Article
Immunology
Mohammed J. S. Al-Ghabban, Nagham Y. Al-Bayati, Qasim S. Al-Mayah, Hisham Y. Al-Matubsi
Summary: The GG genotype of CTLA-4+49G/A polymorphism was found to be significantly less common in CL patients, with the G allele being more common in controls. Newly diagnosed CL patients had significantly higher serum sCTLA-4 levels, which may serve as an additional diagnostic tool.
MICROBIAL PATHOGENESIS
(2021)
Review
Cell Biology
Johannes Nass, Julian Terglane, Volker Gerke
Summary: Vascular endothelial cells play a crucial role in regulating vascular functions and interactions with blood cells to ensure smooth blood flow and specific responses to vascular injury and inflammation. These cells have the ability to rapidly change their surface properties to control blood flow effectively.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Environmental Sciences
Xiangrui Wang, Wen-Xiong Wang
Summary: This study demonstrated that Cu2O microparticles were rapidly dissolved to copper ions inside cells, followed by lysosome-mediated exocytosis. Smaller microparticles had a lower uptake rate but dissolved more quickly, leading to faster exocytosis activation. The rapid release of copper ions resulted in immediate toxic effects, mainly through necrosis, while glutathione buffering ability alleviated copper toxicity. The turnover of intracellular copper was much faster at sublethal exposure levels, but the labile copper(I) concentration only increased by a maximum of 2 times. Tolerance to copper-based nanoparticles depended on their ability to discharge released copper ions.
ENVIRONMENTAL POLLUTION
(2022)
Review
Biochemistry & Molecular Biology
Gil-Ran Kim, Je-Min Choi
Summary: CTLA-4, an immune checkpoint molecule, plays a crucial role in T-cell activation and immune regulation. Its signaling is independent of ligand interaction and relies on tyrosine and lysine motifs. This review summarizes the biology and molecular signaling events of CTLA-4 and discusses strategies to target its signaling for immune modulation and disease therapy.
MOLECULES AND CELLS
(2022)
Review
Immunology
Mara Cenerenti, Margaux Saillard, Pedro Romero, Camilla Jandus
Summary: The article reviews the discovery and characterization of cytotoxic CD4 T cells, and describes their mechanisms of cytotoxicity. The importance of these cells in disease conditions, particularly in cancer, is emphasized, and insights on how to exploit these cells in immunotherapy are provided.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Medicine, General & Internal
Hao-Yun Chang, Chao-Yu Liu, Yen-Li Lo, Shih-Hwa Chiou, Kai-Hsi Lu, Ming-Cheng Lee, Yuan-Hung Wang
Summary: This meta-analysis investigated the potential effects of five polymorphisms in the CTLA-4 gene on breast cancer susceptibility and found that the +49 A/G polymorphism is significantly associated with breast cancer, especially in non-Asian populations and studies with hospital-based controls.
JOURNAL OF THE CHINESE MEDICAL ASSOCIATION
(2023)
Article
Oncology
Hongyuan Wan, Hangsheng Zhou, Yanyan Feng, Yongquan Chen, Lijie Zhu, Yuanyuan Mi
Summary: The rs231775 polymorphism of CTLA-4 gene is associated with different cancer types, and this study verified and analyzed the association. The results showed that this polymorphism may reduce cancer risk, and the association varied among different cancer types.
FRONTIERS IN ONCOLOGY
(2022)
Article
Immunology
Qiao Liu, Lisha Wang, Huayu Lin, Zhiming Wang, Jialin Wu, Junyi Guo, Shuqiong Wen, Ling Ran, Zhengliang Yue, Xingxing Su, Qing Wu, Jianfang Tang, Zhirong Li, Li Hu, Lifan Xu, Lilin Ye, Qizhao Huang
Summary: Cytotoxic CD8(+) T cells are the main focus of anti-tumor immunity and immunotherapy research, but transferred tumor-specific CD8(+) T cells have limited effect on suppressing tumor growth. On the other hand, CD4(+) T cells play an important role in curtailing tumor metastasis.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Dentistry, Oral Surgery & Medicine
Saki Nakane, Kentaro Imamura, Rio Hisanaga, Kazuyuki Ishihara, Atsushi Saito
Summary: The study demonstrated that CTLA-4-Ig can effectively inhibit bone resorption in periodontitis by affecting osteoclast differentiation and activity, potentially through the regulation of the NF-kappa B pathway and PP2A expression.
