Autoimmune effector memory T cells: the bad and the good

Effector-like CD8+ T Cells in the Memory Population Mediate Potent Protective Immunity

(2013) Janelle A. Olson et al.   IMMUNITY

Programmed Death-1 Shapes Memory Phenotype CD8 T Cell Subsets in a Cell-Intrinsic Manner

(2013) J. J. Charlton et al.   JOURNAL OF IMMUNOLOGY

Crohn's Disease Loci Are Common Targets of Protozoa-Driven Selection

(2013) Rachele Cagliani et al.   MOLECULAR BIOLOGY AND EVOLUTION

BACH2 represses effector programs to stabilize Treg-mediated immune homeostasis

(2013) Rahul Roychoudhuri et al.   NATURE

Bach2 maintains T cells in a naive state by suppressing effector memory-related genes

(2013) S.-i. Tsukumo et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Autoimmune Memory T Helper 17 Cell Function and Expansion Are Dependent on Interleukin-23

(2013) Christopher J. Haines et al.   Cell Reports

The immunological identity of tumor

(2013) Jason Miska et al.   OncoImmunology

Memory T Cell Subsets, Migration Patterns, and Tissue Residence

(2012) Scott N. Mueller et al.   Annual Review of Immunology

Autoantigen-specific memory CD4+ T cells are prevalent early in progression to Type 1 diabetes

(2012) Viveka Öling et al.   CELLULAR IMMUNOLOGY

Innate and adaptive immune gene expression profiles as biomarkers in human type 1 diabetes

(2012) D. Han et al.   CLINICAL AND EXPERIMENTAL IMMUNOLOGY

The pathogenesis of systemic lupus erythematosus—an update

(2012) Jinyoung Choi et al.   CURRENT OPINION IN IMMUNOLOGY

Local Autoantigen Expression as Essential Gatekeeper of Memory T-Cell Recruitment to Islet Grafts in Diabetic Hosts

(2012) G. M. Alkemade et al.   DIABETES

Autoimmunity-mediated antitumor immunity: Tumor as an immunoprivileged self

(2012) Jason Miska et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Distribution and Compartmentalization of Human Circulating and Tissue-Resident Memory T Cell Subsets

(2012) Taheri Sathaliyawala et al.   IMMUNITY

Inflammation and type one diabetes

(2012) D. Bending et al.   INTERNATIONAL IMMUNOLOGY

Dual regulation of IRF4 function in T and B cells is required for the coordination of T–B cell interactions and the prevention of autoimmunity

(2012) Partha S. Biswas et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Antigen-Independent Differentiation and Maintenance of Effector-like Resident Memory T Cells in Tissues

(2012) K. A. Casey et al.   JOURNAL OF IMMUNOLOGY

Progressive Loss of Memory T Cell Potential and Commitment to Exhaustion during Chronic Viral Infection

(2012) J. M. Angelosanto et al.   JOURNAL OF VIROLOGY

Incidence and prevalence of adult systemic lupus erythematosus in a large US managed-care population

(2012) DE Furst et al.   LUPUS

The discovery and development of belimumab: the anti-BLyS–lupus connection

(2012) William Stohl et al.   NATURE BIOTECHNOLOGY

High-density genetic mapping identifies new susceptibility loci for rheumatoid arthritis

(2012) Steve Eyre et al.   NATURE GENETICS

Taming lupus—a new understanding of pathogenesis is leading to clinical advances

(2012) Zheng Liu et al.   NATURE MEDICINE

Safety and Activity of Anti–PD-L1 Antibody in Patients with Advanced Cancer

(2012) Julie R. Brahmer et al.   NEW ENGLAND JOURNAL OF MEDICINE

Safety, Activity, and Immune Correlates of Anti–PD-1 Antibody in Cancer

(2012) Suzanne L. Topalian et al.   NEW ENGLAND JOURNAL OF MEDICINE

T Cell Memory in the Context of Persistent Herpes Viral Infections

(2012) Nicole Torti et al.   Viruses-Basel

Integrating Autoimmune Risk Loci with Gene-Expression Data Identifies Specific Pathogenic Immune Cell Subsets

(2011) Xinli Hu et al.   AMERICAN JOURNAL OF HUMAN GENETICS

Relative Resistance of Human CD4+ Memory T Cells to Suppression by CD4+CD25+ Regulatory T Cells

(2011) B. Afzali et al.   AMERICAN JOURNAL OF TRANSPLANTATION

Targeting pathogenic T helper cell memory

(2011) H.-D. Chang et al.   ANNALS OF THE RHEUMATIC DISEASES

Human Blood CXCR5+CD4+ T Cells Are Counterparts of T Follicular Cells and Contain Specific Subsets that Differentially Support Antibody Secretion

(2011) Rimpei Morita et al.   IMMUNITY

Cutting Edge: Tissue-Retentive Lung Memory CD4 T Cells Mediate Optimal Protection to Respiratory Virus Infection

(2011) J. R. Teijaro et al.   JOURNAL OF IMMUNOLOGY

Profound early control of highly pathogenic SIV by an effector memory T-cell vaccine

(2011) Scott G. Hansen et al.   NATURE

Chimeric Antigen Receptor–Modified T Cells in Chronic Lymphoid Leukemia

(2011) David L. Porter et al.   NEW ENGLAND JOURNAL OF MEDICINE

Antitumor activity from antigen-specific CD8 T cells generated in vivo from genetically engineered human hematopoietic stem cells

(2011) D. N. Vatakis et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

E-cadherin promotes accumulation of a unique memory CD8 T-cell population in murine salivary glands

(2011) M. Hofmann et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Genome-Wide Association Study SNPs in the Human Genome Diversity Project Populations: Does Selection Affect Unlinked SNPs with Shared Trait Associations?

