Article
Clinical Neurology
Baris Genc, Kerim Aslan, Sedat Sen, Lutfi Incesu
Summary: The aim of this study is to investigate changes in cortical thickness (CT), sulcal depth (SD), and local gyrification index (LGI) in patients with relapsing-remitting multiple sclerosis (RRMS). The results revealed widespread cortical thinning, decreased sulcal depth in local areas, and decreased gyrification in folds in RRMS patients. These changes were associated with clinical parameters such as the number of attacks, lesion volume, and EDSS scores.
Article
Neuroimaging
Erlei Wang, Yujing Jia, Yang Ya, Jin Xu, Chengjie Mao, Weifeng Luo, Guohua Fan, Zhen Jiang
Summary: Studies on patients with Parkinson's disease revealed widespread lower sulcal depth and relatively localized lower cortical thickness, suggesting that sulcal depth may be more sensitive to brain changes than cortical thickness, and may be mainly affected by white matter damage. The significant positive correlation between sulcal depth and cognitive scores also indicates that sulcal depth could be a potential prognostic indicator for cognitive decline in Parkinson's disease patients.
BRAIN IMAGING AND BEHAVIOR
(2021)
Article
Neurosciences
Hyuk Jin Yun, Juan David Ruiz Perez, Patricia Sosa, J. Alejandro Valdes, Neel Madan, Rie Kitano, Shizuko Akiyama, Brian G. Skotko, Henry A. Feldman, Diana W. Bianchi, P. Ellen Grant, Tomo Tarui, Kiho Im
Summary: Down syndrome is the most common genetic cause of developmental disabilities, and there is a growing interest in analyzing brains from living fetuses with DS due to the impact of genetic factors on early fetal brain development. The study demonstrates that variations in regional sulcal depth in DS fetuses may be a sensitive marker for detecting alterations of cortical development and may be associated with later neurocognitive impairment.
Article
Anatomy & Morphology
Xiao Li, Songyao Zhang, Xi Jiang, Shu Zhang, Junwei Han, Lei Guo, Tuo Zhang
Summary: Postnatal development of the cerebral cortex is crucial for brain function and cognition. This study investigated the longitudinal changes of cortical morphology and topology during early development using a macaque neuroimaging dataset. The results showed that there are four classes of regions based on the changes in surface area and sulcal depth: slowA_slowD, slowA_fastD, fastA_slowD, and fastA_fastD. The study also found correlations between cortical metrics, structural connections, and brain functional sites.
BRAIN STRUCTURE & FUNCTION
(2022)
Article
Anesthesiology
Ye Tu, Jihong Wang, Fei Xiong, Feng Gao
Summary: This study used surface-based morphometry analysis to assess cortical morphology in female patients with fibromyalgia (FM) compared to healthy controls (HC). The results showed differences in cortical thickness, gyrification index, and sulcal depth between FM patients and HC subjects. In FM patients, these differences were correlated with scores on pain catastrophizing scale, pain self-perception scale, and disease duration.
Article
Clinical Neurology
Konstantin L. Makridis, Sebastian Hoyer, Christian E. Elger, Angela M. Kaindl
Summary: This study analyzed the cognitive development of children and adolescents with drug-resistant epilepsy after surgery, and found that there was no deterioration in cognitive abilities post-surgery. Although some patients had a slight decrease in IQ points, their overall cognitive abilities and quality of life improved.
PEDIATRIC NEUROLOGY
(2023)
Article
Neurosciences
Lei Gao, Zhao Ruan, Yaqiong Xiao, Haibo Xu
Summary: Carotid stenosis, even when clinically asymptomatic, is associated with cognitive decline and neuroimaging changes. Patients with severe asymptomatic carotid stenosis exhibit thinner cortex, shallower sulci, abnormal gyrification, and lower complexity in specific brain regions, which are significantly correlated with verbal memory and WMH burden. These findings suggest a neuroanatomical predisposition to dementia and cerebrovascular events in patients with severe asymptomatic carotid stenosis.
