Article
Chemistry, Medicinal
Majid Karandish, Hassan Mozaffari-Khosravi, Seyed Mohammad Mohammadi, Bahman Cheraghian, Maryam Azhdari
Summary: Management of prediabetes is crucial in preventing type-2 diabetes. This clinical trial examined the effects of curcumin and zinc supplementation on glycemic parameters, showing improvements in fasting plasma glucose, 2-hour postprandial glucose, HbA1C, insulin sensitivity, and insulin resistance. Dietary intake, physical activity, weight, and beta-cell function did not significantly differ among the groups after the intervention.
PHYTOTHERAPY RESEARCH
(2021)
Article
Biochemistry & Molecular Biology
Tatiana Ivanova, Maria Churnosova, Maria Abramova, Denis Plotnikov, Irina Ponomarenko, Evgeny Reshetnikov, Inna Aristova, Inna Sorokina, Mikhail Churnosov
Summary: The aim of the study was to investigate the sex-specific features of the correlation between GWAS-significant polymorphisms and HTN. The study found differences in the involvement of HTN-associated SNPs between men and women in European subjects of Russia. BP/HTN-related genes and SNPs were characterized by pronounced polyvector functionality in both men and women, with immune mechanisms being the main signaling pathways.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Peripheral Vascular Disease
Orna Reges, Amy E. Krefman, Shakia T. Hardy, Yuichiro Yano, Paul Muntner, Lindsay R. Pool, Penny Gordon-Larsen, Yaojie Wang, Donald M. Lloyd-Jones, Norrina B. Allen
Summary: This study aimed to assess the associations between age-related blood pressure slope and demographic, clinical, behavioral, psychosocial, and neighborhood characteristics in different race-sex groups. The results showed that there were variations in blood pressure increases among different groups, and these increases were associated with various factors.
Article
Peripheral Vascular Disease
Guoying Wang, Jessie P. Buckley, Tami R. Bartell, Xiumei Hong, Colleen Pearson, Xiaobin Wang
Summary: This study found that cord blood insulin concentration is associated with the occurrence of hypertension in childhood. Fetuses with higher blood insulin concentration are more likely to develop hypertension later in life. Elevated cord blood insulin concentration beyond the normal range may increase the risk of hypertension.
Article
Peripheral Vascular Disease
Han Ma, Fangchao Liu, Jianxin Li, Jichun Chen, Jie Cao, Shufeng Chen, Xiaoqing Liu, Xueli Yang, Keyong Huang, Chong Shen, Ling Yu, Yingxin Zhao, Xianping Wu, Liancheng Zhao, Ying Li, Dongsheng Hu, Jianfeng Huang, Xiangfeng Lu, Dongfeng Gu
Summary: Based on a study conducted in China, the association between socioeconomic status (SES) and hypertension remains uncertain. Individuals with lower SES are at a higher risk of developing hypertension compared to those with higher SES. Moreover, women are more susceptible to the adverse effects of lower SES on hypertension.
Review
Plant Sciences
Tia D. Jeffery, Matthew L. Richardson
Summary: The study reviewed the effectiveness of hibiscus in improving biomarkers of metabolic syndrome, finding significant benefits in blood glucose, cholesterol, weight, and blood pressure, and in some cases hibiscus was more effective than pharmaceuticals.
JOURNAL OF ETHNOPHARMACOLOGY
(2021)
Article
Peripheral Vascular Disease
Zeinab Bidel, Milad Nazarzadeh, Dexter Canoy, Emma Copland, Eva Gerdts, Mark Woodward, Ajay K. Gupta, Christopher M. Reid, William C. Cushman, Kristian Wachtell, Koon Teo, Barry R. Davis, John Chalmers, Carl J. Pepine, Kazem Rahimi
Summary: The effects of blood pressure-lowering treatment on cardiovascular outcomes do not differ by sex, regardless of baseline blood pressure levels and age categories.
Article
Peripheral Vascular Disease
Nobuo Sasaki, Ryo Maeda, Ryoji Ozono, Kenichi Yoshimura, Yukiko Nakano, Yukihito Higashi
Summary: This study found that adipose tissue insulin resistance is associated with blood pressure and hypertension incidence. Compared with hepatic and skeletal muscle insulin resistance, adipose tissue insulin resistance has a stronger impact on the risk of hypertension.
