Article
Multidisciplinary Sciences
Jian Fu, Christian H. K. Lehmann, Xinning Wang, Mandy Wahlbuhl, Ida Allabauer, Benjamin Wilde, Lukas Amon, Sebastian Dolff, Robert Cesnjevar, Andreas Kribben, Joachim Woelfle, Wolfgang Rascher, Peter F. Hoyer, Diana Dudziak, Oliver Witzke, Andre Hoerning
Summary: The study demonstrated that the combination of rapamycin and plerixafor in a fully-mismatched heart transplant model resulted in prolonged allograft survival, reduced fibrosis and myocyte lesions, and increased T-reg cell numbers, possibly through the regulation of pDCs. This pharmacological approach highlights the potential of pDCs as an attractive immunotherapeutic target along with plerixafor treatment.
SCIENTIFIC REPORTS
(2021)
Review
Biochemistry & Molecular Biology
Rachel L. Washburn, Jannette M. Dufour
Summary: Sertoli cells play a crucial role in creating an immunoregulatory environment for spermatogenesis and protecting germ cells from immune destruction. This review focuses on the understudied complement system and its regulation by Sertoli cells. Studies in transplantation models have shown that Sertoli cells can survive activated complement, express complement inhibitors, and modulate immune cell infiltration. Understanding the mechanism of Sertoli cell-mediated complement regulation is important for male reproduction, autoimmunity, and transplantation.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Multidisciplinary Sciences
Huapan Fang, Zhaopei Guo, Jie Chen, Lin Lin, Yingying Hu, Yanhui Li, Huayu Tian, Xuesi Chen
Summary: While immunotherapy has shown promise as a cancer treatment, durable benefits are often limited by immune escape mechanisms. This study combines epigenetic regulation with gene therapy for immune checkpoint blockade to enhance anti-tumor effects and immune responses in vivo, providing a potential strategy for tumor treatment and prevention of relapse and metastasis.
NATURE COMMUNICATIONS
(2021)
Review
Cell Biology
Yuxiang Du, Bo Yan
Summary: The retinal pigment epithelium is crucial for maintaining ocular immune privilege by using various mechanisms to suppress immune responses and prevent inflammation. This review focuses on the role of retinal pigment epithelium cells in immune regulation, particularly the changes that occur under pathological conditions.
JOURNAL OF LEUKOCYTE BIOLOGY
(2023)
Article
Immunology
Bo Zhang, Wanghong Xiao, Geng Qin, Zelin Chen, Lihua Qiu, Xin Wang, Qiang Lin
Summary: Male pregnancy is an evolutionary innovation in syngnathids, and the immune resistance of the father to the fetus is a challenge. Comparative genomic analysis showed that these species lost three essential immune protection genes but compensated for it with altered antigen recognition genes. TLR genes were highly expressed in the placenta inside the seahorse brood pouch and responded to specific pathogenic antigens, suggesting their important role in male pregnancy.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Multidisciplinary Sciences
Ji Lei, Maria M. Coronel, Esma S. Yolcu, Hongping Deng, Orlando Grimany-Nuno, Michael D. Hunckler, Vahap Ulker, Zhihong Yang, Kang M. Lee, Alexander Zhang, Hao Luo, Cole W. Peters, Zhongliang Zou, Tao Chen, Zhenjuan Wang, Colleen S. McCoy, Ivy A. Rosales, James F. Markmann, Haval Shirwan, Andres J. Garcia
Summary: We report a strategy of cotransplanting allogeneic islets and streptavidin (SA)-FasL-presenting microgels to the omentum under transient rapamycin monotherapy, which resulted in robust glycemic control, sustained C-peptide levels, and graft survival in diabetic nonhuman primates. This localized immunomodulatory strategy shows translational potential in beta cell replacement for treating type 1 diabetes.
Review
Immunology
Mingjie Ding, Yuting He, Shuijun Zhang, Wenzhi Guo
Summary: Liver transplantation is an effective therapy for end-stage liver disease, but most postoperative patients require immunosuppressive drugs. Some transplant recipients achieve immune tolerance with normal liver function and no organ rejection after immunosuppressive drug withdrawal. Costimulatory molecules are crucial in T cell-mediated immune responses and tolerance maintenance, with potential for inducing immune tolerance in transplantation through costimulatory blockade.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Oncology
Giorgia Renga, Emilia Nunzi, Marilena Pariano, Matteo Puccetti, Marina Maria Bellet, Giuseppe Pieraccini, Fiorella D'Onofrio, Ilaria Santarelli, Claudia Stincardini, Franco Aversa, Francesca Riuzzi, Cinzia Antognelli, Marco Gargaro, Oxana Bereshchenko, Maurizio Ricci, Stefano Giovagnoli, Luigina Romani, Claudio Costantini
Summary: Microbial metabolites at the interface between microbes and the host immune system can optimize immune checkpoint inhibitor (ICI) therapy without impairing its antitumor activity. This study provides a proof-of-concept demonstration for the development of new therapeutic strategies.
