing a remarkable and efficient sensitization of trans-cis photoisomerization. The complexes exhibited higher trans-to-cis photochemical quantum yields compared to non-coordinated ligands. As cis-isomers formed, a growing emission of 3MLCTRe -> R2bpy was observed, with no reverse cis-> trans photoisomerization process detected under experimental conditions.
JOURNAL OF PHOTOCHEMISTRY AND PHOTOBIOLOGY A-CHEMISTRY
(2021)
Article
Chemistry, Inorganic & Nuclear
Liliana Capulin Flores, Lucas A. Paul, Inke Siewett, Remco Havenith, Noe Zuniga-Villarreal, Edwin Otten
Summary: Metal complexes with ligands coordinated through the nitrogen atom of azo (N=N) or imino (C=N) groups exhibit interesting (opto)electronic properties and reactivity due to their pi-acceptor properties and redox-active nature.
INORGANIC CHEMISTRY
(2022)
Article
Chemistry, Inorganic & Nuclear
Nicola Monti, Veronica Longo, Stefano Zacchini, Giulia Vigarani, Loris Giorgini, Eugenia Bonora, Massimiliano Massi, Valentina Fiorini, Stefano Stagni
Summary: A new family of luminescent Re(I) complexes with alkylated tetrazoles as chelating ligands has been reported, showing high affinity to Bovine Serum Albumin. The complexes were fully characterized using various spectroscopic methods and their molecular structures were confirmed by X-ray crystallography. Notably, the QTZ-R cationic derivatives and neutrally charged tetrazole complex exhibited the highest affinity to BSA among the series of Re(I) tetrazole complexes.
INORGANICA CHIMICA ACTA
(2021)
Article
Chemistry, Inorganic & Nuclear
Dumisani Kama, Angelo Frei, Alice Brink, Henrik Braband, Roger Alberto, Andreas Roodt
Summary: A novel proof-of-concept showed modification of water solubility and potential biological effects of a metal complex by introducing an amine group on the outer periphery of the ligand arm. The synthesized rhenium and technetium complexes were characterized by various spectroscopic techniques and showed potential as radio models for further radiotoxicity studies. Preliminary antimicrobial evaluation demonstrated no activity against selected fungi and bacteria.
DALTON TRANSACTIONS
(2021)
Article
Pharmacology & Pharmacy
Joachim Delasoie, Philippe Schiel, Sandra Vojnovic, Jasmina Nikodinovic-Runic, Fabio Zobi
Article
Biochemistry & Molecular Biology
Sara Nasiri Sovari, Isabelle Kolly, Kevin Schindler, Youri Cortat, Shing-Chi Liu, Aurelien Crochet, Aleksandar Pavic, Fabio Zobi
Summary: The reaction between rhenium alpha-diimine tricarbonyl complexes and nitrosonium tetrafluoroborate yields dicarbonyl-nitrosyl [Re(CO)(2)(NO)(N-N)X](+) species, showing potential antimicrobial applications. The metal ion in the complexes behaves as a hard Re acid with strong affinity for pi-basic ligands, making it difficult to replace with other ligands. The complexes can be photo-activated towards CO release, representing a new class of photoCORMs.
Review
Chemistry, Analytical
Lucyano J. A. Macedo, Fernando P. Rodrigues, Ayaz Hassan, Leandro N. C. Maximo, Fabio Zobi, Roberto S. da Silva, Frank N. Crespilho
Summary: Recent emergence of FTIR spectromicroscopy (micro-FTIR) as a dynamic spectroscopy for imaging to study biological chemistry has opened new possibilities for investigating in situ drug release, redox chemistry effects on biological molecules, DNA and drug interactions, membrane dynamics, and redox reactions with proteins at the single cell level. Micro-FTIR applied to metallodrugs has been playing an important role since the last decade because of its great potential to achieve more robust and controlled pharmacological effects against several diseases, including cancer. An important aspect in the development of these drugs is to understand their cellular properties, such as uptake, accumulation, activity, and toxicity. The review highlights both the potential application of micro-FTIR and its importance for studying metal-based drugs, emphasizing the perspectives of chemistry of living cells and the significance of bioimaging for localization of cellular processes to understand the mechanism of action.
ANALYTICAL METHODS
(2022)
Article
Chemistry, Multidisciplinary
Kevin Schindler, Fabio Zobi
Summary: Luminescent rhenium complexes are of growing scientific interest for catalytic, diagnostic, and therapeutic applications, with a focus on their photophysical and photochemical properties. The choice of ligands and strategies to exploit the potential of these molecules in medicinal applications are crucial. Their applications include being used as luminescent cellular probes and developing photoactive carbon monoxide-releasing molecules for anticancer and antimicrobial purposes.
Article
Chemistry, Medicinal
Sara Nasiri Sovari, Natasa Radakovic, Paul Roch, Aurelien Crochet, Aleksandar Pavic, Fabio Zobi
Summary: Antimicrobial resistance poses a major threat to public health, with lack of financial incentive leading pharmaceutical companies to halt antibiotic discovery programs. Metal complexes have untapped antibiotic potential with unique action mechanisms, offering effective and non-toxic solutions for various infections.
