Article
Oncology
Erik Hellbacher, Christer Sundstrom, Daniel Molin, Eva Baecklund, Peter Hollander
Summary: This study investigated the expression of PD-1 and its ligands in lymphoma patients with pre-existing rheumatic diseases. The key findings include an association between disease severity of rheumatoid arthritis (RA) and increased expression of PD-L1 in tumor cells in patients with subsequent diffuse large B-cell lymphoma.
Article
Biochemistry & Molecular Biology
Dorota Suszczyk, Wiktoria Skiba, Witold Zardzewialy, Anna Pawlowska, Karolina Wlodarczyk, Grzegorz Polak, Rafal Tarkowski, Iwona Wertel
Summary: This study found that the PD-L1/PD-L2 pathway plays an important role in EMS. In the peritoneal fluid of EMS patients, there is an increased proportion of mDCs and pDCs expressing PD-L1 or PD-L2, as well as a higher concentration of soluble PD-L1 and PD-L2. This suggests that the peritoneal cavity environment and the PD-1/PD-L1/PD-L2 axis may play a crucial role in regulating immune response and the development and/or progression of EMS.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Immunology
Siqing Jiang, Xin Li, Lihua Huang, Zhensheng Xu, Jinguan Lin
Summary: Head and neck cancer is highly heterogeneous with poor prognosis. Prognostic markers such as PD-1, PD-L1, and PD-L2 have been studied, but their value is still debated. This article summarizes the different prognostic values of these markers in head and neck cancer based on cell types, tissue localization, and protein forms. It suggests the need for further research and the development of new evaluation systems.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Kimberly Krueger, Zsuzsanna Mayer, Marc Kottmaier, Miriam Gerckens, Stefan Boeck, Peter Luppa, Stefan Holdenrieder
Summary: The study investigated the interaction between PD-1 receptor and its ligands PD-L1 and PD-L2 and its importance in self-tolerance, immune escape of cancer, cardiovascular diseases, and COVID-19. The researchers tested various preanalytical conditions and found that the biomarkers showed good stability, allowing reliable quantification in oncoimmunology research and clinical settings of anti-cancer immunotherapy.
Review
Oncology
Seri Jeong, Nuri Lee, Min-Jeong Park, Kibum Jeon, Wonkeun Song
Summary: This study reviewed laboratory techniques for detecting the PD-1 axis in metastatic breast cancer patients undergoing immunotherapy and highlighted the impact of variations in assay methods on result interpretation and clinical utility. The development of new methodologies for assessing PD-L1 expression and soluble PD-L1 has provided more accessible and non-invasive options for monitoring immune checkpoint levels in patients.
Article
Biochemistry & Molecular Biology
Kimberly Krueger, Zsuzsanna Mayer, Miriam Gerckens, Stefan Boeck, Peter Luppa, Stefan Holdenrieder
Summary: A novel ELISA method was developed to measure soluble PD-1, PD-L1 and PD-L2 in blood samples, demonstrating high sensitivity and reliability through analytical validation, suitable for clinical study settings.
Article
Oncology
Tingting Zhang, Hengqi Liu, Lei Jiao, Zhenzhen Zhang, Jin He, Lanfang Li, Lihua Qiu, Zhengzi Qian, Shiyong Zhou, Wenchen Gong, Bin Meng, Xiubao Ren, Huilai Zhang, Xianhuo Wang
Summary: This study identifies a new genetic basis for PD-L1 overexpression and characterizes certain genetic alterations of CD73/A2aR in DLBCL. The degree of T-cell dysfunction is correlated with clinical outcomes. Therefore, strategies that inhibit PD-1/PD-L1/L2 and combine with CD73/A2aR to reverse T-cell dysfunction may serve as effective therapeutic options for DLBCL.
JOURNAL FOR IMMUNOTHERAPY OF CANCER
(2022)
Article
Multidisciplinary Sciences
Changsheng Huang, Shengxiang Ren, Yaqi Chen, Anyi Liu, Qi Wu, Tao Jiang, Panjing Lv, Da Song, Fuqing Hu, Jingqing Lan, Li Sun, Xue Zheng, Xuelai Luo, Qian Chu, Keyi Jia, Yan Li, Jun Wang, Caicun Zou, Junbo Hu, Guihua Wang
Summary: This research discovered that PD-L1 K162 was methylated by SETD7 and demethylated by LSD2. Additionally, PD-L1 K162 methylation controlled the PD1/PD-L1 interaction and significantly enhanced the suppression of T cell activity in controlling cancer immune surveillance. The study demonstrated that PD-L1 hypermethylation was the key mechanism for anti-PD-L1 therapy resistance, identified PD-L1 K162 methylation as a negative predictive marker for anti-PD-1 treatment in patients with non-small cell lung cancer, and showed that the PD-L1 K162 methylation:PD-L1 ratio was a more accurate biomarker for predicting anti-PD-(L)1 therapy sensitivity.
