Article
Cardiac & Cardiovascular Systems
Christine Veith, Ipek Varturk-Ozcan, Magdalena Wujak, Stefan Hadzic, Cheng-Yu Wu, Fenja Knoepp, Simone Kraut, Aleksandar Petrovic, Marija Gredic, Oleg Pak, Monika Brosien, Marie Heimbrodt, Jochen Wilhelm, Friederike C. Weisel, Kathrin Malkmus, Katharina Schaefer, Henning Gall, Khodr Tello, Djuro Kosanovic, Akylbek Sydykov, Akpay Sarybaev, Andreas Guenther, Ralf P. Brandes, Werner Seeger, Friedrich Grimminger, Hossein A. Ghofrani, Ralph T. Schermuly, Grazyna Kwapiszewska, Natascha Sommer, Norbert Weissmann
Summary: This study provides evidence for the involvement of SPARC in the pathogenesis of human PH and chronic hypoxia-induced PH in mice, most likely by affecting vascular cell function.
Article
Hematology
Yanan Guo, Zhihan Tang, Binjie Yan, Hao Yin, Shi Tai, Juan Peng, Yuting Cui, Yu Gui, Darrell Belke, Shenghua Zhou, Xi-Long Zheng
Summary: This study reveals the direct effects of PCSK9 on vascular smooth muscle cells and highlights its significance in degenerative vascular diseases.
ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Fabian Hammer, Salvatore S. Buehling, Jaber Masyout, Uwe Malzahn, Tobias Hauser, Tilman Auer, Soeren Grebe, Martina Feger, Rashad Tuffaha, Gerald Degenhart, Florian Lang, Andreas Pasch, Ioana Alesutan, Christoph Wanner, Vera Krane, Jakob Voelkl
Summary: This study investigated the potential beneficial effects of spironolactone on vascular calcification in CKD patients. The results showed that spironolactone treatment improved serum calcification propensity and reduced vascular calcification and expression of osteogenic markers. These observations support a potential benefit of spironolactone treatment in CKD-associated vascular calcification.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2021)
Article
Biochemistry & Molecular Biology
Hong-yu Zhong, Chong Yuan, Xiao-lin Liu, Qian-qian Wang, Xiao Li, Ya-chao Zhao, Xuan Li, Dong-dong Liu, Teng-fei Zheng, Mei Zhang
Summary: This study reveals that mechanical stretch downregulates EZH2 through the YAP-TEAD1 pathway, thereby aggravating smooth muscle cell apoptosis and vascular remodeling.
INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Ilaria Cimmino, Francesco Prisco, Sonia Orso, Ayewa L. Agognon, Pasquale Liguoro, Davide De Biase, Nunzianna Doti, Menotti Ruvo, Orlando Paciello, Francesco Beguinot, Pietro Formisano, Francesco Oriente
Summary: The study investigated the role of Prep1 in Prep1(i/+) mouse aorta and VSMCs, revealing that Prep1 reduces apoptosis by modulating Bcl-xL and p53 in both murine aorta and VSMCs. Additionally, the age-dependent increase in IL-6 and Prep1 in senescent VSMCs and old mice may be involved in aging-related vascular dysfunction.
Article
Pharmacology & Pharmacy
Joo-Hui Han, Kyung-Sun Heo, Chang-Seon Myung
Summary: The study revealed that CIAPIN1 is overexpressed in the neointimal region, and its deficiency inhibits intimal hyperplasia and VSMC proliferation and migration while overexpression promotes these processes. CIAPIN1 negatively regulates Tp53 transcription, promoting cell cycle progression and migration, and increases JAK2 expression to enhance phenotypic switching in response to vascular injury. These findings suggest CIAPIN1 as a potential therapeutic target for vascular proliferative diseases.