Article
Neuroimaging
Fangling Li, Yimin Guo, Gaoqiang Xu, Ying Liu, Xiaoxi Chen, Tijiang Zhang
Summary: The purpose of this study is to observe the changes in cortical morphological characteristics and their potential impact on cognitive function in ALL survivors. The study found that pediatric ALL survivors had decreased cortical thickness in the prefrontal and temporal regions, and increased sulcal depth in the left rostral middle frontal cortex. There were no statistically significant differences in gyrification and fractal dimension between the two groups, and cortical thickness and sulcal depth showed no significant correlation with cognitive function parameters in ALL survivors.
BRAIN IMAGING AND BEHAVIOR
(2023)
Article
Neurosciences
Nagehan Demirci, Mia E. Hoffman, Maria A. Holland
Summary: Humans have differences in cortical thickness, with thicker gyral folds and thinner sulcal folds. The forces generated during cortical folding contribute to these thickness differences. This study investigates the scaling of cortical thickness in 12 primate species and reveals a systematic folding mechanism relating cortical thickness to geometry.
Article
Clinical Neurology
Lorenzo Caciagli, Corey Ratcliffe, Fenglai Xiao, Louis A. A. van Graan, Karin Trimmel, Christian Vollmar, Maria Centeno, John S. S. Duncan, Pamela J. J. Thompson, Sallie Baxendale, Matthias J. J. Koepp, Britta Wandschneider
Summary: The objective of this study was to characterize the cognitive profile of juvenile absence epilepsy (JAE), identify familial cognitive traits, determine the clinical significance of JAE-associated cognitive traits, compare JAE with juvenile myoclonic epilepsy (JME) to identify shared or syndrome-specific cognitive traits, and identify relationships between cognitive abilities and clinical characteristics.
Article
Radiology, Nuclear Medicine & Medical Imaging
Ajin Joy, Rajakumar Nagarajan, Eric S. Daar, Jhelum Paul, Andres Saucedo, Santosh K. Yadav, Mario Guerrero, Ebrahim Haroon, Paul Macey, M. Albert Thomas
Summary: This study used high-resolution images to reveal detailed brain structural changes in HIV-infected individuals, including alterations in gyrification, cortical thickness, and sulcal depth. The findings suggest that the results of voxel-based morphometry (VBM) may not only be related to volumetric changes, but also to alterations in these additional metrics. Additionally, age was found to significantly accelerate gray matter loss in HIV-infected individuals compared to uninfected healthy controls.
MAGNETIC RESONANCE IMAGING
(2023)
Article
Clinical Neurology
Fengmei Fan, Junchao Huang, Shuping Tan, Zhiren Wang, Yanli Li, Song Chen, Hui Li, Stephanie Hare, Xiaoming Du, Fude Yang, Baopeng Tian, Peter Kochunov, Yunlong Tan, L. Elliot Hong
Summary: Treatment resistance in schizophrenia is associated with reduced cortical thickness in specific brain regions. These regions include the right caudal middle frontal gyrus, superior frontal cortex, fusiform gyrus, pars opercularis of the inferior frontal cortex, and supramarginal cortex. The reductions in cortical thickness in these regions are significantly correlated with cognitive deficits. Moreover, cortical abnormalities in the right caudal middle frontal gyrus, superior frontal cortex, and pars opercularis of the inferior frontal cortex mediate the effects of cognitive deficits on treatment resistance.
PSYCHIATRY AND CLINICAL NEUROSCIENCES
(2023)
Article
Psychiatry
Jun Zhong, Huawang Wu, Fengchun Wu, Hongbo He, Zhaohua Zhang, Jiaxin Huang, Penghui Cao, Ni Fan
Summary: This study found that chronic ketamine users have reduced cortical thickness in multiple brain areas, especially in the prefrontal cortex. The dose, frequency, and duration of ketamine use were negatively correlated with cortical thickness in some brain areas. Chronic ketamine users also showed significantly poorer cognitive performance in working memory, visual learning, processing speed, and overall cognition, but there was no correlation between reduced cortical thickness and decreased cognitive performance.