(2011) Amanda M. Casto et al.   PLoS Genetics

Specific elimination of effector memory CD4+ T cells due to enhanced Fas signaling complex formation and association with lipid raft microdomains

(2010) M Ramaswamy et al.   CELL DEATH AND DIFFERENTIATION

Immune Tolerance Induction by Integrating Innate and Adaptive Immune Regulators

(2010) Jun Suzuki et al.   CELL TRANSPLANTATION

Dynamic T cell migration program provides resident memory within intestinal epithelium

(2010) David Masopust et al.   JOURNAL OF EXPERIMENTAL MEDICINE

The changing demographic pattern of multiple sclerosis epidemiology

(2010) Nils Koch-Henriksen et al.   LANCET NEUROLOGY

Extreme Evolutionary Disparities Seen in Positive Selection across Seven Complex Diseases

(2010) Erik Corona et al.   PLoS One

Single dose of anti-CTLA-4 enhances CD8+ T-cell memory formation, function, and maintenance

(2010) V. A. Pedicord et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Memory T cells persisting within the brain after local infection show functional adaptations to their tissue of residence

(2010) L. M. Wakim et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Expansion of circulating T cells resembling follicular helper T cells is a fixed phenotype that identifies a subset of severe systemic lupus erythematosus

(2009) Nicholas Simpson et al.   ARTHRITIS AND RHEUMATISM

Pathogenic mechanisms in systemic lupus erythematosus

(2009) Andras Perl   AUTOIMMUNITY

CTLA4 Variants, UV-Induced Tolerance, and Risk of Non-Melanoma Skin Cancer

(2009) M. M. Welsh et al.   CANCER RESEARCH

Defects in IL-2R Signaling Contribute to Diminished Maintenance of FOXP3 Expression in CD4+CD25+ Regulatory T-Cells of Type 1 Diabetic Subjects

(2009) S. A. Long et al.   DIABETES

Increased CD4+ and CD8+ effector memory T cells in patients with aplastic anemia

(2009) X. Hu et al.   HAEMATOLOGICA

Human T Regulatory Cell Therapy: Take a Billion or So and Call Me in the Morning

(2009) James L. Riley et al.   IMMUNITY

Parasites represent a major selective force for interleukin genes and shape the genetic predisposition to autoimmune conditions

(2009) Matteo Fumagalli et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Follicular helper T cells are required for systemic autoimmunity

(2009) Michelle A. Linterman et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Incidence trends for childhood type 1 diabetes in Europe during 1989–2003 and predicted new cases 2005–20: a multicentre prospective registration study

(2009) Christopher C Patterson et al.   LANCET

Instability of the transcription factor Foxp3 leads to the generation of pathogenic memory T cells in vivo

(2009) Xuyu Zhou et al.   NATURE IMMUNOLOGY

Memory T cells in nonlymphoid tissue that provide enhanced local immunity during infection with herpes simplex virus

(2009) Thomas Gebhardt et al.   NATURE IMMUNOLOGY

Different routes of bacterial infection induce long-lived TH1 memory cells and short-lived TH17 cells

(2009) Marion Pepper et al.   NATURE IMMUNOLOGY

Effector memory T cell responses are associated with protection of rhesus monkeys from mucosal simian immunodeficiency virus challenge

(2009) Scott G Hansen et al.   NATURE MEDICINE

PD-1 and Its Ligands in Tolerance and Immunity

(2008) Mary E. Keir et al.   Annual Review of Immunology

Cytokine-induced human IFN- -secreting effector-memory Th cells in chronic autoimmune inflammation

(2008) A. Sattler et al.   BLOOD

Functional Genetic Variations in Cytotoxic T-Lymphocyte Antigen 4 and Susceptibility to Multiple Types of Cancer

(2008) T. Sun et al.   CANCER RESEARCH

Analysis of islet inflammation in human type 1 diabetes

(2008) A. Willcox et al.   CLINICAL AND EXPERIMENTAL IMMUNOLOGY

Central Role of Defective Interleukin-2 Production in the Triggering of Islet Autoimmune Destruction

(2008) Qizhi Tang et al.   IMMUNITY

Autoregulation of Th1-mediated inflammation bytwist1

(2008) Uwe Niesner et al.   JOURNAL OF EXPERIMENTAL MEDICINE

ICOS-dependent extrafollicular helper T cells elicit IgG production via IL-21 in systemic autoimmunity

(2008) Jared M. Odegard et al.   JOURNAL OF EXPERIMENTAL MEDICINE

T cells hang in the balance

(2008) Emily A. Stevens et al.   NATURE

The aryl hydrocarbon receptor links TH17-cell-mediated autoimmunity to environmental toxins

(2008) Marc Veldhoen et al.   NATURE

Control of Treg and TH17 cell differentiation by the aryl hydrocarbon receptor

(2008) Francisco J. Quintana et al.   NATURE

The Immunological Genome Project: networks of gene expression in immune cells

(2008) Tracy S P Heng et al.   NATURE IMMUNOLOGY

Developments in the scientific understanding of lupus

(2008) Stacy P Ardoin et al.   ARTHRITIS RESEARCH & THERAPY