Article
Pharmacology & Pharmacy
Jerome Dormoi, Remy Amalvict, Mathieu Gendrot, Bruno Pradines
Summary: The untreated malaria can quickly progress to severe forms, and drug resistance poses a threat to malaria protection efforts worldwide. Therefore, the development of new chemotherapy is necessary. This study contributes new data on the use of methylene blue (MB) in combination with common antimalarial drugs for the treatment of malaria and cerebral malaria. The results show that the combination of MB and AQ is a good candidate for preventing cerebral malaria.
Article
Infectious Diseases
Moses Ikegbunam, Johnson A. Ojo, Kossiwa Kokou, Ugonna Morikwe, Chukwuemeka Nworu, Chibuzo Uba, Charles Esimone, Thirumalaisamy P. Velavan, Olusola Ojurongbe
Summary: This study investigated artemisinin resistance-associated gene polymorphisms in two regions of Nigeria and did not observe mutations associated with artemisinin resistance. The findings suggest that artemisinin remains highly effective in treating malaria in the study areas.
Article
Microbiology
Laura M. Hagenah, Satish K. Dhingra, Jennifer L. Small-Saunders, Tarrick Qahash, Andreas Willems, Kyra A. Schindler, Gabriel W. Rangel, Eva Gil-Iturbe, Jonathan Kim, Emiliya Akhundova, Tomas Yeo, John Okombo, Filippo Mancia, Matthias Quick, Paul D. Roepe, Manuel Llinas, David A. Fidock
Summary: Efforts to eliminate malaria in Southeast Asia have been hampered by multidrug-resistant Plasmodium falciparum. A specific mutation in the PfCRT gene is associated with high-grade resistance to piperaquine, a commonly used antimalarial drug. This mutation not only causes resistance but also affects the growth of the parasite. Recent studies have found additional mutations that compensate for the growth defect caused by the original mutation. Removing drug pressure results in the loss of resistance, highlighting the transient nature of piperaquine resistance.
Article
Infectious Diseases
Navaporn Posayapisit, Jutharat Pengon, Philip J. Shaw, Chairat Uthaipibull, Darin Kongkasuriyachai, Aung Pyae Phyo, Francois Nosten, Yongyuth Yuthavong, Sumalee Kamchonwongpaisan
Summary: The effectiveness of antimalarial drug P218 against artemisinin-resistant Plasmodium falciparum is still uncertain, despite its efficacy against other drug-resistant parasites.
INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS
(2023)
Article
Multidisciplinary Sciences
Tanyaluck Kampoun, Pimpisid Koonyosying, Jetsada Ruangsuriya, Parichat Prommana, Philip J. Shaw, Sumalee Kamchonwongpaisan, Hery Suwito, Ni Nyoman Tri Puspaningsih, Chairat Uthaipibull, Somdet Srichairatanakool
Summary: This study found that the antimalarial compound C3 and iron chelators have similar antimalarial effects and inhibit the action of iron ions on dihydroartemisinin (DHA). The results suggest that drugs with inhibitory effects on the Fd/FNR redox system should be avoided as partner drugs for DHA in combination therapy.
Article
Infectious Diseases
Annarita Botta, Agnese Comelli, Iacopo Vellere, Flavia Chechi, Leila Bianchi, Gardini Giulia, Lina Rachele Tomasoni, Michele Spinicci, Luisa Galli, Francesco Castelli, Alessandro Bartoloni, Lorenzo Zammarchi
Summary: A retrospective cohort study compared the effects of IVA + IVQ and IVA treatment for imported severe malaria and found that IVA + IVQ treatment did not show better outcomes and had more adverse events in adults. Further research is needed to investigate whether IVA + IVQ could be an effective strategy in areas with high artemisinin resistance.
Article
Microbiology
Nicole M. Davis, Michelle M. Lissner, Crystal L. Richards, Victoria Chevee, Avni S. Gupta, Frank C. Gherardini, David S. Schneider
Summary: The study focuses on how host metabolism changes in relation to disease severity in murine malaria, identifying plasma metabolic biomarkers for different malarial pathologies. The research also reveals connections between plasma metabolomes of human malaria patients and metabolic changes in malarial mice. Specifically, liver damage in infected mice releases hepatic arginase-1 into circulation, leading to plasma arginine depletion, which may have implications for malaria therapeutics.