FRONTIERS IN PSYCHIATRY
(2021)
Article
Clinical Neurology
Bo-yong Park, Sara Lariviere, Raul Rodriguez-Cruces, Jessica Royer, Shahin Tavakol, Yezhou Wang, Lorenzo Caciagli, Maria Eugenia Caligiuri, Antonio Gambardella, Luis Concha, Simon S. Keller, Fernando Cendes, Marina K. M. Alvim, Clarissa Yasuda, Leonardo Bonilha, Ezequiel Gleichgerrcht, Niels K. Focke, Barbara A. K. Kreilkamp, Martin Domin, Felix von Podewils, Soenke Langner, Christian Rummel, Michael Rebsamen, Roland Wiest, Pascal Martin, Raviteja Kotikalapudi, Benjamin Bender, Terence J. O'Brien, Meng Law, Benjamin Sinclair, Lucy Vivash, Patrick Kwan, Patricia M. Desmond, Charles B. Malpas, Elaine Lui, Saud Alhusaini, Colin P. Doherty, Gianpiero L. Cavalleri, Norman Delanty, Reetta Kalviainen, Graeme D. Jackson, Magdalena Kowalczyk, Mario Mascalchi, Mira Semmelroch, Rhys H. Thomas, Hamid Soltanian-Zadeh, Esmaeil Davoodi-Bojd, Junsong Zhang, Matteo Lenge, Renzo Guerrini, Emanuele Bartolini, Khalid Hamandi, Sonya Foley, Bernd Weber, Chantal Depondt, Julie Absil, Sarah J. A. Carr, Eugenio Abela, Mark P. Richardson, Orrin Devinsky, Mariasavina Severino, Pasquale Striano, Costanza Parodi, Domenico Tortora, Sean N. Hatton, Sjoerd B. Vos, John S. Duncan, Marian Galovic, Christopher D. Whelan, Nuria Bargallo, Jose Pariente, Estefania Conde-Blanco, Anna Elisabetta Vaudano, Manuela Tondelli, Stefano Meletti, Xiang-Zhen Kong, Clyde Francks, Simon E. Fisher, Benoit Caldairou, Mina Ryten, Angelo Labate, Sanjay M. Sisodiya, Paul M. Thompson, Carrie R. McDonald, Andrea Bernasconi, Neda Bernasconi, Boris C. Bernhardt
Summary: This study compared the spatial distribution of grey matter asymmetry and atrophy in temporal lobe epilepsy using the ENIGMA-Epilepsy dataset. The results showed marked differences between the two measures, with asymmetry revealing anomalies in ipsilateral limbic circuits and atrophy displaying diffuse and bilateral patterns. Additionally, cortical atrophy was correlated with disease duration and age at seizure onset.
Article
Clinical Neurology
Helena Gauffin, Anne-Marie Landtblom, Patrick Vigren, Andreas Frick, Maria Engstroem, Anita McAllister, Thomas Karlsson
Summary: This study compared cognitive function and quality of life in young adults with focal or generalized epilepsy. The results showed similar impairments in cognitive function between the two types of epilepsy. Participants with focal epilepsy reported lower quality of life and both epilepsy groups had lower self-esteem values.