JOURNAL OF PERIODONTAL RESEARCH
(2021)
Article
Immunology
Shun Tanemoto, Tomohisa Sujino, Kentaro Miyamoto, Jonathan Moody, Yusuke Yoshimatsu, Yoshinari Ando, Ikuko Koya, Yosuke Harada, Anna Okuzawa Tojo, Keiko Ono, Yukie Hayashi, Kaoru Takabayashi, Koji Okabayashi, Toshiaki Teratani, Yohei Mikami, Nobuhiro Nakamoto, Naoki Hosoe, Haruhiko Ogata, Chung-Chau Hon, Jay W. Shin, Takanori Kanai
Summary: This study identified the presence of cytotoxic CD4(+)CD8(+) T cells in the human intestine, with a significantly reduced percentage in patients with inflammatory bowel disease.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Immunology
Jiajia Liu, Xiaoyi Tian, Yan Wang, Xixiong Kang, Wenqi Song
Summary: The study aimed to investigate the significance of serum sCTLA-4 levels as a noninvasive biomarker for diagnosis and prognosis evaluation in glioma patients. Results showed that serum sCTLA-4 levels were increased in glioma patients, positively correlated with tumor grade, and could be a valuable predictive biomarker for diagnosis and prognosis evaluation in glioma. The ROC curve analysis and survival analysis demonstrated that sCTLA-4 levels were associated with tumor grade and could be an independent prognostic factor for progression-free survival in glioma patients.
Article
Biochemistry & Molecular Biology
Osamu Katsumata-Kato, Megumi Yokoyama, Junko Fujita-Yoshigaki
Summary: This study found that newly formed parotid gland granules have secretory ability, and the secretion of procathepsin B can be used to distinguish granule secretion from cell leakage. These newly formed granules have secretory ability prior to membrane remodeling.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2023)
Article
Immunology
Yanling Liang, Qumiao Xu, Songming Liu, Jie Li, Fei Wang, Ziyi Li, Lijuan Liao, Yuting Lu, Yijian Li, Feng Mu, Hai-Xi Sun, Linnan Zhu
Summary: This study revealed the antitumor effects and multifaceted killing mechanisms of CD4(+) TCR-Ts, indicating that MHC class I-restricted CD4(+) TCR-Ts could serve as potential adoptive T cell therapies.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Virology
Cory J. Knudson, Maria Ferez, Pedro Alves-Peixoto, Dan A. Erkes, Carolina R. Melo-Silva, Lingjuan Tang, Christopher M. Snyder, Luis J. Sigal
Summary: This study reveals the induction and differentiation mechanisms of CD4-CTL during viral infection, showing that CD4-CTL are derived from terminal differentiation of classical Th1 cells and require sustained antigen presentation. The research demonstrates that CD4-CTL upregulate protein levels of transcription factors posttranscriptionally, suggesting further posttranscriptional regulation is necessary for CD4-CTL differentiation.
JOURNAL OF VIROLOGY
(2021)
Review
Immunology
Ting-Wei Lin, Ya-Chiao Hu, Yao-Hsu Yang, Yin-Hsiu Chien, Ni-Chung Lee, Hsin-Hui Yu, Bor-Luen Chiang, Li-Chieh Wang
Summary: We reported a case of a patient with multiple disorders, including autoimmune disease, immunodeficiency, enteropathy, organomegaly and lymphocytic infiltration. The patient showed excellent response to abatacept treatment.