Article
Microbiology
Amuza Byaruhanga Lucky, Chengqi Wang, Ahmad Rushdi Shakri, Mohammad Kalamuddin, Anongruk Chim-Ong, Xiaolian Li, Jun Miao
Summary: This study demonstrates the critical role of PfGCN5 gene in stress responses of Plasmodium falciparum, indicating its potential as a target for malaria intervention.
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
(2023)
Article
Chemistry, Medicinal
Hao Zhang, John Ginn, Wenhu Zhan, Annie Leung, Yi J. Liu, Akinori Toita, Rei Okamoto, Tzu-Tshin Wong, Toshihiro Imaeda, Ryoma Hara, Mayako Michino, Takafumi Yukawa, Sevil Chelebieva, Patrick K. Tumwebaze, Jeremie Vendome, Thijs Beuming, Kenjiro Sato, Kazuyoshi Aso, Philip J. Rosenthal, Roland A. Cooper, Nigel Liverton, Michael Foley, Peter T. Meinke, Carl F. Nathan, Laura A. Kirkman, Gang Lin
Summary: Targeting the Plasmodium proteasome is a promising strategy to combat malaria, especially with the increasing reports of resistance to current therapies. In this study, we conducted structure-activity relationship studies on a macrocyclic scaffold and identified compound TDI-8414, which showed potent antiparasitic activity, high selectivity, improved solubility, and enhanced metabolic stability.
JOURNAL OF MEDICINAL CHEMISTRY
(2023)
Article
Infectious Diseases
Marvin Duvalsaint, Melissa D. Conrad, Stephen Tukwasibwe, Patrick K. Tumwebaze, Jennifer Legac, Roland A. Cooper, Philip J. Rosenthal
Summary: The study found that WT N86/184F parasites were less fit than parasites with other haplotypes. Culturing with chloroquine favored 86Y mutant parasites, while culturing with lumefantrine favored N86 WT parasites. Parasites with double WT were in equilibrium with double mutant, but 86Y/Y184 overgrew N86/184F.
Article
Microbiology
Yawei Du, Carlo Giannangelo, Wei He, Gerald J. Shami, Wenya Zhou, Tuo Yang, Darren J. Creek, Con Dogovski, Xinsong Li, Leann Tilley
Summary: This study introduces a liposome-like prodrug as a treatment for artemisinin-resistant malaria. The results show that this multilamellar liposome-like assembly can sustainably release the drug and enhance the efficacy against resistant parasites in vitro. Analysis of parasite proteostasis pathways reveals the mechanism of action of this liposome-like assembly.
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
(2022)
Editorial Material
Biology
Colin Sutherland, Didier Menard
Summary: A tool that analyzes the genome of parasites in the blood of malaria patients can assist policymakers in making informed decisions on how to address the increase in drug-resistant infections.
Article
Microbiology
Lucien Platon, David A. Baker, Didier Menard
Summary: The ring-stage survival assay is the reference assay to measure in vitro Plasmodium falciparum artemisinin partial resistance. The main challenge of the standard protocol is to generate 0-to-3-h postinvasion ring stages (the stage least susceptible to artemisinin) from schizonts obtained by sorbitol treatment and Percoll gradient.
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
(2023)
Article
Medicine, General & Internal
Harvie P. Portugaliza, H. Magloire Natama, Pieter Guetens, Eduard Rovira-Vallbona, Athanase M. Some, Aida Millogo, D. Florence Ouedraogo, Innocent Valea, Hermann Sorgho, Halidou Tinto, Nguyen Van Hong, Antonio Sitoe, Rosauro Varo, Quique Bassat, Alfred Cortes, Anna Rosanas-Urgell
Summary: The study found that in most infections from African cohorts, increased expression of pfap2-g and other sexual ring biomarkers was observed after treatment. The estimated parasite age at the time of treatment was negatively correlated with the increase in pfap2-g transcript levels, suggesting that younger parasites are less susceptible to stimulation of sexual conversion.