FRONTIERS IN NEUROLOGY
(2022)
Article
Geriatrics & Gerontology
Mitzi M. Gonzales, Philip S. Insel, Craig Nelson, Duygu Tosun, Michael Schoell, Niklas Mattsson, Simona Sacuiu, David Bickford, Michael W. Weiner, R. Scott Mackin
INTERNATIONAL JOURNAL OF GERIATRIC PSYCHIATRY
(2018)
Article
Neurosciences
Fon Powell, Duygu Tosun, Roksana Sadeghi, Michael Weiner, Ashish Raj
JOURNAL OF ALZHEIMERS DISEASE
(2018)
Article
Clinical Neurology
Chin Hong Tan, Luke W. Bonham, Chun Chieh Fan, Elizabeth C. Mormino, Leo P. Sugrue, Iris J. Broce, Christopher P. Hess, Jennifer S. Yokoyama, Gil D. Rabinovici, Bruce L. Miller, Kristine Yaffe, Gerard D. Schellenberg, Karolina Kauppi, Dominic Holland, Linda K. McEvoy, Walter A. Kukull, Duygu Tosun, Michael W. Weiner, Reisa A. Sperling, David A. Bennett, Bradley T. Hyman, Ole A. Andreassen, Anders M. Dale, Rahul S. Desikan
Article
Clinical Neurology
Neha Prakash, Chelsea Caspell-Garcia, Christopher Coffey, Andrew Siderowf, Caroline M. Tanner, Karl Kieburtz, Brit Mollenhauer, Douglas Galasko, Kalpana Merchant, Tatiana Foroud, Lana M. Chahine, Daniel Weintraub, Cindy Casaceli, Ray Dorsey, Renee Wilson, Margaret Herzog, Nichole Daegele, Vanessa Arnedo, Mark Frasier, Todd Sherer, Ken Marek, Samuel Frank, Danna Jennings, Tanya Simuni, Kenneth Marek, Andrew Siderowf, John Seibyl, Christopher Coffey, Caroline Tanner, Duygu Tosun-Turgut, Tanya Simunir, Leslie Shaw, John Trojanowski, Andrew Singleton, Karl Kieburtz, Arthur Toga, Brit Mollenhauer, Douglas Galasko, Werner Poewe, Tatiana Foroud, Kathleen Poston, Todd Sherer, Sohini Chowdhury, Mark Frasier, Catherine Kopil, Vanessa Arnedo, Nichole Daegele, Cynthia Casaceli, Ray Dorsey, Renee Wilson, Sugi Mahes, Christina Salerno, Chelsea Caspell-Garcia, Arthur Toga, Karen Crawford, Tatiana Foroud, Paola Casalin, Giulia Malferrari, Mali Gani Weisz, Avi Orr-Urtreger, John Trojanowski, Leslie Shaw, Thomas Montine, David Russell, Tanya Simuni, Nabila Dahodwala, Nir Giladi, Stewart Factor, Penelope Hogarth, David Standaert, Robert Hauser, Joseph Jankovic, Marie Saint-Hilaire, Irene Richard, David Shprecher, Hubert Fernandez, Katrina Brockmann, Liana Rosenthal, Paolo Barone, Alberto Espay, Dominic Rowe, Karen Marder, Anthony Santiago, Susan Bressman, Shu-Ching Hu, Stuart Isaacson, Jean-Christophe Corvol, Javiar Ruiz Martinez, Eduardo Tolosa, Yen Tai, Marios Politis, Debra Smejdir, Linda Rees, Karen Williams, Farah Kausar, Karen Williams, Whitney Richardson, Diana Willeke, Shawnees Peacock, Beatrice Heim, Anat Mirelman, Barbara Sommerfeld, Alison Freed, Katrina Wakeman, Courtney Blair, Stephanie Guthrie, Leigh Harrell, Christine Hunter, Cathi-Ann Thomas, Raymond James, Grace Zimmerman, Victoria Brown, Jennifer Mule, Ella Hilt, Kori Ribb, Susan Ainscough, Misty Wethington, Madelaine Ranola, Helen Mejia Santana, Juliana Moreno, Deborah Raymond, Krista Speketer, Lisbeth Carvajal, Stephanie Carvalho, Ioana Croitoru, Alicia Garrido, Laura Marie Payne, Veena Viswanth, Lawrence Severt, Maurizio Facheris, Holly Soares, Mark A. Mintun, Jesse Cedarbaum, Peggy Taylor, Kevin Biglan, Emily Vandenbroucke, Zulfiqar Haider Sheikh, Buis Bingol, Tanya Fischer, Pablo Sardi, Remi Forrat, Alastair Reith, Jan Egebjerg, Gabrielle Ahlberg Hillert, Barbara Saba, Chris Min, Robert Umek, Joe Mather, Susan De Santi, Anke Post, Frank Boess, Kirsten Taylor, Igor Grachev, Andreja Avbersek, Pierandrea Muglia, Kaplana Merchant, Johannes Tauscher
