Short non-coding RNA biology and neurodegenerative disorders: novel disease targets and therapeutics

The Bifunctional microRNA miR-9/miR-9* Regulates REST and CoREST and Is Downregulated in Huntington's Disease

(2009) A. N. Packer et al.   JOURNAL OF NEUROSCIENCE

Biogenesis of small RNAs in animals

(2009) V. Narry Kim et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

MicroRNA-like off-target transcript regulation by siRNAs is species specific

(2009) J. Burchard et al.   RNA

Variation in the miRNA-433 Binding Site of FGF20 Confers Risk for Parkinson Disease by Overexpression of α-Synuclein

(2008) Gaofeng Wang et al.   AMERICAN JOURNAL OF HUMAN GENETICS

Small-Molecule Inhibitors of MicroRNA miR-21 Function

(2008) Kiranmai Gumireddy et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

MicroRNAs: regulators of oncogenesis and stemness

(2008) Thales Papagiannakopoulos et al.   BMC Medicine

Introduction and Historical Background

(2008) Zissimos Mourelatos   BRAIN PATHOLOGY

MicroRNAs (miRNAs) in Neurodegenerative Diseases

(2008) Peter T. Nelson et al.   BRAIN PATHOLOGY

Getting to the Root of miRNA-Mediated Gene Silencing

(2008) Ana Eulalio et al.   CELL

Engineering and optimization of the miR-106b cluster for ectopic expression of multiplexed anti-HIV RNAs

(2008) L A Aagaard et al.   GENE THERAPY

DNA methylation of retrotransposon genes is regulated by Piwi family members MILI and MIWI2 in murine fetal testes

(2008) S. Kuramochi-Miyagawa et al.   GENES & DEVELOPMENT

Mouse ES cells express endogenous shRNAs, siRNAs, and other Microprocessor-independent, Dicer-dependent small RNAs

(2008) J. E. Babiarz et al.   GENES & DEVELOPMENT

Common variation in the miR-659 binding-site of GRN is a major risk factor for TDP43-positive frontotemporal dementia

(2008) Rosa Rademakers et al.   HUMAN MOLECULAR GENETICS

Dysregulation of miRNA 181b in the temporal cortex in schizophrenia

(2008) Natalie J. Beveridge et al.   HUMAN MOLECULAR GENETICS

MicroRNA-298 and MicroRNA-328 Regulate Expression of Mouse β-Amyloid Precursor Protein-converting Enzyme 1

(2008) Vincent Boissonneault et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Piecing Together the Mosaic of Early Mammalian Development through MicroRNAs

(2008) Adriana Blakaj et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Primary microRNA transcript retention at sites of transcription leads to enhanced microRNA production

(2008) Jan M. Pawlicki et al.   JOURNAL OF CELL BIOLOGY

Neurodegeneration and Motor Dysfunction in a Conditional Model of Parkinson's Disease

(2008) S. Nuber et al.   JOURNAL OF NEUROSCIENCE

Conditional Loss of Dicer Disrupts Cellular and Tissue Morphogenesis in the Cortex and Hippocampus

(2008) T. H. Davis et al.   JOURNAL OF NEUROSCIENCE

The Expression of MicroRNA miR-107 Decreases Early in Alzheimer's Disease and May Accelerate Disease Progression through Regulation of  -Site Amyloid Precursor Protein-Cleaving Enzyme 1

(2008) W.-X. Wang et al.   JOURNAL OF NEUROSCIENCE

Localization of Double-stranded Small Interfering RNA to Cytoplasmic Processing Bodies Is Ago2 Dependent and Results in Up-Regulation of GW182 and Argonaute-2

(2008) Aarti Jagannath et al.   MOLECULAR BIOLOGY OF THE CELL

A piRNA Pathway Primed by Individual Transposons Is Linked to De Novo DNA Methylation in Mice

(2008) Alexei A. Aravin et al.   MOLECULAR CELL

Posttranscriptional Regulation of miRNAs Harboring Conserved Terminal Loops

(2008) Gracjan Michlewski et al.   MOLECULAR CELL

Expressed Anti-HBV Primary MicroRNA Shuttles Inhibit Viral Replication Efficiently In Vitro and In Vivo

(2008) Abdullah Ely et al.   MOLECULAR THERAPY

AAV Vector–mediated RNAi of Mutant Huntingtin Expression Is Neuroprotective in a Novel Genetic Rat Model of Huntington's Disease

(2008) Nicholas R Franich et al.   MOLECULAR THERAPY

Efficient In Vivo Delivery of siRNA to the Liver by Conjugation of α-Tocopherol

(2008) Kazutaka Nishina et al.   MOLECULAR THERAPY

Artificial MicroRNAs as siRNA Shuttles: Improved Safety as Compared to shRNAs In vitro and In vivo

