Article
Food Science & Technology
Rui Dong, Xiaojie Qin, Shoukui He, Xiujuan Zhou, Yan Cui, Chunlei Shi, Yiping He, Xianming Shi
Summary: The study revealed that DsrA plays a crucial role in promoting oxidative stress resistance in S. Typhimurium by regulating the expression of antioxidant enzymes and maintaining intracellular redox balance.
Article
Microbiology
Yu Han, Yu Li, Zhiwei Zeng, Wenjing Li, Saixiang Feng, Weisheng Cao
Summary: This study explores the resistance mechanism and activity of the antimicrobial peptide MccY against Salmonella strains. The deletion of Ton system genes resulted in resistance to MccY and mutants showed increased susceptibility to MccY under a low-iron condition. MccY may decrease the virulence of S. Typhimurium by altering multiple physiological properties.
MICROBIOLOGY SPECTRUM
(2022)
Article
Chemistry, Analytical
Han Du, Xu Zhang, Mingru Yao, Qingli Yang, Wei Wu
Summary: This study successfully constructed aptamer-guided luminous microspheres using carbon dots fluorescence, which can efficiently recognize and detect Salmonella enterica serovar Typhimurium. The method shows high sensitivity and has broad application prospects.
SENSORS AND ACTUATORS B-CHEMICAL
(2022)
Article
Microbiology
Stephanie Paulini, Florian D. Fabiani, Anna S. Weiss, Ana Laura Moldoveanu, Sophie Helaine, Baerbel Stecher, Kirsten Jung
Summary: Pyruvate, the simplest of the alpha-keto acids, plays a crucial role in the metabolic pathways of bacteria and eukaryotes. This study identified two specific transporters, BtsT and CstA, in Salmonella enterica serovar Typhimurium, which are important for pyruvate uptake and have significant effects on bacterial survival, infection, and persistence.
Article
Microbiology
Jiwon Baek, Hyunjin Yoon
Summary: Cyclic di-GMP is a signaling molecule that controls the transition between motile and nonmotile lifestyles in bacteria. It regulates biofilm formation and dispersal, and it can alter carbon metabolic pathways in Salmonella enterica serovar Typhimurium.
MICROBIOLOGY SPECTRUM
(2023)
Article
Microbiology
R. Kavi Bharathi, C. S. Srinandan, N. Sai Subramanian
Summary: This study investigates the cooperative ability and matrix sharing between specialist and generalist strains during biofilm formation. The results show that the matrix aids in survival during antibiotic, chlorine, and predatory stress, and possible sharing of the matrix occurs in co-culture.
Article
Microbiology
Seul Kim, Eunsuk Kim, Hyunjin Yoon
Summary: Salmonella alters cellular processes to improve intracellular fitness during host infection by rewiring cellular transcriptional regulation through alternative sigma factors such as rpoS. Deprivation of outer membrane protein YcfR in Salmonella Typhimurium leads to decreased intracellular survival and downregulation of SPI-2 genes, which is abolished in the absence of rpoS. RpoS-associated stress responses in Salmonella due to impaired envelope integrity may reciprocally downregulate the expression of SPI-2 genes to reduce its virulence.
FRONTIERS IN MICROBIOLOGY
(2021)
Article
Microbiology
Yuan Yuan, Yara Seif, Kevin Rychel, Reo Yoo, Siddharth Chauhan, Saugat Poudel, Tahani Al-bulushi, Bernhard O. Palsson, Anand Sastry
Summary: By combining pan-genome and transcriptomic analytics, variations in transcriptional regulatory networks across six strains of Salmonella enterica serovar Typhimurium were revealed.
Article
Food Science & Technology
Hui Li, Keren Agyekumwaa Addo, Yi-gang Yu, Xing-long Xiao
Summary: The study investigated the influence of cuminaldehyde (CUM) on cell membrane and genomic DNA of Salmonella enterica serovar Typhimurium (S. Typhimurium), and revealed its antibacterial mechanism. CUM could bind to bacterial membrane proteins and change its structure and conformation, leading to the leakage of intracellular substances and the destruction of cell integrity. DNA interaction analysis showed that CUM bound to genomic DNA through groove mode, affecting the normal functioning of S. Typhimurium.