PARKINSONISM & RELATED DISORDERS
(2019)
Article
Clinical Neurology
Matthew J. Betts, Evgeniya Kirilina, Maria C. G. Otaduy, Dimo Ivanov, Julio Acosta-Cabronero, Martina F. Callaghan, Christian Lambert, Arturo Cardenas-Blanco, Kerrin Pine, Luca Passamonti, Clare Loane, Max C. Keuken, Paula Trujillo, Falk Luesebrink, Hendrik Mattern, Kathy Y. Liu, Nikos Priovoulos, Klaus Fliessbach, Martin J. Dahl, Anne Maass, Christopher F. Madelung, David Meder, Alexander J. Ehrenberg, Oliver Speck, Nikolaus Weiskopf, Raymond Dolan, Ben Inglis, Duygu Tosun, Markus Morawski, Fabio A. Zucca, Hartwig R. Siebner, Mara Mather, Kamil Uludag, Helmut Heinsen, Benedikt A. Poser, Robert Howard, Luigi Zecca, James B. Rowe, Lea T. Grinberg, Heidi I. L. Jacobs, Emrah Duezel, Dorothea Haemmerer
Article
Geriatrics & Gerontology
Rachel L. Nosheny, Philip S. Insel, Niklas Mattsson, Duygu Tosun, Shannon Buckley, Diana Truran, N. Schuff, Paul S. Aisen, Michael W. Weiner
NEUROBIOLOGY OF AGING
(2019)
Article
Clinical Neurology
Tanya Simuni, Liz Uribe, Hyunkeun Ryan Cho, Chelsea Caspell-Garcia, Christopher S. Coffey, Andrew Siderowf, John Q. Trojanowski, Leslie M. Shaw, John Seibyl, Andrew Singleton, Arthur W. Toga, Doug Galasko, Tatiana Foroud, Duygu Tosun, Kathleen Poston, Daniel Weintraub, Brit Mollenhauer, Caroline M. Tanner, Karl Kieburtz, Lana M. Chahine, Alyssa Reimer, Samantha J. Hutten, Susan Bressman, Kenneth Marek, Vanessa Arnedo, Adrienne Clark, Mark Fraiser, Catherine Kopil, Sohini Chowdhury, Todd Sherer, Nichole Daegele, Christina Salerno, Cynthia Casaceli, Ray Dorsey, Renee Wilson, Sugi Mahes, Karen Crawford, Paola Casalin, Giulia Malferrari, Mali GaniWeisz, Avi Orr-Urtreger, Thomas Montine, Chris Baglieri, Amanda Christini, David Russell, Nabila Dahodwala, Nir Giladi, Stewart Factor, Penelope Hogarth, David Standaert, Robert Hauser, Joseph Jankovic, Marie Saint-Hilaire, Irene Richard, David Shprecher, Hubert Fernandez, Katrina Brockmann, Liana Rosenthal, Paolo Barone, Alberto Espay, Dominic Rowe, Karen Marder, Anthony Santiago, Shu-Ching Hu, Stuart Isaacson, Jean-Christophe Corvol, Javiar Ruiz Martinez, Eduardo Tolosa, Yen Tai, Marios Politis, Debra Smejdir, Linda Rees, Karen Williams, Farah Kausar, Karen Williams, Whitney Richardson, Diana Willeke, Shawnees Peacock, Barbara Sommerfeld, Alison Freed, Katrina Wakeman, Courtney Blair, Stephanie Guthrie, Leigh Harrell, Christine Hunter, Cathi-Ann Thomas, Raymond James, Grace Zimmerman, Victoria Brown, Jennifer Mule, Ella Hilt, Kori Ribb, Susan Ainscough, Misty Wethington, Madelaine Ranola, Helen Mejia Santana, Juliana Moreno, Deborah Raymond, Krista Speketer, Stephanie Carvalo, Ioana Croitoru, Alicia Garrido, Laura Marie Payne, Veena Viswanth, Lawrence Severt, Maurizio Facheris, Holly Soares, Mark A. Mintun, Jesse Cedarbaum, Peggy Taylor, Kevin Biglan, Emily Vandenbroucke, Zulfiqar Haider Sheikh, Baris Bingol, Tanya Fischer, Pablo Sardi, Remi Forrat, Alastair Reith, Jan Egebjerg, Gabrielle Ahlberg Hillert, Barbara Saba, Chris Min, Robert Umek, Joe Mather, Susan De Santi, Anke Post, Frank Boess, Kirsten Taylor, Igor Grachev, Andreja Avbersek, Pierandrea Muglia, Kaplana Merchant, Johannes Tauscher
