Review
Microbiology
Sean L. Carlson, Liya Mathew, Michael Savage, Klaartje Kok, James O. Lindsay, Carol A. Munro, Neil E. Mccarthy
Summary: The gut microbiome, consisting of bacteria, viruses, and fungi, plays a crucial role in the development of inflammatory bowel disease. Candida albicans, a common gut commensal and pathogenic fungus, has been extensively studied for its impact on the pathophysiology of IBD.
Article
Chemistry, Medicinal
Sumaiah J. Alarfaj, Sally Abdallah Mostafa, Walaa A. Negm, Thanaa A. El-Masry, Marwa Kamal, Mohamed Elsaeed, Ahmed Mohamed El Nakib
Summary: Individual differences exist in the severity, behavior, progression, and therapy response of IBD patients. The evaluation of mucosal gene expression is crucial in understanding IBD, as it is initiated by a break in the intestinal epithelial barrier. Molecular analysis of biomarkers in intestinal biopsies provides a reliable means of assessing localized inflammation. This investigation aimed to identify changes in gene expression in the inflamed mucosa of IBD patients undergoing treatment with 5-aminosalicylic acid (5ASA) or anti-TNF drugs.
Article
Gastroenterology & Hepatology
Kei Nishioka, Haruei Ogino, Takatoshi Chinen, Eikichi Ihara, Yoshimasa Tanaka, Kazuhiko Nakamura, Yoshihiro Ogawa
Summary: This study aimed to identify factors for predicting treatment response in IBD patients receiving biologics. The expression levels of specific genes in the mucosa were found to be associated with resistance to anti-TNF and ustekinumab (UST) treatment. The results suggest that mucosal gene expression analysis can help predict response to biologics in IBD patients, providing valuable information for optimizing treatment strategies.
JOURNAL OF GASTROENTEROLOGY
(2021)
Review
Gastroenterology & Hepatology
Monica State, Lucian Negreanu, Theodor Voiosu, Andrei Voiosu, Paul Balanescu, Radu Bogdan Mateescu
Summary: This study summarized the performance of noninvasive biomarkers in assessing MH in IBD patients. Fecal markers were the main focus, with fecal calprotectin being the most investigated marker, while among serum markers, the endoscopic healing index showed the best performance.
WORLD JOURNAL OF GASTROENTEROLOGY
(2021)
Article
Gastroenterology & Hepatology
Markus F. Neurath, Michael Vieth
Summary: Mucosal healing is an important prognostic factor in the management of patients with inflammatory bowel disease. It can predict clinical remission and resection-free survival. There are two levels of mucosal healing: endoscopic healing and histological healing. Drug therapies and new techniques can have an impact on mucosal healing, but cannot provide a definitive cure.
Review
Gastroenterology & Hepatology
Eduardo J. Villablanca, Katja Selin, Charlotte R. H. Hedin
Summary: Current treatments for inflammatory bowel disease (IBD) mainly focus on inhibiting inflammation, but the use of immunosuppressive therapy can lead to infectious and neoplastic diseases. Therefore, finding a way to achieve mucosal healing without immunosuppression is important. The lack of treatments that directly promote mucosal healing and regeneration in IBD may be due to a lack of understanding of the underlying pathways. Stem cells, growth factors, and organoid culture and stem cell therapy are potential novel mechanisms to restore barrier function in IBD.
NATURE REVIEWS GASTROENTEROLOGY & HEPATOLOGY
(2022)
Article
Gastroenterology & Hepatology
Gengfeng Li, Jian Lin, Cui Zhang, Han Gao, Huiying Lu, Xiang Gao, Ruixin Zhu, Zhitao Li, Mingsong Li, Zhanju Liu
Summary: Host-microbial cross-talk is important for gut homeostasis. Butyrate was found to inhibit proinflammatory responses of neutrophils in IBD and may have therapeutic potential. The mechanism of action involves HDAC inhibition and modulation of neutrophil functions.
Review
Immunology
John P. Thomas, Dezso Modos, Simon M. Rushbrook, Nick Powell, Tamas Korcsmaros
Summary: This review examines the interaction between bile acid metabolites and intestinal inflammation in inflammatory bowel disease (IBD), highlighting their role in regulation of the inflammatory milieu through pathways such as autophagy, apoptosis, and the inflammasome pathway. The study also discusses the potential of novel experimental and bioinformatics approaches to further advance our understanding of the role of bile acids in IBD and inform therapeutic strategies.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Medicine, Research & Experimental
Anna Onody, Apor Veres-Szekely, Domonkos Pap, Reka Rokonay, Beata Szebeni, Erna Sziksz, Franz Oswald, Gabor Veres, Aron Cseh, Attila J. Szabo, Adam Vannay
Summary: The study demonstrates increased IL-24 expression in serum and colon samples of children with IBD and DSS treated mice. Inflammatory factors such as IL-1 beta, LPS, and H2O2 can increase IL24 expression in PBMCs and LPMCs. IL-24 treatment promotes the expression of TGF-beta and PDGF-B in HT-29 cells, as well as enhances ECM-related gene expression and motility in CCD-18Co cells.
