Review
Biochemistry & Molecular Biology
Hussein F. Sakr, Srinivasa Rao Sirasanagandla, Srijit Das, Abdulhadi I. Bima, Ayman Z. Elsamanoudy
Summary: Factors such as aging, unhealthy lifestyle, snacking, a Western diet, and smoking contribute to high blood pressure and increase the risk of heart disease. A low-carbohydrate, high-fat diet can improve insulin sensitivity, reduce atherosclerosis risk factors, and help control blood pressure. This review emphasizes the importance of lifestyle changes and the potential benefits of the LCHF diet in managing hypertension and reducing the need for medication.
Review
Biochemistry & Molecular Biology
Veronica Maria Tagi, Francesca Mainieri, Francesco Chiarelli
Summary: Insulin resistance is a major factor contributing to the development of hypertension in patients with diabetes. Several pathways are involved in this mechanism. Guidelines specifically addressing the treatment of hypertension in children with diabetes have been published recently.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Endocrinology & Metabolism
Kai-Yue Han, Jianing Gu, Zhangsheng Wang, Jie Liu, Su Zou, Chen-Xi Yang, Dan Liu, Yingjia Xu
Summary: The study found a significant association between METS-IR levels and pre-hypertension or hypertension in normoglycemia individuals in Japan. For each 1 unit increase in METS-IR, there was a 7% increase in pre-hypertension prevalence and a 13% increase in hypertension prevalence. These findings suggest that METS-IR may be a useful monitoring indicator for developing primary prevention and management strategies for hypertension in the future.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Pharmacology & Pharmacy
Yang Liu, Liang-Liang Tang, Chen Liang, Ming-Ming Wu, Zhi-Ren Zhang
Summary: Antiangiogenic tyrosine kinase inhibitors like sunitinib induce hypertension by causing vascular dysfunction and insulin resistance, leading to decreased endothelium-dependent relaxation and inhibition of AKT/eNOS/NO signaling. This study in rats showed that sunitinib administration resulted in elevated blood pressure, abnormal metabolism, and hormone levels, providing insights into the mechanisms underlying sunitinib-induced endothelial dysfunction and hypertension.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Peripheral Vascular Disease
James M. Luther, Dawei S. Wei, Kakali Ghoshal, Dungeng Peng, Gail K. Adler, Adina F. Turcu, Hui Nian, Chang Yu, Carmen C. Solorzano, Ambra Pozzi, Nancy J. Brown
Summary: Epoxyeicosatrienoic acids (EETs) are lipid signaling molecules generated by the action of CYP450s, with vasodilatory, anti-inflammatory, and insulin-enhancing effects. Treatment of primary aldosteronism led to an increase in EET concentrations, particularly 14,15-DHETs.
Review
Cell Biology
Daniela Sorriento, Maria Rosaria Rusciano, Valeria Visco, Antonella Fiordelisi, Federica Andrea Cerasuolo, Paolo Poggio, Michele Ciccarelli, Guido Iaccarino
Summary: Insulin resistance is a pathophysiological condition associated with obesity, glucose intolerance, dyslipidemia, and hypertension, leading to type 2 diabetes and cardiovascular diseases. Studies have identified G Protein Coupled Receptor Kinase type 2 (GRK2) as a potential therapeutic target for insulin resistance and its associated phenotypes.
Article
Peripheral Vascular Disease
James M. Luther, Justina Ray, Dawei Wei, John R. Koethe, Latoya Hannah, Anthony DeMatteo, Robert Manning, Andrew S. Terker, Dungeng Peng, Hui Nian, Chang Yu, Mona Mashayekhi, Jorge Gamboa, Nancy J. Brown
Summary: The use of the sEH inhibitor GSK2256294 for 7 days effectively inhibits sEH activity in plasma, muscle, and adipose tissue, reducing the level of F2-isoprostanes. However, it does not improve insulin sensitivity or blood pressure.
Article
Peripheral Vascular Disease
Odayme Quesada, Brian Claggett, Fatima Rodriguez, Jianwen Cai, Ashley E. Moncrieft, Karin Garcia, Marina Del Rios Rivera, David B. Hanna, Martha L. Daviglus, Gregory A. Talavera, C. Noel Bairey Merz, Scott D. Solomon, Susan Cheng, Natalie A. Bello
Summary: In a study of Hispanic/Latino adults without diabetes or taking antihypertensive medications, insulin resistance was found to be positively associated with both systolic and diastolic blood pressure. The association between insulin resistance and systolic blood pressure was linear in men but nonlinear in women. Prediabetes status did not significantly affect the association between insulin resistance and blood pressure.
Article
Cardiac & Cardiovascular Systems
Zegui Huang, Xiong Ding, Qing Yue, Xianxuan Wang, Zekai Chen, Zefeng Cai, Weijian Li, Zhiwei Cai, Guanzhi Chen, Yulong Lan, Weiqiang Wu, Shouling Wu, Youren Chen
Summary: This study investigated the association between TyG index trajectory and stroke risk among hypertensive patients. The findings suggest that a long-term elevated TyG index is associated with an increased risk of stroke, especially ischemic stroke, in hypertensive patients.
CARDIOVASCULAR DIABETOLOGY
(2022)
Article
Peripheral Vascular Disease
Bo Li, Cong Hou, Lianxia Li, Ming Li, Shan Gao
Summary: This study aimed to assess the associations between hypertension and four adipokine levels in Chinese youth, and to examine the extent to which these associations are mediated by insulin resistance (IR). The results showed that youth with hypertension had lower adiponectin and higher leptin, FGF21, and RBP4 levels. The coexistence of multiple abnormal adipokine levels increased the risk of hypertension, and the associations between adipokines and hypertension were mediated by IR.