(2008) Ryan L Boudreau et al.   MOLECULAR THERAPY

Widespread changes in protein synthesis induced by microRNAs

(2008) Matthias Selbach et al.   NATURE

SMAD proteins control DROSHA-mediated microRNA maturation

(2008) Brandi N. Davis et al.   NATURE

Sequence- and target-independent angiogenesis suppression by siRNA via TLR3

(2008) Mark E. Kleinman et al.   NATURE

Pseudogene-derived small interfering RNAs regulate gene expression in mouse oocytes

(2008) Oliver H. Tam et al.   NATURE

Asymmetric RNA duplexes mediate RNA interference in mammalian cells

(2008) Xiangao Sun et al.   NATURE BIOTECHNOLOGY

Altered brain microRNA biogenesis contributes to phenotypic deficits in a 22q11-deletion mouse model

(2008) Kimberly L Stark et al.   NATURE GENETICS

Linking SNPs to CAG repeat length in Huntington's disease patients

(2008) Wanzhao Liu et al.   NATURE METHODS

miR-19, miR-101 and miR-130 co-regulate ATXN1 levels to potentially modulate SCA1 pathogenesis

(2008) Yoontae Lee et al.   NATURE NEUROSCIENCE

Biological principles of microRNA-mediated regulation: shared themes amid diversity

(2008) Alex S. Flynt et al.   NATURE REVIEWS GENETICS

Small non-coding RNAs in animal development

(2008) Giovanni Stefani et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Endogenous small interfering RNAs in animals

(2008) Katsutomo Okamura et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Primary microRNA transcripts are processed co-transcriptionally

(2008) Mariangela Morlando et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

MicroRNA regulation of Alzheimer's Amyloid precursor protein expression

(2008) Sébastien S. Hébert et al.   NEUROBIOLOGY OF DISEASE

Heterogeneous dysregulation of microRNAs across the autism spectrum

(2008) Kawther Abu-Elneel et al.   NEUROGENETICS

Potent inhibition of microRNA in vivo without degradation

(2008) Scott Davis et al.   NUCLEIC ACIDS RESEARCH

Frequency and fate of microRNA editing in human brain

(2008) Y. Kawahara et al.   NUCLEIC ACIDS RESEARCH

Inhibition of HIV-1 by multiple siRNAs expressed from a single microRNA polycistron

(2008) Ying Poi Liu et al.   NUCLEIC ACIDS RESEARCH

Effect of asymmetric terminal structures of short RNA duplexes on the RNA interference activity and strand selection

(2008) Masayuki Sano et al.   NUCLEIC ACIDS RESEARCH

miR2Disease: a manually curated database for microRNA deregulation in human disease

(2008) Q. Jiang et al.   NUCLEIC ACIDS RESEARCH

Chemical Modification of siRNAs for In Vivo Use

(2008) Mark A. Behlke   OLIGONUCLEOTIDES

The Efficacy of Generating Three Independent Anti-HIV-1 siRNAs from a Single U6 RNA Pol III-Expressed Long Hairpin RNA

(2008) Sheena Saayman et al.   PLoS One

A miRNA Signature of Prion Induced Neurodegeneration

(2008) Reuben Saba et al.   PLoS One

Allele-Specific RNA Silencing of Mutant Ataxin-3 Mediates Neuroprotection in a Rat Model of Machado-Joseph Disease

(2008) Sandro Alves et al.   PLoS One

Loss of microRNA cluster miR-29a/b-1 in sporadic Alzheimer's disease correlates with increased BACE1/ -secretase expression

(2008) S. S. Hebert et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Artificial miRNAs mitigate shRNA-mediated toxicity in the brain: Implications for the therapeutic development of RNAi

(2008) J. L. McBride et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Huntington's disease protein contributes to RNA-mediated gene silencing through association with Argonaute and P bodies

(2008) J. N. Savas et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

MicroRNA-directed transcriptional gene silencing in mammalian cells

(2008) D. H. Kim et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

In vitro reconstitution of the human RISC-loading complex

(2008) I. J. MacRae et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Taking microRNAs to heart

(2008) Thomas E. Callis et al.   TRENDS IN MOLECULAR MEDICINE

Neurobiology and treatment of Parkinson's disease

(2008) Anthony H.V. Schapira   TRENDS IN PHARMACOLOGICAL SCIENCES

REST Regulates Distinct Transcriptional Networks in Embryonic and Neural Stem Cells

(2008) Rory Johnson et al.   PLOS BIOLOGY

Unexpected off-targeting effects of anti-huntingtin ribozymes and siRNA in vivo

(2007) Eileen M. Denovan-Wright et al.   NEUROBIOLOGY OF DISEASE