Wiskott-Aldrich syndrome protein - dynamic regulation of actin homeostasis: from activation through function and signal termination in T lymphocytes

The Wiskott-Aldrich Syndrome: The Actin Cytoskeleton and Immune Cell Function

(2013) Michael P. Blundell et al.   DISEASE MARKERS

Cutting Edge: Cell Surface Linker for Activation of T Cells Is Recruited to Microclusters and Is Active in Signaling

(2013) L. Balagopalan et al.   JOURNAL OF IMMUNOLOGY

Disease-associated missense mutations in the EVH1 domain disrupt intrinsic WASp function causing dysregulated actin dynamics and impaired dendritic cell migration

(2012) A. J. J. Worth et al.   BLOOD

Wiskott-Aldrich syndrome protein (WASP) and N-WASP are critical for peripheral B-cell development and function

(2012) L. S. Westerberg et al.   BLOOD

Excess F-actin mechanically impedes mitosis leading to cytokinesis failure in X-linked neutropenia by exceeding Aurora B kinase error correction capacity

(2012) D. A. Moulding et al.   BLOOD

SCAR knockouts inDictyostelium: WASP assumes SCAR’s position and upstream regulators in pseudopods

(2012) Douwe M. Veltman et al.   JOURNAL OF CELL BIOLOGY

Stoichiometry of Nck-dependent actin polymerization in living cells

(2012) Jonathon A. Ditlev et al.   JOURNAL OF CELL BIOLOGY

Arp2/3 complex–dependent actin networks constrain myosin II function in driving retrograde actin flow

(2012) Qing Yang et al.   JOURNAL OF CELL BIOLOGY

F-actin polymerization and retrograde flow drive sustained PLCγ1 signaling during T cell activation

(2012) Alexander Babich et al.   JOURNAL OF CELL BIOLOGY

Diffusion, capture and recycling of SCAR/WAVE and Arp2/3 complexes observed in cells by single-molecule imaging

(2012) A. Millius et al.   JOURNAL OF CELL SCIENCE

A novel primary human immunodeficiency due to deficiency in the WASP-interacting protein WIP

(2012) Gaetana Lanzi et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Ubiquitylation-Dependent Negative Regulation of WASp Is Essential for Actin Cytoskeleton Dynamics

(2012) B. Reicher et al.   MOLECULAR AND CELLULAR BIOLOGY

Actin retrograde flow and actomyosin II arc contraction drive receptor cluster dynamics at the immunological synapse in Jurkat T cells

(2012) Jason Yi et al.   MOLECULAR BIOLOGY OF THE CELL

Studying the Dynamics of SLP-76, Nck, and Vav1 Multimolecular Complex Formation in Live Human Cells with Triple-Color FRET

(2012) M. H. Pauker et al.   Science Signaling

Autoimmunity in Wiskott–Aldrich Syndrome: An Unsolved Enigma

(2012) Marco Catucci et al.   Frontiers in Immunology

Defective inhibition of B-cell proliferation by Wiskott-Aldrich syndrome protein-deficient regulatory T cells

(2011) M. Adriani et al.   BLOOD

Three-dimensional reconstructions of Arp2/3 complex with bound nucleation promoting factors

(2011) Xiao-Ping Xu et al.   EMBO JOURNAL

β1 integrins regulate fibroblast chemotaxis through control of N-WASP stability

(2011) Samantha J King et al.   EMBO JOURNAL

The Wiskott-Aldrich syndrome protein permits assembly of a focused immunological synapse enabling sustained T-cell receptor signaling

(2011) R. Calvez et al.   HAEMATOLOGICA

Identification of Fyn as the binding partner for the WASP N-terminal domain in T cells

(2011) M. Sato et al.   INTERNATIONAL IMMUNOLOGY

A peptide derived from the Wiskott-Aldrich syndrome (WAS) protein-interacting protein (WIP) restores WAS protein level and actin cytoskeleton reorganization in lymphocytes from patients with WAS mutations that disrupt WIP binding

(2011) Michel J. Massaad et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Functional Cooperation between the Proteins Nck and ADAP Is Fundamental for Actin Reorganization

(2011) M. H. Pauker et al.   MOLECULAR AND CELLULAR BIOLOGY

Molecular mechanism and physiological functions of clathrin-mediated endocytosis

(2011) Harvey T. McMahon et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Structural and biochemical characterization of two binding sites for nucleation-promoting factor WASp-VCA on Arp2/3 complex

(2011) S.-C. Ti et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Arp2/3 complex is bound and activated by two WASP proteins

(2011) S. B. Padrick et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

X-linked thrombocytopenia (XLT) due to WAS mutations: clinical characteristics, long-term outcome, and treatment options

