Identification of seven genes essential for male fertility through a genome-wide association study of non-obstructive azoospermia and RNA interference-mediated large-scale functional screening in Drosophila

Obesity-associated variants within FTO form long-range functional connections with IRX3

(2014) Scott Smemo et al.   NATURE

Potential biomarkers of nonobstructive azoospermia identified in microarray gene expression analysis

(2013) Agnieszka Malcher et al.   FERTILITY AND STERILITY

Mutations ofNANOS1, a human homologue of theDrosophilamorphogen, are associated with a lack of germ cells in testes or severe oligo-astheno-teratozoospermia

(2013) Kamila Kusz-Zamelczyk et al.   JOURNAL OF MEDICAL GENETICS

Functional Knowledge Transfer for High-accuracy Prediction of Under-studied Biological Processes

(2013) Christopher Y. Park et al.   PLoS Computational Biology

Human Spermatogenic Failure Purges Deleterious Mutation Load from the Autosomes and Both Sex Chromosomes, including the Gene DMRT1

(2013) Alexandra M. Lopes et al.   PLoS Genetics

The receptor tyrosine phosphatase Lar regulates adhesion between Drosophila male germline stem cells and the niche

(2012) S. Srinivasan et al.   DEVELOPMENT

Differential confounding of rare and common variants in spatially structured populations

(2012) Iain Mathieson et al.   NATURE GENETICS

Systematic Localization of Common Disease-Associated Variation in Regulatory DNA

(2012) M. T. Maurano et al.   SCIENCE

Guidelines for Genome-Wide Association Studies

(2012) Gregory S. Barsh et al.   PLoS Genetics

The Drosophila Estrogen-Related Receptor Directs a Metabolic Switch that Supports Developmental Growth

(2011) Jason M. Tennessen et al.   Cell Metabolism

The stem cell niche: lessons from the Drosophila testis

(2011) M. de Cuevas et al.   DEVELOPMENT

What should the genome-wide significance threshold be? Empirical replication of borderline genetic associations

(2011) Orestis A Panagiotou et al.   INTERNATIONAL JOURNAL OF EPIDEMIOLOGY

Positive Regulation of Apoptosis Signal-regulating Kinase 1 Signaling by ZPR9 Protein, a Zinc Finger Protein

(2011) Hyun-A Seong et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

A genome-wide association study in Chinese men identifies three risk loci for non-obstructive azoospermia

(2011) Zhibin Hu et al.   NATURE GENETICS

A genome-scale shRNA resource for transgenic RNAi in Drosophila

(2011) Jian-Quan Ni et al.   NATURE METHODS

Germline Stem Cells

(2011) A. Spradling et al.   Cold Spring Harbor Perspectives in Biology

Dynein light chain 1 functions in somatic cyst cells regulate spermatogonial divisions in Drosophila

(2011) Prakash Joti et al.   Scientific Reports

Human Male Infertility Associated with Mutations in NR5A1 Encoding Steroidogenic Factor 1

(2010) Anu Bashamboo et al.   AMERICAN JOURNAL OF HUMAN GENETICS

Strategies for Genetic Studies of Complex Diseases

(2010) Kai Wang et al.   CELL

The Drosophila Female Germline Stem Cell Lineage Acts to Spatially Restrict DPP Function Within the Niche

(2010) M. Liu et al.   Science Signaling

Beyond genome-wide association studies: genetic heterogeneity and individual predisposition to cancer

(2010) Antonella Galvan et al.   TRENDS IN GENETICS

An Open Access Database of Genome-wide Association Results

(2009) Andrew D Johnson et al.   BMC Medical Genetics

Drosophila models of peroxisomal biogenesis disorder: peroxins are required for spermatogenesis and very-long-chain fatty acid metabolism

(2009) Haiyang Chen et al.   HUMAN MOLECULAR GENETICS

Yip1A regulates the COPI-independent retrograde transport from the Golgi complex to the ER

(2009) F. Kano et al.   JOURNAL OF CELL SCIENCE

YIPF5 and YIF1A recycle between the ER and the Golgi apparatus and are involved in the maintenance of the Golgi structure

(2008) Yumi Yoshida et al.   EXPERIMENTAL CELL RESEARCH

The biology of infertility: research advances and clinical challenges

(2008) Martin M Matzuk et al.   NATURE MEDICINE