JOURNAL OF TRANSLATIONAL MEDICINE
(2021)
Article
Biochemistry & Molecular Biology
Sanghyun Kim, Junhyoung Byun, Semyung Jung, Byoungjae Kim, Kangwon Lee, Hanjo Jeon, Jaemin Lee, Hyuksoon Choi, Eunsun Kim, Yoontae Jeen, Hongsik Lee, Hoonjai Chun, Bora Keum, Taehoon Kim
Summary: The study found that SIRT7 plays an important role in the inflammatory response in the colon of mice, and SIRT7 inhibitors can reduce colonic inflammation, potentially playing a role in the pathogenesis of immune-mediated intestinal inflammation.
Article
Medicine, General & Internal
Lidia Neamti, Tudor Drugan, Cristina Drugan, Ciprian Silaghi, Lidia Ciobanu, Alexandra Craciun
Summary: This study aimed to analyze the most commonly used biomarkers for patient monitoring and follow-up, both independently and as a group, in order to propose an improved activity score that accurately reflects the changes at the intestinal level, to reduce the number of colonoscopic interventions.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Immunology
Jean-Paul Motta, Corinne Rolland, Anissa Edir, Ana-Carolina Florence, David Sagnat, Chrystelle Bonnart, Perrine Rousset, Laura Guiraud, Muriel Quaranta-Nicaise, Emmanuel Mas, Delphine Bonnet, Elena F. Verdu, Derek M. McKay, Etienne Buscail, Laurent Alric, Nathalie Vergnolle, Celine Deraison
Summary: Imbalance between proteases and their inhibitors is crucial in the development of Inflammatory Bowel Diseases (IBD). This study identifies a previously unrevealed production of elastase 2A (ELA2A) by colonic epithelial cells in IBD patients, leading to inflammation and loss of barrier function. Targeting ELA2A hyperactivity could be a potential treatment for IBD.
MUCOSAL IMMUNOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Xiaohong Zhou, Jin Wang, Wenyan Li, Caiqun Zhang, Yanling Gu
Summary: This study reveals that miRNA-9a-5p inhibits TLR4 signaling activation by targeting FOXO1, thereby exerting a protective effect on mucosal barrier injury in inflammatory bowel disease. MiRNA-9a-5p can suppress FOXO1 expression, downregulate TLR4 signaling activation, inhibit mucosal barrier injury, and elevate the expressions of tight junction proteins.
JOURNAL OF BIOCHEMICAL AND MOLECULAR TOXICOLOGY
(2022)
Review
Gastroenterology & Hepatology
Ralley E. Prentice, Emily K. Wright, Emma Flanagan, Rod W. Hunt, Gregory T. Moore, Claudia A. Nold-Petry, Sally J. Bell, Marcel F. Nold, Rimma Goldberg
Summary: Autoimmune and inflammatory disorders in women of childbearing age may affect the development of the neonatal immune system, potentially increasing the risk of disease. Maternal inflammation, IBD-associated intestinal dysbiosis, and the use of immunomodulatory drugs may all have an impact on infant immune system development.
CELLULAR AND MOLECULAR GASTROENTEROLOGY AND HEPATOLOGY
(2023)
Review
Nutrition & Dietetics
Ning Liu, Gang Feng, Xiaoying Zhang, Qingjuan Hu, Shiqiang Sun, Jiaqi Sun, Yanan Sun, Ran Wang, Yan Zhang, Pengjie Wang, Yixuan Li
Summary: Inflammatory bowel disease (IBD) including UC and CD, is associated with intestinal mucosal immune disorder. Nutrients play a key role in inflammation, gut barrier integrity, and immune cell modulation in IBD. Lactoferrin (LF), a dietary bioactive component, has diverse biological functions and can help maintain intestine mucosal immune homeostasis.