JOURNAL OF MICROBIOLOGY IMMUNOLOGY AND INFECTION
(2022)
Article
Biochemistry & Molecular Biology
Erin E. Swinstead, Tina B. Miranda, Ville Paakinaho, Songjoon Baek, Ido Goldstein, Mary Hawkins, Tatiana S. Karpova, David Ball, Davide Mazza, Luke D. Lavis, Jonathan B. Grimm, Tatsuya Morisaki, Lars Grontved, Diego M. Presman, Gordon L. Hager
Article
Immunology
Diego A. Vargas-Inchaustegui, Andrew Demers, Julia M. Shaw, Guobin Kang, David Ball, Iskra Tuero, Thomas Musich, Venkatramanan Mohanram, Thorsten Demberg, Tatiana S. Karpova, Qingsheng Li, Marjorie Robert-Guroff
JOURNAL OF IMMUNOLOGY
(2016)
Article
Biochemistry & Molecular Biology
David A. Ball, Gunjan D. Mehta, Ronit Salomon-Kent, Davide Mazza, Tatsuya Morisaki, Florian Mueller, James G. McNally, Tatiana S. Karpova
NUCLEIC ACIDS RESEARCH
(2016)
Article
Biochemical Research Methods
Diego M. Presman, David A. Ball, Ville Paakinaho, Jonathan B. Grimm, Luke D. Lavis, Tatiana S. Karpova, Gordon L. Hager
Article
Multidisciplinary Sciences
Ville Paakinaho, Diego M. Presman, David A. Ball, Thomas A. Johnson, R. Louis Schiltz, Peter Levitt, Davide Mazza, Tatsuya Morisaki, Tatiana S. Karpova, Gordon L. Hager
NATURE COMMUNICATIONS
(2017)
Article
Oncology
Roshan L. Shrestha, Grace S. Ahn, Mae I. Staples, Kizhakke M. Sathyan, Tatiana S. Karpova, Daniel R. Foltz, Munira A. Basrai
Article
Immunology
Mohammad Arif Rahman, Katherine M. McKinnon, Tatiana S. Karpova, David A. Ba, David J. Venzon, Wenjin Fang, Guobin Kang, Qingsheng Li, Marjorie Robert-Guroff
JOURNAL OF IMMUNOLOGY
(2018)
Article
Biochemical Research Methods
Leonid A. Serebryannyy, David A. Ball, Tatiana S. Karpova, Tom Misteli
Article
Multidisciplinary Sciences
Aizea Morales-Kastresana, Bill Telford, Thomas A. Musich, Katherine McKinnon, Cassandra Clayborne, Zach Braig, Ari Rosner, Thorsten Demberg, Dionysios C. Watson, Tatiana S. Karpova, Gordon J. Freeman, Rosemarie H. DeKruyff, George N. Pavlakis, Masaki Terabe, Marjorie Robert-Guroff, Jay A. Berzofsky, Jennifer C. Jones
SCIENTIFIC REPORTS
(2017)
Article
Genetics & Heredity
Sameer B. Shah, David Parmiter, Christian Constantine, Paul Elizalde, Michael Naldrett, Tatiana S. Karpova, John S. Choy
Article
Biochemistry & Molecular Biology
Gunjan D. Mehta, David A. Ball, Peter R. Eriksson, Razvan Chereji, David J. Clark, James G. McNally, Tatiana S. Karpova
Article
Cell Biology
Roshan L. Shrestha, Austin Rossi, Darawalee Wangsa, Ann K. Hogan, Kimberly S. Zaldana, Evelyn Suva, Yang Jo Chung, Chelsea L. Sanders, Simone Difilippantonio, Tatiana S. Karpova, Baktiar Karim, Daniel R. Foltz, Daniele Fachinetti, Peter D. Aplan, Thomas Ried, Munira A. Basrai
Summary: The overexpression of CENP-A leads to chromosomal instability, affecting kinetochore integrity and microtubule attachments, increasing cell invasion, and causing aneuploidy. These results provide a molecular link between CENP-A overexpression and aneuploidy, suggesting karyotypic heterogeneity may contribute to the aggressive phenotype of CENP-A-overexpressing cancers.
JOURNAL OF CELL BIOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Keyvan Torabi, Darawalee Wangsa, Immaculada Ponsa, Markus Brown, Anna Bosch, Maria Vila-Casadesus, Tatiana S. Karpova, Maria Calvo, Antoni Castells, Rosa Miro, Thomas Ried, Jordi Camps
Meeting Abstract
Oncology
Ville Paakinaho, Diego M. Presman, Erin E. Swinstead, Tina B. Miranda, David A. Ball, Tatiana S. Karpova, Gordon L. Hager
Article
Developmental Biology
Ramakrishnan Kannan, Jeong-Kuen Song, Tatiana Karpova, Akanni Clarke, Madhuri Shivalkar, Benjamin Wang, Lyudmila Kotlyanskaya, Irina Kuzina, Qun Gu, Edward Giniger