Review
Critical Care Medicine
Raul Riquelme
Summary: Hantaviruses are lipid-enveloped RNA viruses that can cause hemorrhagic fever with renal syndrome and hantavirus cardiopulmonary syndrome. The major pathogenic mechanisms include direct injury to microvascular endothelial cells and an exaggerated host immune response. Treatment focuses on high-quality supportive care, while management and preventative strategies are still under research.
SEMINARS IN RESPIRATORY AND CRITICAL CARE MEDICINE
(2021)
Article
Virology
Ana Claudia Pereira Tercas-Trettel, Alba Valeria Gomes de Melo, Renata Carvalho de Oliveira, Alexandro Guterres, Jorlan Fernandes, Liana Stretch Pereira, Marina Atanaka, Mariano Martinez Espinosa, Bernardo Rodrigues Teixeira, Cibele Rodrigues Bonvicino, Paulo Sergio D'Andrea, Elba Regina Sampaio de Lemos
Summary: This study investigated the seroprevalence of orthohantavirus infections in the Utiariti Indigenous land in the Brazilian Amazon, revealing prevalence rates of 12.4% in 2014 and 13.4% in 2015. Analysis of paired samples from 110 Indigenous individuals who participated in both study stages identified four individuals who seroconverted during the study period.
Review
Urology & Nephrology
Felix C. Koehler, Veronica Di Cristanziano, Martin R. Spath, K. Johanna R. Hoyer-Allo, Manuel Wanken, Roman-Ulrich Muller, Volker Burst
Summary: Hantavirus-induced diseases, such as hemorrhagic fever and cardiopulmonary syndrome, have been frequently reported in different parts of the world. They primarily affect the endothelial cell barrier and immune response, with disease severity associated with genetic vulnerability. Currently, there are no specific treatments, and preventive measures and public awareness are crucial in reducing the risk of infection.
CLINICAL KIDNEY JOURNAL
(2022)
Review
Environmental Sciences
Sima Singh, Arshid Numan, Dinesh Sharma, Rahul Shukla, Amit Alexander, Gaurav Kumar Jain, Farhan Jalees Ahmad, Prashant Kesharwani
Summary: The outbreak of the COVID-19 pandemic in 2019 and 2020 has led to a new era of communicable infectious diseases, with the emergence of Hantavirus infection posing a new public health emergency. Hantavirus, a zoonotic pathogen, causes two major clinical manifestations - HFRS and HCPS. Despite the lack of effective treatments or vaccines, public awareness and precautionary measures can help reduce the spread of the virus.
INTERNATIONAL JOURNAL OF ENVIRONMENTAL HEALTH RESEARCH
(2022)
Article
Infectious Diseases
Rene Lopez, Mauricio Espinoza, Jeronimo Graf, Gregory Mertz, Marcela Ferres, Mario Calvo, Cecilia Vial, Pablo A. Vial
Summary: Proteinuria is a common finding in patients with HCPS caused by Andes virus and is associated with a higher mortality rate.
INTERNATIONAL JOURNAL OF INFECTIOUS DISEASES
(2021)
Article
Virology
Rene Lopez, Rodrigo Perez-Araos, Alvaro Salazar, Mauricio Espinoza, Cecilia Vial, Analia Cuiza, Pablo A. Vial, Jeronimo Graf
Summary: HVHF may contribute to supporting severe HCPS patients and avoiding the need for VA ECMO in some cases. Early connection to HVHF and a targeted strategy may increase the chance of success in these patients.
JOURNAL OF MEDICAL VIROLOGY
(2021)
Article
Medicine, General & Internal
Ayelen Alumine Iglesias, Natalia Periolo, Carla Maria Bellomo, Lorena Cecilia Lewis, Camila Paula Olivera, Constanza Rosario Anselmo, Marina Garcia, Rocio Maria Coelho, Daniel Oscar Alonso, Bonnie Dighero-Kemp, Heema Sharma, Jens H. Kuhn, Nicholas Di Paola, Mariano Sanchez-Lockhart, Gustavo Palacios, Luis Pablo Schierloh, Valeria Paula Martinez
Summary: This study found that the levels of activated CD4+ and CD8(+) T cells were increased in HPS patients, independent of disease severity. Higher levels of certain proinflammatory mediators were observed during the acute phase, but viral clearance was more closely related to high titers of neutralizing antibodies.