Review
Immunology
Youliang Zhao, Yaqian Qu, Changfu Hao, Wu Yao
Summary: Fibrosis is a pathological process characterized by excessive accumulation of extracellular matrix, leading to permanent scarring and organ failure. The immune system, particularly the immune checkpoint molecule PD-1/PD-L1 axis, plays a crucial role in the initiation and progression of fibrosis. The therapeutic targeting of PD-1/PD-L1 axis for tumor immunotherapy has provided new insights for its potential use in fibrotic diseases. This review discusses the structure, function, and regulatory mechanism of PD-1 and PD-L1, and summarizes the research progress of PD-1/PD-L1 signaling in fibrotic diseases.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Pathology
Valentina B. Stevenson, Samantha N. Perry, Michelle Todd, William R. Huckle, Tanya LeRoith
Summary: In both canine and human melanoma, overexpression of the PD-1/PD-L1/PD-L2 axis is a common feature. High levels of PD-1 and PD-L1 are associated with increased numbers of CD3(+) cells.
VETERINARY PATHOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Liudmila Spirina, Zahar Yurmazov, Evgeny Usynin, Irina Kondakova, Ekaterine Ladutko, Evgeny Choynzonov
Summary: The study revealed the importance of PD-L2 expression in metastatic ccRCC for tumor progression, as well as the impact of VHL expression and p-VHL content on aggressive cancer behavior. The dissemination of cancer is associated with an increase in mRNA and VHL content.
CURRENT ISSUES IN MOLECULAR BIOLOGY
(2021)
Article
Pathology
Joel Pinczewski, Rebecca C. Obeng, Craig L. Slingluff, Victor H. Engelhard
Summary: Beta-catenin, an important downstream effector in the Wnt signaling pathway, plays crucial roles in the development and progression of melanoma. Expression of pS33-beta cat varies widely in primary and metastatic melanomas, mainly localized in the cytoplasm with low nuclear staining rates. High expression of pS33-beta cat in dividing cells is associated with increased PD-L1 and PD-L2 expression, potentially guiding personalized therapies for tumors with high pS33-beta cat expression.
PATHOLOGY RESEARCH AND PRACTICE
(2021)
Article
Oncology
Denis Leonardo Jardim, Karthikeyan Murugesan, Julia A. Elvin, Richard S. P. Huang, Razelle Kurzrock
Summary: PD-L1 (CD274) amplification level and focality have an impact on PD-L1 protein expression. PD-L1 amplification was detected using a comparative genomic hybridization-like method and PD-L1 protein expression was analyzed by immunohistochemistry (IHC) using the DAKO 22C3 antibody. A total of 60,793 samples were analyzed, with the most common histologies being lung adenocarcinoma (20%), colon adenocarcinoma (12%), and lung squamous carcinoma (8%). The study found that 1.21% of tumors (738/60,793) had PD-L1 amplification. Focality categories ranged from <0.1 mB (2.4%) to >= 20 mB (24.4%). Lower levels of PD-L1 amplification were more frequently non-focal, while more focal amplifications correlated with higher PD-L1 IHC expression. The median tumor proportion score (TPS) for PD-L1 amplified samples according to focality ranged from 87.5% (<0.1 mB) to 1% (>= 20mB). In conclusion, PD-L1 protein expression is influenced by the level and focality of PD-L1 amplification.
JOURNAL FOR IMMUNOTHERAPY OF CANCER
(2023)
Article
Oncology
Drolaiz H. W. Liu, Heike I. I. Grabsch, Beat Gloor, Rupert Langer, Bastian Dislich
Summary: This study investigates the concordance rate of PD-L1 combined positive score (CPS) between primary gastric adenocarcinoma (GC) and regional or distant metastasis. It suggests that multiple biopsies of primary GC and metastatic sites might be necessary before treatment options are considered. Additionally, the study indicates that tumor cells acquire PD-L1 expression during disease progression.
JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY
(2023)
Article
Oncology
Iwona Kwiecien, Elzbieta Rutkowska, Malgorzata Polubiec-Kownacka, Agata Raniszewska, Piotr Rzepecki, Joanna Domagala-Kulawik
Summary: This study investigated the expression of PD-L2 and PD-L1 on AMs in BALF of lung cancer patients, finding that AMs in clBALF were positive for PD-L1 and PD-L2, and the proportion of PD-1+ T lymphocytes was higher in clBALF compared to hlBALF and PB. The study discussed the potential of exploring the PD-1-PD-L1/PD-L2 pathway in lung cancer environment.
TRANSLATIONAL LUNG CANCER RESEARCH
(2021)
Article
Gastroenterology & Hepatology
Weiwu Gao, Zhengcai Jia, Yi Tian, Penghui Yang, Hui Sun, Chenhui Wang, Yi Ding, Mengjie Zhang, Yi Zhang, Di Yang, Zhiqiang Tian, Jian Zhou, Zhihua Ruan, Yuzhang Wu, Bing Ni
Article
Biochemical Research Methods
Songlin Zhang, Jian Chen, Peijian Hong, Jinru Li, Yi Tian, Yuzhang Wu, Shufeng Wang
JOURNAL OF IMMUNOLOGICAL METHODS
(2020)
Article
Multidisciplinary Sciences
Li Wang, Jun Tang, Xia Yang, Peter Zanvit, Kairong Cui, Wai Lim Ku, Wenwen Jin, Dunfang Zhang, Nathan Goldberg, Alexander Cain, Bing Ni, Keji Zhao, Yuzhang Wu, WanJun Chen
NATURE COMMUNICATIONS
(2020)
Correction
Immunology
Jintao Li, Ji Zhang, Hongxia Guo, Shimin Yang, Weiping Fan, Nan Ye, Zhiqiang Tian, Tiantian Yu, Guoping Ai, Zigang Shen, Haiyang He, Ping Yan, Hui Lin, Xue Luo, Hongli Li, Yuzhang Wu
FRONTIERS IN IMMUNOLOGY
(2020)
Letter
Immunology
Xiangyu Chen, Ren Li, Zhiwei Pan, Chunfang Qian, Yang Yang, Renrong You, Jing Zhao, Pinghuang Liu, Leiqiong Gao, Zhirong Li, Qizhao Huang, Lifan Xu, Jianfang Tang, Qin Tian, Wei Yao, Li Hu, Xiaofeng Yan, Xinyuan Zhou, Yuzhang Wu, Kai Deng, Zheng Zhang, Zhaohui Qian, Yaokai Chen, Lilin Ye
CELLULAR & MOLECULAR IMMUNOLOGY
(2020)
Article
Immunology
Huang Huang, Xiaoping Wu, Dongwei Meng, Yizhou Feng, Lan Zhou, Zhenyu Liu, Shupei Tang, Xueqin Li, Yi Cao, Haiyang He, Zhunyi Xie, Jingbo Zhang, Yongwen Chen, Tingting Zhao, Yuzhang Wu, Xinyuan Zhou
Summary: The study demonstrated that LXR beta deficiency leads to a reduction in single-positive (SP) thymocytes and increased apoptosis, indicating the crucial role of LXR beta in promoting the survival of SP thymocytes. The findings also suggest that LXR beta positively regulates the expression of IL-7R alpha in SP thymocytes, which is essential for their survival.
CELLULAR & MOLECULAR IMMUNOLOGY
(2021)
Article
Infectious Diseases
Bo Diao, Kun Wen, Ji Zhang, Jian Chen, Chao Han, Yongwen Chen, Shufeng Wang, Guohong Deng, Hongwei Zhou, Yuzhang Wu
Summary: The FIC assay for NP antigen testing shows high specificity and relatively high sensitivity in early-phase SARS-CoV-2 diagnosis, according to a study conducted in Wuhan and Chongqing between February 10 and 15, 2020.
CLINICAL MICROBIOLOGY AND INFECTION
(2021)
Article
Endocrinology & Metabolism
Lina Wang, Ping Sun, Yuzhang Wu, Li Wang
Summary: Obesity-induced low-grade chronic inflammation in metabolic tissues is a major factor for various diseases. Tissue-resident macrophages and adaptive CD8(+) T cells play important roles in this process, but further research is needed to understand the mechanisms involved.