BRITISH JOURNAL OF PHARMACOLOGY
(2021)
Review
Pharmacology & Pharmacy
Gabriel Hoi-Huen Chan, Enoch Chan, Carsten Tsun-Ka Kwok, George Pak-Heng Leung, Simon Ming-Yuen Lee, Sai-Wang Seto
Summary: Ageing is a risk factor for degenerative diseases, including cardiovascular diseases. The tumor suppressor gene p53 may play a regulatory role in vascular remodeling, atherosclerosis, and pulmonary hypertension. Further studies are needed to fully understand the effects of p53 in cardiovascular function and its therapeutic potential.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Medicine, Research & Experimental
Yarong Liu, Aiwei Song, Hongfei Wu, Yin Sun, Min Dai
Summary: Paeonol induces autophagy in VSMCs by activating the III class PI3K/Beclin-1 signaling pathway, ultimately inhibiting VSMCs apoptosis.
Article
Medicine, Research & Experimental
Yongji Yan, Xujie Liu, Xuanchen Li, Xuan Zhou, Chaozhi Yang, Jintao Tian, Jun Pu, Xiaoqun Niu
Summary: The study found that fibulin-5 inhibits aldosterone-induced apoptosis in HA-VSMC cells, and this effect is influenced by the concentration of aldosterone.
EXPERIMENTAL AND THERAPEUTIC MEDICINE
(2021)
Article
Biotechnology & Applied Microbiology
Xuelin Zhang, Yang Che, Lin Mao, Dandan Li, Jianqing Deng, Yilong Guo, Quanyi Zhao, Xingzhong Zhang, Li Wang, Xiang Gao, Yinan Chen, Tao Zhang
Summary: This study reveals the important role of histone variant H3.3B in aortic dissection by regulating gene expression and influencing the phenotype transition of vascular smooth muscle cells.
Review
Cardiac & Cardiovascular Systems
Mandy O. J. Grootaert, Martin R. Bennett
Summary: Vascular smooth muscle cells play a key role in atherosclerosis by forming a protective fibrous cap and exhibiting various phenotypes that can affect plaque formation and stability. They are a larger proportion of atherosclerotic plaques than previously thought and their plasticity is regulated by various mechanisms.
CARDIOVASCULAR RESEARCH
(2021)
Article
Medicine, Research & Experimental
Yueyue Yang, Lianhong Yin, Manning Zhu, Shasha Song, Changjie Sun, Xu Han, Youwei Xu, Yanyan Zhao, Yan Qi, Lina Xu, J-Y Peng
Summary: Dioscin attenuates PAH by adjusting the GRB2/ERK/PI3K-AKT signal pathway to inhibit PASMCs proliferation and migration, promote apoptosis, and may be developed as a therapeutic strategy for treating PAH in the future.
BIOMEDICINE & PHARMACOTHERAPY
(2021)
Article
Cardiac & Cardiovascular Systems
Lingfeng Luo, Yujun Cai, Yishuai Zhang, Chia G. Hsu, Vyacheslav A. Korshunov, Xiaochun Long, Peter A. Knight, Bradford C. Berk, Chen Yan
Summary: The study revealed that PDE10A contributes to SMC proliferation and intimal hyperplasia by antagonizing the CNP/NPR2/cGMP/PKG1alpha signaling pathway, suggesting that PDE10A may be a novel drug target for treating vascular occlusive disease.
CARDIOVASCULAR RESEARCH
(2022)
Article
Respiratory System
Mingzhou Guo, Mengzhe Zhang, Xiaopei Cao, Xiaoyu Fang, Ke Li, Lu Qin, Yuanzhou He, Jianping Zhao, Yongjian Xu, Xiansheng Liu, Xiaochen Li
Summary: This study reveals the important role of the Notch4-ERK/JNK/P38 MAPK axis in hypoxic pulmonary remodeling. Increased expression of Notch4 promotes proliferation and migration of HPASMCs and inhibits apoptosis through the ERK, JNK, and P38 signaling pathways. Silencing Notch4 partially alleviates the increase in RVSP and pulmonary vascular remodeling caused by hypoxia. These findings provide a potential therapeutic target for patients with HPH.
