Mechanical regulation of T-cell functions

Improved Ligand Discrimination by Force-Induced Unbinding of the T Cell Receptor from Peptide-MHC

(2013) Enrico Klotzsch et al.   BIOPHYSICAL JOURNAL

Controversy and consensus regarding myosin II function at the immunological synapse

(2013) John A Hammer et al.   CURRENT OPINION IN IMMUNOLOGY

Mechanobiology of bone marrow stem cells: From myosin-II forces to compliance of matrix and nucleus in cell forms and fates

(2013) Jae-Won Shin et al.   DIFFERENTIATION

The Kindlin 3 Pleckstrin Homology Domain Has an Essential Role in Lymphocyte Function-associated Antigen 1 (LFA-1) Integrin-mediated B Cell Adhesion and Migration

(2013) Rosie Hart et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Complete integrin headpiece opening in eight steps

(2013) Jieqing Zhu et al.   JOURNAL OF CELL BIOLOGY

Cyclic Mechanical Reinforcement of Integrin–Ligand Interactions

(2013) Fang Kong et al.   MOLECULAR CELL

Actin depolymerization under force is governed by lysine 113:glutamic acid 195-mediated catch-slip bonds

(2013) C.-y. Lee et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Tension modulates actin filament polymerization mediated by formin and profilin

(2013) N. Courtemanche et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

B Cells Use Mechanical Energy to Discriminate Antigen Affinities

(2013) E. Natkanski et al.   SCIENCE

Formin mDia1 senses and generates mechanical forces on actin filaments

(2013) Antoine Jégou et al.   Nature Communications

Receptor Signaling Clusters in the Immune Synapse

(2012) Michael L. Dustin et al.   Annual Review of Biophysics

Determination of Interaction Kinetics between the T Cell Receptor and Peptide-Loaded MHC Class II via Single-Molecule Diffusion Measurements

(2012) Markus Axmann et al.   BIOPHYSICAL JOURNAL

Mechanical Modulation of Receptor-Ligand Interactions at Cell-Cell Interfaces

(2012) Jun F. Allard et al.   BIOPHYSICAL JOURNAL

Kinetics and Mechanics of Two-Dimensional Interactions between T Cell Receptors and Different Activating Ligands

(2012) Philippe Robert et al.   BIOPHYSICAL JOURNAL

Mechanosensing in T Lymphocyte Activation

(2012) Edward Judokusumo et al.   BIOPHYSICAL JOURNAL

Distinct roles for talin-1 and kindlin-3 in LFA-1 extension and affinity regulation

(2012) C. T. Lefort et al.   BLOOD

Chemokine-triggered leukocyte arrest: force-regulated bi-directional integrin activation in quantal adhesive contacts

(2012) Ronen Alon et al.   CURRENT OPINION IN CELL BIOLOGY

SLP-76 is required for optimal CXCR4-stimulated T lymphocyte firm arrest to ICAM-1 under shear flow

(2012) Dooyoung Lee et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Resolving Two-dimensional Kinetics of the Integrin αIIbβ3-Fibrinogen Interactions Using Binding-Unbinding Correlation Spectroscopy

(2012) Rustem I. Litvinov et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Signal-dependent Slow Leukocyte Rolling Does Not Require Cytoskeletal Anchorage of P-selectin Glycoprotein Ligand-1 (PSGL-1) or Integrin αLβ2

(2012) Bojing Shao et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Talin activates integrins by altering the topology of the β transmembrane domain

(2012) Chungho Kim et al.   JOURNAL OF CELL BIOLOGY

Structural specializations of α4β7, an integrin that mediates rolling adhesion

(2012) Yamei Yu et al.   JOURNAL OF CELL BIOLOGY

Observing force-regulated conformational changes and ligand dissociation from a single integrin on cells

(2012) Wei Chen et al.   JOURNAL OF CELL BIOLOGY

F-actin polymerization and retrograde flow drive sustained PLCγ1 signaling during T cell activation

(2012) Alexander Babich et al.   JOURNAL OF CELL BIOLOGY

Substrate Rigidity Regulates Human T Cell Activation and Proliferation

(2012) R. S. O'Connor et al.   JOURNAL OF IMMUNOLOGY

Actin retrograde flow and actomyosin II arc contraction drive receptor cluster dynamics at the immunological synapse in Jurkat T cells

(2012) Jason Yi et al.   MOLECULAR BIOLOGY OF THE CELL

Membrane bending by protein–protein crowding

(2012) Jeanne C. Stachowiak et al.   NATURE CELL BIOLOGY

Conformational states of the kinase Lck regulate clustering in early T cell signaling

