期刊
PHARMACEUTICS
卷 12, 期 5, 页码 -出版社
MDPI
DOI: 10.3390/pharmaceutics12050480
关键词
diatoms; drug delivery system; HCT-116; porphyrin; vitamin B-12; carbon monoxide releasing molecule; rhenium; cancer
资金
- Swiss National Science Foundation [PP00P2_170589]
- University of Fribourg
- Institute of molecular Genetics and Genetic Engineering from the University of Belgrade (Ministry of Education, Science and Technological Development of the Republic of Serbia) [173048]
- Swiss National Science Foundation (SNF) [PP00P2_170589] Funding Source: Swiss National Science Foundation (SNF)
Systemic toxicity and severe side effects are commonly associated with anticancer chemotherapies. New strategies based on enhanced drug selectivity and targeted delivery to cancer cells while leaving healthy tissue undamaged can reduce the global patient burden. Herein, we report the design, synthesis and characterization of a bio-inspired hybrid multifunctional drug delivery system based on diatom microalgae. The microalgae's surface was chemically functionalized with hybrid vitamin B-12-photoactivatable molecules and the materials further loaded with highly active rhenium(I) tricarbonyl anticancer complexes. The constructs showed enhanced adherence to colorectal cancer (CRC) cells and slow release of the chemotherapeutic drugs. The overall toxicity of the hybrid multifunctional drug delivery system was further enhanced by photoactivation of the microalgae surface. Depending on the construct and anticancer drug, a 2-fold increase in the cytotoxic efficacy of the drug was observed upon light irradiation. The use of this targeted drug delivery strategy, together with selective spatial-temporal light activation, may lead to lower effective concentration of anticancer drugs, thereby reducing medication doses, possible side effects and overall burden for the patient.
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