RESPIRATORY RESEARCH
(2022)
Review
Developmental Biology
Arndt F. Siekmann
Summary: This review discusses the functions of vascular mural cells in blood vessel formation and diameter regulation, as well as their interactions with endothelial cells. It also introduces the signaling pathways controlling mural cell development and highlights distinguishing features of mural cells located on different types of blood vessels. Therapeutic strategies involving mural cells to improve tissue ischemia and vascular efficiency in various diseases are explored.
Meeting Abstract
Biochemistry & Molecular Biology
Ross Feldman, Qingming Ding, Jozef Chorazyczewski, Robert Gros
Meeting Abstract
Biochemistry & Molecular Biology
Paulina Kowalewska, Maria Sancho, Sergio Fabris, Murray Huff, Robert Gros, Donald Welsh
Article
Cell Biology
Jacquelyn S. Brandenburg, Ross M. Clark, Brittany Coffman, Geetanjali Sharma, Helen J. Hathaway, Eric R. Prossnitz, Thomas R. Howdieshell
WOUND REPAIR AND REGENERATION
(2020)
Article
Immunology
Srijana Pokhrel, Kathleen D. Triplett, Seth M. Daly, Jason A. Joyner, Geetanjali Sharma, Helen J. Hathaway, Eric R. Prossnitz, Pamela R. Hall
JOURNAL OF IMMUNOLOGY
(2020)
Article
Immunology
Ioannis Karagiannidis, Stephanie J. Jerman, Damian Jacenik, Brandon B. Phinney, Ruoxin Yao, Eric R. Prossnitz, Ellen J. Beswick
FRONTIERS IN IMMUNOLOGY
(2020)
Review
Cell Biology
Richard A. Pepermans, Geetanjali Sharma, Eric R. Prossnitz
Summary: Estrogen plays crucial roles in various cancers, metabolism, and immune regulation. The G protein-coupled estrogen receptor (GPER) has been found to contribute to endocrine therapy resistance in breast cancer and has potential therapeutic value in targeting other diseases such as obesity and diabetes. Ongoing clinical trials are exploring the use of GPER-selective agonists like G-1 in combination with immune checkpoint inhibition for cancer treatment.
Article
Oncology
Hugo Arias-Pulido, Ashley Marie Cimino-Mathews, Nabila Chaher, Clifford Ray Qualls, Nancy Joste, Cecile Colpaert, Jonathan Douglas Marotti, Mary Dickinson Chamberlin, Maxwell Gabriel Foisey, Eric Robert Prossnitz, Leisha Ann Emens, Steven Fiering
Summary: This study evaluated epidemiologic and immune factors associated with pCR, BCSS, and DFS outcomes in IBC and LABC patients. High TILs, PD-L1(+) carcinoma cells, and combined CD20(+) and PD-L1(+) carcinoma cells were correlated with pCR in both IBC and LABC patients, with pCR correlating with improved BCSS and DFS outcomes.
