The Chaperone Balance Hypothesis: The Importance of the Extracellular to Intracellular HSP70 Ratio to Inflammation-Driven Type 2 Diabetes, the Effect of Exercise, and the Implications for Clinical Management

The fat cell senescence hypothesis

(2014) Philip Newsholme et al.   CURRENT OPINION IN CLINICAL NUTRITION AND METABOLIC CARE

Obesity depresses the anti-inflammatory HSP70 pathway, contributing to NAFLD progression

(2014) Fábio Cangeri Di Naso et al.   Obesity

Extracellular Hsp72 concentration relates to a minimum endogenous criteria during acute exercise-heat exposure

(2013) Oliver R. Gibson et al.   CELL STRESS & CHAPERONES

Elevated levels of extracellular heat-shock protein 72 (eHSP72) are positively correlated with insulin resistancein vivoand cause pancreatic β-cell dysfunction and deathin vitro

(2013) Mauricio Krause et al.   CLINICAL SCIENCE

Divergence of intracellular and extracellular HSP72 in type 2 diabetes: does fat matter?

(2012) Josianne Rodrigues-Krause et al.   CELL STRESS & CHAPERONES

Effects of Habitual Exercise on the eHsp72-Induced Release of Inflammatory Cytokines by Macrophages from Obese Zucker Rats

(2012) J. Garcia et al.   INTERNATIONAL JOURNAL OF SPORTS MEDICINE

Physiological concentrations of interleukin-6 directly promote insulin secretion, signal transduction, nitric oxide release, and redox status in a clonal pancreatic β-cell line and mouse islets

(2012) Mauricio da Silva Krause et al.   JOURNAL OF ENDOCRINOLOGY

The anti-inflammatory mechanisms of Hsp70

(2012) Thiago J. Borges et al.   Frontiers in Immunology

HSP70 expression: does it a novel fatigue signalling factor from immune system to the brain?

(2011) Thiago Gomes Heck et al.   CELL BIOCHEMISTRY AND FUNCTION

Plasma heat shock protein 72 as a biomarker of sarcopenia in elderly people

(2011) Kishiko Ogawa et al.   CELL STRESS & CHAPERONES

Skeletal Muscle Insulin Resistance in Morbid Obesity: The Role of Interleukin-6 and Leptin

(2011) P. Mitrou et al.   EXPERIMENTAL AND CLINICAL ENDOCRINOLOGY & DIABETES

l-Arginine is essential for pancreatic β-cell functional integrity, metabolism and defense from inflammatory challenge

(2011) Mauricio S Krause et al.   JOURNAL OF ENDOCRINOLOGY

Serum HSP70

(2011) Sudhir K. Dutta et al.   PANCREAS

Extracellular heat shock proteins, cellular export vesicles, and the Stress Observation System: A form of communication during injury, infection, and cell damage

(2010) Antonio De Maio   CELL STRESS & CHAPERONES

Increased serum HSP70 levels are associated with the duration of diabetes

(2010) Manouchehr Nakhjavani et al.   CELL STRESS & CHAPERONES

Extracellular heat shock protein 70 (HSPA1A) and classical vascular risk factors in a general population

(2010) Elena Dulin et al.   CELL STRESS & CHAPERONES

Heat and exercise acclimation increases intracellular levels of Hsp72 and inhibits exercise-induced increase in intracellular and plasma Hsp72 in humans

(2010) Flávio de Castro Magalhães et al.   CELL STRESS & CHAPERONES

Increased Toll-Like Receptor (TLR) Activation and TLR Ligands in Recently Diagnosed Type 2 Diabetic Subjects

(2010) M. R. Dasu et al.   DIABETES CARE

Toll-like receptor 2-deficient mice are protected from insulin resistance and beta cell dysfunction induced by a high-fat diet

(2010) J. A. Ehses et al.   DIABETOLOGIA

Heat Shock Proteins Are Important Mediators of Skeletal Muscle Insulin Sensitivity

(2010) Paige C. Geiger et al.   EXERCISE AND SPORT SCIENCES REVIEWS

A possible role of NF-κB and HSP72 in skeletal muscle hypertrophy induced by heat stress in rats