JOURNAL FOR IMMUNOTHERAPY OF CANCER
(2022)
Article
Biochemistry & Molecular Biology
Lu Chen, Jing Yang, Henry Klassen
Summary: The study assessed the immune response to repeated intravitreal transplants of allogeneic retinal progenitor cells in a mouse model. The results showed that there was no immune-mediated destruction of the grafts and the allogeneic grafts survived following repeat dosing, indicating that repeated injection of allogeneic RPCs is tolerated in patients with retinitis pigmentosa.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Immunology
Xiaoming Zhang, Laura Kracht, Antonio M. Lerario, Marissa L. Dubbelaar, Nieske Brouwer, Evelyn M. Wesseling, Erik W. G. M. Boddeke, Bart J. L. Eggen, Susanne M. Kooistra
Summary: This study provides insight into epigenetic profiles and transcription factor networks associated with transcriptional signatures of tolerized and trained microglia in vivo, leading to a better understanding of innate immune memory of microglia.
JOURNAL OF NEUROINFLAMMATION
(2022)
Article
Oncology
Eizoh Gondoh, Yusuke Hamada, Tomohisa Mori, Yusuke Iwazawa, Asami Shinohara, Michiko Narita, Daisuke Sato, Hiroyuki Tezuka, Takayasu Yamauchi, Mayu Tsujimura, Sara Yoshida, Kenichi Tanaka, Kensuke Yamashita, Haruka Akatori, Kimio Higashiyama, Kazuhiko Arakawa, Yukari Suda, Kanako Miyano, Masako Iseki, Eiichi Inada, Naoko Kuzumaki, Minoru Narita
Summary: This study found that systemic administration of the peripheral mu-opioid receptor (MOR) antagonist naldemedine improved the immune system in tumour-bearing mice, reducing tumour volume and prolonging survival. The blockade of peripheral MORs may lead to anti-tumour effects by recovering T-cell exhaustion and promoting the tumour-killing system.
BRITISH JOURNAL OF CANCER
(2022)
Review
Oncology
Julien Faget, Solange Peters, Xavier Quantin, Etienne Meylan, Nathalie Bonnefoy
Summary: Neutrophils in tumors have been highlighted as playing a pivotal role in modulating the tumor microenvironment and antitumor immune response. Research targeting neutrophils could offer new treatment opportunities in the development of immune checkpoint blockade-based immunotherapies. Expanding the study of neutrophil impact on the response to immune checkpoint inhibitors may lead to new translational research avenues for better understanding neutrophil biology and improving patient treatment.
JOURNAL FOR IMMUNOTHERAPY OF CANCER
(2021)
Article
Multidisciplinary Sciences
Munetoyo Toda, Morio Ueno, Jun Yamada, Asako Hiraga, Kazuko Asada, Junji Hamuro, Chie Sotozono, Shigeru Kinoshita
Summary: This study found that injection of cultured human corneal endothelial cell suspension into the anterior chamber can induce immune tolerance that contributes to the survival of reconstituted endothelium, and no signs of immune rejection were observed during the 5-8 years of postoperative follow-up.
SCIENTIFIC REPORTS
(2022)
Review
Immunology
Daan K. J. Pieren, Mardi C. Boer, Jelle de Wit
Summary: Respiratory infectious diseases encountered early in life can be life-threatening for neonates due to their immature immune system. Vaccinations have significantly reduced childhood mortality, but infants require multiple doses to develop protective immunity and not all vaccines are equally effective in young age. Recent studies have shown that the early life adaptive immune system possesses strong innate-like effector function and is regulated by a tolerogenic counterpart. This shift from innate-like to immune memory formation may explain the different efficacy of infant vaccination during immune development. The presence of innate-like and tolerogenic features of the immune system can be used as a biomarker to improve vaccination strategies for respiratory and other infections in early life.
FRONTIERS IN IMMUNOLOGY
(2022)
Review
Veterinary Sciences
Hafiz Ishfaq Ahmad, Abdul Jabbar, Nadia Mushtaq, Zainab Javed, Muhammad Umar Hayyat, Javaria Bashir, Iqra Naseeb, Zain Ul Abideen, Nisar Ahmad, Jinping Chen
Summary: The immune system reduces the harmful impact of infections on the host by using immune-driven resistance and disease tolerance mechanisms. Disease tolerance controls tissue damage and allows the body to fight infections more effectively.
