Article
Integrative & Complementary Medicine
Chih-Chia Chang, Kun-Ling Tsai, Hui-Ching Cheng, Wan-Ching Chou, Yu-Ting Huang, Pei-Ling Hsieh, Shin-Da Lee
Summary: Mangiferin (MGN) has the potential to alleviate cardiac hypertrophy. By suppressing the MAPK signaling and NF-kappa Bp65/iNOS axis, MGN can attenuate cell size, expression of hypertrophy markers, and oxidative stress in cardiomyocytes.
AMERICAN JOURNAL OF CHINESE MEDICINE
(2023)
Article
Biochemistry & Molecular Biology
Michael Birk, Ewa Baum, Jenia Kouchek Zadeh, Caroline Manicam, Norbert Pfeiffer, Andreas Patzak, Johanna Helmstaedter, Sebastian Steven, Marin Kuntic, Andreas Daiber, Adrian Gericke
Summary: The study found that Ang II may induce endothelial dysfunction in mouse ophthalmic arteries via AT1R activation and NOX2-dependent ROS formation. Blocking AT1R signaling and/or NOX2 may be helpful in maintaining or restoring endothelial function in ocular blood vessels in certain ocular diseases.
Article
Environmental Sciences
Yen-Lun Kung, Cheng-You Lu, Khan Fareen Badrealam, Wei-Wen Kuo, Marthandam Asokan Shibu, Cecilia Hsuan Day, Ray-Jade Chen, Shang-Yeh Lu, Viswanadha Vijaya Padma, Chih-Yang Huang
Summary: The study demonstrates that AMG can alleviate Ang II-induced cardiomyocyte enlargement, reduce the expression of hypertrophic and inflammatory markers, and increase oxidative stress related proteins. These findings highlight the cardio-protective role of AMG against Ang II-induced cardiomyopathies.
ENVIRONMENTAL TOXICOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Zheng-Da Pang, Xia Sun, Ru-Yue Bai, Meng-Zhuan Han, Yong-Jian Zhang, Wei Wu, Yu Zhang, Bao-Chang Lai, Yi Zhang, Yan Wang, Xiao-Jun Du, Xiu-Ling Deng
Summary: This study found that vascular endothelial dysfunction is an early event in hypertension, and that Ang II upregulates Gal-3 expression in vascular endothelium by increasing YAP nuclear localization, resulting in endothelial dysfunction and the development of hypertension.
CELLULAR AND MOLECULAR LIFE SCIENCES
(2023)
Article
Cardiac & Cardiovascular Systems
Naofumi Amioka, Toru Miyoshi, Tomoko Yonezawa, Megumi Kondo, Satoshi Akagi, Masashi Yoshida, Yukihiro Saito, Kazufumi Nakamura, Hiroshi Ito
Summary: This study found that Pemafibrate has a preventive effect on AAA rupture, reducing ROS, inflammation, and extracellular matrix degradation. The protective effect against AAA rupture is partly mediated by the antioxidative effect of catalase induced by Pemafibrate.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2022)
Article
Immunology
Bei Ren, Jinping Feng, Ning Yang, Yujun Guo, Cheng Chen, Qin Qin
Summary: The study demonstrated that Rg3 can attenuate myocardial hypertrophy and fibrosis by inhibiting the NLRP3 inflammasome and oxidative stress, and promoting SIRT1/NF-kappa B pathway.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2021)
Article
Cell Biology
Linmao Lyu, Jiazheng Chen, Wei Wang, Tao Yan, Jiamao Lin, Hongmei Gao, Hui Li, Ruijuan Lv, Feng Xu, Lijun Fang, Yuguo Chen
Summary: Scoparone can alleviate Ang II-induced myocardial hypertrophy and fibrosis by inhibiting oxidative stress mediated by RAC1. It also blocks Ang II-induced cardiomyocyte hypertrophy and cardiac fibroblast collagen synthesis.