(2012) Jérémie Rossy et al.   NATURE IMMUNOLOGY

Low 2-Dimensional CD4 T Cell Receptor Affinity for Myelin Sets in Motion Delayed Response Kinetics

(2012) Kristen M. Rosenthal et al.   PLoS One

Molecular basis for complement recognition by integrin  X 2

(2012) X. Chen et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Ideal, catch, and slip bonds in cadherin adhesion

(2012) S. Rakshit et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

TCR Mechanobiology: Torques and Tunable Structures Linked to Early T Cell Signaling

(2012) Sun Taek Kim et al.   Frontiers in Immunology

Mechanisms of T Cell Development and Transformation

(2011) Ute Koch et al.   Annual Review of Cell and Developmental Biology

T Cell Receptor Signaling Is Limited by Docking Geometry to Peptide-Major Histocompatibility Complex

(2011) Jarrett J. Adams et al.   IMMUNITY

Lymphocyte Signaling Converges on Microtubules

(2011) Alexander Babich et al.   IMMUNITY

Two-Stage Cooperative T Cell Receptor-Peptide Major Histocompatibility Complex-CD8 Trimolecular Interactions Amplify Antigen Discrimination

(2011) Ning Jiang et al.   IMMUNITY

High prevalence of low affinity peptide–MHC II tetramer–negative effectors during polyclonal CD4+T cell responses

(2011) Joseph J. Sabatino et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Mechanical Interactions between Dendritic Cells and T Cells Correlate with T Cell Responsiveness

(2011) T. S. Lim et al.   JOURNAL OF IMMUNOLOGY

Basic amino-acid side chains regulate transmembrane integrin signalling

(2011) Chungho Kim et al.   NATURE

Force Measurements of TCR/pMHC Recognition at T Cell Surface

(2011) Pierre-Henri Puech et al.   PLoS One

Structural Basis and Kinetics of Force-Induced Conformational Changes of an αA Domain-Containing Integrin

(2011) Xue Xiang et al.   PLoS One

Basic residues in the T-cell receptor   cytoplasmic domain mediate membrane association and modulate signaling

(2011) H. Zhang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Molecular Dynamics Simulations of Forced Unbending of Integrin αVβ3

(2011) Wei Chen et al.   PLoS Computational Biology

Molecular T Cell Biology – Basic and Translational Challenges in the Twenty-First Century

(2011) Ellis L. Reinherz et al.   Frontiers in Immunology

Rolling Cell Adhesion

(2010) Rodger P. McEver et al.   Annual Review of Cell and Developmental Biology

Triphasic Force Dependence of E-Selectin/Ligand Dissociation Governs Cell Rolling under Flow

(2010) Annica M. Wayman et al.   BIOPHYSICAL JOURNAL

Rolling on E- or P-selectin induces the extended but not high-affinity conformation of LFA-1 in neutrophils

(2010) Y. Kuwano et al.   BLOOD

Stretchy Proteins on Stretchy Substrates: The Important Elements of Integrin-Mediated Rigidity Sensing

(2010) Simon W. Moore et al.   DEVELOPMENTAL CELL

Forcing Switch from Short- to Intermediate- and Long-lived States of the αA Domain Generates LFA-1/ICAM-1 Catch Bonds

(2010) Wei Chen et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Recreation of the terminal events in physiological integrin activation

(2010) Feng Ye et al.   JOURNAL OF CELL BIOLOGY

Cutting Edge: Mechanical Forces Acting on T Cells Immobilized via the TCR Complex Can Trigger TCR Signaling

(2010) Y. C. Li et al.   JOURNAL OF IMMUNOLOGY

Tension directly stabilizes reconstituted kinetochore-microtubule attachments

(2010) Bungo Akiyoshi et al.   NATURE

The kinetics of two-dimensional TCR and pMHC interactions determine T-cell responsiveness

(2010) Jun Huang et al.   NATURE

TCR–peptide–MHC interactions in situ show accelerated kinetics and increased affinity

(2010) Johannes B. Huppa et al.   NATURE

Mechanical regulation of cell function with geometrically modulated elastomeric substrates

(2010) Jianping Fu et al.   NATURE METHODS

Evidence for a functional sidedness to the   TCR

(2010) M. S. Kuhns et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Integrins and Extracellular Matrix in Mechanotransduction