FRONTIERS IN VETERINARY SCIENCE
(2022)
Review
Immunology
Amos Gilhar, Adam G. Schrum, Amos Etzioni, Herman Waldmann, Ralf Paus
AUTOIMMUNITY REVIEWS
(2016)
Article
Medical Laboratory Technology
Herman Waldmann
CLINICAL BIOCHEMISTRY
(2016)
Article
Multidisciplinary Sciences
Ryuichi Hotta, Masahiro Ohira, Toshiharu Matsuura, Izumi Muraoka, Panagiotis Tryphonopoulos, Ji Fan, Akin Tekin, Gennaro Selvaggi, David Levi, Phillip Ruiz, Camillo Ricordi, Rodrigo Vianna, Hideki Ohdan, Herman Waldmann, Andreas G. Tzakis, Seigo Nishida
Article
Immunology
Robert Hilbrands, Ye Chen, Adrian R. Kendal, Elizabeth Adams, Stephen P. Cobbold, Herman Waldmann, Duncan Howie
FRONTIERS IN IMMUNOLOGY
(2016)
Article
Immunology
Maja Wallberg, Asha Recino, Jenny Phillips, Duncan Howie, Margaux Vienne, Christopher Paluch, Miyuki Azuma, F. Susan Wong, Herman Waldmann, Anne Cooke
Article
Immunology
Alix Besancon, Marije Baas, Tania Goncalves, Fabrice Valette, Herman Waldmann, Lucienne Chatenoud, Sylvaine You
FRONTIERS IN IMMUNOLOGY
(2017)
Article
Immunology
Masato Tsuda, Yukiko Tone, Chihiro Ogawa, Yoshiko Nagaoka, Makoto Katsumata, Andra Necula, Duncan Howie, Esteban Masuda, Herman Waldmann, Masahide Tone
FRONTIERS IN IMMUNOLOGY
(2017)
Article
Immunology
Krista Stockenhuber, Ahmed N. Hegazy, Nathaniel R. West, Nicholas E. Ilott, Alexander Stockenhuber, Samuel J. Bullers, Emily E. Thornton, Isabelle C. Arnold, Andrea Tucci, Herman Waldmann, Graham S. Ogg, Fiona Powrie
JOURNAL OF EXPERIMENTAL MEDICINE
(2018)
Article
Immunology
Anke Fuchs, Mateusz Gliwinski, Nathali Grageda, Rachel Spiering, Abul K. Abbas, Silke Appel, Rosa Bacchetta, Manuela Battaglia, David Berglund, Bruce Blazar, Jeffrey A. Bluestone, Martin Bornhaeuser, Anja ten Brinke, Todd M. Brusko, Nathalie Cools, Maria Cristina Cuturi, Edward Geissler, Nick Giannoukakis, Karolina Golab, David A. Hafler, S. Marieke van Ham, Joanna Hester, Keli Hippen, Mauro Di Ianni, Natasa Ilic, John Isaacs, Fadi Issa, Dorota Iwaszkiewicz-Grzes, Elmar Jaeckel, Irma Joosten, David Klatzmann, Hans Koenen, Cees van Kooten, Olle Korsgren, Karsten Kretschmer, Megan Levings, Natalia Maria Marek-Trzonkowska, Marc Martinez-Llordella, Djordje Miljkovic, Kingston H. G. Mills, Joana P. Miranda, Ciriaco A. Piccirillo, Amy L. Putnam, Thomas Ritter, Maria Grazia Roncarolo, Shimon Sakaguchi, Silvia Sanchez-Ramon, Birgit Sawitzki, Ljiljana Sofronic-Milosavljevic, Megan Sykes, Qizhi Tang, Marta Vives-Pi, Herman Waldmann, Piotr Witkowski, Kathryn J. Wood, Silvia Gregori, Catharien M. U. Hilkens, Giovanna Lombardi, Phillip Lord, Eva M. Martinez-Caceres, Piotr Trzonkowski
FRONTIERS IN IMMUNOLOGY
(2018)
Article
Immunology
Robert A. Benson, Fabien Garcon, Asha Recino, John R. Ferdinand, Menna R. Clatworthy, Herman Waldmann, James M. Brewer, Klaus Okkenhaug, Anne Cooke, Paul Garside, Maja Wallberg
FRONTIERS IN IMMUNOLOGY
(2018)
Review
Immunology
Duncan Howie, Annemieke Ten Bokum, Andra Stefania Necula, Stephen Paul Cobbold, Herman Waldmann
FRONTIERS IN IMMUNOLOGY
(2018)
Article
Immunology
Stephen P. Cobbold, Elizabeth Adams, Duncan Howie, Herman Waldmann
FRONTIERS IN IMMUNOLOGY
(2018)
Article
Engineering, Biomedical
Jiatao Li, Xisheng Li, Cai Liang, Lijun Ling, Zhiwei Chen, Chun Kwok Wong, Herman Waldmann, Kathy O. Lui
Article
Cell Biology
Herman Waldmann, Luis Graca
CELLULAR IMMUNOLOGY
(2020)