Article
Immunology
Rui Tang, Shubin Lei, Liping Zhu, Yuzhen Lv, Hong Li
Summary: This study aimed to evaluate the preventative efficacy of omalizumab for seasonal allergic rhinoconjunctivitis (SARC) and explore its influencing factors. The retrospective analysis of patients' medical records found that pre-seasonal omalizumab treatment could significantly alleviate SARC-related symptoms and reduce medication use. The dosage and number of injections of omalizumab did not affect the preventative efficacy, with a single dose of 150mg achieving satisfactory outcomes.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Obstetrics & Gynecology
Louise Ekelund, Inga Gloppen, Torbjorn Oien, Melanie Rae Simpson
Summary: The study found that longer breastfeeding reduced the risk of wheeze and showed a protective trend against allergic rhinoconjunctivitis (ARC) in early childhood. However, there were no conclusive associations between the duration of breastfeeding or age at introduction to complementary foods and the prevention of asthma and eczema.
INTERNATIONAL BREASTFEEDING JOURNAL
(2021)
Article
Allergy
Felix Forster, Markus Johannes Ege, Jessica Gerlich, Tobias Weinmann, Sylvia Kreissl, Gudrun Weinmayr, Jon Genuneit, Dennis Nowak, Erika von Mutius, Christian Vogelberg, Katja Radon
Summary: Distinct trajectories of asthma and allergy symptoms establish from childhood through adolescence and stabilize during early adulthood. Wheeze-related latent classes showed the strongest positive associations with environmental exposures in adolescence/young adulthood, indicating that not only childhood but also adolescence is relevant for disease development.
Article
Respiratory System
Hanna Creese, Eric Lai, Kate Mason, Daniela K. Schlueter, Sejal Saglani, David Taylor-Robinson, Sonia Saxena
Summary: The study found through causal mediation analysis that perinatal characteristics and early home environment factors are more important in explaining socioeconomic inequalities in persistent asthma in British adolescents.
Article
Medicine, General & Internal
Snehal M. Pinto Pereira, Nina T. Rogers, Christine Power
Summary: This study aimed to investigate whether adult retrospective report of child abuse is associated with greater risk of harm in childhood assessed prospectively. The findings suggest that adult retrospective report of child abuse is indeed related to harmful childhood environments, supporting the validity of retrospective report-based research. Additionally, the study found that retrospective report of child abuse in adulthood is not biased by depression.
Article
Allergy
Ji Soo Park, Dong In Suh, Dae Jin Song, Hey-Sung Baek, Meeyong Shin, Young Yoo, Ji-Won Kwon, Gwang Cheon Jang, Hyeon-Jong Yang, Eun Lee, Hwan Soo Kim, Ju-Hee Seo, Sung-Il Woo, Hyung Young Kim, Youn Ho Shin, Ju Suk Lee, Jisun Yoon, Sungsu Jung, Minkyu Han, Eunjin Eom, Jinho Yu, Woo Kyung Kim, Dae Hyun Lim, Jin Tack Kim
Summary: This study aimed to predict exacerbation-prone asthma (EPA) in children. The findings suggest that in addition to asthma control level, baseline lung function and white blood cell count are important factors for predicting EPA.
PEDIATRIC ALLERGY AND IMMUNOLOGY
(2022)
Article
Multidisciplinary Sciences
Zhaozhong Zhu, Yijun Li, Robert J. Freishtat, Juan C. Celedon, Janice A. Espinola, Brennan Harmon, Andrea Hahn, Carlos A. Camargo, Liming Liang, Kohei Hasegawa
Summary: This study investigates the role of DNA methylation in the severity of bronchiolitis in infants. The authors analyze blood DNA methylation data from hospitalized infants and identify differentially methylated CpGs associated with disease severity. These CpGs are found to be differentially methylated in blood immune cells and enriched in various tissues, cells, and pathways. Additionally, they are also associated with respiratory and immune traits. The study highlights the importance of DNA methylation in understanding the pathobiology of bronchiolitis and its severity.