HYPERTENSION RESEARCH
(2023)
Article
Cardiac & Cardiovascular Systems
Jie Fan, Lian Yong Liu, Xing Zhen Liu
Summary: The study found that fasting insulin negatively moderated the association between insulin resistance (IR) and blood pressure, suggesting that hyperinsulinemia may buffer the effect of IR on hypertension.
NUTRITION METABOLISM AND CARDIOVASCULAR DISEASES
(2021)
Article
Medicine, Research & Experimental
Maryam Farahmand, Maryam Rahmati, Fereidoun Azizi, Fahimeh Ramezani Tehrani
Summary: This study compared the effect of breastfeeding (BF) in women with and without gestational diabetes mellitus (GDM) on metabolic syndrome (MetS) incidence. The findings showed that BF, especially exclusive BF, has a protective effect on MetS incidence risk, and it is more effective in reducing the risk of MetS among women with a history of GDM.
JOURNAL OF TRANSLATIONAL MEDICINE
(2023)
Article
Cardiac & Cardiovascular Systems
Liao Tan, Yubo Liu, Jie Liu, Guogang Zhang, Zhaoya Liu, Ruizheng Shi
Summary: This study found a positive association between elevated levels of the TyG index and the prevalence of uncontrolled hypertension and arterial stiffness among US adults with hypertension.
CARDIOVASCULAR DIABETOLOGY
(2023)
Review
Biochemistry & Molecular Biology
Sok Kuan Wong, Fitri Fareez Ramli, Adli Ali, Nurul Izzah Ibrahim
Summary: Metabolic syndrome is a cluster of metabolic dysregulations, including insulin resistance, obesity, hypertension, and dyslipidemia. This review summarizes the genetic information of cholesterol-related genes in metabolic syndrome, which may potentially serve as biomarkers for early prevention and management of the syndrome.
Review
Plant Sciences
Tia D. Jeffery, Matthew L. Richardson
Summary: The study reviewed the effectiveness of hibiscus in improving biomarkers of metabolic syndrome, finding significant benefits in blood glucose, cholesterol, weight, and blood pressure, and in some cases hibiscus was more effective than pharmaceuticals.
JOURNAL OF ETHNOPHARMACOLOGY
(2021)
Editorial Material
Urology & Nephrology
C. John Sperati, Adam Whaley-Connell
ADVANCES IN CHRONIC KIDNEY DISEASE
(2015)
Article
Urology & Nephrology
Akhilesh Rao, Vishwam Pandya, Adam Whaley-Connell
ADVANCES IN CHRONIC KIDNEY DISEASE
(2015)
Article
Urology & Nephrology
Sivakumar Ardhanari, Rohini Kannuswamy, Kunal Chaudhary, Warren Lockette, Adam Whaley-Connell
ADVANCES IN CHRONIC KIDNEY DISEASE
(2015)
Editorial Material
Urology & Nephrology
Sankar D. Navaneethan, Adam Whaley-Connell
CLINICAL JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY
(2015)
Article
Urology & Nephrology
David J. Leehey, Jane H. Zhang, Nicholas V. Emanuele, Adam Whaley-Connell, Paul M. Palevsky, Robert F. Reilly, Peter Guarino, Linda F. Fried
CLINICAL JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY
(2015)
Editorial Material
Urology & Nephrology
C. John Sperati, Adam Whaley-Connell
CURRENT OPINION IN NEPHROLOGY AND HYPERTENSION
(2015)
Article
Peripheral Vascular Disease
Guanghong Jia, Javad Habibi, Vincent G. DeMarco, Luis A. Martinez-Lemus, Lixin Ma, Adam T. Whaley-Connell, Annayya R. Aroor, Timothy L. Domeier, Yi Zhu, Gerald A. Meininger, Katelee Barrett Mueller, Iris Z. Jaffe, James R. Sowers
Article
Peripheral Vascular Disease
Vincent G. DeMarco, Javad Habibi, Guanghong Jia, Annayya R. Aroor, Francisco I. Ramirez-Perez, Luis A. Martinez-Lemus, Shawn B. Bender, Mona Garro, Melvin R. Hayden, Zhe Sun, Gerald A. Meininger, Camila Manrique, Adam Whaley-Connell, James R. Sowers
Editorial Material
Peripheral Vascular Disease
Adam Whaley-Connell, James R. Sowers
JOURNAL OF CLINICAL HYPERTENSION
(2016)
Editorial Material
Peripheral Vascular Disease
Adam Whaley-Connell, James R. Sowers
Article
Endocrinology & Metabolism
J. A. Kanaley, T. D. Heden, Y. Liu, A. T. Whaley-Connell, A. Chockalingam, K. C. Dellsperger, T. J. Fairchild
INTERNATIONAL JOURNAL OF OBESITY
(2014)
Editorial Material
Peripheral Vascular Disease
Adam Whaley-Connell, James R. Sowers
JOURNAL OF THE AMERICAN SOCIETY OF HYPERTENSION
(2014)
Article
Urology & Nephrology
Manjula Kurella Tamura, Suying Li, Shu-Cheng Chen, Kerri L. Cavanaugh, Adam T. Whaley-Connell, Peter A. McCullough, Rajnish L. Mehrotra
KIDNEY INTERNATIONAL
(2014)
Article
Multidisciplinary Sciences
Shanyan Chen, Fanjun Meng, Zhenzhou Chen, Brittany N. Tomlinson, Jennifer M. Wesley, Grace Y. Sun, Adam T. Whaley-Connell, James R. Sowers, Jiankun Cui, Zezong Gu
Article
Peripheral Vascular Disease
Guanghong Jia, Javad Habibi, Brian P. Bostick, Lixin Ma, Vincent G. DeMarco, Annayya R. Aroor, Melvin R. Hayden, Adam T. Whaley-Connell, James R. Sowers