Article
Microbiology
YaQun Liu, XueYan Liang, Jian Li, JiangTao Chen, HuiYing Huang, YuZhong Zheng, JinQuan He, Carlos Salas Ehapo, Urbano Monsuy Eyi, PeiKui Yang, LiYun Lin, WeiZhong Chen, GuangYu Sun, XiangZhi Liu, GuangCai Zha, JunLi Wang, ChunFang Wang, HuaGui Wei, Min Lin
Summary: This study evaluated the drug resistance of Pfk13, Pfcrt, Pfpm2, and Pfmdr1 genes in Bioko Island, Equatorial Guinea from 2017 to 2019, showing a severe antimalarial drug resistance situation on the island and highlighting the importance of continuous drug monitoring to control malaria.
MICROBIOLOGY SPECTRUM
(2022)
Article
Multidisciplinary Sciences
Andrea C. S. M. Gomes, Samuel R. Dos Santos, Maycon C. Ribeiro, Pedro V. L. Cravo, Jose Daniel G. Vieira, Keili M. C. De Souza, Andre C. Amaral
ANAIS DA ACADEMIA BRASILEIRA DE CIENCIAS
(2018)
Review
Biochemistry & Molecular Biology
Carolina Horta Andrade, Bruno Junior Neves, Cleber Camilo Melo-Filho, Juliana Rodrigues, Diego Cabral Silva, Rodolpho Campos Braga, Pedro Vitor Lemos Cravo
CURRENT MEDICINAL CHEMISTRY
(2019)
Article
Infectious Diseases
Pedro Cravo, Renato B. Machado, Juliana A. Leite, Taizy Leda, Rossarin Suwanarusk, Najara Bittencourt, Letusa Albrecht, Carla Judice, Stefanie C. P. Lopes, Marcus V. G. Lacerda, Marcelo U. Ferreira, Irene S. Soares, Yun Shan Goh, Daniel Y. Bargieri, Francois Nosten, Bruce Russell, Laurent Renia, Fabio T. M. Costa
Article
Chemistry, Multidisciplinary
Jean M. F. Custodio, Lidiane J. Michelini, Mirian Rita C. de Castro, Wesley F. Vaz, Bruno J. Neves, Pedro V. L. Cravo, Francisco S. Barreto, Manoel O. M. Filho, Caridad N. Perez, Hamilton B. Napolitano
NEW JOURNAL OF CHEMISTRY
(2018)
Article
Pharmacology & Pharmacy
Marilia N. N. Lima, Cleber C. Melo-Filho, Gustavo C. Cassiano, Bruno J. Neves, Vinicius M. Alves, Rodolpho C. Braga, Pedro V. L. Cravo, Eugene N. Muratov, Juliana Calit, Daniel Y. Bargieri, Fabio T. M. Costa, Carolina H. Andrade
FRONTIERS IN PHARMACOLOGY
(2018)
Article
Parasitology
Francesca Chapadense, Ricardo Luiz Dantas Machado, Ana Maria Revoredo da Silva Ventura, Andre Areas, Renato Beilner Machado, Giselle Rachid Viana, Mariano Gustavo Zalis, Ana Maria de Castro, Pedro Cravo
REVISTA DA SOCIEDADE BRASILEIRA DE MEDICINA TROPICAL
(2019)
Review
Infectious Diseases
Liliana Rodrigues, Pedro Cravo, Miguel Viveiros
EXPERT REVIEW OF ANTI-INFECTIVE THERAPY
(2020)
Article
Microbiology
Leticia Tiburcio Ferreira, Juliana Rodrigues, Gustavo Capatti Cassiano, Tatyana Almeida Tavella, Kaira Cristina Peralis Tomaz, Djane Clarys Baia-da-Silva, Macejane Ferreira Souza, Marilia Nunes do Nascimento Lima, Melina Mottin, Ludimila Dias Almeida, Juliana Calit, Maria Carolina Silva de Barros Puca, Gisely Cardoso Melo, Daniel Youssef Bargieri, Stefanie Costa Pinto Lopes, Marcus Vinicius Guimaraes Lacerda, Elizabeth Bilsland, Per Sunnerhagen, Bruno Junior Neves, Carolina Horta Andrade, Pedro Vitor Lemos Cravo, Fabio Trindade Maranhao Costa
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
(2020)
Correction
Microbiology
Leticia Tiburcio Ferreira, Juliana Rodrigues, Gustavo Capatti Cassiano, Tatyana Almeida Tavella, Kaira Cristina Peralis Tomaz, Djane Clarys Baia-da-Silva, Macejane Ferreira Souza, Marilia Nunes do Nascimento Lima, Melina Mottin, Ludimila Dias Almeida, Juliana Calit, Maria Carolina Silva de Barros Puca, Gisely Cardoso Melo, Daniel Youssef Bargieri, Stefanie Costa Pinto Lopes, Marcus Vinicius Guimaraes Lacerda, Elizabeth Bilsland, Per Sunnerhagen, Bruno Junior Neves, Carolina Horta Andrade, Pedro Vitor Lemos Cravo, Fabio Trindade Maranhao Costa
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
(2020)
Review
Microbiology
Julyana Cerqueira Buery, Filomena Euridice Carvalho de Alencar, Ana Maria Ribeiro de Castro Duarte, Ana Carolina Loss, Creuza Rachel Vicente, Lucas Mendes Ferreira, Blima Fux, Marcia Melo Medeiros, Pedro Cravo, Ana Paula Arez, Crispim Cerutti Junior
Summary: This study summarizes investigations of malaria cases outside the traditional endemic Amazon region in southern and southeastern Brazil, suggesting a potential interspecies transfer of the disease between humans and monkeys through Anopheles mosquitoes.
