Article
Biochemistry & Molecular Biology
Xinyang Zhang, Dongyan Huang, Zihui Zhao, Xuwang Cai, Wentong Cai, Ganwu Li
Summary: Research has found that the biosynthesis of bis-molybdopterin guanine dinucleotide (bis-MGD) plays a crucial role in modulating the expression of hemolysin in uropathogenic Escherichia coli (UPEC), especially under anaerobic conditions. Further studies revealed that NtrC acts as a direct repressor of c3566-c3568-hlyCABD expression, and intact bis-MGD biosynthesis downregulates ntrC expression, partially explaining the positive role of bis-MGD in modulating hemolysin expression.
MOLECULAR MICROBIOLOGY
(2021)
Review
Microbiology
Lindsey Dzierozynski, Jessica Queen, Cynthia L. Sears
Summary: This commentary discusses the influence of host genetics on the microbiome and highlights the need for mechanistic experimental studies to understand the interplay between host genes and the microbiome.
CELL HOST & MICROBE
(2023)
Article
Chemistry, Multidisciplinary
Jiaoyan Huang, Liuhui Fu, Jida Huang, Jie Zhao, Xin Zhang, Wenyan Wang, Yeyang Liu, Bowen Sun, Ju Qiu, Xiaoyu Hu, Zhihua Liu, Xiaohuan Guo
Summary: Bladder-resident ILCs play a critical role in the host defense against UPEC infection, particularly ILC3, which controls UPEC infection by activating IL-17A.
Article
Microbiology
Noble Selasi Gati, Imke Johanna Temme, Barbara Middendorf-Bauchart, Alexander Kehl, Ulrich Dobrindt, Alexander Mellmann
Summary: Hybrid Shiga toxin-producing Escherichia coli strains are positioned between STEC and UPEC, causing both diarrhea and urinary tract infections, with potential to adapt to both intestinal and extraintestinal environments.
INTERNATIONAL JOURNAL OF MEDICAL MICROBIOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Yeseul Kim, Sanghun Kim, Kiu-Hyung Cho, Jin-Hyung Lee, Jintae Lee
Summary: Bacterial biofilm formation can be effectively inhibited by cinnamaldehyde and its derivatives, especially 4-nitrocinnamaldehyde. These compounds exhibit strong antibiofilm activities against UPEC and S. aureus, making them promising candidates for the treatment of biofilm-associated diseases.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Cell Biology
Timothy Kudinha, Fanrong Kong
Summary: The study found that the papGII gene is more closely associated with other VF genes compared to the papGIII gene in E. coli causing urinary tract infections, explaining the abundance of these genes in pyelonephritis and cystitis isolates.
JOURNAL OF BIOMEDICAL SCIENCE
(2022)
Article
Gastroenterology & Hepatology
Danielle D. Munhoz, Amanda C. Richards, Fernanda F. Santos, Matthew A. Mulvey, Roxane M. F. Piazza
Summary: Pathogenic subsets of Escherichia coli include diarrheagenic (DEC) strains and extraintestinal pathogenic E. coli (ExPEC) strains. The newly reclassified hybrid strain BA1250 possesses genetic features of both DEC and ExPEC and has the potential to cause disease outside of the gut. The adhesin E. coli common pilus (ECP) acts as a colonization and virulence factor for BA1250, and changes in its activation may affect the fitness of the strain.
Article
Microbiology
Aspen Kremer, Grant Whitmer, Alondra Diaz, Alima Sajwani, Alexis Navarro, Mehreen Arshad
Summary: ESBL-producing Escherichia coli strains in the gut may have enhanced fitness and antimicrobial resistance. Using a mouse model, it was confirmed that ESBL E. coli strains have a strong ability to colonize the infant gut, even in the absence of antibiotic pressure.
MICROBIOLOGY SPECTRUM
(2022)
Article
Microbiology
George L. Katumba, Hung Tran, Jeffrey P. Henderson
Summary: This study reveals that extracellular copper ions can stimulate the production of multifunctional iron siderophore Ybt in extraintestinal pathogenic Escherichia coli, suggesting the important role of dual regulation in infection pathogenesis.
Article
Microbiology
George L. Katumba, Hung Tran, Jeffrey P. Henderson
Summary: Siderophores are iron chelators utilized by microbes to acquire iron, but the study found extracellular copper ions can rapidly stimulate Ybt production in extraintestinal pathogenic Escherichia coli. This stimulation pathway involves formation of a Cu(II)-Ybt complex, internalization through a TonB-dependent outer membrane transporter, and transcriptional regulation by the specialized transcription factor YbtA. The dual regulation by iron and copper indicates a multifunctional metallophore role for Ybt in stress responses during infection pathogenesis.
Article
Cell Biology
Xian-liang Zhao, Zhuang-gui Chen, Tian-ci Yang, Ming Jiang, Jie Wang, Zhi-xue Cheng, Man-jun Yang, Jia-xin Zhu, Tian-tuo Zhang, Hui Li, Bo Peng, Xuan-xian Peng
Summary: Exogenous glutamine can enhance the killing effect of antibiotics against multidrug-resistant bacteria, promote the influx of antibiotics, increase intracellular antibiotic concentrations, effectively prevent the development of antibiotic resistance, and provide new insights for the prevention or management of chronic, multidrug-resistant bacterial infections, bacterial persistence, and difficult-to-treat bacterial biofilms.