HYPERTENSION RESEARCH
(2022)
Article
Peripheral Vascular Disease
Nobuo Sasaki, Ryo Maeda, Ryoji Ozono, Kenichi Yoshimura, Yukiko Nakano, Yukihito Higashi
Summary: This study investigated the association of insulin resistance in different tissues with blood pressure and hypertension incidence. The findings suggest that insulin resistance is associated with blood pressure control regardless of the tissue in which it occurs, but the risk of hypertension is determined by insulin resistance in adipose tissue rather than in liver or muscle tissue.
HYPERTENSION RESEARCH
(2022)
Article
Medicine, General & Internal
Valentino Condoleo, Raffaele Maio, Velia Cassano, Leonilde Bonfrate, Corrado Pelaia, Giuseppe Armentaro, Sofia Miceli, Teresa Vanessa Fiorentino, Maria Perticone, Elena Succurro, Francesco Andreozzi, Giorgio Sesti, Angela Sciacqua
Summary: This study demonstrates an association between circadian blood pressure pattern and altered glycemic response during OGTT in newly diagnosed hypertensive patients, particularly in subjects with blood glucose levels >= 155, who are more likely to exhibit a non-dipper blood pressure pattern.
INTERNAL AND EMERGENCY MEDICINE
(2023)
Article
Pharmacology & Pharmacy
Valentina Trimarco, Raffaele Izzo, Pasquale Mone, Maria Lembo, Maria Virginia Manzi, Daniela Pacella, Angela Falco, Paola Gallo, Giovanni Esposito, Carmine Morisco, Gaetano Santulli, Bruno Trimarco
Summary: Therapeutic concordance significantly improves the outcome of antihypertensive treatment in patients with therapy-resistant hypertension.
PHARMACOLOGICAL RESEARCH
(2023)
Article
Chemistry, Medicinal
Ji-Su Kim, Hyun-Ju Kim, Eun-Byeol Lee, Ji-Hye Choi, Jieun Jung, Hwan-Hee Jang, Shin-Young Park, Ki-Chan Ha, Yu-Kyung Park, Jong-Cheon Joo, Sung-Hyen Lee
Summary: This study investigated the effects of Allium hookeri (AH) on glycemia in prediabetic subjects. The results showed that AH supplementation moderately reduced blood glucose and insulin levels, and improved insulin sensitivity.
Article
Endocrinology & Metabolism
Delia Almeida Gonzalez, Maria del Cristo Rodriguez-Perez, Manuel Fuentes Ferrer, Francisco Javier Cuevas Fernandez, Itahisa Mercelino Rodriguez, Antonio Cebrera de Leon
Summary: This study aimed to evaluate the cardiovascular protective role of irisin in the general population. A cross-sectional analysis was conducted on a large sample, and the results showed that irisin was associated with factors such as heart rate, blood pressure, body mass index, and lifestyle. These findings suggest that irisin plays a protective role in maintaining cardiometabolic health.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Review
Biochemistry & Molecular Biology
Elena Barbu, Mihaela-Roxana Popescu, Andreea-Catarina Popescu, Serban-Mihai Balanescu
Summary: There is still controversy surrounding the precise characterization of prediabetes, with the need to phenotype the population for better risk assessment and prevention. Inflammation is a common denominator in prediabetes and its associated risk factors.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Multidisciplinary Sciences
Jung Hyun Kwak, Yoon-Hyeong Choi
Summary: The study found an inverse association between vitamin D concentration and the risk of high pulse pressure, especially showing a dose-dependent relationship in females and non-overweight individuals.
SCIENTIFIC REPORTS
(2021)
Article
Biology
Feifei Yan, Yanyan Liu, Jianwen Cai, Haibo Zhou
Summary: An estimated quadratic inference function method is proposed for correlated failure time data with auxiliary covariates. The method efficiently utilizes auxiliary information and can handle large cluster sizes. A chi-squared test based on the estimated quadratic inference function is also proposed. Simulation studies validate the small-sample performance of the method. The method is applied to analyze real data as an illustration.