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
(2021)
Review
Biochemistry & Molecular Biology
Kevin Schindler, Fabio Zobi
Summary: Organometallic compounds of rhenium, particularly its tri- and dicarbonyl complexes, have shown promising potential as anticancer and antibiotic drugs due to their ease of preparation, stability, and unique photophysical and luminescent properties. This review focuses on discussing the structural variations and in vitro efficacy of these complexes in the past seven years, with an initial emphasis on tricarbonyl complexes and a later discussion on the future prospects of dicarbonyl species in this field.
Article
Multidisciplinary Sciences
Hagir B. Suliman, Zachary Healy, Fabio Zobi, Bryan D. Kraft, Karen Welty-Wolf, Joshua Smith, Christina Barkauskas, Claude A. Piantadosi
Summary: The preclinical model of bleomycin-induced lung fibrosis is useful to study mechanisms related to human pulmonary fibrosis. The study found that HO-1/NRF-1 signaling protects lung AT2 cells against injury and fibrosis by maintaining mitochondrial health and suppressing the TGF beta 1 pathway.
Article
Biochemistry & Molecular Biology
Sara Nasiri Sovari, Taryn M. Golding, Mziyanda Mbaba, Roxanne Mohunlal, Timothy J. Egan, Gregory S. Smith, Fabio Zobi
Summary: A small library of aminoquinoline and imidazolopiperidine (IMP)-based ligands showed potent inhibitory activities against chloroquine-sensitive (CQS) and multidrug-resistant (MDR) strains of P. falciparum. The compounds may act through hemozoin inhibition and the quinoline-based compounds exhibited higher binding affinities than the reference drug chloroquine.
JOURNAL OF INORGANIC BIOCHEMISTRY
(2022)
Article
Chemistry, Medicinal
Kevin Schindler, Youri Cortat, Miroslava Nedyalkova, Aurelien Crochet, Marco Lattuada, Aleksandar Pavic, Fabio Zobi
Summary: Antimicrobial resistance poses a significant threat to human health and has a major impact on the global economy. Metal complexes, including rhenium complexes, have untapped potential as antimicrobial agents. This study investigates the antimicrobial potential of rhenium di- and tricarbonyl diimine complexes and identifies two potential targets for these compounds. The findings have implications for the future design of rhenium tricarbonyl diimine-based antibiotics.
Article
Chemistry, Organic
Fatlinda Rahmani, Aurelien Crochet, Fabio Zobi
Summary: In this study, (E)-3-(2-(4-methylthiazol-2-yl)hydrazineylidene)chromane-2,4-dione was synthesized for the first time and characterized using various spectroscopic techniques. The chemical structure and isomeric configuration of the molecule were confirmed by single-crystal X-ray diffraction.
Article
Infectious Diseases
Youri Cortat, Miroslava Nedyalkova, Kevin Schindler, Parth Kadakia, Gozde Demirci, Sara Nasiri Sovari, Aurelien Crochet, Stefan Salentinig, Marco Lattuada, Olimpia Mamula Steiner, Fabio Zobi
Summary: In the context of the global health issue caused by antimicrobial resistance (AMR), the need for novel antimicrobial agents is urgent. Inorganic and organometallic complexes show potential as untapped sources of antibiotics. This study used a computer-aided drug design approach to synthesize and evaluate fac-Re(I) tricarbonyl complexes as antibacterial agents, with promising results.
Article
Chemistry, Inorganic & Nuclear
Kevin Schindler, Justine Horner, Gozde Demirci, Youri Cortat, Aurelien Crochet, Olimpia Mamula Steiner, Fabio Zobi
Summary: Cancer is still a leading cause of death worldwide, and the interest in organometallic complexes as anticancer drug candidates is crucial. Rhenium dicarbonyl complexes have been given less attention compared to tricarbonyl complexes. This study tested various rhenium dicarbonyl complexes in vitro against different cancer cell lines and found that some compounds showed good activity against specific cancer lines but were also toxic to healthy cells.
Review
Pharmacology & Pharmacy
Youri Cortat, Fabio Zobi
Summary: This review discusses the research work on coordination derivatives of antifungal azoles (AAs) synthesized for medical purposes, highlighting the most promising compounds and emphasizing the efficiency of AAs and their metallic species.
Article
Chemistry, Inorganic & Nuclear
Sara Nasiri Sovari, Isabelle Kolly, Kevin Schindler, Ana Djuric, Tatjana Srdic-Rajic, Aurelien Crochet, Aleksandar Pavic, Fabio Zobi
Summary: This study reports the synthesis, characterization, and in vivo evaluation of a series of rhenium tricarbonyl complexes containing 5- and 6-(halomethyl)-2,2'-bipyridine ligands. The aim was to investigate the role of a reactive halomethyl substituent on the diimine ligand system in the design of effective and non-toxic anticancer agents. Compounds capable of undergoing ligand-based alkylating reactions exhibited significant antiproliferative activity against colorectal and pancreatic cell lines. One specific compound (5-(chloromethyl)-2,2'-bipyridine derivative) displayed significant inhibition of pancreatic tumor growth in vivo in zebrafish-Panc-1 xenografts at a concentration of 8 μM, lower than its in vitro IC50 values, and also inhibited in vivo cancer cell dissemination.
DALTON TRANSACTIONS
(2023)
Article
Chemistry, Multidisciplinary
Kevin Schindler, Aurelien Crochet, Fabio Zobi
Summary: The article introduces new synthetic routes to produce aerobically stable and substitutionally labile alpha-diimine rhenium(i) dicarbonyl complexes. These complexes can be prepared in high yield and exhibit different reactions in various solvents, providing a convenient entry into the chemistry of the core.