Article
Chemistry, Medicinal
Tatyana Almeida Tavella, Noeli Soares Melo da Silva, Natalie Spillman, Ana Carolina Andrade Vitor Kayano, Gustavo Capatti Cassiano, Adrielle Ayumi Vasconcelos, Antonio Pedro Camargo, Djane Clarys Baia da Silva, Diana Fontinha, Luis Carlos Salazar Alvarez, Leticia Tiburcio Ferreira, Kaira Cristina Peralis Tomaz, Bruno Junior Neves, Ludimila Dias Almeida, Daniel Youssef Bargieri, Marcus Vinicius Guimaraes de Lacerda, Pedro Vitor Lemos Cravo, Per Sunnerhagen, Miguel Prudencio, Carolina Horta Andrade, Stefanie Costa Pinto Lopes, Marcelo Falsarella Carazzolle, Leann Tilley, Elizabeth Bilsland, Julio Cesar Borges, Fabio Trindade Maranhao Costa
Summary: The natural compound violacein affects protein homeostasis in the malaria parasite, resulting in parasite growth inhibition. It could potentially be developed as a new anti-malarial drug due to its effects on the parasite's stress response.
ACS INFECTIOUS DISEASES
(2021)
Article
Chemistry, Medicinal
Anyse P. Essoh, Angela Liberal, Angela Fernandes, Maria Ines Dias, Carla Pereira, Filipa Mandim, Margarida Moldao-Martins, Pedro Cravo, Maria Paula Duarte, Monica Moura, Maria M. Romeiras, Lillian Barros
Summary: The present study investigated the bioactive properties of three native plants from Cabo Verde Islands, showing that they have good antioxidant and anti-tumor properties, as well as some anti-inflammatory effects. These findings contribute to the understanding of these plants and open up new possibilities for their use in a wider range of health conditions.
Article
Parasitology
Pedro Cravo
Summary: Malaria is a devastating disease, and the evolution and propagation of drug-resistant parasites are major barriers to its control. By experimentally evolving drug resistance and comparing genomes, the genes and mutations responsible for resistance can be identified. P. chabaudi serves as a fast-track predictive model to identify candidate genetic markers of resistance and enhance our understanding of resistance biology.
PARASITOLOGY INTERNATIONAL
(2022)
Article
Plant Sciences
Anyse P. Essoh, Gustavo Capatti Cassiano, Filipa Mandim, Lillian Barros, Isildo Gomes, Marcia Melo Medeiros, Monica Moura, Pedro Vitor Lemos Cravo, Maria M. Romeiras
Summary: This study investigated the in vitro antiplasmodial activities of four native plants from Cabo Verde. The results showed that the ethanolic extract of Artemisia gorgonum and infusions of Tamarix senegalensis exhibited high antiplasmodial activities without cytotoxicity. Lavandula rotundifolia and Sideroxylon marginatum extracts showed moderate activities. The findings support the traditional use of these plants against malaria and suggest their potential as future antimalarials.
Review
Social Sciences, Interdisciplinary
Sandra Bailoa, Pedro Cravo
ZBORNIK VELEUCILISTA U RIJECI-JOURNAL OF THE POLYTECHNICS OF RIJEKA
(2020)