From inception to output, Tcf1 and Lef1 safeguard development of T cells and innate immune cells

Lithium Prevents and Ameliorates Experimental Autoimmune Encephalomyelitis

(2014) P. De Sarno et al.   JOURNAL OF IMMUNOLOGY

Pre-TCR-Induced  -Catenin Facilitates Traversal through  -Selection

(2014) M. Xu et al.   JOURNAL OF IMMUNOLOGY

TCF-1 and LEF-1 act upstream of Th-POK to promote the CD4+ T cell fate and interact with Runx3 to silence Cd4 in CD8+ T cells

(2014) Farrah C Steinke et al.   NATURE IMMUNOLOGY

A far downstream enhancer for murine Bcl11b controls its T-cell specific expression

(2013) L. Li et al.   BLOOD

 -Catenin activation synergizes with Pten loss and Myc overexpression in Notch-independent T-ALL

(2013) D. Kaveri et al.   BLOOD

TCF-1 mediates repression of Notch pathway in T lineage-committed early thymocytes

(2013) S. Yu et al.   BLOOD

A Network of High-Mobility Group Box Transcription Factors Programs Innate Interleukin-17 Production

(2013) Nidhi Malhotra et al.   IMMUNITY

Canonical Wnt Signaling Negatively Modulates Regulatory T Cell Function

(2013) Jorg van Loosdregt et al.   IMMUNITY

T Cell Factor 1 Is Required for Group 2 Innate Lymphoid Cell Generation

(2013) Qi Yang et al.   IMMUNITY

TCF-1 Controls ILC2 and NKp46+ROR t+ Innate Lymphocyte Differentiation and Protection in Intestinal Inflammation

(2013) L. A. Mielke et al.   JOURNAL OF IMMUNOLOGY

Identification of DNA-dependent protein kinase catalytic subunit as a novel interaction partner of lymphocyte enhancer factor 1

(2013) Atsushi Shimomura et al.   Medical Molecular Morphology

Runx3-mediated Transcriptional Program in Cytotoxic Lymphocytes

(2013) Joseph Lotem et al.   PLoS One

 -Catenin induces T-cell transformation by promoting genomic instability

(2013) M. Dose et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

β-Catenin-Independent Activation of TCF1/LEF1 in Human Hematopoietic Tumor Cells through Interaction with ATF2 Transcription Factors

(2013) Luca Grumolato et al.   PLoS Genetics

Diversity, function, and transcriptional regulation of gut innate lymphocytes

(2013) Lucille Rankin   Frontiers in Immunology

Regulation of mature T cell responses by the Wnt signaling pathway

(2012) Hai-Hui Xue et al.   Annals of the New York Academy of Sciences

Wnt/β-Catenin Signaling and Disease

(2012) Hans Clevers et al.   CELL

Nuclear IGF1R is a transcriptional co-activator of LEF1/TCF

(2012) Dudi Warsito et al.   EMBO REPORTS

The Wnt inhibitor secreted Frizzled-Related Protein 1 (sFRP1) promotes human Th17 differentiation

(2012) Yoon-Sook Lee et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Tales of the Unexpected: Tcf1 Functions as a Tumor Suppressor for Leukemias

(2012) Frank J.T. Staal et al.   IMMUNITY

The Transcription Factor GATA-3 Controls Cell Fate and Maintenance of Type 2 Innate Lymphoid Cells

(2012) Thomas Hoyler et al.   IMMUNITY

The TCF-1 and LEF-1 Transcription Factors Have Cooperative and Opposing Roles in T Cell Development and Malignancy

(2012) Shuyang Yu et al.   IMMUNITY

The Transcription Factors T-bet and Eomes Control Key Checkpoints of Natural Killer Cell Maturation

(2012) Scott M. Gordon et al.   IMMUNITY

Conditional deletion of cytokine receptor chains reveals that IL-7 and IL-15 specify CD8 cytotoxic lineage fate in the thymus

(2012) Tom M. McCaughtry et al.   JOURNAL OF EXPERIMENTAL MEDICINE

T Cell Factor-1 and  -Catenin Control the Development of Memory-like CD8 Thymocytes

(2012) A. Sharma et al.   JOURNAL OF IMMUNOLOGY

β-Catenin/TCF-1 Pathway in T Cell Development and Differentiation

(2012) Jian Ma et al.   Journal of Neuroimmune Pharmacology

Transcription factor RORα is critical for nuocyte development

(2012) See Heng Wong et al.   NATURE IMMUNOLOGY

Molecular basis for the tissue specificity of β-catenin oncogenesis

(2012) A Sharma et al.   ONCOGENE

The Nuclear Effector of Wnt-Signaling, Tcf1, Functions as a T-Cell–Specific Tumor Suppressor for Development of Lymphomas

(2012) Machteld M. Tiemessen et al.   PLOS BIOLOGY

Canonical Wnt Signaling Regulates Hematopoiesis in a Dosage-Dependent Fashion

(2011) Tiago C. Luis et al.   Cell Stem Cell

Signaling in thymic selection

(2011) Nicholas RJ Gascoigne et al.   CURRENT OPINION IN IMMUNOLOGY

TOX Is Required for Development of the CD4 T Cell Lineage Gene Program

(2011) P. Aliahmad et al.   JOURNAL OF IMMUNOLOGY

T Cell Factor-1 Negatively Regulates Expression of IL-17 Family of Cytokines and Protects Mice from Experimental Autoimmune Encephalomyelitis