Article
Clinical Neurology
Tanya Simuni, Michael C. Brumm, Liz Uribe, Chelsea Caspell-Garcia, Christopher S. Coffey, Andrew Siderowf, Roy Alcalay, John Q. Trojanowski, Leslie M. Shaw, John Seibyl, Andrew Singleton, Arthur W. Toga, Doug Galasko, Tatiana Foroud, Kelly Nudelman, Duygu Tosun-Turgut, Kathleen Poston, Daniel Weintraub, Brit Mollenhauer, Caroline M. Tanner, Karl Kieburtz, Lana M. Chahine, Alyssa Reimer, Samantha Hutten, Susan Bressman, Kenneth Marek, Christopher Coffey, Caroline Tanner, Arthur Toga, Douglas Galasko, Werner Poewe, Vanessa Arnedo, Adrienne Clark, Mark Frasier, Catherine Kopil, Sohini Chowdhury, Todd Sherer, Nichole Daegele, Cynthia Casaceli, Ray Dorsey, Renee Wilson, Sugi Mahes, Christina Salerno, Karen Crawford, Paola Casalin, Giulia Malferrari, Mali Gani Weisz, Avi Orr-Urtreger, John Trojanowski, Leslie Shaw, Thomas Montine, Chris Baglieri, Amanda Christini, David Russell, Nabila Dahodwala, Nir Giladi, Stewart Factor, Penelope Hogarth, David Standaert, Robert Hauser, Joseph Jankovic, Marie Saint-Hilaire, Irene Richard, David Shprecher, Hubert Fernandez, Katrina Brockmann, Liana Rosenthal, Paolo Barone, Alberto Espay, Dominic Rowe, Karen Marder, Anthony Santiago, Shu-Ching Hu, Stuart Isaacson, Jean-Christophe Corvol, Javiar Ruiz Martinez, Eduardo Tolosa, Yen Tai, Marios Politis, Debra Smejdir, Linda Rees, Karen Williams, Farah Kausar, Whitney Richardson, Diana Willeke, Shawnees Peacock, Barbara Sommerfeld, Alison Freed, Katrina Wakeman, Courtney Blair, Stephanie Guthrie, Leigh Harrell, Christine Hunter, Cathi-Ann Thomas, Raymond James, Grace Zimmerman, Victoria Brown, Jennifer Mule, Ella Hilt, Kori Ribb, Susan Ainscough, Misty Wethington, Madelaine Ranola, Helen Mejia Santana, Juliana Moreno, Deborah Raymond, Krista Speketer, Lisbeth Carvajal, Stephanie Carvalo, Ioana Croitoru, Alicia Garrido, Laura Marie Payne, Veena Viswanth, Lawrence Severt, Maurizio Facheris, Holly Soares, Mark A. Mintun, Jesse Cedarbaum, Peggy Taylor, Kevin Biglan, Emily Vandenbroucke, Zulfiqar Haider Sheikh, Baris Bingol, Tanya Fischer, Pablo Sardi, Remi Forrat, Alastair Reith, Jan Egebjerg, Gabrielle Ahlberg Hillert, Barbara Saba, Chris Min, Robert Umek, Joe Mather, Susan De Santi, Anke Post, Frank Boess, Kirsten Taylor, Igor Grachev, Andreja Avbersek, Pierandrea Muglia, Kaplana Merchant, Johannes Tauscher
MOVEMENT DISORDERS
(2020)
Article
Biology
Ryan Ellis, Erik Ellestad, Brett Elicker, Michael D. Hope, Duygu Tosun
COMPUTERS IN BIOLOGY AND MEDICINE
(2020)
Article
Neurosciences
R. Scott Mackin, Philip S. Insel, Susan Landau, David Bickford, Ruth Morin, Emma Rhodes, Duygu Tosun, Howie J. Rosen, Meryl Butters, Paul Aisen, Rema Raman, Andrew Saykin, Arthur Toga, Clifford Jack, Robert Koeppe, Michael W. Weiner, Craig Nelson
Summary: The study evaluated the role of cortical amyloid deposition in memory dysfunction and dementia risk associated with late-life depression. Contrary to expectations, the late-life depression group showed less A13 deposition than the non-depressed group, and A13 deposition was not associated with depression history characteristics. However, A13 deposition was associated with memory performance.
