Immuno-Genomic Profiling of Patients with Inflammatory Bowel Disease

Advances in IBD genetics

(2014) Johan Van Limbergen et al.   Nature Reviews Gastroenterology & Hepatology

Genes in inflammatory bowel disease: lessons from complex diseases

(2013) P. Henderson et al.   CLINICAL MEDICINE

Bacteria penetrate the normally impenetrable inner colon mucus layer in both murine colitis models and patients with ulcerative colitis

(2013) Malin E V Johansson et al.   GUT

Recent advances in inflammatory bowel disease: mucosal immune cells in intestinal inflammation

(2013) M Zaeem Cader et al.   GUT

TLR4, IL10RA, and NOD2 mutation in paediatric Crohn’s disease patients: an association with Mycobacterium avium subspecies paratuberculosis and TLR4 and IL10RA expression

(2013) Josef Wagner et al.   MEDICAL MICROBIOLOGY AND IMMUNOLOGY

Involvement of JAK/STAT signaling in the pathogenesis of inflammatory bowel disease

(2013) Mehmet Coskun et al.   PHARMACOLOGICAL RESEARCH

The Microaerophilic Microbiota of De-Novo Paediatric Inflammatory Bowel Disease: The BISCUIT Study

(2013) Richard Hansen et al.   PLoS One

Detection of muramyl dipeptide-sensing pathway defects in monocytes of patients with Crohn's disease using phospho-specific whole blood flow cytometry

(2013) Krista Kuuliala et al.   SCANDINAVIAN JOURNAL OF CLINICAL & LABORATORY INVESTIGATION

From genetics of inflammatory bowel disease towards mechanistic insights

(2013) Daniel B. Graham et al.   TRENDS IN IMMUNOLOGY

Interplay of autophagy and innate immunity in Crohn's disease: A key immunobiologic feature

(2013) Györgyi Műzes   WORLD JOURNAL OF GASTROENTEROLOGY

Synergistic effect of interleukin-10-receptor variants in a case of early-onset ulcerative colitis

(2013) Martina Galatola   WORLD JOURNAL OF GASTROENTEROLOGY

Impact of exome sequencing in inflammatory bowel disease

(2013) Christopher J Cardinale   WORLD JOURNAL OF GASTROENTEROLOGY

Respiratory syncytial virus infection augments NOD2 signaling in an IFN-β-dependent manner in human primary cells

(2012) Marloes Vissers et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Loss of Interleukin-10 Signaling and Infantile Inflammatory Bowel Disease: Implications for Diagnosis and Therapy

(2012) Daniel Kotlarz et al.   GASTROENTEROLOGY

Exome sequencing identifies novel compound heterozygous mutations of IL-10 receptor 1 in neonatal-onset Crohn's disease

(2012) H Mao et al.   GENES AND IMMUNITY

IL-10R Polymorphisms Are Associated with Very-early-onset Ulcerative Colitis

(2012) Christopher J. Moran et al.   INFLAMMATORY BOWEL DISEASES

Clinical outcome in IL-10– and IL-10 receptor–deficient patients with or without hematopoietic stem cell transplantation

(2012) Karin R. Engelhardt et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Host–microbe interactions have shaped the genetic architecture of inflammatory bowel disease

(2012) Luke Jostins et al.   NATURE

Defective IL10 Signaling Defining a Subgroup of Patients With Inflammatory Bowel Disease

(2011) Bernadette Begue et al.   AMERICAN JOURNAL OF GASTROENTEROLOGY

Inflammation profile of four early onset Crohn patients

(2011) Annalisa Marcuzzi et al.   GENE

Crohn's disease: NOD2, autophagy and ER stress converge

(2011) T. Fritz et al.   GUT

New IBD genetics: common pathways with other diseases

(2011) C. W. Lees et al.   GUT

The effect of IL-10 genetic variation and interleukin 10 serum levels on Crohn's disease susceptibility in a New Zealand population

(2011) Alice H. Wang et al.   HUMAN IMMUNOLOGY

Interleukin-10 Signaling in Regulatory T Cells Is Required for Suppression of Th17 Cell-Mediated Inflammation

(2011) Ashutosh Chaudhry et al.   IMMUNITY

Genetics and pathogenesis of inflammatory bowel disease

(2011) Bernard Khor et al.   NATURE

Deep resequencing of GWAS loci identifies independent rare variants associated with inflammatory bowel disease

(2011) Manuel A Rivas et al.   NATURE GENETICS

The Pathogen Recognition Receptor NOD2 Regulates Human FOXP3+ T Cell Survival

(2010) M. K. Rahman et al.   JOURNAL OF IMMUNOLOGY

A human gut microbial gene catalogue established by metagenomic sequencing

(2010) Junjie Qin et al.   NATURE

Genome-wide meta-analysis increases to 71 the number of confirmed Crohn's disease susceptibility loci

(2010) Andre Franke et al.   NATURE GENETICS

Differential regulation of interleukin 17 and interferon   production in inflammatory bowel disease

(2009) L. Rovedatti et al.   GUT

MDP-Induced selective tolerance to TLR4 ligands: Impairment in NOD2 mutant Crohnʼs disease patients

(2009) Elisabet Cantó et al.   INFLAMMATORY BOWEL DISEASES

NOD2 stimulation induces autophagy in dendritic cells influencing bacterial handling and antigen presentation

(2009) Rachel Cooney et al.   NATURE MEDICINE

Inflammatory Bowel Disease and Mutations Affecting the Interleukin-10 Receptor

(2009) Erik-Oliver Glocker et al.   NEW ENGLAND JOURNAL OF MEDICINE

Evidence for Impaired CARD15 Signalling in Crohn's Disease without Disease Linked Variants

(2009) Jakob Benedict Seidelin et al.   PLoS One

Toll-like receptor-induced granulocyte-macrophage colony-stimulating factor secretion is impaired in Crohn's disease by nucleotide oligomerization domain 2-dependent and -independent pathways

(2008) A. Brosbøl-Ravnborg et al.   CLINICAL AND EXPERIMENTAL IMMUNOLOGY

Role of the intestinal barrier in inflammatory bowel disease

(2008) Mike G Laukoetter et al.   WORLD JOURNAL OF GASTROENTEROLOGY

Crohn’s disease patients homozygous for the 3020insC NOD2 mutation have a defective NOD2/TLR4 cross-tolerance to intestinal stimuli

(2007) Bart Jan Kullberg et al.   IMMUNOLOGY

Novel CARD15/NOD2 mutations in Finnish patients with Crohnʼs disease and their relation to phenotypic variation in vitro and in vivo

(2007) Maarit Lappalainen et al.   INFLAMMATORY BOWEL DISEASES