(2011) Qing Yu et al.   JOURNAL OF IMMUNOLOGY

T Cell Factor 1 Regulates Thymocyte Survival via a ROR t-Dependent Pathway

(2011) R. Wang et al.   JOURNAL OF IMMUNOLOGY

A critical role for TCF-1 in T-lineage specification and differentiation

(2011) Brittany Nicole Weber et al.   NATURE

T-bet in disease

(2011) Vanja Lazarevic et al.   NATURE IMMUNOLOGY

Critical Role of TCF-1 in Repression of the IL-17 Gene

(2011) Jian Ma et al.   PLoS One

T-cell factor 1 is a gatekeeper for T-cell specification in response to Notch signaling

(2011) K. Germar et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

On becoming a T cell, a convergence of factors kick it up a Notch along the way

(2011) Patrycja K. Thompson et al.   SEMINARS IN IMMUNOLOGY

Alternative memory in the CD8 T cell lineage

(2011) You Jeong Lee et al.   TRENDS IN IMMUNOLOGY

Transcription control of early B cell differentiation

(2010) Elizabeth M Mandel et al.   CURRENT OPINION IN IMMUNOLOGY

Regulated Expression of Nuclear Receptor RORγt Confers Distinct Functional Fates to NK Cell Receptor-Expressing RORγt+ Innate Lymphocytes

(2010) Cedric Vonarbourg et al.   IMMUNITY

Notch Signaling in the Immune System

(2010) Freddy Radtke et al.   IMMUNITY

Differentiation and Persistence of Memory CD8+ T Cells Depend on T Cell Factor 1

(2010) Xinyuan Zhou et al.   IMMUNITY

TCF1 and β-catenin regulate T cell development and function

(2010) Qing Yu et al.   IMMUNOLOGIC RESEARCH

Multilayered specification of the T-cell lineage fate

(2010) Ellen V. Rothenberg et al.   IMMUNOLOGICAL REVIEWS

Suppressive Regulatory T Cell Activity Is Potentiated by Glycogen Synthase Kinase 3β Inhibition

(2010) Jay A. Graham et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The zinc-finger protein MAZR is part of the transcription factor network that controls the CD4 versus CD8 lineage fate of double-positive thymocytes

(2010) Shinya Sakaguchi et al.   NATURE IMMUNOLOGY

Signaling by intrathymic cytokines, not T cell antigen receptors, specifies CD8 lineage choice and promotes the differentiation of cytotoxic-lineage T cells

(2010) Jung-Hyun Park et al.   NATURE IMMUNOLOGY

Notch regulation of early thymocyte development

(2010) Yumi Yashiro-Ohtani et al.   SEMINARS IN IMMUNOLOGY

IL-17-producing γδ T cells

(2009) Rebecca L. O'Brien et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

GATA-3 is required for early T lineage progenitor development

(2009) Tomonori Hosoya et al.   JOURNAL OF EXPERIMENTAL MEDICINE

CD4-CD8 Lineage Differentiation: Thpok-ing into the Nucleus

(2009) L. Wang et al.   JOURNAL OF IMMUNOLOGY

 -Catenin/Tcf Determines the Outcome of Thymic Selection in Response to   TCR Signaling

(2009) D. Kovalovsky et al.   JOURNAL OF IMMUNOLOGY

T cell factor 1 initiates the T helper type 2 fate by inducing the transcription factor GATA-3 and repressing interferon-γ

(2009) Qing Yu et al.   NATURE IMMUNOLOGY

β-Catenin hits chromatin: regulation of Wnt target gene activation

(2009) Christian Mosimann et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

RUNX3 Attenuates β-Catenin/T Cell Factors in Intestinal Tumorigenesis

(2008) Kosei Ito et al.   CANCER CELL

CD4-CD8 Lineage Commitment Is Regulated by a Silencer Element at the ThPOK Transcription-Factor Locus

(2008) Xi He et al.   IMMUNITY

Lymphoid enhancer factor interacts with GATA-3 and controls its function in T helper type 2 cells

(2008) Mohammad B. Hossain et al.   IMMUNOLOGY

Multi-genetic events collaboratively contribute to Pten-null leukaemia stem-cell formation

(2008) Wei Guo et al.   NATURE

ThPOK acts late in specification of the helper T cell lineage and suppresses Runx-mediated commitment to the cytotoxic T cell lineage

(2008) Takeshi Egawa et al.   NATURE IMMUNOLOGY

Distinct functions for the transcription factors GATA-3 and ThPOK during intrathymic differentiation of CD4+ T cells

(2008) Lie Wang et al.   NATURE IMMUNOLOGY

Beta-catenin stabilization extends regulatory T cell survival and induces anergy in nonregulatory T cells

(2008) Yi Ding et al.   NATURE MEDICINE

Repression of the Transcription Factor Th-POK by Runx Complexes in Cytotoxic T Cell Development

(2008) R. Setoguchi et al.   SCIENCE