Article
Biology
Dasom Lee, Shu Yang, Lin Dong, Xiaofei Wang, Donglin Zeng, Jianwen Cai
Summary: This study proposes a calibration weighting estimator that combines the complementary features of randomized controlled trials and observational studies to estimate the average treatment effect of a target population. By utilizing semiparametric efficiency theory, a doubly robust augmented calibration weighting estimator is derived, achieving the efficiency bound under the identification assumptions. Additionally, a nonparametric sieve method is provided as an alternative to the parametric approach for robust approximation of the nuisance functions and data-adaptive selection of outcome predictors for calibration.
Editorial Material
Cardiac & Cardiovascular Systems
Marina Del Rios, Brahmajee K. Nallamothu, Paul S. Chan
CIRCULATION-CARDIOVASCULAR QUALITY AND OUTCOMES
(2023)
Editorial Material
Critical Care Medicine
Sarah M. Perman, Melissa A. Vogelsong, Marina Del Rios
Article
Anesthesiology
Aditya C. Shekhar, Ryan A. Coute, Timothy J. Mader, Marina Del Rios, Katherine R. Peeler, N. Clay Mann, Manu Madhok
Summary: This study investigates disparities in endotracheal intubation success rates among infants experiencing out-of-hospital cardiac arrest (OHCA) based on race/ethnicity and sex. Analyzing data from a national-level registry, the study finds that white infants have higher success rates compared to Black or African American infants and Hispanic/Latino infants. Female infants also show slightly higher success rates than male infants. These findings highlight important demographic disparities in infant OHCA resuscitation and call for further research to identify the underlying reasons and develop strategies to eliminate these disparities.
TRENDS IN ANAESTHESIA AND CRITICAL CARE
(2023)
Review
Cardiac & Cardiovascular Systems
Daniel C. Schroeder, Federico Semeraro, Robert Greif, Janet Bray, Peter Morley, Michael Parr, Naomi Kondo Nakagawa, Taku Iwami, Simon-Richard Finke, Carolina Malta Hansen, Andrew Lockey, Marina Del Rios, Farhan Bhanji, Comilla Sasson, Stephen M. Schexnayder, Tommaso Scquizzato, Wolfgang A. Wetsch, Bernd W. Bottiger
Summary: Based on existing literature, schoolchildren show high motivation to learn basic life support. It is recommended to use the CHECK-CALL-COMPRESS algorithm for all students and provide regular training. Young children from 4 years old can assess the first links in the chain of survival, while older students can achieve effective chest compressions and ventilation volumes. A combination of theoretical and practical training is recommended, with schoolteachers serving as effective instructors.
Editorial Material
Critical Care Medicine
Marina Del Rios
Article
Medicine, General & Internal
Esther K. Choo, Matthew Strehlow, Marina Del Rios, Evrim Oral, Ruth Pobee, Andrew Nugent, Stephen Lim, Christian Hext, Sarah Newhall, Diana Ko, Srihari Chari, Amy Wilson, Joshua J. Baugh, David Callaway, Mucio Kit Delgado, Zoe Glick, Christian J. Graulty, Nicholas Hall, Abdusebur Jemal, Madhav Kc, Aditya Mahadevan, Milap Mehta, Andrew C. Meltzer, Dar'ya Pozhidayeva, Daniel Resnick-Ault, Christian Schulz, Sam Shen, Lauren Southerland, Daniel Du Pont, Danielle M. McCarthy
Summary: This study examined the operational approaches taken by US hospitals in response to the COVID-19 pandemic over a one-year period. The findings showed variation in strategy uptake over time, with some strategies related to geographic region and phase of the pandemic. The study identified commonly used and sustained strategies, such as limiting staff in COVID-19 rooms and increasing telehealth capacity, as well as strategies that were rarely used or not sustained, such as increasing hospital bed capacity.
Article
Critical Care Medicine
Pavitra Kotini-Shah, Nicole Blum, Shaveta Khosla, Joseph Weber, Eddie Markul, Katie Tataris, Teri Campbell, Terry Vanden Hoek, Marina Del Rios
Summary: The survival rate of out-of-hospital cardiac arrest (OHCA) varies widely across the United States. The impact of hospital OHCA volume and ST-elevation myocardial infarction (STEMI) Receiving Center (SRC) designation on survival is not fully understood.
