A novel antagonist of the prostaglandin E2 EP4 receptor inhibits Th1 differentiation and Th17 expansion and is orally active in arthritis models

In Vitro Differentiation of Dendritic Cells in the Presence of Prostaglandin E2 Alters the IL-12/IL-23 Balance and Promotes Differentiation of Th17 Cells

(2014) T. Khayrullina et al.   JOURNAL OF IMMUNOLOGY

Prostanoid receptor antagonists: development strategies and therapeutic applications

(2009) RL Jones et al.   BRITISH JOURNAL OF PHARMACOLOGY

Prostaglandin E2 enhances Th17 responses via modulation of IL-17 and IFN-γ production by memory CD4+ T cells

(2009) Giorgio Napolitani et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Th17 cytokines and their emerging roles in inflammation and autoimmunity

(2009) Lynette A. Fouser et al.   IMMUNOLOGICAL REVIEWS

Prostaglandin E2 regulates Th17 cell differentiation and function through cyclic AMP and EP2/EP4 receptor signaling

(2009) Katia Boniface et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Crucial role of the interleukin-6/interleukin-17 cytokine axis in the induction of arthritis by glucose-6-phosphate isomerase

(2008) Keiichi Iwanami et al.   ARTHRITIS AND RHEUMATISM

Prostaglandin E2 synergistically with interleukin-23 favors human Th17 expansion

(2008) C. Chizzolini et al.   BLOOD

MF498 [N- -2-(2-methoxyphenyl)acetamide], a Selective E Prostanoid Receptor 4 Antagonist, Relieves Joint Inflammation and Pain in Rodent Models of Rheumatoid and Osteoarthritis

(2008) P. Clark et al.   JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS

Therapeutic effects of antibodies to tumor necrosis factor-α, interleukin-6 and cytotoxic T-lymphocyte antigen 4 immunoglobulin in mice with glucose-6-phosphate isomerase induced arthritis

(2008) Isao Matsumoto et al.   ARTHRITIS RESEARCH & THERAPY

Effect of prostanoid EP4 receptor antagonist, CJ-042,794, in rat models of pain and inflammation

(2007) Akio Murase et al.   EUROPEAN JOURNAL OF PHARMACOLOGY