(2010) M. A. Schwartz   Cold Spring Harbor Perspectives in Biology

Cyclic hardening in bundled actin networks

(2010) K. M. Schmoller et al.   Nature Communications

Force-induced cleavage of single VWFA1A2A3 tridomains by ADAMTS-13

(2009) T. Wu et al.   BLOOD

Structure of an integrin with an αI domain, complement receptor type 4

(2009) Can Xie et al.   EMBO JOURNAL

The Cellular Context of T Cell Signaling

(2009) Michael L. Dustin   IMMUNITY

Integrin Activation Dynamics between the RGD-binding Site and the Headpiece Hinge

(2009) Eileen Puklin-Faucher et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The αβ T Cell Receptor Is an Anisotropic Mechanosensor

(2009) Sun Taek Kim et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Demonstration of catch bonds between an integrin and its ligand

(2009) Fang Kong et al.   JOURNAL OF CELL BIOLOGY

Crystal structure of the complete integrin αVβ3 ectodomain plus an α/β transmembrane fragment

(2009) Jian-Ping Xiong et al.   JOURNAL OF CELL BIOLOGY

Src Homology 2-Domain Containing Leukocyte-Specific Phosphoprotein of 76 kDa Is Mandatory for TCR-Mediated Inside-Out Signaling, but Dispensable for CXCR4-Mediated LFA-1 Activation, Adhesion, and Migration of T Cells

(2009) J. Horn et al.   JOURNAL OF IMMUNOLOGY

Regulation of conformer-specific activation of the integrin LFA-1 by a chemokine-triggered Rho signaling module

(2009) Matteo Bolomini-Vittori et al.   NATURE IMMUNOLOGY

T cell antigen receptor signaling and immunological synapse stability require myosin IIA

(2009) Tal Ilani et al.   NATURE IMMUNOLOGY

The Tail of Integrins, Talin, and Kindlins

(2009) M. Moser et al.   SCIENCE

Stretching Single Talin Rod Molecules Activates Vinculin Binding

(2009) A. del Rio et al.   SCIENCE

Mechanoenzymatic Cleavage of the Ultralarge Vascular Protein von Willebrand Factor

(2009) X. Zhang et al.   SCIENCE

Mechanically Activated Integrin Switch Controls  5 1 Function

(2009) J. C. Friedland et al.   SCIENCE

Modular Design of Immunological Synapses and Kinapses

(2009) M. L. Dustin   Cold Spring Harbor Perspectives in Biology

A Role for Rebinding in Rapid and Reliable T Cell Responses to Antigen

(2009) Omer Dushek et al.   PLoS Computational Biology

Mechanisms for Flow-Enhanced Cell Adhesion

(2008) Cheng Zhu et al.   ANNALS OF BIOMEDICAL ENGINEERING

The Actin Cytoskeleton in T Cell Activation

(2008) Janis K. Burkhardt et al.   Annual Review of Immunology

Substrate Modulus Directs Neural Stem Cell Behavior

(2008) Krishanu Saha et al.   BIOPHYSICAL JOURNAL

Separable requirements for cytoplasmic domain of PSGL-1 in leukocyte rolling and signaling under flow

(2008) J. J. Miner et al.   BLOOD

Regulation of T Cell Receptor Activation by Dynamic Membrane Binding of the CD3ɛ Cytoplasmic Tyrosine-Based Motif

(2008) Chenqi Xu et al.   CELL

T-cell activation through immunological synapses and kinapses

(2008) Michael L. Dustin   IMMUNOLOGICAL REVIEWS

T-cell receptor binding affinities and kinetics: impact on T-cell activity and specificity

(2008) Jennifer D. Stone et al.   IMMUNOLOGY

Replacing a Lectin Domain Residue in L-selectin Enhances Binding to P-selectin Glycoprotein Ligand-1 but Not to 6-Sulfo-sialyl Lewis x

(2008) Arkadiusz G. Klopocki et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

FimH Forms Catch Bonds That Are Enhanced by Mechanical Force Due to Allosteric Regulation

(2008) Olga Yakovenko et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

PSGL-1 engagement by E-selectin signals through Src kinase Fgr and ITAM adapters DAP12 and FcRγ to induce slow leukocyte rolling

(2008) Alexander Zarbock et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Structure of a Complete Integrin Ectodomain in a Physiologic Resting State and Activation and Deactivation by Applied Forces

(2008) Jianghai Zhu et al.   MOLECULAR CELL

Surface-Anchored Monomeric Agonist pMHCs Alone Trigger TCR with High Sensitivity

(2008) Zhengyu Ma et al.   PLOS BIOLOGY

The receptor deformation model of TCR triggering

(2007) Zhengyu Ma et al.   FASEB JOURNAL