SCIENCE TRANSLATIONAL MEDICINE
(2021)
Article
Microbiology
Ulrik Engelsoy, Maria A. A. Svensson, Isak Demirel
Summary: In this study, it was found that estradiol exposure increased UPEC growth and biofilm formation, as well as colonization and invasion of bladder epithelial cells. Additionally, estradiol altered the expression of genes associated with iron acquisition system and metabolic pathways in UPEC.
FRONTIERS IN MICROBIOLOGY
(2021)
Article
Microbiology
Vi L. T. Tran, Elinor Hortle, Warwick J. Britton, Stefan H. Oehlers
Summary: Research using a zebrafish model found that commonly prescribed anti-haemostatic medications may worsen the outcome of UPEC infection.
MICROBIOLOGICAL RESEARCH
(2022)
Article
Biology
Kathrin Tomasek, Alexander Leithner, Ivana Glatzova, Michael S. Lukesch, Calin C. Guet, Michael Sixt, Ivan Zanoni
Summary: This study investigates how bacteria evade the host's immune response and identifies the interaction between the type 1 pilus protein FimH of Escherichia coli and the co-receptor CD14 on mouse dendritic cells as a key factor in immune evasion. The binding of FimH to CD14 affects immune cell migration and T cell activation. This finding provides a potential target for intervention in persistent and recurrent infections.
Article
Medicine, Research & Experimental
Xiaoyang Zhang, Yanfeng Yan, Yunxia Lv, Xin Li, Leiyao Chen, Zihui Huang, Junbo Zhou, Yong Wang, Xiaoming Wang, Xu Wang, Hongwei Gu
Summary: Urinary tract infections (UTI) caused by uropathogenic Escherichia coli (UPEC) can be attenuated by Dendrobium officinale polysaccharides (DOPs), which possess anti-inflammatory properties and inhibit the activation of NLRP3 pathway and ROS signal. DOPs effectively mitigate UPEC-induced pyroptosis in macrophage cells by reducing cell damage and pro-inflammatory cytokine secretion.
BIOMEDICINE & PHARMACOTHERAPY
(2022)
Article
Microbiology
Colin W. Russell, Matthew A. Mulvey
Review
Microbiology
Amelia E. Barber, J. Paul Norton, Travis J. Wiles, Matthew A. Mulvey
MICROBIOLOGY AND MOLECULAR BIOLOGY REVIEWS
(2016)
Article
Biochemistry & Molecular Biology
Morgan A. Wambaugh, Viplendra P. S. Shakya, Adam J. Lewis, Matthew A. Mulvey, Jessica C. S. Brown
Letter
Immunology
Amelia E. Barber, Matthew A. Mulvey
CLINICAL INFECTIOUS DISEASES
(2014)
Article
Immunology
Amelia E. Barber, J. Paul Norton, Adam M. Spivak, Matthew A. Mulvey
CLINICAL INFECTIOUS DISEASES
(2013)
Review
Microbiology
Travis J. Wiles, Matthew A. Mulvey
FUTURE MICROBIOLOGY
(2013)
Article
Immunology
Patrick D. Vigil, Travis J. Wiles, Michael D. Engstrom, Lev Prasov, Matthew A. Mulvey, Harry L. T. Mobley
INFECTION AND IMMUNITY
(2012)
Article
Immunology
Grant T. Donovan, J. Paul Norton, Jean M. Bower, Matthew A. Mulvey
INFECTION AND IMMUNITY
(2013)
Article
Immunology
Irina Debnath, J. Paul Norton, Amelia E. Barber, Elizabeth M. Ott, Bijaya K. Dhakal, Richard R. Kulesus, Matthew A. Mulvey
INFECTION AND IMMUNITY
(2013)
Article
Multidisciplinary Sciences
Matthew G. Blango, Elizabeth M. Ott, Andreja Erman, Peter Veranic, Matthew A. Mulvey
Article
Genetics & Heredity
Travis J. Wiles, J. Paul Norton, Colin W. Russell, Brian K. Dalley, Kael F. Fischer, Matthew A. Mulvey
Article
Microbiology
Travis J. Wiles, J. Paul Norton, Sara N. Smith, Adam J. Lewis, Harry L. T. Mobley, Sherwood R. Casjens, Matthew A. Mulvey
Article
Immunology
Colin W. Russell, Amanda C. Richards, Alexander S. Chang, Matthew A. Mulvey
INFECTION AND IMMUNITY
(2017)
Article
Chemistry, Multidisciplinary
Suvendu Biswas, Brandon S. McCullough, Elena S. Ma, Dollie LaJoie, Colin W. Russell, D. Garrett Brown, June L. Round, Katharine S. Ullman, Matthew A. Mulvey, Amy M. Barrios
CHEMICAL COMMUNICATIONS
(2017)
Article
Microbiology
Adam J. Lewis, Amanda C. Richards, Matthew A. Mulvey
MICROBIOLOGY SPECTRUM
(2016)