NATURE COMMUNICATIONS
(2023)
Article
Respiratory System
Bright Nwaru, Holly Tibble, Syed A. Shah, Rebecca Pillinger, Susannah McLean, Dermot P. Ryan, Hilary Critchley, David B. Price, Catherine M. Hawrylowicz, Colin R. Simpson, Ireneous N. Soyiri, Francis Appiagyei, Aziz Sheikh
Summary: The study found that the use of hormonal contraceptives may reduce the risk of severe asthma exacerbation in reproductive-age women with asthma, and longer duration of use was associated with better outcomes.
Article
Respiratory System
Casey Crump, Jan Sundquist, Kristina Sundquist
Summary: This study aimed to determine the asthma risks in individuals born at different gestational ages and found a significant association between preterm birth and higher asthma risks from infancy to mid-adulthood.
Article
Respiratory System
Gillian M. Mahon, Gerard H. Koppelman, Judith M. Vonk
Summary: The study found that maternal grandmaternal smoking during pregnancy is associated with a higher risk of asthma and lower lung function in male grandchildren, with a reverse effect in male grandchildren of subsequent generations. This highlights the deep-rooted effects of tobacco smoking across generations.
Article
Respiratory System
Ted Dolby, Vahe Nafilyan, Ann Morgan, Constantinos Kallis, Aziz Sheikh, Jennifer K. Quint
Summary: The study aimed to determine whether individuals with poorly controlled or severe asthma have a higher risk of hospitalization and/or death from COVID-19. The results suggest that individuals with mild and well-controlled asthma do not have a significantly increased risk of hospitalization or death from COVID-19 compared to individuals without asthma.
Article
Public, Environmental & Occupational Health
Angela Pinot De Moira, Neil Pearce, Marie Pedersen, Anne-Marie Nybo Andersen
Summary: This study explored factors that may modify associations of early-life animal exposure with asthma and allergic disease, and found that type of animal, source of exposure, parental history of asthma or allergy, and timing of exposure can modify these associations. It is important to consider these factors when assessing the risks associated with early-life animal exposure.
INTERNATIONAL JOURNAL OF EPIDEMIOLOGY
(2023)
Article
Respiratory System
Subhabrata Moitra, Anne-Elie Carsin, Michael J. Abramson, Simone Accordini, Andre F. S. Amaral, Josep Anto, Roberto Bono, Lidia Casas Ruiz, Isa Cerveri, Leda Chatzi, Pascal Demoly, Sandra Dorado-Arenas, Bertil Forsberg, Frank Gilliland, Thorarinn Gislason, Jose A. Gullon, Joachim Heinrich, Mathias Holm, Christer Janson, Rain Jogi, Francisco Gomez Real, Debbie Jarvis, Benedicte Leynaert, Dennis Nowak, Nicole Probst-Hensch, Jose Luis Sanchez-Ramos, Chantal Raherison-Semjen, Valerie Siroux, Stefano Guerra, Manolis Kogevinas, Judith Garcia-Aymerich
Summary: This study is the first to show that adults with asthma have a higher risk of developing obesity compared to those without asthma, especially among non-atopic individuals, those with longer disease duration, or those taking oral corticosteroids.
Article
Allergy
Jessica Atwell, Martha Chico, Maritza Vaca, Andrea Arevalo-Cortes, Ruth Karron, Philip J. J. Cooper
Summary: This study in Ecuador found that early viral respiratory diseases contribute to childhood respiratory illnesses, especially in the presence of airway inflammation-related infections. The associations between wheezing illness, asthma, and rhinoconjunctivitis were examined in relation to early viral respiratory diseases and other factors.
CLINICAL AND TRANSLATIONAL ALLERGY
(2023)
Article
Respiratory System
Bronwyn Brew, Alison Gibberd, Guy B. Marks, Natalie Strobel, Clare Wendy Allen, Louisa Jorm, Georgina Chambers, Sandra Eades, Bridgette McNamara
Summary: This study identified potentially preventable risk factors for hospitalised asthma in Australian Aboriginal children, with risk factors including hospitalisation for acute respiratory tract infection, area-level disadvantage, prematurity, and low birth weight. Improving care for pregnant Aboriginal women and Aboriginal infants with ARTI may help reduce the burden of asthma in the Indigenous population.