Review
Immunology
Farides Saavedra, Fabian E. Diaz, Angello Retamal-Diaz, Camila Covian, Pablo A. Gonzalez, Alexis M. Kalergis
Summary: Orthohantaviruses, formerly known as hantaviruses, cause two emerging zoonotic diseases with varying fatality rates. Specific treatments or vaccines have not been approved by the FDA yet. The immune response plays a crucial role in the disease progression.
Article
Virology
Gabriela Meza-Fuentes, Rene Lopez, Cecilia Vial, Lina Jimena Cortes, Mauricio A. Retamal, Iris Delgado, Pablo Vial
Summary: This study explores the potential of soluble Receptors for Advanced Glycation End-products (sRAGE) as a biomarker for assessing pulmonary epithelial damage in severe Hantavirus cardiopulmonary syndrome (HCPS) and suggests that it may aid in tracking disease progression and guiding therapeutic strategies.
Review
Immunology
Joao Toledo, Michelle M. Haby, Ludovic Reveiz, Leopoldo Sosa Leon, Rodrigo Angerami, Sylvain Aldighieri
Summary: The balance of evidence does not support the claim of human-to-human transmission of hantavirus infection. Further research, including well-designed cohort and case-control studies, is needed to provide more accurate information and inform public health recommendations.
JOURNAL OF INFECTIOUS DISEASES
(2022)
Review
Immunology
Roman Kuchta, Marta Kolodziej-Sobocinska, Jan Brabec, Daniel Mlocicki, Ruslan Salamatin, Tomas Scholz
Summary: Sparganosis is a foodborne and waterborne disease caused by species of the tapeworm genus Spirometra, with global distribution across inhabited continents including Europe. The presence of two different species of Spirometra in Europe has been confirmed, with Spirometra erinaceieuropaei restricted to Europe and Spirometra tnansoni representing a lineage mainly distributed across Asia and Oceania. The parasite is common in Eastern Europe and its distribution has potential to expand, increasing the risks of human infection.
CLINICAL INFECTIOUS DISEASES
(2021)
Article
Microbiology
Ilona Rissanen, Stefanie A. Krumm, Robert Stass, Annalis Whitaker, James E. Voss, Emily A. Bruce, Sylvia Rothenberger, Stefan Kunz, Dennis R. Burton, Juha T. Huiskonen, Jason W. Botten, Thomas A. Bowden, Katie J. Doores
Summary: Research demonstrates that the Gn glycoprotein of HTNV can elicit a neutralizing antibody response in rabbits, leading to the isolation of neutralizing and non-neutralizing monoclonal antibodies. Molecular-level insights on how the Gn glycoprotein may be targeted by the antibody-mediated immune response are provided for the first time. These findings may inform rational vaccine design approaches focused on targeting the hantavirus glycoprotein envelope.
Article
Urology & Nephrology
Felix C. Koehler, Linda Blomberg, Thomas Theo Brehm, Stefan Buettner, Oliver A. Cornely, Olaf Degen, Veronica Di Cristanziano, Sebastian Dolff, Lukas Eberwein, Elion Hoxha, K. Johanna R. Hoyer-Allo, Sarah Rudolf, Martin R. Spaeth, Manuel Wanken, Roman-Ulrich Mueller, Volker Burst
Summary: HantaReg is a novel registry platform designed to facilitate multinational research on hantavirus-caused diseases, providing standardized data entry and management. With a modular structure, the platform automatically displays relevant questions and items based on the specific case, offering researchers a convenient tool for information collection.