JOURNAL OF CELLULAR AND MOLECULAR MEDICINE
(2021)
Article
Biochemistry & Molecular Biology
Lampson M. Fan, Fangfei Liu, Junjie Du, Li Geng, Jian-Mei Li
Summary: LMH001, a small chemical compound, effectively inhibits the activation of endothelial Nox2 and superoxide production induced by AngII by blocking the interaction between phosphorylated p(47phox) and p(22phox). It shows potential as a therapeutic candidate for oxidative stress-related cardiovascular diseases.
Review
Biochemistry & Molecular Biology
Gabriel Mendez-Valdes, Vicente Perez-Carreno, Maria Chiara Bragato, Malthe Hundahl, Silvia Chichiarelli, Luciano Saso, Ramon Rodrigo
Summary: Ischemia/reperfusion injury is a detrimental process during cardiac interventions, leading to activation of cell death pathways and increased cardiovascular risk. Multiple NADPH oxidases, activated via AT1R occupancy, contribute to the generation of ROS. In addition, ROS can induce proinflammatory responses. On the other hand, the Ang II/AT2R axis exerts cardioprotective effects. AT1R blockers may be used to inhibit the Ang II/AT1R axis and reduce ROS burst, while combination with other cardioprotective agents shows promising outcomes in experimental studies.
Article
Physiology
Bruna Bezerra Lins, Fernando Augusto Malavazzi Casare, Flavia Ferreira Fontenele, Guilherme Lopes Goncalves, Maria Oliveira-Souza
Summary: The study explored the relationship between high plasma angiotensin II (Ang II) levels and chronic kidney diseases (CKDs), revealing that prolonged Ang II infusion/AT1 receptor activation can induce oxidative stress and endoplasmic reticulum (ER) stress. Ang II also affects tubular Na+ transport mechanisms. The findings suggest the therapeutic potential of losartan in preventing the progression of Ang II-induced CKD by reducing oxidative and ER stress.
FRONTIERS IN PHYSIOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Wei-Wen Kuo, Rathinasamy Baskaran, Jing-Ying Lin, Cecilia Hsuan Day, Yueh-Min Lin, Tsung-Jung Ho, Ray-Jade Chen, Mei-Yi Lin, Viswanadha Vijaya Padma, Chih-Yang Huang
Summary: Low-dose rapamycin is found to reduce hypertension-induced testicular damage and prevent testicular toxicity caused by angiotensin II through multiple molecular mechanisms.
JOURNAL OF BIOCHEMICAL AND MOLECULAR TOXICOLOGY
(2022)
Article
Endocrinology & Metabolism
Xingqi Meng, Lixuan Peng, Jie Xu, Dongming Guo, Wenyu Cao, Yang Xu, Suyun Li
Summary: This study investigates whether betaine has a therapeutic effect on sperm deformity and vitality under chronic restraint stress (CRS) and its mechanism. The results show that betaine injections can improve spermatogenesis dysfunction caused by CRS, which may provide potential dietary guidance.
REPRODUCTIVE BIOLOGY AND ENDOCRINOLOGY
(2022)
Article
Endocrinology & Metabolism
Barbara A. Laraia, Cindy W. Leung, A. Janet Tomiyama, Lorrene D. Ritchie, Patricia B. Crawford, Elissa S. Epel
Summary: The study found that the drive for thinness in adolescence can persist into adulthood and predict reward-based compulsive eating behavior and higher weight status in adults. Adolescent drive for thinness has long-term effects on adult eating behaviors, while reward-based eating drive is not related to adult weight status.
Article
Biochemistry & Molecular Biology
Rajesh Choudhary, Jaya Shree, Amrita Singh, Surendra H. Bodakhe
Summary: The study evaluated the role of the renin-angiotensin system in angiotensin-II-induced cataract formation in hypertensive rats, finding that olmesartan administered orally or topically significantly reduced cataract progression and restored antioxidants and protein contents in the lenses. The results suggest that the ocular RAS exacerbates lenticular oxidative stress, playing an independent and important role in cataract formation under hypertensive conditions.
