期刊
NATURE METHODS
卷 5, 期 11, 页码 951-953出版社
NATURE PUBLISHING GROUP
DOI: 10.1038/nmeth.1261
关键词
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资金
- NIH Diabetes and Endocrinology Research [5P30DK32520-25]
- US National Institutes of Health [NS38194, 1P01NS058793]
- National Institute of Neurological Disorders and Stroke [NS042861]
- CHDI, Inc.
Allele-specific silencing using small interfering RNAs targeting heterozygous single-nucleotide polymorphisms (SNPs) is a promising therapy for human trinucleotide repeat diseases such as Huntington's disease. Linking SNP identities to the two HTT alleles, normal and disease-causing, is a prerequisite for allele-specific RNA interference. Here we describe a method, SNP linkage by circularization (SLiC), to identify linkage between CAG repeat length and nucleotide identity of heterozygous SNPs using Huntington's disease patient peripheral blood samples.
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