Article
Dermatology
A. Hoyer, E. M. Rehbinder, M. Fardig, S. Asad, K. C. Lodrup Carlsen, K. M. A. Endre, B. Granum, G. Haugen, G. Hedlin, C. Monceyron Jonassen, S. Katayama, J. R. Konradsen, L. Landro, M. LeBlanc, C. A. Olsson Magi, K. Rudi, H. O. Skjerven, A. C. Staff, R. Vettukattil, M. Bradley, B. Nordlund, C. Soderhall
Summary: In this study, FLG gene mutations were found to be associated with eczema and dry skin in infancy, but not with impaired skin barrier function or dry skin in general at 3 months of age.
BRITISH JOURNAL OF DERMATOLOGY
(2022)
Article
Environmental Sciences
Alicia Abellan, Sara M. Mensink-Bout, Raquel Garcia-Esteban, Andrea Beneito, Leda Chatzi, Talita Duarte-Salles, Mariana F. Fernandez, Judith Garcia-Aymerich, Berit Granum, Carmen Iniguez, Vincent W. V. Jaddoe, Kurunthachalam Kannan, Aitana Lertxundi, Maria-Jose Lopez-Espinosa, Claire Philippat, Amrit K. Sakhi, Susana Santos, Valerie Siroux, Jordi Sunyer, Leonardo Trasande, Marina Vafeiadi, Fernando Vela-Soria, Tiffany C. Yang, Carlos Zabaleta, Martine Vrijheid, Liesbeth Duijts, Maribel Casas
Summary: This study found that in utero exposure to BPA may increase the odds of asthma and wheeze in school-age girls. The associations of BPF and BPS with respiratory outcomes were inconsistent in overall and sex-stratified analyses.
ENVIRONMENT INTERNATIONAL
(2022)
Article
Dentistry, Oral Surgery & Medicine
Randi Jacobsen Bertelsen, Antonio Manuel Perez Barrionuevo, Rajesh Shigdel, Stein Atle Lie, Huang Lin, Francisco Gomez Real, Tamar Ringel-Kulka, Anne Nordrehaug Astrom, Cecilie Svanes
Summary: Research findings have shown that increasing self-reported gingival bleeding frequency is associated with increased gingival bacterial diversity. Frequent gingival bleeding is associated with increased abundance of certain bacteria (such as Porphyromonas endodontalis, Treponema denticola, and Fretibacterium spp.), but decreased abundance of bacteria within the gram-positive phyla Firmicutes and Actinobacteria. Additionally, using dental floss and mouthwash twice daily is associated with increased total abundance of bacteria in the Proteobacteria phylum, but decreased bacterial diversity.
JOURNAL OF CLINICAL PERIODONTOLOGY
(2022)
Article
Medicine, General & Internal
Cecilie Svanes, Ane Johannessen, Randi Jacobsen Bertelsen, Shyamali Dharmage, Bryndis Benediktsdottir, Lennart Braback, Thorarinn Gislason, Mathias Holm, Oskar Jogi, Caroline J. Lodge, Andrei Malinovschi, Jesus Martinez-Moratalla, Anna Oudin, Jose Luis Sanchez-Ramos, Signe Timm, Christer Janson, Francisco Gomez Real, Vivi Schlunssen
Summary: The RHINESSA cohort aims to investigate the impact of exposures before conception and in previous generations on health and disease, particularly allergies and respiratory health. Data collected so far suggests that parental environment and male prepuberty may play important roles in asthma and lung function. Future plans include follow-up studies and linkage with health registries.
Article
Microbiology
Hilde Kristin Vindenes, Huang Lin, Rajesh Shigdel, Tamar Ringel-Kulka, Francisco Gomez Real, Cecilie Svanes, Shyamal D. Peddada, Randi J. Bertelsen
Summary: This study explores the impact of antimicrobial and environmental chemicals on the composition of oral bacteria. The results show that high levels of certain chemicals are associated with changes in the abundance of oral bacteria, highlighting the need for a better understanding of how antimicrobial chemical exposure influences the human microbiome.