JOURNAL OF BIOCHEMICAL AND MOLECULAR TOXICOLOGY
(2021)
Article
Geriatrics & Gerontology
Caglar Cosarderelioglu, Lolita S. Nidadavolu, Claudene J. George, Ruth Marx-Rattner, Laura Powell, Qian-Li Xue, Jing Tian, Joy Salib, Esther S. Oh, Luigi Ferrucci, Pervin Dincer, David A. Bennett, Jeremy D. Walston, Peter M. Abadir
Summary: Aging is a key risk factor in the development and progression of Alzheimer's dementia. This study identifies changes in AT(1)R in the brains of AD patients, which are associated with inflammation, oxidative stress, lower cognitive performance, and higher levels of amyloid-beta and tangle pathologies.
JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES
(2022)
Article
Biology
Heiko T. Jansen, Brandon Evans Hutzenbiler, Hannah R. Hapner, Madeline L. McPhee, Anthony M. Carnahan, Joanna L. Kelley, Michael W. Saxton, Charles T. Robbins
Summary: Feeding glucose to hibernating bears partially restores metabolic parameters to active season levels, with some indicators remaining incomplete due to the suppression of circulating free fatty acids. The study provides a controlled model to examine the relationship between nutrient availability and metabolism on the hibernation phenotype in bears.
JOURNAL OF EXPERIMENTAL BIOLOGY
(2021)
Article
Health Care Sciences & Services
Aslinur Albayrak, Bilgen Basgut, Gulbin Aygencel Bikmaz, Bensu Karahalil
Summary: The study highlights the importance of clinical pharmacists in identifying and analyzing DRPs in ICU patients. Implementing clinical pharmacy services like the one described can significantly improve patient safety and outcomes. Intervention by pharmacists is highly effective in reducing DRPs and enhancing patient care.
BMC HEALTH SERVICES RESEARCH
(2022)
Article
Pharmacology & Pharmacy
Aysel Pehlivanli, Rezzan Eren-Sadioglu, Merve Aktar, Sahin Eyupoglu, Sule Sengul, Kenan Keven, Sehsuvar Erturk, Bilgen Basgut, Arif Tanju Ozcelikay
Summary: This study compared four frequently used online databases to determine clinically relevant potential drug-drug interactions of immunosuppressants in kidney transplant recipients. The results showed that there was weak compatibility between each database examined and the Renal Drug Handbook.
INTERNATIONAL JOURNAL OF CLINICAL PHARMACY
(2022)
Article
Oncology
Dubem Henry Bosah, Nevzat Birand, Bilgen Basgut, Abdikarim Abdi
Summary: This study assessed the preparedness of community pharmacists in North Cyprus in terms of knowledge, role perception, and barriers for providing cancer health promotion. The findings showed that although community pharmacists had a moderate awareness of cancer-related facts and hesitancy about their knowledge, they still perceived their role in cancer health promotion.
JOURNAL OF ONCOLOGY PHARMACY PRACTICE
(2023)
Article
Evolutionary Biology
Richard J. Wang, Yadira Pena-Garcia, Madeleine G. Bibby, Muthuswamy Raveendran, R. Alan Harris, Heiko T. Jansen, Charles T. Robbins, Jeffrey Rogers, Joanna L. Kelley, Matthew W. Hahn
Summary: This study examines the per-generation mutation rate in a brown bear pedigree and finds that both male bias and per-generation mutation rates are similar to that of non-hibernating species, contradicting previous theories. These findings provide new evidence for the determinants of mutation rates and mutation biases.
GENOME BIOLOGY AND EVOLUTION
(2022)
Review
Pharmacology & Pharmacy
Mohammed Khaled Al-Alaili, Abdikarim Mohamed Abdi, Bilgen Basgut
Summary: This review provides an update on the scales used in hypertension to evaluate adherence, comparing and analyzing their reliability and validity. A total of 22 reliable and validated tools were identified, with good overall Cronbach's alpha, ICC, and correlation coefficient values. The validity analysis showed acceptable sensitivity and specificity, with a good Area Under Curve.