BIOLOGICAL PSYCHIATRY
(2021)
Article
Geriatrics & Gerontology
Julie Lutz, R. Scott Mackin, Marcela C. Otero, Ruth Morin, David Bickford, Duygu Tosun, Derek D. Satre, Christine E. Gould, J. Craig Nelson, Sherry A. Beaudreau
Summary: The study revealed that decreased functional disability following psychotherapy for depression was associated with reduced suicide ideation among older adults, particularly in relation to feelings of worthlessness. Therefore, treatments aimed at reducing functional disability may help mitigate the risk of suicide in this population.
AMERICAN JOURNAL OF GERIATRIC PSYCHIATRY
(2021)
Article
Clinical Neurology
Duygu Tosun, Zeynep Demir, Dallas P. Veitch, Daniel Weintraub, Paul Aisen, Clifford R. Jack, William J. Jagust, Ronald C. Petersen, Andrew J. Saykin, Leslie M. Shaw, John Q. Trojanowski, Michael W. Weiner
Summary: Aβ, tau, and neurodegeneration have significant impacts on cognitive impairment and cognitive decline, while AD risk factors also play an important role in affecting disease progression.
ALZHEIMERS & DEMENTIA
(2022)
Article
Clinical Neurology
Duygu Tosun, Pamela Thropp, Sudeepti Southekal, Bruce Spottiswoode, Rachid Fahmi
Summary: This study used an unsupervised data-driven whole-brain pattern analysis to identify distinct tau accumulation profiles and build baseline models predictive of tau-accumulation type. Screening for fast tau accumulation and A beta positivity in early Alzheimer's disease requires a lower sample size to achieve 80% power for a specific treatment.
ALZHEIMERS & DEMENTIA
(2023)
Article
Clinical Neurology
Duygu Tosun, Ozlem Yardibi, Tammie L. S. Benzinger, Walter A. Kukull, Colin L. Masters, Richard J. Perrin, Michael W. Weiner, Arthur Simen, Adam J. Schwarz, lzheimers Dis Neuroimaging Initiative
Summary: In this study, a multilabel non-ADNC classifier using MRI signatures was developed for the identification of non-Alzheimer's disease neuropathological changes. The model showed high accuracy in distinguishing TDP-43, LBD, and CAA, outperforming reference models without MRI and ADNC biomarkers. Considering non-ADNC decreased the required sample size to detect cognitive decline.
ALZHEIMERS & DEMENTIA
(2023)
Article
Clinical Neurology
Fon Powell, Duygu Tosun, Ashish Raj
Summary: Current methods for measuring the chronic rates of cognitive decline and degeneration in Alzheimer's disease rely on longitudinal neuropsychological batteries and clinical neuroimaging. Predicting future disease progression has proven challenging, with brain network diffusion models offering a potential solution to accurately estimate pathology transmission rates. Using machine learning, a new metric based on MRI-derived atrophy data was able to predict disease progression across different diagnostic groups and genetic risk factors.
BRAIN COMMUNICATIONS
(2021)