MicroRNA regulation of T-cell differentiation and function

T cell activation induces proteasomal degradation of Argonaute and rapid remodeling of the microRNA repertoire

(2013) Yelena Bronevetsky et al.   JOURNAL OF EXPERIMENTAL MEDICINE

GATA3 suppresses metastasis and modulates the tumour microenvironment by regulating microRNA-29b expression

(2013) Jonathan Chou et al.   NATURE CELL BIOLOGY

Eri1 regulates microRNA homeostasis and mouse lymphocyte development and antiviral function

(2012) M. F. Thomas et al.   BLOOD

The miR-17-92 cluster expands multipotent hematopoietic progenitors whereas imbalanced expression of its individual oncogenic miRNAs promotes leukemia in mice

(2012) Y. Li et al.   BLOOD

Proliferation and Tumorigenesis of a Murine Sarcoma Cell Line in the Absence of DICER1

(2012) Arvind Ravi et al.   CANCER CELL

MicroRNAs in Stress Signaling and Human Disease

(2012) Joshua T. Mendell et al.   CELL

Roles for MicroRNAs in Conferring Robustness to Biological Processes

(2012) Margaret S. Ebert et al.   CELL

STATs Shape the Active Enhancer Landscape of T Cell Populations

(2012) Golnaz Vahedi et al.   CELL

Kinetic analysis reveals successive steps leading to miRNA-mediated silencing in mammalian cells

(2012) Julien Béthune et al.   EMBO REPORTS

The GENCODE v7 catalog of human long noncoding RNAs: Analysis of their gene structure, evolution, and expression

(2012) T. Derrien et al.   GENOME RESEARCH

Interleukin-2 Inhibits Germinal Center Formation by Limiting T Follicular Helper Cell Differentiation

(2012) André Ballesteros-Tato et al.   IMMUNITY

T-follicular helper cell differentiation and the co-option of this pathway by non-helper cells

(2012) Michelle A. Linterman et al.   IMMUNOLOGICAL REVIEWS

STAT5 Protein Negatively Regulates T Follicular Helper (Tfh) Cell Generation and Function

(2012) Roza I. Nurieva et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

miR-146acontrols the resolution of T cell responses in mice

(2012) Lili Yang et al.   JOURNAL OF EXPERIMENTAL MEDICINE

The origins, function, and regulation of T follicular helper cells

(2012) Cindy S. Ma et al.   JOURNAL OF EXPERIMENTAL MEDICINE

STAT5 is a potent negative regulator of TFHcell differentiation

(2012) Robert J. Johnston et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Micro-RNA 155 Is Required for Optimal CD8+ T Cell Responses to Acute Viral and Intracellular Bacterial Challenges

(2012) E. F. Lind et al.   JOURNAL OF IMMUNOLOGY

miR-29ab1 Deficiency Identifies a Negative Feedback Loop Controlling Th1 Bias That Is Dysregulated in Multiple Sclerosis

(2012) K. M. Smith et al.   JOURNAL OF IMMUNOLOGY

MicroRNA miR-155 Affects Antiviral Effector and Effector Memory CD8 T Cell Differentiation

(2012) C.-Y. Tsai et al.   JOURNAL OF VIROLOGY

Transcriptome-wide miR-155 Binding Map Reveals Widespread Noncanonical MicroRNA Targeting

(2012) Gabriel B. Loeb et al.   MOLECULAR CELL

An integrated encyclopedia of DNA elements in the human genome

(2012)   NATURE

TGF-β and retinoic acid induce the microRNA miR-10a, which targets Bcl-6 and constrains the plasticity of helper T cells

(2012) Hayato Takahashi et al.   NATURE IMMUNOLOGY

The development and fate of follicular helper T cells defined by an IL-21 reporter mouse

(2012) Katja Lüthje et al.   NATURE IMMUNOLOGY

MicroRNA 10a Marks Regulatory T Cells

(2012) Lukas T. Jeker et al.   PLoS One

Temporal expression of microRNA cluster miR-17-92 regulates effector and memory CD8+ T-cell differentiation

(2012) T. Wu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

microRNA-301a regulation of a T-helper 17 immune response controls autoimmune demyelination