BREAST CANCER RESEARCH AND TREATMENT
(2021)
Article
Pharmacology & Pharmacy
Stephen P. H. Alexander, Arthur Christopoulos, Anthony P. Davenport, Eamonn Kelly, Alistair Mathie, John A. Peters, Emma L. Veale, Jane F. Armstrong, Elena Faccenda, Simon D. Harding, Adam J. Pawson, Christopher Southan, Jamie A. Davies, Maria Pia Abbracchio, Wayne Alexander, Khaled Al-hosaini, Magnus Baeck, Nicholas M. Barnes, Ross Bathgate, Jean-Martin Beaulieu, Kenneth E. Bernstein, Bernhard Bettler, Nigel J. M. Birdsall, Victoria Blaho, Francois Boulay, Corinne Bousquet, Hans Braeuner-Osborne, Geoffrey Burnstock, Girolamo Calo, Justo P. Castano, KevinJ Catt, Stefania Ceruti, Paul Chazot, Nan Chiang, Bice Chini, Jerold Chun, Antonia Cianciulli, Olivier Civelli, Lucie H. Clapp, Rejean Couture, Zsolt Csaba, Claes Dahlgren, Gordon Dent, Khuraijam Dhanachandra Singh, Steven D. Douglas, Pascal Dournaud, Satoru Eguchi, Emanuel Escher, Edward J. Filardo, Tung Fong, Marta Fumagalli, Raul R. Gainetdinov, Marc de Gasparo, Craig Gerard, Marvin Gershengorn, Fernand Gobeil, Theodore L. Goodfriend, Cyril Goudet, Karen J. Gregory, Andrew L. Gundlach, Joerg Hamann, Julien Hanson, Richard L. Hauger, Debbie L. Hay, Akos Heinemann, Morley D. Hollenberg, Nicholas D. Holliday, Mastgugu Horiuchi, Daniel Hoyer, Laszlo Hunyady, Ahsan Husain, Adriaan P. IJzerman, Tadashi Inagami, Kenneth A. Jacobson, Robert T. Jensen, Ralf Jockers, Deepa Jonnalagadda, Sadashiva Karnik, Klemens Kaupmann, Jacqueline Kemp, Charles Kennedy, Yasuyuki Kihara, Takio Kitazawa, Pawel Kozielewicz, Hans-Juergen Kreienkamp, Jyrki P. Kukkonen, Tobias Langenhan, Katie Leach, Davide Lecca, John D. Lee, Susan E. Leeman, Jerome Leprince, Xaria X. Li, Tom Lloyd Williams, Stephen J. Lolait, Amelie Lupp, Robyn Macrae, Janet Maguire, Jean Mazella, Craig A. McArdle, Shlomo Melmed, Martin C. Michel, Laurence J. Miller, Vincenzo Mitolo, Bernard Mouillac, Christa E. Mueller, Philip Murphy, Jean-Louis Nahon, Tony Ngo, Xavier Norel, Duuamene Nyimanu, Anne-Marie Ocarroll, Stefan Offermanns, Maria Antonietta Panaro, Marc Parmentier, Roger G. Pertwee, Jean-Philippe Pin, Eric R. Prossnitz, Mark Quinn, Rithwik Ramachandran, Manisha Ray, Rainer K. Reinscheid, Philippe Rondard, G. Enrico Rovati, Chiara Ruzza, Gareth J. Sanger, Torsten Schoeneberg, Gunnar Schulte, Stefan Schulz, Deborah L. Segaloff, Charles N. Serhan, Leigh A. Stoddart, Yukihiko Sugimoto, Roger Summers, Valerie P. Tan, David Thal, Walter (Wally) Thomas, PieterB M. W. M. Timmermans, Kalyan Tirupula, Giovanni Tulipano, Hamiyet Unal, Thomas Unger, Celine Valant, Patrick Vanderheyden, David Vaudry, Hubert Vaudry, Jean-Pierre Vilardaga, Christopher S. Walker, Ji Ming Wang, Donald T. Ward, Hans-Juergen Wester, Gary B. Willars, Trent M. Woodruff, Chengcan Yao, Richard D. Ye
Summary: The Concise Guide to PHARMACOLOGY 2021/22 presents concise overviews of nearly 1900 human drug targets with an emphasis on selective pharmacology, along with links to a more detailed knowledgebase. It serves as a permanent, citable record for researchers, providing useful information in the field of pharmacology.