Review
Biochemistry & Molecular Biology
Yiwei Zhang, Zhiyuan Wei, Hui Dong, Jian Zhou, Jizhao Yuan, Bing Ni, Yuzhang Wu, Chao Han, Yi Tian
Summary: This review summarizes the role of RNA-binding proteins, microRNAs, and long non-coding RNAs in regulating the fate of Th17 cells, as well as the impact of RNA modifications and nonsense-mediated mRNA decay in Th17 cells. Ongoing research may provide insights into practical applications for regulating mRNA stability in the context of Th17-related autoimmune diseases.
Article
Multidisciplinary Sciences
Xinyun Chen, Ying Liu, Chen Xu, Lina Ba, Zhuo Liu, Xiuya Li, Jie Huang, Ed Simpson, Hongyu Gao, Dayan Cao, Wei Sheng, Hanping Qi, Hongrui Ji, Maria Sanderson, Chen-Leng Cai, Xiaohui Li, Lei Yang, Jie Na, Kenichi Yamamura, Yunlong Liu, Guoying Huang, Weinian Shou, Ning Sun
Summary: The RNA-binding protein Quaking (QKI) plays a crucial role in cardiac development and contractile physiology through its regulation of alternative splicing in genes involved in Z-disc formation and contractile physiology. Deficiency of QKI results in the failure of cardiomyocytes to mature into functional cells, highlighting its importance in cardiac pathophysiology.
NATURE COMMUNICATIONS
(2021)
Article
Multidisciplinary Sciences
Yi Tian, Chao Han, Zhiyuan Wei, Hui Dong, Xiaohe Shen, Yiqiang Cui, Xiaolan Fu, Zhiqiang Tian, Shufeng Wang, Jian Zhou, Di Yang, Yi Sun, Jizhao Yuan, Bing Ni, Yuzhang Wu
Summary: This study identified a novel enhancer, RORCE2, for the transcription factor RORγt, which interacts with Sox5 to modulate RORγt expression at the promoter level, providing insights into the regulation of Th17 differentiation and functions.
NATURE COMMUNICATIONS
(2021)
Article
Biochemistry & Molecular Biology
Yiwei Zhang, Jian Zhou, Zhiyuan Wei, Hui Dong, Di Yang, Yuanyu Deng, Jiahui Li, Saiyu Shi, Yi Sun, Huimin Lu, Jizhao Yuan, Bing Ni, Yuzhang Wu, Yi Tian, Chao Han
Summary: Dendritic cells play a crucial role in the immune system by regulating defense against pathogens and tolerance to self. This review highlights the significance of mRNA stability regulation in dendritic cells for their function and immune therapy.
Review
Immunology
Hui Sun, Yuzhang Wu, Yi Zhang, Bing Ni
Summary: This study focuses on the production mechanisms of IL-10 in ILCs, the key role of IL-10 in NK and ILC2 cells, and the potential impact of IL-10-producing ILCs in diseases such as infections, allergies, and cancers.
FRONTIERS IN IMMUNOLOGY
(2021)
Letter
Cardiac & Cardiovascular Systems
Dayan Cao, Ying Liu, Xin Chen, Jie Liu, Jie Liu, Wenjing Lai, Shuhui Li, Wenjia Wang, Wenjun Zhang, Deyong Xiao, Kai Yang, Baiyan Li, Zhongjun Zhou, Chen-Leng Cai, Xiaohui Li, Weinian Shou
Article
Biochemistry & Molecular Biology
Yanyan Zhang, Baohua Li, Qiang Bai, Pengcheng Wang, Gang Wei, Zhirong Li, Li Hu, Qin Tian, Jing Zhou, Qizhao Huang, Zhiming Wang, Shuai Yue, Jialin Wu, Liuqing Yang, Xinyuan Zhou, Lubin Jiang, Ting Ni, Lilin Ye, Yuzhang Wu
Summary: The study identified a key lncRNA-Snhg1 in CD8 T cells that promotes memory formation and inhibits effector cell differentiation. Snhg1 interacts with Vps13D and regulates IL-7 signaling to play a crucial role in memory CD8 cell generation. The Snhg1-Vps13D-IL-7R-TCF1 axis is central in memory CD8 establishment and a potential target for enhancing vaccination effects against ongoing pandemics.
SIGNAL TRANSDUCTION AND TARGETED THERAPY
(2021)