(2012) M. P. Mycko et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

MicroRNA turnover: when, how, and why

(2012) Stefan Rüegger et al.   TRENDS IN BIOCHEMICAL SCIENCES

A Resource for the Conditional Ablation of microRNAs in the Mouse

(2012) Chong Yon Park et al.   Cell Reports

Genome-wide Analysis of Pre-mRNA 3′ End Processing Reveals a Decisive Role of Human Cleavage Factor I in the Regulation of 3′ UTR Length

(2012) Georges Martin et al.   Cell Reports

Epistasis between MicroRNAs 155 and 146a during T Cell-Mediated Antitumor Immunity

(2012) Thomas B. Huffaker et al.   Cell Reports

Follicular Helper CD4 T Cells (TFH)

(2011) Shane Crotty   Annual Review of Immunology

Molecular dissection of the miR-17-92 cluster's critical dual roles in promoting Th1 responses and preventing inducible Treg differentiation

(2011) S. Jiang et al.   BLOOD

How T Cells Earn the Follicular Rite of Passage

(2011) Carola G. Vinuesa et al.   IMMUNITY

MicroRNA-29 Regulates T-Box Transcription Factors and Interferon-γ Production in Helper T Cells

(2011) David F. Steiner et al.   IMMUNITY

Intrinsic and extrinsic control of peripheral T-cell tolerance by costimulatory molecules of the CD28/ B7 family

(2011) Hélène Bour-Jordan et al.   IMMUNOLOGICAL REVIEWS

miR-150 regulates the development of NK and iNKT cells

(2011) Natalie A. Bezman et al.   JOURNAL OF EXPERIMENTAL MEDICINE

miR-146ais a significant brake on autoimmunity, myeloproliferation, and cancer in mice

(2011) Mark P. Boldin et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Cutting Edge: Distinct Waves of BCL6 Expression during T Follicular Helper Cell Development

(2011) D. Baumjohann et al.   JOURNAL OF IMMUNOLOGY

Plasticity of Human Regulatory T Cells in Healthy Subjects and Patients with Type 1 Diabetes

(2011) Stephanie A. McClymont et al.   JOURNAL OF IMMUNOLOGY

Mechanisms and Consequences of Alternative Polyadenylation

(2011) Dafne Campigli Di Giammartino et al.   MOLECULAR CELL

Multiple targets of miR-302 and miR-372 promote reprogramming of human fibroblasts to induced pluripotent stem cells

(2011) Deepa Subramanyam et al.   NATURE BIOTECHNOLOGY

A resource of vectors and ES cells for targeted deletion of microRNAs in mice

(2011) Haydn M Prosser et al.   NATURE BIOTECHNOLOGY

MicroRNAs can generate thresholds in target gene expression

(2011) Shankar Mukherji et al.   NATURE GENETICS

The thymic epithelial microRNA network elevates the threshold for infection-associated thymic involution via miR-29a mediated suppression of the IFN-α receptor

(2011) Aikaterini S Papadopoulou et al.   NATURE IMMUNOLOGY

Distinct microRNA signatures in human lymphocyte subsets and enforcement of the naive state in CD4+ T cells by the microRNA miR-125b

(2011) Riccardo L Rossi et al.   NATURE IMMUNOLOGY

The microRNA miR-29 controls innate and adaptive immune responses to intracellular bacterial infection by targeting interferon-γ

(2011) Feng Ma et al.   NATURE IMMUNOLOGY

Foxp3+ follicular regulatory T cells control the germinal center response

(2011) Michelle A Linterman et al.   NATURE MEDICINE

The Role of Incoherent MicroRNA-Mediated Feedforward Loops in Noise Buffering

(2011) Matteo Osella et al.   PLoS Computational Biology

Regulation of mRNA Translation and Stability by microRNAs

(2010) Marc Robert Fabian et al.   Annual Review of Biochemistry

Differentiation of Effector CD4 T Cell Populations

(2010) Jinfang Zhu et al.   Annual Review of Immunology

Function of miR-146a in Controlling Treg Cell-Mediated Regulation of Th1 Responses

(2010) Li-Fan Lu et al.   CELL

Transcriptome-wide Identification of RNA-Binding Protein and MicroRNA Target Sites by PAR-CLIP