Article
Nutrition & Dietetics
Weihua Tan, Yuanyuan Tian, Qingya Zhang, Siwei Miao, Wenrong Wu, Xiaoqing Miao, Haiou Kuang, Wenchao Yang
Summary: In this study, it was found that Apis laboriosa honey (ALH) harvested in China has antibacterial activity against Salmonella enterica serovar Typhimurium (S. Typhimurium). The physicochemical parameters and antioxidant activity of ALH were influenced by the time and region of harvest. The minimum inhibitory concentration (MIC) and minimum bactericidal concentration (MBC) of ALH against S. Typhimurium were similar to UMF5+ manuka honey. Proteomic experiment revealed the antibacterial mechanism of ALH.
FRONTIERS IN NUTRITION
(2023)
Article
Food Science & Technology
Ji-Yeon Kim, Hana Song, Danbi Kim, Sun-Young Lee
Summary: Mild heat treatment can enhance the thermal resistance of S. Typhimurium and reduce membrane damage and heat-induced injury, leading to increased tolerance against heat, alcohol, and salt stress. Further research into the heat shock response mechanism of S. Typhimurium may provide insights for developing microbial control measures in food processing.
Article
Multidisciplinary Sciences
Hussein A. Almehdar, Nawal Abd El-Baky, Ehab H. Mattar, Raed Albiheyri, Atif Bamagoos, Abdullah Aljaddawi, Vladimir N. Uversky, Elrashdy M. Redwan
Summary: Camel lactoferrin obtained from different clans of camels in Saudi Arabia exhibits antimicrobial action against S. typhimurium and S. sonnei, and is more effective than bovine and human lactoferrin. It can kill the bacterial strains by iron chelation, affecting bacterial proteins, binding to bacterial LPS and membrane proteins, and disrupting the integrity of bacterial cells and membranes when used alone or in combination with antibiotics.
Article
Immunology
Zecai Zhang, Siyu Liu, Jiang Huang, Yueqi Cui, Yu Liu, Yulong Zhou, Zhanbo Zhu
Summary: The study found that phloretin can alleviate intestinal damage caused by Salmonella and inhibit its translocation to other organs. Phloretin protects colonic tissue by reducing inflammation and oxidative stress levels, and prevents Salmonella from damaging the colonic epithelium barrier by regulating ZO-1 and occludin levels. Additionally, phloretin does not inhibit Salmonella growth but reduces its internalization into Caco-2 cells.
MICROBIAL PATHOGENESIS
(2021)
Article
Virology
Cedric Woudstra, Sophie A. Granier
Summary: This study investigates the anti-phage defenses in Salmonella Typhimurium using bioinformatics and identifies nucleic acid degradation and abortive infection mechanisms. Mobile genetic elements containing anti-phage systems were also found in Salmonella and the Enterobacteriaceae family. This research provides insights for designing preventive measures against the spread of phage resistance.
Article
Nutrition & Dietetics
Keyuan Chen, Jiufeng Wang, Liang Guo, Jing Wang, Lan Yang, Ting Hu, Yiqing Zhao, Xue Wang, Yaohong Zhu
Summary: Salmonella enterica serovar Typhimurium (S. Typhimurium) has evolved mechanisms to evade the host's nutritional immunity and promote bacterial growth by using host iron. However, the detailed mechanisms of S. Typhimurium-induced dysregulation of iron homeostasis and the potential alleviative effect of Lactobacillus johnsonii L531 on iron metabolism disorder caused by S. Typhimurium remains unclear. In this study, it was found that S. Typhimurium activated the expression of iron regulatory protein 2 (IRP2) and other iron-related proteins while suppressing the expression of iron exporter ferroportin, resulting in iron overload and oxidative stress. Pretreatment with L. johnsonii L531 effectively reversed these effects. Knockdown of IRP2 inhibited iron overload and oxidative damage induced by S. Typhimurium, while overexpression of IRP2 promoted these effects. Furthermore, the protective effect of L. johnsonii L531 on iron homeostasis and antioxidant function was blocked by IRP2 overexpression, indicating that L. johnsonii L531 attenuates disruption of iron homeostasis and oxidative damage caused by S. Typhimurium via the IRP2 pathway, contributing to the prevention of S. Typhimurium diarrhea in mice.