FRONTIERS IN MICROBIOLOGY
(2022)
Article
Pediatrics
Caroline-Aleksi Olsson Magi, Ashild Wik Despriee, Milada Cvancarova Smastuen, Catarina Almqvist, Fuad Bahram, Egil Bakkeheim, Anders Bjerg, Kari Glavin, Berit Granum, Guttorm Haugen, Gunilla Hedlin, Christine Monceyron Jonassen, Karin C. Lodrup Carlsen, Eva Maria Rehbinder, Leif-Bjarte Rolfsjord, Anne Cathrine Staff, Havard Ove Skjerven, Riyas Vettukattil, Bjorn Nordlund, Cilla Soderhall
Summary: This study aimed to explore the associations between maternal perceived stress and salivary cortisol levels during pregnancy with cortisol levels in early infancy, and to identify early life factors associated with infants' cortisol levels. The results showed that maternal stress and salivary cortisol levels were not associated with infants' cortisol levels, while birth weight, maternal marital status, and infant feeding may influence cortisol levels.
Article
Nursing
Live S. Nordhagen, Vibeke S. Lofsgaard, Milada C. Smastuen, Kari Glavin, Kai-Hakon Carlsen, Monica Hauger Carlsen, Berit Granum, Malen Gubrandsgard, Guttorm Haugen, Gunilla Hedlin, Christine M. Jonassen, Bjorn Nordlund, Eva Maria Rehbinder, Knut Rudi, Carina M. Saunders, Havard O. Skjerven, Anne Cathrine Staff, Cilla Soderhall, Riyas Vettukattil, Hilde Aaneland, Karin C. Lodrup Carlsen
Summary: This study found that 19.8% of breastfeeding women avoided at least one food item during breastfeeding, with cow's milk being the most commonly avoided. Food avoidance was usually due to the child's condition, maternal factors, or lifestyle choices. Food avoidance diets were associated with food allergy and celiac disease in the mother.
Article
Obstetrics & Gynecology
Johanna Wiik, Magdalena R. Vaernesbranden, Christine M. Jonassen, Anne Cathrine Staff, Karin C. L. Carlsen, Berit Granum, Guttorm Haugen, Gunilla Hedlin, Katarina Hilde, Bo Jacobsson, Staffan Nilsson, Bjorn Nordlund, Anbjorg Rangberg, Eva Maria Rehbinder, Verena Sengpiel, Havard Skjerven, Birgitte K. Sundet, Cilla Soderhall, Riyas Vettukattil, Katrine Sjoborg
Summary: This study aimed to explore the relationship between human papillomavirus (HPV) infection and adverse obstetric outcomes including preterm delivery, preterm prelabor rupture of membranes, and chorioamnionitis. The analysis of a prospective multicenter cohort study in Norway and Sweden revealed that HPV infection during pregnancy was not significantly associated with an increased risk of these adverse obstetric outcomes.
ACTA OBSTETRICIA ET GYNECOLOGICA SCANDINAVICA
(2023)
Article
Environmental Sciences
Hesham Amin, Ian P. G. Marshall, Randi J. Bertelsen, Inge M. Wouters, Vivi Schlunssen, Torben Sigsgaard, Tina Santl-Temkiv
Summary: By improving the efficiency of DNA extraction, we have successfully increased the DNA yield of bacterial components collected by the passive sampling device EDC, enabling further research on airborne bacterial and fungal communities. We have also developed a method for simultaneous extraction of DNA and endotoxin, which can be used in large-scale epidemiological studies.
SCIENCE OF THE TOTAL ENVIRONMENT
(2023)
Review
Environmental Sciences
Veronika Ehrlich, Wieneke Bil, Rob Vandebriel, Berit Granum, Mirjam Luijten, Birgitte Lindeman, Philippe Grandjean, Andreas-Marius Kaiser, Ingrid Hauzenberger, Christina Hartmann, Claudia Gundacker, Maria Uhl
Summary: PFAS are a public health concern due to their persistent occurrence and adverse effects on the immune system. The mechanisms underlying the impact on the immune system are not fully understood. Various PFAS affect multiple aspects of the immune system, with the developing immune system being particularly vulnerable to toxic insults.