(2010) Markus Hafner et al.   CELL

MicroRNA Activity Is Suppressed in Mouse Oocytes

(2010) Jun Ma et al.   CURRENT BIOLOGY

Many Families of C. elegans MicroRNAs Are Not Essential for Development or Viability

(2010) Ezequiel Alvarez-Saavedra et al.   CURRENT BIOLOGY

MicroRNA Function Is Globally Suppressed in Mouse Oocytes and Early Embryos

(2010) Nayoung Suh et al.   CURRENT BIOLOGY

Mammalian microRNAs: experimental evaluation of novel and previously annotated genes

(2010) H. R. Chiang et al.   GENES & DEVELOPMENT

Defective erythroid differentiation in miR-451 mutant mice mediated by 14-3-3 

(2010) D. M. Patrick et al.   GENES & DEVELOPMENT

Analysis of microRNA knockouts in mice

(2010) C. Y. Park et al.   HUMAN MOLECULAR GENETICS

Regulation of MicroRNA Expression and Abundance during Lymphopoiesis

(2010) Stefan Kuchen et al.   IMMUNITY

MicroRNA-155 Promotes Autoimmune Inflammation by Enhancing Inflammatory T Cell Development

(2010) Ryan M. O'Connell et al.   IMMUNITY

Small RNA Regulators of T Cell-Mediated Autoimmunity

(2010) Lukas T. Jeker et al.   JOURNAL OF CLINICAL IMMUNOLOGY

Stress-dependent cardiac remodeling occurs in the absence of microRNA-21 in mice

(2010) David M. Patrick et al.   JOURNAL OF CLINICAL INVESTIGATION

Phosphoinositide 3-Kinase Activity in T Cells Regulates the Magnitude of the Germinal Center Reaction

(2010) J. Rolf et al.   JOURNAL OF IMMUNOLOGY

Posttranscriptional Regulation of MicroRNA Biogenesis in Animals

(2010) Haruhiko Siomi et al.   MOLECULAR CELL

Smad Proteins Bind a Conserved RNA Sequence to Promote MicroRNA Maturation by Drosha

(2010) Brandi N. Davis et al.   MOLECULAR CELL

Mammalian microRNAs predominantly act to decrease target mRNA levels

(2010) Huili Guo et al.   NATURE

The microRNA miR-182 is induced by IL-2 and promotes clonal expansion of activated helper T lymphocytes

(2010) Anna-Barbara Stittrich et al.   NATURE IMMUNOLOGY

A quantitative targeted proteomics approach to validate predicted microRNA targets in C. elegans

(2010) Marko Jovanovic et al.   NATURE METHODS

The emerging role of microRNAs in multiple sclerosis

(2010) Andreas Junker et al.   Nature Reviews Neurology

MicroRNAs miR-17 and miR-20a Inhibit T Cell Activation Genes and Are Under-Expressed in MS Whole Blood

(2010) Mathew B. Cox et al.   PLoS One

Dicer controls CD8+ T-cell activation, migration, and survival

(2010) N. Zhang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A Novel miRNA Processing Pathway Independent of Dicer Requires Argonaute2 Catalytic Activity

(2010) D. Cifuentes et al.   SCIENCE

Mechanisms Underlying Lineage Commitment and Plasticity of Helper CD4+ T Cells

(2010) J. J. O'Shea et al.   SCIENCE

MicroRNA profiling of multiple sclerosis lesions identifies modulators of the regulatory protein CD47

(2009) Andreas Junker et al.   BRAIN

The Centrality of RNA

(2009) Phillip A. Sharp   CELL

MicroRNAs: Target Recognition and Regulatory Functions

(2009) David P. Bartel   CELL

Origins and Mechanisms of miRNAs and siRNAs

(2009) Richard W. Carthew et al.   CELL

Genetic dissection of the miR-17 92 cluster of microRNAs in Myc-induced B-cell lymphomas

(2009) P. Mu et al.   GENES & DEVELOPMENT

miR-19 is a key oncogenic component of mir-17-92

(2009) V. Olive et al.   GENES & DEVELOPMENT

Chromatin poises miRNA- and protein-coding genes for expression

(2009) A. Barski et al.   GENOME RESEARCH

Foxp3-Dependent MicroRNA155 Confers Competitive Fitness to Regulatory T Cells by Targeting SOCS1 Protein