CLINICAL KIDNEY JOURNAL
(2021)
Article
Immunology
Guillaume Castel, Ravi Kant, Sylvestre Badou, Jonas Etougbetche, Henri-Joel Dossou, Philippe Gauthier, Gualbert Houemenou, Teemu Smura, Tarja Sironen, Gauthier Dobigny
Summary: The Seoul virus, a zoonotic pathogen carried by the brown rat Rattus norvegicus, was found in 37.5% of brown rats captured in the Autonomous Port of Cotonou, Benin. Phylogenetic analyses classify this virus in Seoul virus lineage 7.
EMERGING INFECTIOUS DISEASES
(2021)
Article
Microbiology
Olesia V. Ohlopkova, Sergey A. Yakovlev, Kabwe Emmanuel, Alexey A. Kabanov, Dmitry A. Odnoshevsky, Mikhail Yu. Kartashov, Alexey D. Moshkin, Igor V. Tuchkov, Nikita Yu. Nosov, Andrey A. Kritsky, Milana A. Agalakova, Yuriy N. Davidyuk, Svetlana F. Khaiboullina, Sergey P. Morzunov, Magasuba N'Fally, Sanaba Bumbali, Mamadou Fode Camara, Mamadou Yero Boiro, Alexander P. Agafonov, Elena V. Gavrilova, Rinat A. Maksyutov
Summary: This study aims to monitor the presence of Coxiella burnetii in ticks collected from small mammals and cattle in the Republic of Guinea. The results showed that bacterial DNA was detected in 11 small mammals and 695 tick samples, indicating that ticks are the main transmitters of C. burnetii in Guinea.
Article
Immunology
Jessica R. Spengler, Greg Saturday, Kerry J. Lavender, Cynthia Martellaro, James G. Keck, Stuart T. Nichol, Christina F. Spiropoulou, Heinz Feldmann, Joseph Prescott
JOURNAL OF INFECTIOUS DISEASES
(2018)
Article
Immunology
Kerry J. Lavender, Brandi N. Williamson, Greg Saturday, Cynthia Martellaro, Amanda Griffin, Kim J. Hasenkrug, Heinz Feldmann, Joseph Prescott
JOURNAL OF INFECTIOUS DISEASES
(2018)
Article
Immunology
Joseph Prescott, Darryl Falzarano, Emmie de Wit, Kath Hardcastle, Friederike Feldmann, Elaine Haddock, Dana Scott, Heinz Feldmann, Vincent Jacobus Munster
FRONTIERS IN IMMUNOLOGY
(2018)
Article
Cell Biology
Jose L. Garrido, Joseph Presscott, Mario Calvo, Felipe Bravo, Raymond Alvarez, Alexis Salas, Raul Riquelme, Maria L. Rioseco, Brandi N. Williamson, Elaine Haddock, Heinz Feldmann, Maria I. Barria
SCIENCE TRANSLATIONAL MEDICINE
(2018)
Article
Virology
Tony Schountz, Corey Campbell, Kaitlyn Wagner, Joel Rovnak, Cynthia Martellaro, Blair L. DeBuysscher, Heinz Feldmann, Joseph Prescott
Article
Immunology
Kathryn M. Edenborough, Marcel Bokelmann, Angelika Lander, Emmanuel Couacy-Hymann, Johanna Lechner, Oliver Drechsel, Bernhard Y. Renard, Aleksandar Radonic, Heinz Feldmann, Andreas Kurth, Joseph Prescott
FRONTIERS IN IMMUNOLOGY
(2019)
Article
Microbiology
Joseph Prescott, Jonathan C. Guito, Jessica R. Spengler, Catherine E. Arnold, Amy J. Schuh, Brian R. Amman, Tara K. Sealy, Lisa W. Guerrero, Gustavo F. Palacios, Mariano Sanchez-Lockhart, Cesar G. Albarino, Jonathan S. Towner
Review
Immunology
David M. Wozniak, Kerry J. Lavender, Joseph Prescott, Jessica R. Spengler
Article
Biochemistry & Molecular Biology
Jonathan C. Guito, Joseph B. Prescott, Catherine E. Arnold, Brian R. Amman, Amy J. Schuh, Jessica R. Spengler, Tara K. Sealy, Jessica R. Harmon, Joann D. Coleman-McCray, Kirsten A. Kulcsar, Elyse R. Nagle, Raina Kumar, Gustavo F. Palacios, Mariano Sanchez-Lockhart, Jonathan S. Towner
Summary: In this study, researchers found that Egyptian rousette bats infected with a bat isolate of Marburg virus demonstrated upregulation of canonical antiviral genes typical of mammalian systems, while showing a lack of significant induction of proinflammatory genes classically implicated in primate filoviral pathogenesis. This offers the first in vivo functional evidence for disease tolerance as an immunological mechanism by which bats asymptomatically host Marburg virus, highlighting potential defensive strategies utilized by bat hosts of other emerging pathogens.
