期刊
IMMUNOLOGICAL REVIEWS
卷 260, 期 1, 页码 50-66出版社
WILEY
DOI: 10.1111/imr.12179
关键词
B lymphocytes; microbiota; innate immunity; intestinal barrier; IgA; gut-associated lymphoid tissue
类别
资金
- Ambizione Fellowship from the Swiss National Science Foundation [PZ00P3_136742]
- JDRFI [36-2008-926]
- Swiss National Science Foundation [310030_140700, Sinergia CRSII3_136286]
- Swiss National Science Foundation (SNF) [310030_140700, PZ00P3_136742] Funding Source: Swiss National Science Foundation (SNF)
Mutualism with our intestinal microbiota is a prerequisite for healthy existence. This requires physical separation of the majority of the microbiota from the host (by secreted antimicrobials, mucus, and the intestinal epithelium) and active immune control of the low numbers of microbes that overcome these physical and chemical barriers, even in healthy individuals. In this review, we address how B-cell responses to members of the intestinal microbiota form a robust network with mucus, epithelial integrity, follicular helper T cells, innate immunity, and gut-associated lymphoid tissues to maintain host-microbiota mutualism.
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