JOURNAL OF CLINICAL PHARMACY AND THERAPEUTICS
(2022)
Article
Pharmacology & Pharmacy
Servet Goksin, Abdikarim Abdi, Louai Alsaloumi, Bilgen Basgut
Summary: The study evaluated drug-related problems and health-related quality of life among chronic disease patients in a rural region of North Cyprus. The findings showed that non-adherence and drug-related problems were common, while therapy targets were rarely met. This suggests that community pharmacists have the potential to improve outcomes in the management of non-communicable diseases.
TROPICAL JOURNAL OF PHARMACEUTICAL RESEARCH
(2022)
Article
Physiology
Ellery P. Vincent, Blair W. Perry, Joanna L. Kelley, Charles T. Robbins, Heiko T. Jansen
Summary: Hibernation and circadian rhythms play important roles in energy conservation for brown bears. The study shows that culturing cells at hibernation body temperature delays ATP production peak and alters the timing and amplitudes of mitochondrial gene transcription and circadian gene transcripts. Key metabolic genes linked to the circadian system and energy balance also show changes.
JOURNAL OF COMPARATIVE PHYSIOLOGY B-BIOCHEMICAL SYSTEMS AND ENVIRONMENTAL PHYSIOLOGY
(2023)
Article
Cell Biology
Blair W. Perry, Anna L. Mcdonald, Shawn Trojahn, Michael W. Saxton, Ellery P. Vincent, Courtney Lowry, Brandon D. Evans Hutzenbiler, Omar E. Cornejo, Charles T. Robbins, Heiko T. Jansen, Joanna L. Kelley
Summary: Hibernation in bears involves changes in gene expression in multiple tissues, including insulin resistance, and feeding bears glucose during hibernation can partially restore active season physiological phenotypes. This study analyzes gene expression in adipose, liver, and muscle tissues to identify genes that respond to midhibernation glucose feeding and drive metabolic and physiological shifts. The results suggest that peroxisome proliferator-activated receptor gamma (PPARG) and other regulators of insulin sensitivity play a role in shifting metabolic phenotypes between hibernation and active states.
PHYSIOLOGICAL GENOMICS
(2023)
Article
Medicine, General & Internal
Bruke Berhanu Billoro, Abdikarem Mohamed Abdi, Wondimu Assefa Abero, Abdi Bedassa Fite, Bilgen Basgut
Summary: This study evaluated the impact of pharmaceutical care on clinical outcomes and medication adherence in T2DM patients in Ethiopia. The results showed that pharmaceutical care intervention significantly improved blood glucose, blood pressure, cholesterol levels, and kidney function in patients, while also increasing medication adherence.
AFRICAN HEALTH SCIENCES
(2022)
Meeting Abstract
Pharmacology & Pharmacy
Sarah Khamis, Hebah Sallom, Bilgen Basgut
INTERNATIONAL JOURNAL OF CLINICAL PHARMACY
(2021)
Meeting Abstract
Pharmacology & Pharmacy
Rawen Abdullah, Abdikarim M. Abdi, Suha S. Shangula, Bilgen Basgut
INTERNATIONAL JOURNAL OF CLINICAL PHARMACY
(2021)
Meeting Abstract
Pharmacology & Pharmacy
Servet Goksin, Abdikarim M. Abdi, Loui Alsaloumi, Bilgen Basgut
INTERNATIONAL JOURNAL OF CLINICAL PHARMACY
(2021)
Meeting Abstract
Pediatrics
Ilke Beyitler, Bilgen Basgut, Abdikarim Abdi, Hanife Ozkayalar, Alper Soylu, Sarah Khamis, Nerin Bahceciler, Salih Kavukcu
PEDIATRIC NEPHROLOGY
(2021)
Article
Medicine, General & Internal
A. A. Laban, N. Birand, U. Chukwunyere, A. Abdi, B. Basgut
Summary: This study compared two electronic databases on drug-drug interactions in cancer treatment. The results showed a moderate agreement between the databases, with Drugs.com being more sensitive and Lexicomp providing more detailed clinical information. Using at least two drug databases is recommended for quality screening, especially for patients predisposed to polypharmacy.
NIGERIAN JOURNAL OF CLINICAL PRACTICE
(2021)