BRITISH JOURNAL OF PHARMACOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Matthias Barton, Daniel E. Frigo, Zeynep Madak-Erdogan, Franck Mauvais-Jarvis, Eric R. Prossnitz
Article
Endocrinology & Metabolism
C. Brent Wakefield, Vanessa R. Lee, Danielle Johnston, Parastoo Boroumand, Nicolas J. Pillon, Samar Sayedyahossein, Brooke L. O'Donnell, Justin Tang, Rafael E. Sanchez-Pupo, Kevin J. Barr, Robert Gros, Lauren Flynn, Nica M. Borradaile, Amira Klip, Frank Beier, Silvia Penuela
Summary: PANX3 expression in male adult mouse adipose tissue may regulate adipocyte numbers, influencing fat accumulation and inflammation. Male KO mice fed a chow diet had lower body weight and lower fat mass, reduced to the same extent as WT mice with forced exercise, suggesting a potential role of PANX3 in regulating body weight. Additionally, KO mice exhibited a more anti-inflammatory phenotype on a high-fat diet compared to WT mice, with significantly lower expression of multiple pro-inflammatory genes in white adipose tissue.
INTERNATIONAL JOURNAL OF OBESITY
(2022)
Article
Pharmacology & Pharmacy
Qingming Ding, Jozef Chorazyczewski, Robert Gros, Harvey J. Motulsky, Lee E. Limbird, Ross D. Feldman
Summary: By studying the ability of aldosterone to compete for the binding of [H-3] 2-methoxyestradiol ([H-3] 2-ME), a high potency GPER-selective agonist, we confirm the direct interaction between aldosterone and G protein-coupled estrogen receptors (GPER). This finding supports the explanation that aldosterone mediates its GPER-dependent effects through direct binding to GPER.
PHARMACOLOGY RESEARCH & PERSPECTIVES
(2022)
Article
Cardiac & Cardiovascular Systems
Julia M. Assini, Justin R. Clark, Amer Youssef, Chuce Xing, Alexandria M. Doerfler, So Hyun Park, Lavanya Saxena, Adam B. Yaseen, Jan Boren, Robert Gros, Gang Bao, William R. Lagor, Michael B. Boffa, Marlys L. Koschinsky
Summary: Lp(a) has been shown to contribute to the development of more severe atherosclerotic lesions, especially in female mice. This suggests a potential pro-inflammatory role of Lp(a) in atherosclerosis.
Review
Endocrinology & Metabolism
Eric R. Prossnitz, Matthias Barton
Summary: Oestrogens and their receptors have a significant impact on physiology and diseases, including the protection against various diseases in women. GPER, as a 7-transmembrane G protein-coupled receptor, plays a role in rapid signaling and transcriptional regulation. The research on GPER is important for understanding physiology, diseases, and potential therapeutic targets and prognostic indicators.
NATURE REVIEWS ENDOCRINOLOGY
(2023)
Article
Clinical Neurology
Liliana German-Castelan, Hayley R. C. Shanks, Robert Gros, Takashi Saito, Takaomi C. Saido, Lisa M. Saksida, Timothy J. Bussey, Marco A. M. Prado, Taylor W. Schmitz, Vania F. Prado
Summary: The relationship between cholinergic signaling and amyloid pathology in Alzheimer's Disease (AD) is causally modulated by biological sex, as observed in male mice and ovariectomized female mice. However, this relationship is decoupled in ovary-intact and ovariectomized females receiving estradiol. In elderly individuals, cholinergic loss exacerbates amyloid beta (A beta).
ALZHEIMERS & DEMENTIA
(2023)
Article
Medicine, Research & Experimental
Daniela Staquicini, E. Magda Barbu, Rachel L. Zemans, Beth K. Dray, Fernanda Staquicini, Prashant Dogra, Marina Cardo-Vila, Cindy K. Miranti, Wallace B. Baze, Luisa L. Villa, Jorge Kalil, Geetanjali Sharma, Eric R. Prossnitz, Zhihui Wang, Vittorio Cristini, Richard L. Sidman, Andrew R. Berman, Reynold A. Panettieri, Rubin M. Tuder, Renata Pasqualini, Wadih Arap
Summary: This study utilized the lungs as a route for drug delivery and developed a method for systemic immune targeting vaccination through ligand-directed pulmonary delivery. By screening a phage display peptide library, a specific targeting ligand was identified, leading to successful pulmonary delivery of targeted phage particles in animals, eliciting systemic and specific immune responses.