(2010) V. Ohno et al.   GENERAL PHYSIOLOGY AND BIOPHYSICS

β-Arrestin 2 regulates toll-like receptor 4-mediated apoptotic signalling through glycogen synthase kinase-3β

(2010) Hui Li et al.   IMMUNOLOGY

p27 Suppresses Arsenite-induced Hsp27/Hsp70 Expression through Inhibiting JNK2/c-Jun- and HSF-1-dependent Pathways

(2010) Jinyi Liu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Extracellular heat shock proteins (eHSP70) in exercise: Possible targets outside the immune system and their role for neurodegenerative disorders treatment

(2010) Mauricio Krause et al.   MEDICAL HYPOTHESES

Heat shock factors: integrators of cell stress, development and lifespan

(2010) Malin Åkerfelt et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

TLR4 and Insulin Resistance

(2010) Jane J. Kim et al.   Gastroenterology Research and Practice

AMPK-mediated GSK3β inhibition by isoliquiritigenin contributes to protecting mitochondria against iron-catalyzed oxidative stress

(2009) Song Hwa Choi et al.   BIOCHEMICAL PHARMACOLOGY

Hematopoietic Cell-Specific Deletion of Toll-like Receptor 4 Ameliorates Hepatic and Adipose Tissue Insulin Resistance in High-Fat-Fed Mice

(2009) Maziyar Saberi et al.   Cell Metabolism

Oxidative Stress, Diabetes, and Diabetic Complications

(2009) Wei Wei et al.   HEMOGLOBIN

Heat shock proteins and exercise: a primer

(2008) Earl G. Noble et al.   Applied Physiology Nutrition and Metabolism

Atherosclerosis: A redox-sensitive lipid imbalance suppressible by cyclopentenone prostaglandins

(2008) Lucila Ludmila Paula Gutierrez et al.   BIOCHEMICAL PHARMACOLOGY

Dual Role of Interleukin-6 in Regulating Insulin Sensitivity in Murine Skeletal Muscle

(2008) I. Nieto-Vazquez et al.   DIABETES

Elevated Toll-Like Receptor 4 Expression and Signaling in Muscle From Insulin-Resistant Subjects

(2008) S. M. Reyna et al.   DIABETES

Heat Treatment Improves Glucose Tolerance and Prevents Skeletal Muscle Insulin Resistance in Rats Fed a High-Fat Diet

(2008) A. A. Gupte et al.   DIABETES

Skeletal Muscle Pathways of Contraction-Enhanced Glucose Uptake

(2008) J. Santos et al.   INTERNATIONAL JOURNAL OF SPORTS MEDICINE

Contribution of IL-6 to the Hsp72, Hsp25, and αβ-crystallin responses to inflammation and exercise training in mouse skeletal and cardiac muscle

(2008) Kimberly A. Huey et al.   JOURNAL OF APPLIED PHYSIOLOGY

Heat shock factor 1 inhibits nuclear factor–κB nuclear binding activity during endotoxin tolerance and heat shock

(2008) Mingchen Song et al.   JOURNAL OF CRITICAL CARE

Inducible Toll-like Receptor and NF-κB Regulatory Pathway Expression in Human Adipose Tissue

(2008) Olga I. Vitseva et al.   Obesity

HSP72 protects against obesity-induced insulin resistance

(2008) J. Chung et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The effect of stress-inducible extracellular Hsp72 on human neutrophil chemotaxis: A role during acute intense exercise

(2008) Eduardo Ortega et al.   STRESS-THE INTERNATIONAL JOURNAL ON THE BIOLOGY OF STRESS

Heat shock protein 72 : release and biological significance during exercise

(2007) Martin Whitham   Frontiers in Bioscience-Landmark

Association between heat-shock protein 70 gene polymorphisms and DNA damage in peripheral blood lymphocytes among coke-oven workers

(2007) X. Yang et al.   MUTATION RESEARCH-GENETIC TOXICOLOGY AND ENVIRONMENTAL MUTAGENESIS