(2009) Li-Fan Lu et al.   IMMUNITY

The Transcriptional Repressor Bcl-6 Directs T Follicular Helper Cell Lineage Commitment

(2009) Di Yu et al.   IMMUNITY

Cutting Edge: The Foxp3 Target miR-155 Contributes to the Development of Regulatory T Cells

(2009) S. Kohlhaas et al.   JOURNAL OF IMMUNOLOGY

Active turnover modulates mature microRNA activity in Caenorhabditis elegans

(2009) Saibal Chatterjee et al.   NATURE

Instability of the transcription factor Foxp3 leads to the generation of pathogenic memory T cells in vivo

(2009) Xuyu Zhou et al.   NATURE IMMUNOLOGY

MicroRNA miR-326 regulates TH-17 differentiation and is associated with the pathogenesis of multiple sclerosis

(2009) Changsheng Du et al.   NATURE IMMUNOLOGY

Biogenesis of small RNAs in animals

(2009) V. Narry Kim et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Preferential Generation of Follicular B Helper T Cells from Foxp3+ T Cells in Gut Peyer's Patches

(2009) M. Tsuji et al.   SCIENCE

Bcl6 and Blimp-1 Are Reciprocal and Antagonistic Regulators of T Follicular Helper Cell Differentiation

(2009) R. J. Johnston et al.   SCIENCE

Bcl6 Mediates the Development of T Follicular Helper Cells

(2009) R. I. Nurieva et al.   SCIENCE

Concordant Regulation of Translation and mRNA Abundance for Hundreds of Targets of a Human microRNA

(2009) David G. Hendrickson et al.   PLOS BIOLOGY

miRiad Roles for the miR-17-92 Cluster in Development and Disease

(2008) Joshua T. Mendell   CELL

Targeted Deletion Reveals Essential and Overlapping Functions of the miR-17∼92 Family of miRNA Clusters

(2008) Andrea Ventura et al.   CELL

Mouse ES cells express endogenous shRNAs, siRNAs, and other Microprocessor-independent, Dicer-dependent small RNAs

(2008) J. E. Babiarz et al.   GENES & DEVELOPMENT

Most mammalian mRNAs are conserved targets of microRNAs

(2008) R. C. Friedman et al.   GENOME RESEARCH

MicroRNA-155 Suppresses Activation-Induced Cytidine Deaminase-Mediated Myc-Igh Translocation

(2008) Yair Dorsett et al.   IMMUNITY

The RNAseIII enzyme Drosha is critical in T cells for preventing lethal inflammatory disease

(2008) Mark M.W. Chong et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Dicer-dependent microRNA pathway safeguards regulatory T cell function

(2008) Adrian Liston et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Selective miRNA disruption in T reg cells leads to uncontrolled autoimmunity

(2008) Xuyu Zhou et al.   JOURNAL OF EXPERIMENTAL MEDICINE

The impact of microRNAs on protein output

(2008) Daehyun Baek et al.   NATURE

Widespread changes in protein synthesis induced by microRNAs

(2008) Matthias Selbach et al.   NATURE

SMAD proteins control DROSHA-mediated microRNA maturation

(2008) Brandi N. Davis et al.   NATURE

Tandem array–based expression screens identify host mRNA targets of virus-encoded microRNAs

(2008) Joseph M Ziegelbauer et al.   NATURE GENETICS

Embryonic stem cell–specific microRNAs regulate the G1-S transition and promote rapid proliferation

(2008) Yangming Wang et al.   NATURE GENETICS

Lymphoproliferative disease and autoimmunity in mice with increased miR-17-92 expression in lymphocytes

(2008) Changchun Xiao et al.   NATURE IMMUNOLOGY

Mechanisms of post-transcriptional regulation by microRNAs: are the answers in sight?

(2008) Witold Filipowicz et al.   NATURE REVIEWS GENETICS

Proliferating Cells Express mRNAs with Shortened 3' Untranslated Regions and Fewer MicroRNA Target Sites

(2008) R. Sandberg et al.   SCIENCE