RESUSCITATION PLUS
(2023)
Article
Biochemistry & Molecular Biology
Dalin Li, Ana Jimena Pavlovitch-Bedzyk, Joseph E. Ebinger, Abdul Khan, Mohamed Hamideh, Akil Merchant, Jane C. Figueiredo, Susan Cheng, Mark M. Davis, Dermot P. B. McGovern, Gil Y. Melmed, Alexander M. Xu, Jonathan Braun
Summary: Quantitative metrics for vaccine-induced T-cell responses are essential for developing protection correlates and their applications in vaccine-based medical management and public health. This study presents an untargeted private TCR method that measures breadth and depth of T-cell responses to vaccine challenge, providing antigen-agnostic and individual-autonomous vaccine-response metrics.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Cardiac & Cardiovascular Systems
Ryan Huebinger, Marina Del Rios, Benjamin S. Abella, Bryan McNally, Carrie Bakunas, Richard Witkov, Micah Panczyk, Eric Boerwinkle, Bentley Bobrow
Summary: This study evaluated the impact of receiving hospital on outcome disparities in out-of-hospital cardiac arrest patients. The results showed that patients in Black and Hispanic or Latino communities were less likely to be treated at higher-performing hospitals, and adjusting for receiving hospital improved outcome disparities in out-of-hospital cardiac arrest.
JOURNAL OF THE AMERICAN HEART ASSOCIATION
(2023)
Review
Immunology
Kimia Sobhani, Susan Cheng, Raquel A. Binder, Nicholas J. Mantis, James M. Crawford, Nkemakonam Okoye, Jonathan G. Braun, Sandy Joung, Minhao Wang, Gerard Lozanski, Christopher L. King, John D. Roback, Douglas A. Granger, Suresh B. Boppana, Amy B. Karger, Ralph A. Tripp
Summary: In this article, the established clinical use cases for SARS-CoV-2 antibody measures are reviewed, and the definition of an antibody correlate of protection (CoP) for SARS-CoV-2 is examined. The use of binding antibody tests and neutralization tests, as well as the considerations of antibody responses in different populations, vaccine types, and variants, are discussed. The importance of cellular immunity in the nature and durability of protection is also addressed.
Article
Biochemistry & Molecular Biology
Mona Alotaibi, Yunxian Liu, Gino A. Magalang, Alan C. Kwan, Joseph E. Ebinger, William C. Nichols, Michael W. Pauciulo, Mohit Jain, Susan Cheng
Summary: High-dimensional metabolomics analyses can identify convergent and divergent markers for diseases like pulmonary arterial hypertension (PAH). Both conventional and statistical learning techniques can provide concordant or discordant results, expanding the scientific yield of a study.
Review
Critical Care Medicine
Daniel C. Schroeder, Federico Semeraro, Robert Greif, Janet Bray, Peter Morley, Michael Parr, Naomi Kondo Nakagawa, Taku Iwami, Simon-Richard Finke, Carolina Malta Hansen, Andrew Lockey, Marina Del Rios, Farhan Bhanji, Comilla Sasson, Stephen M. Schexnayder, Tommaso Scquizzato, Wolfgang A. Wetsch, Bernd W. Boettiger, International Liaison Committee Resuscitation
Summary: Teaching schoolchildren basic life support is an effective way to increase bystander CPR rates. Students are motivated to learn and regular training consolidates long-term skills. Schoolteachers serve as effective instructors and social media tools can be used for teaching.
Article
Respiratory System
Hayley B. Gershengorn, Kelly C. Vranas, David Ouyang, Susan Cheng, Angela J. Rogers, Liana Schweiger, Colin R. Cooke, Christopher G. Slatore
Summary: The COVID-19 pandemic did not significantly impact the proportion of female authors in both COVID-19 and non-COVID-19 research. However, there were disparities in manuscript acceptance rates, with lower acceptance rates for non-COVID-19 manuscripts submitted during the COVID-19 era. This suggests the need for journals to address these disparities and for academic institutions to consider these findings in promotion decisions.
ANNALS OF THE AMERICAN THORACIC SOCIETY
(2023)