Article
Biochemistry & Molecular Biology
Zhixia Zhou, Chengyu Yang, Fuyan Lv, Wenmiao Liu, Shengli Yan, Hongwei Zang, Miaomiao Li, Fang Wang, Yucui Zang, Shiguo Liu
JOURNAL OF CELLULAR BIOCHEMISTRY
(2018)
Article
Biochemistry & Molecular Biology
Xin Pang, Zhixia Zhou, Zhuang Yu, Lichun Han, Zhijuan Lin, Xiang Ao, Chang Liu, Yuqi He, Murugavel Ponnusamy, Peifeng Li, Jianxun Wang
Review
Oncology
Zhixia Zhou, Qi Gong, Zhijuan Lin, Yin Wang, Mengkun Li, Lu Wang, Hongfei Ding, Peifeng Li
FRONTIERS IN ONCOLOGY
(2020)
Review
Oncology
Zhixia Zhou, Qi Gong, Yin Wang, Mengkun Li, Lu Wang, Hongfei Ding, Peifeng Li
BIOMARKER RESEARCH
(2020)
Article
Oncology
Peipei Shan, Feifei Yang, Hongzhao Qi, Yunjie Hu, Sujie Zhu, Zhenqing Sun, Zhe Zhang, Chuanxiao Wang, Caixia Hou, Jie Yu, Lirong Wang, Zhixia Zhou, Peifeng Li, Hua Zhang, Kun Wang
Summary: The study reveals the essential role of MDM2 in TNBC progression, suggesting that targeting the HDAC1-MDM2-MDMX axis with a hydroxamate-based HDAC1 could be a promising therapeutic strategy for TNBC.
Review
Oncology
Zhixia Zhou, Yinfeng Zhang, Jinning Gao, Xiaodan Hao, Chan Shan, Jing Li, Cuiyun Liu, Yin Wang, Peifeng Li
Summary: Circular RNAs (circRNAs) and autophagy are closely linked in the occurrence and development of cancer, with circRNAs influencing cancer progression by activating or inhibiting autophagy. Research has shown that the regulatory role of circRNAs in cancer is crucial for understanding the mechanisms of carcinogenesis.
MOLECULAR THERAPY-ONCOLYTICS
(2021)
Review
Medicine, General & Internal
Xiao-Dan Hao, Hua Gao, Wen-Hua Xu, Chan Shan, Ying Liu, Zhi-Xia Zhou, Kun Wang, Pei-Feng Li
Summary: Keratoconus is an etiologically heterogeneous corneal ectatic disorder. This study reviewed and analyzed genes, gene ontology (GO), and pathways involved in keratoconus, and found potential relationships and mechanisms related to the pathogenesis of keratoconus. The study provides insights into the gene-based etiology and pathogenesis of keratoconus.
FRONTIERS IN MEDICINE
(2022)
Review
Oncology
Zhixia Zhou, Zhan Wang, Jie Gao, Zhijuan Lin, Yin Wang, Peipei Shan, Mengkun Li, Tingting Zhou, Peifeng Li
Summary: This review focuses on the regulation of noncoding RNAs (ncRNAs), including miRNAs, lncRNAs, and circRNAs, in the crosstalk between macrophages and tumor cells in hepatocellular carcinoma (HCC). These ncRNAs act as oncogenes or tumor suppressors, contributing to tumor progression by regulating the physiological and pathological processes of tumor cells as well as controlling macrophage infiltration, activation, polarization, and function. The review also explores the potential therapeutic strategies targeting crosstalk-related ncRNAs for HCC treatment.
MOLECULAR THERAPY-ONCOLYTICS
(2022)
Article
Cell & Tissue Engineering
Yalan Xu, Jie Mu, Zhixia Zhou, Yu Leng, Yali Yu, Xiuyue Song, Aihua Liu, Hai Zhu, Jing Li, Dong Wang
Summary: The study isolated and cultured a novel type of castration-resistant intermediate prostate stem cells that can rapidly proliferate in 2D culture dishes and be maintained for over six months. These stem cells express markers of both basal and luminal cells, and can differentiate into prostate organoids and tissues.
STEM CELL RESEARCH & THERAPY
(2022)
Review
Fisheries
Zhixia Zhou, Yanxin He, Shoushi Wang, Yin Wang, Peipei Shan, Peifeng Li
Summary: Autophagy is a conserved cellular process essential for maintaining metabolism and energy balance, with implications in various physiological functions and clinical diseases. However, little is known about autophagy in teleost fish. This review provides an overview of the current knowledge of autophagy in teleosts, focusing on its physiological and pathological regulation in different processes. The potential options for targeting autophagy in teleosts for domestication, farming, or therapeutic strategies are also explored.