ENVIRONMENTAL HEALTH
(2023)
Article
Nutrition & Dietetics
Holly C. Y. Lam, Catherine Neukirch, Christer Janson, Judith Garcia-Aymerich, Michael Clausen, N. Sabrina Idrose, Pascal Demoly, Randi J. Bertelsen, Lidia C. Ruiz, Chantal Raherison, Deborah L. Jarvis
Summary: This study investigates the factors associated with severe food reactions, age of onset, and changes in sensitization to foods in adults. The prevalence of self-reported food hypersensitivity is 13.5%, with 26.4% reporting severe reactions. A history of asthma and younger age of onset are associated with a higher risk of severe food reactions. The prevalence of sensitization to foods remains stable over 10 years.
EUROPEAN JOURNAL OF CLINICAL NUTRITION
(2023)
Article
Medicine, Research & Experimental
Maryia Khomich, Huang Lin, Andrei Malinovschi, Susanne Brix, Lucia Cestelli, Shyamal Peddada, Ane Johannessen, Carsten Eriksen, Francisco Gomez Real, Cecilie Svanes, Randi Jacobsen Bertelsen
Summary: This study investigated the association between oral microbiota composition and fractional exhaled nitric oxide (F-eNO) levels. The overall composition of oral bacteria was found to be significantly associated with increasing F-eNO levels, and 27 bacterial genera showed differences between individuals with high F-eNO and low F-eNO levels. Hexa- and penta-acylated LPS producers accounted for 2.4% and 40.8% of the oral bacterial genera, respectively. The similarity within each community and F-eNO levels were associated with increasing F-eNO levels, but only penta-acylated LPS producers appeared to be reduced or absent in individuals with high F-eNO.
JOURNAL OF TRANSLATIONAL MEDICINE
(2023)
Article
Medicine, Legal
Corrado L. Galli, Ulrike Bernauer, Laurent Bodin, Qasim Chaudhry, Pieter Jan Coenraads, Maria Dusinska, Janine Ezendam, Berit Granum, Eric Gaffet, Eirini Panteri, Vera Rogiers, Christophe Rousselle, Maciej Stepnik, Tamara Vanhaecke, Susan Wijnhoven, Aglaia Koutsodimou, Wolfgang Uter, Natalie von Goetz
Summary: SCCS has issued opinions on Acid Yellow 3 - C054 on May 7th and July 23rd, 2021.
REGULATORY TOXICOLOGY AND PHARMACOLOGY
(2023)
Article
Medicine, Research & Experimental
Jan Kuehnisch, Tianyu Zhao, Randi J. Bertelsen, Rudolf A. Joerres, Dennis Nowak, Joachim Heinrich
Summary: Gingivitis may trigger a decline in lung function, as shown in a recent observational study. This multidisciplinary study aims to test the hypothesis that improving gingivitis can improve lung function in non-smoking subjects aged 18-30.
Article
Engineering, Environmental
Hesham Amin, Tina Santl-Temkiv, Christine Cramer, Kai Finster, Francisco Gomez Real, Thorarinn Gislason, Mathias Holm, Christer Janson, Nils Oskar Jogi, Rain Jogi, Andrei Malinovschi, Ian P. G. Marshall, Lars Modig, Dan Norback, Rajesh Shigdel, Torben Sigsgaard, Cecilie Svanes, Hulda Thorarinsdottir, Inge M. Wouters, Vivi Schlunssen, Randi J. Bertelsen
Summary: There is limited research on the factors influencing the indoor bacterial community. This study investigated the airborne microbiomes in the homes of 1038 participants from five cities in Northern Europe and identified environmental factors that affect the composition of indoor bacterial communities. The results showed that households in Tartu and Aarhus had higher bacterial load and diversity than those in Bergen and Reykjavik, possibly due to elevated concentrations of outdoor bacterial taxa associated with low precipitation and high wind speeds.
ENVIRONMENTAL SCIENCE & TECHNOLOGY
(2023)