(2010) M. H. Albert et al.   BLOOD

Cooperative interactions at the SLP-76 complex are critical for actin polymerization

(2010) Mira Barda-Saad et al.   EMBO JOURNAL

The space and time frames of T cell activation at the immunological synapse

(2010) Salvatore Valitutti et al.   FEBS LETTERS

The Wiskott-Aldrich syndrome protein regulates CTL cytotoxicity and is required for efficient killing of B cell lymphoma targets

(2010) Julie De Meester et al.   JOURNAL OF LEUKOCYTE BIOLOGY

WASP Family Proteins: Their Evolution and Its Physiological Implications

(2010) Douwe M. Veltman et al.   MOLECULAR BIOLOGY OF THE CELL

Structure and control of the actin regulatory WAVE complex

(2010) Zhucheng Chen et al.   NATURE

A nucleator arms race: cellular control of actin assembly

(2010) Kenneth G. Campellone et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Adhesion and Degranulation Promoting Adapter Protein (ADAP) Is a Central Hub for Phosphotyrosine-Mediated Interactions in T Cells

(2010) Marc Sylvester et al.   PLoS One

WASH and WAVE actin regulators of the Wiskott-Aldrich syndrome protein (WASP) family are controlled by analogous structurally related complexes

(2010) D. Jia et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The adapter protein Nck: Role of individual SH3 and SH2 binding modules for protein interactions in T lymphocytes

(2010) Marcus Lettau et al.   PROTEIN SCIENCE

Dynamics of Subsynaptic Vesicles and Surface Microclusters at the Immunological Synapse

(2010) M. A. Purbhoo et al.   Science Signaling

Nuclear Role of WASp in the Pathogenesis of Dysregulated TH1 Immunity in Human Wiskott-Aldrich Syndrome

(2010) M. D. Taylor et al.   Science Translational Medicine

Recent advances in understanding the pathophysiology of Wiskott-Aldrich syndrome

(2009) M. Bosticardo et al.   BLOOD

Actin nucleation and elongation factors: mechanisms and interplay

(2009) Melissa A Chesarone et al.   CURRENT OPINION IN CELL BIOLOGY

A FAM21-Containing WASH Complex Regulates Retromer-Dependent Sorting

(2009) Timothy S. Gomez et al.   DEVELOPMENTAL CELL

Characterization of  Wiskott–Aldrich syndrome (WAS) mutants usingSaccharomyces cerevisiae

(2009) Rajamuthiah Rajmohan et al.   FEMS YEAST RESEARCH

Wiskott–Aldrich Syndrome: Immunodeficiency resulting from defective cell migration and impaired immunostimulatory activation

(2009) Gerben Bouma et al.   IMMUNOBIOLOGY

Endocytic events in TCR signaling: focus on adapters in microclusters

(2009) Lakshmi Balagopalan et al.   IMMUNOLOGICAL REVIEWS

Cdc42 Regulates Fcγ Receptor-mediated Phagocytosis through the Activation and Phosphorylation of Wiskott-Aldrich Syndrome Protein (WASP) and Neural-WASP

(2009) Haein Park et al.   MOLECULAR BIOLOGY OF THE CELL

A Reciprocal Interdependence between Nck and PI(4,5)P2 Promotes Localized N-WASp-Mediated Actin Polymerization in Living Cells

(2009) Gonzalo M. Rivera et al.   MOLECULAR CELL

p53-cofactor JMY is a multifunctional actin nucleation factor

(2009) J. Bradley Zuchero et al.   NATURE CELL BIOLOGY

Unleashing formins to remodel the actin and microtubule cytoskeletons

(2009) Melissa A. Chesarone et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Phosphorylation of WASp is a key regulator of activity and stability in vivo

(2009) M. P. Blundell et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A large kindred with X-linked neutropenia with an I294T mutation of the Wiskott-Aldrich syndrome gene

(2008) Karolien Beel et al.   BRITISH JOURNAL OF HAEMATOLOGY

WHAMM Is an Arp2/3 Complex Activator That Binds Microtubules and Functions in ER to Golgi Transport

(2008) Kenneth G. Campellone et al.   CELL

T-cell activation through immunological synapses and kinapses

(2008) Michael L. Dustin   IMMUNOLOGICAL REVIEWS

Hierarchical Regulation of WASP/WAVE Proteins

(2008) Shae B. Padrick et al.   MOLECULAR CELL

X-Ray Scattering Study of Activated Arp2/3 Complex with Bound Actin-WCA

(2008) Malgorzata Boczkowska et al.   STRUCTURE