Review
Pharmacology & Pharmacy
Zhixia Zhou, Qianqian Cao, Yujing Diao, Yin Wang, Linhai Long, Shoushi Wang, Peifeng Li
Summary: In recent years, natural active substances from the marine environment have attracted great attention in the development of new antitumor drugs. Although a series of marine-derived compounds with potential antitumor effects have been discovered, their mechanisms of action are still not well understood. Emerging studies have found that noncoding RNAs (ncRNAs) play important roles in the antitumor mechanisms of marine-derived agents. This review summarizes the latest research progress on the regulation of ncRNAs associated with marine-derived agents in tumor cell proliferation, apoptosis, cell cycle, invasion, migration, drug sensitivity, and resistance. The review also discusses recent advances in marine food-derived ncRNAs as antitumor agents that modulate cross-species gene expression.
FRONTIERS IN PHARMACOLOGY
(2022)
Review
Immunology
Zhixia Zhou, Cuibo Leng, Zhan Wang, Linhai Long, Yiju Lv, Ziru Gao, Yin Wang, Shoushi Wang, Peifeng Li
Summary: Research in the past two decades has confirmed that noncoding RNAs (ncRNAs), present in cells from yeast to vertebrates, are functional regulators involved in cellular and physiological processes. Dysregulation of ncRNAs is linked to imbalances in cellular homeostasis and the development of diseases. In mammals, ncRNAs like long noncoding RNAs (lncRNAs) and microRNAs (miRNAs) serve as biomarkers and intervention targets in growth, development, immunity, and disease progression. The lncRNA-miRNA-mRNA axis, in which lncRNAs act as competing endogenous RNAs (ceRNAs), is the predominant mode of lncRNA-miRNA crosstalk. However, the role and mechanism of the lncRNA-miRNA-mRNA axis in teleost species have received little attention. This review provides an overview of the physiological and pathological regulation of the teleost lncRNA-miRNA-mRNA axis in growth and development, reproduction, skeletal muscle, immunity to bacterial and viral infections, and stress-related immune responses. It also explores the potential application of the lncRNA-miRNA-mRNA axis in the aquaculture industry.
FRONTIERS IN IMMUNOLOGY
(2023)
Review
Oncology
Xiao-Ru Liang, Yan-Fei Liu, Feng Chen, Zhi-Xia Zhou, Li-Jie Zhang, Zhi-Juan Lin
Summary: Long non-coding RNAs (lncRNAs) are involved in various biological processes and regulate key proteins in the cell cycle of cancer cells. Understanding their role in cell cycle regulation can lead to new therapeutic strategies for cancer treatment. This review article summarizes recent studies on lncRNA control of cell cycle-related proteins and discusses their emerging role in cancer diagnosis and therapy.
CANCER MANAGEMENT AND RESEARCH
(2023)
Review
Pharmacology & Pharmacy
Shuyuan Yi, Xinyi Tao, Yin Wang, Qianqian Cao, Zhixia Zhou, Shoushi Wang
Summary: Macrophages, along with monocytes and dendritic cells, make up the monocyte immune system, which plays a crucial role in immune response. Propofol, a commonly used anesthetic, has various effects including anti-inflammatory and anti-oxidation properties. This article summarizes the effects of propofol on macrophage functions in inflammation, infection, tumors, and organ reperfusion injury, and discusses its impact on pathology and prognosis.
FRONTIERS IN PHARMACOLOGY
(2022)
Review
Biochemistry & Molecular Biology
Chan Shan, Xinzhe Chen, Hongjing Cai, Xiaodan Hao, Jing Li, Yinfeng Zhang, Jinning Gao, Zhixia Zhou, Xinmin Li, Cuiyun Liu, Peifeng Li, Kun Wang
Summary: Autophagy is a crucial process in maintaining cell homeostasis and abnormal autophagy is associated with various diseases, including cancer. MicroRNAs (miRNAs) regulate gene expression and play important roles in fundamental biological processes like autophagy. Studying autophagy-related miRNAs in cancer can offer insights into cancer biology and support the development of novel anti-cancer strategies.
INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES
(2021)