FRONTIERS IN NUTRITION
(2021)
Meeting Abstract
Rheumatology
I. Sahbudin, L. Pickup, Z. Cader, A. Abishek, C. D. Buckley, G. Allen, P. Nightingale, P. de Pablo, K. Raza, A. Filer
ANNALS OF THE RHEUMATIC DISEASES
(2015)
Meeting Abstract
Rheumatology
I. Sahbudin, P. de Pablo, L. Pickup, Z. Cader, G. Allen, P. Nightingale, C. D. Buckley, K. Raza, A. Filer
ANNALS OF THE RHEUMATIC DISEASES
(2016)
Meeting Abstract
Rheumatology
I. Sahbudin, L. Pickup, P. Nightingale, G. Allen, Z. Cader, P. de Pablo, C. D. Buckley, K. Raza, A. Filer
ANNALS OF THE RHEUMATIC DISEASES
(2016)
Meeting Abstract
Rheumatology
I. Sahbudin, L. Pickup, P. Nightingale, G. Allen, Z. Cader, P. de Pablo, C. D. Buckley, K. Raza, A. Filer
ANNALS OF THE RHEUMATIC DISEASES
(2016)
Article
Immunology
M. Zaeem Cader, Katharina Boroviak, Qifeng Zhang, Ghazaleh Assadi, Sarah L. Kempster, Gavin W. Sewell, Svetlana Saveljeva, Jonathan W. Ashcroft, Simon Clare, Subhankar Mukhopadhyay, Karen P. Brown, Markus Tschurtschenthaler, Tim Raine, Brendan Doe, Edwin R. Chilvers, Jules L. Griffin, Nicole C. Kaneider, R. Andres Floto, Mauro D'Amato, Allan Bradley, Michael J. O. Wakelam, Gordon Dougan, Arthur Kaser
Article
Rheumatology
Ilfita Sahbudin, Luke Pickup, Peter Nightingale, Gina Allen, Zaeem Cader, Ruchir Singh, Paola de Pablo, Christopher D. Buckley, Karim Raza, Andrew Filer
Article
Biochemistry & Molecular Biology
Georg Schneditz, Joshua E. Elias, Ester Pagano, M. Zaeem Cader, Svetlana Saveljeva, Kathleen Long, Subhankar Mukhopadhyay, Maryam Arasteh, Trevor D. Lawley, Gordon Dougan, Andrew Bassett, Tom H. Karlsen, Arthur Kaser, Nicole C. Kaneider
Article
Biochemistry & Molecular Biology
M. Zaeem Cader, Rodrigo Pereira de Almeida Rodrigues, James A. West, Gavin W. Sewell, Muhammad N. Md-Ibrahim, Stephanie Reikine, Giuseppe Sirago, Lukas W. Unger, Ana Belen Inglesias-Romero, Katharina Ramshorn, Lea-Maxie Haag, Svetlana Saveljeva, Jana-Fabienne Ebel, Philip Rosenstiel, Nicole C. Kaneider, James C. Lee, Trevor D. Lawley, Allan Bradley, Gordon Dougan, Yorgo Modis, Julian L. Griffin, Arthur Kaser
Correction
Biochemistry & Molecular Biology
M. Zaeem Cader, Rodrigo Pereira de Almeida Rodrigues, James A. West, Gavin W. Sewell, Muhammad N. Md-Ibrahim, Stephanie Reikine, Giuseppe Sirago, Lukas W. Unger, Ana Belen Iglesias-Romero, Katharina Ramshorn, Lea-Maxie Haag, Svetlana Saveljeva, Jana-Fabienne Ebel, Philip Rosenstiel, Nicole C. Kaneider, James C. Lee, Trevor D. Lawley, Allan Bradley, Gordon Dougan, Yorgo Modis, Julian L. Griffin, Arthur Kaser
Article
Multidisciplinary Sciences
Chenzhi Jing, Tomas Castro-Dopico, Nathan Richoz, Zewen K. Tuong, John R. Ferdinand, Laurence S. C. Lok, Kevin W. Loudon, Gemma D. Banham, Rebeccah J. Mathews, Zaeem Cader, Susan Fitzpatrick, Kathleen R. Bashant, Mariana J. Kaplan, Arthur Kaser, Randall S. Johnson, Michael P. Murphy, Richard M. Siegel, Menna R. Clatworthy
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2020)
Article
Cell Biology
Tomas Castro-Dopico, Aaron Fleming, Thomas W. Dennison, John R. Ferdinand, Katherine Harcourt, Benjamin J. Stewart, Zaeem Cader, Zewen K. Tuong, Chenzhi Jing, Laurence S. C. Lok, Rebeccah J. Mathews, Anais Portet, Arthur Kaser, Simon Clare, Menna R. Clatworthy
Article
Cell Biology
Svetlana Saveljeva, Gavin W. Sewell, Katharina Ramshorn, M. Zaeem Cader, James A. West, Simon Clare, Lea-Maxie Haag, Rodrigo Pereira de Almeida Rodrigues, Lukas W. Unger, Ana Belen Iglesias-Romero, Lorraine M. Holland, Christophe Bourges, Muhammad N. Md-Ibrahim, James O. Jones, Richard S. Blumberg, James C. Lee, Nicole C. Kaneider, Trevor D. Lawley, Allan Bradley, Gordon Dougan, Arthur Kaser
Summary: FAMIN plays a crucial role in regulating immune responses, protecting against excessive T cell activation and autoimmune reactions.
Editorial Material
Biochemistry & Molecular Biology
M. Zaeem Cader, Arthur Kaser
Summary: This translational study uncovers the involvement of interleukin-1-fibroblast-neutrophil signaling in drug-resistant inflammatory bowel disease, offering a potential avenue for targeted treatment.
Meeting Abstract
Rheumatology
Ilfita Sahbudin, Paola de Pablo, Luke Pickup, Zaeem Cader, Gina Allen, Peter Nightingale, Christopher D. Buckley, Karim Raza, Andrew Filer
Meeting Abstract
Rheumatology
Ilfita Sahbudin, Luke Pickup, Paola de Pablo, Jason Bell, Zaeem Cader, Abhishek Abhishek, Gina Allen, Peter Nightingale, Alison Jordan, Paresh Jobanputra, Simon Bowman, Christopher Buckley, Karim Raza, Andrew Filer