Prostaglandin E2 and T cells: friends or foes?

In Vitro Differentiation of Dendritic Cells in the Presence of Prostaglandin E2 Alters the IL-12/IL-23 Balance and Promotes Differentiation of Th17 Cells

(2014) T. Khayrullina et al.   JOURNAL OF IMMUNOLOGY

PGE2 inhibits natural killer and γδ T cell cytotoxicity triggered by NKR and TCR through a cAMP-mediated PKA type I-dependent signaling

(2010) Ludovic Martinet et al.   BIOCHEMICAL PHARMACOLOGY

A novel antagonist of the prostaglandin E2 EP4 receptor inhibits Th1 differentiation and Th17 expansion and is orally active in arthritis models

(2010) Q Chen et al.   BRITISH JOURNAL OF PHARMACOLOGY

Progress in COX-2 Inhibitors: A Journey So Far

(2010) Asit Chakraborti et al.   CURRENT MEDICINAL CHEMISTRY

Prostaglandin E2, an Immunoactivator

(2010) Daiji Sakata et al.   JOURNAL OF PHARMACOLOGICAL SCIENCES

Dual roles of PGE2-EP4 signaling in mouse experimental autoimmune encephalomyelitis

(2010) Y. Esaki et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The COX-2/PGE2 pathway: key roles in the hallmarks of cancer and adaptation to the tumour microenvironment

(2009) A. Greenhough et al.   CARCINOGENESIS

Nonsteroidal Anti-Inflammatory Drugs: A Critical Review on Current Concepts Applied to Reduce Gastrointestinal Toxicity

(2009) Mona Abdel-Tawab et al.   CURRENT MEDICINAL CHEMISTRY

Inhibitors of the Microsomal Prostaglandin E2 Synthase-1 as Alternative to Non Steroidal Anti-Inflammatory Drugs (NSAIDs) – A Critical Review

(2009) A. Koeberle et al.   CURRENT MEDICINAL CHEMISTRY

Nonsteroid anti-inflammatory drug-induced gastroduodenal injury

(2009) Larry H Lai et al.   CURRENT OPINION IN GASTROENTEROLOGY

Prostaglandin E2 enhances Th17 responses via modulation of IL-17 and IFN-γ production by memory CD4+ T cells

(2009) Giorgio Napolitani et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Prostaglandin E2 regulates Th17 cell differentiation and function through cyclic AMP and EP2/EP4 receptor signaling

(2009) Katia Boniface et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Prostaglandin E2–EP4 signaling promotes immune inflammation through TH1 cell differentiation and TH17 cell expansion

(2009) Chengcan Yao et al.   NATURE MEDICINE

Prostaglandin E2 synergistically with interleukin-23 favors human Th17 expansion

(2008) C. Chizzolini et al.   BLOOD

Prostaglandin E2 enhances T-cell proliferation by inducing the costimulatory molecules OX40L, CD70, and 4-1BBL on dendritic cells

(2008) P. Krause et al.   BLOOD

Antagonism of the prostaglandin E receptor EP4 inhibits metastasis and enhances NK function

(2008) Namita Kundu et al.   BREAST CANCER RESEARCH AND TREATMENT

Prevention of Both Direct and Cross-Priming of Antitumor CD8+ T-Cell Responses following Overproduction of Prostaglandin E2 by Tumor Cells In vivo

(2008) M. Ahmadi et al.   CANCER RESEARCH

Ability of Mature Dendritic Cells to Interact with Regulatory T Cells Is Imprinted during Maturation

(2008) R. Muthuswamy et al.   CANCER RESEARCH

Prostanoids in health and disease: Fig. 1.

(2008) Emer M. Smyth et al.   JOURNAL OF LIPID RESEARCH