Article
Virology
David M. Wozniak, Norman Kirchoff, Katharina Hansen-Kant, Nafomon Sogoba, David Safronetz, Joseph Prescott
Summary: This study presents basic blood parameters of the multimammate rat in laboratory settings, aiming to provide scientific insights into this important rodent species.
Article
Cell Biology
Blair L. DeBuysscher, Dana P. Scott, Rebecca Rosenke, Victoria Wahl, Heinz Feldmann, Joseph Prescott
Summary: Nipah virus is a highly pathogenic zoonotic virus that primarily targets vascular endothelial cells, leading to cytopathic effects and vasculitis. Smooth muscle cells may also play an important role in disease development by producing progeny virus without experiencing cytopathogenic consequences.
Article
Virology
Marcel Bokelmann, Uwe Vogel, Franka Debeljak, Ariane Duex, Silke Riesle-Sbarbaro, Angelika Lander, Annette Wahlbrink, Nicole Kromarek, Stuart Neil, Emmanuel Couacy-Hymann, Joseph Prescott, Andreas Kurth
Summary: Recent studies suggest that the Angolan free-tailed bat may be a possible reservoir for Ebola virus, with bat cells showing high tolerance and the virus's ability to persist without mutation for up to 150 days. This provides further evidence for the role of this bat species as a likely reservoir for ebolaviruses.
Article
Biochemistry & Molecular Biology
Lay Teng Ang, Alana T. Nguyen, Kevin J. Liu, Angela Chen, Xiaochen Xiong, Matthew Curtis, Renata M. Martin, Brian C. Raftry, Chun Yi Ng, Uwe Vogel, Angelika Lander, Benjamin J. Lesch, Jonas L. Fowler, Alyssa R. Holman, Timothy Chai, Siva Vijayakumar, Fabian P. Suchy, Toshinobu Nishimura, Joydeep Bhadury, Matthew H. Porteus, Hiromitsu Nakauchi, Christine Cheung, Steven C. George, Kristy Red-Horse, Joseph B. Prescott, Kyle M. Loh
Summary: This study successfully generated >90% pure human artery or vein endothelial cells from pluripotent stem cells within 3-4 days and used them to investigate the infection and effects of Nipah and Hendra viruses on arteries. They found that these viruses preferentially infected arteries, which expressed higher levels of the viral-entry receptor. Virally infected artery cells quickly fused into syncytia containing multiple nuclei, but rapidly died. However, these viruses largely evaded innate immune detection and minimally elicited interferon signaling during artery infection.
Article
Immunology
D. M. Wozniak, S. A. Riesle-Sbarbaro, N. Kirchoff, K. Hansen-Kant, A. Wahlbrink, A. Stern, A. Lander, K. Hartmann, S. Krasemann, A. Kurth, J. Prescott
Summary: Lassa virus, a Risk Group-4 zoonotic haemorrhagic fever virus, causes significant impact in sub-Saharan African countries. The Natal multimammate mouse is identified as the natural reservoir of LASV, but little is known about the infection dynamics. Research shows that different inoculation routes lead to disparate dissemination outcomes in LASV infection in its natural reservoir.
EMERGING MICROBES & INFECTIONS
(2021)
Article
Pharmacology & Pharmacy
Joseph Prescott, Heinz Feldmann, David Safronetz
ANTIVIRAL RESEARCH
(2017)