Article
Neurosciences
Jenna N. Adams, Anne Maass, David Berron, Theresa M. Harrison, Suzanne L. Baker, Wesley P. Thomas, Morgan Stanfill, William J. Jagust
Summary: Tau deposition in aging and Alzheimer's disease affects medial temporal lobe (MTL) neural function, impacting repetition suppression. Different levels of tau pathology are associated with activity changes in distinct MTL subregions, with high tau pathology leading to widespread neural dysfunction.
JOURNAL OF NEUROSCIENCE
(2021)
Article
Neurosciences
Eva Berlot, Nicola J. Popp, Scott T. Grafton, Jorn Diedrichsen
Summary: In the context of motor sequence learning, fMRI studies revealed differences in neuronal representations between premotor and parietal regions compared to the primary motor cortex (M1). While M1 showed specific representation of the first finger of each sequence, parietal areas represented the identity of the entire sequence and remained relatively stable during different executions. This suggests that the RS effect in M1 reflects a preparatory signal for movement initiation rather than a trained sequence representation.
JOURNAL OF NEUROSCIENCE
(2021)
Review
Behavioral Sciences
Daniel Feuerriegel, Rufin Vogels, Gyula Kovacs
Summary: Recent research has identified confounding factors that may impact the true effects of expectation suppression, casting doubt on its findings across different experimental contexts. However, evidence for genuine expectation suppression was found in specific statistical learning designs.
NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS
(2021)
Article
Neurosciences
Joris Dietziker, Matthias Staib, Sascha Fruhholz
Summary: Through neuroimaging in humans, a study found neural competition between understanding others' speech while producing speech utterances, showing specific mechanisms for self and other speech processing in different brain regions. Contrary to previous studies, the left anterior superior temporal cortex supported self speech processing, while other speech recognition in the context of listening to recorded self speech led to symmetric activity in other regions.
Article
Neurosciences
Francesco Tomaiuolo, Serena Campana, Loredana Voci, Stefano Lasaponara, Fabrizio Doricchi, Michael Petrides
Summary: This study reports four patients with pure speech apraxia, with critical lesions in specific brain areas in the left hemisphere. The damage is primarily located in the insula, adjacent subcentral opercular cortex, and the most inferior part of the central sulcus.
Article
Neurosciences
Anila M. D'Mello, Isabelle R. Frosch, Steven L. Meisler, Hannah Grotzinger, Tyler K. Perrachione, John D. E. Gabrieli
Summary: Repeated exposure to a stimulus leads to reduced neural response, known as repetition suppression, in brain regions responsible for processing that stimulus. This is believed to be important for learning and strengthening of perceptual expectations. Reduced sensitivity to repetition has been found in autism spectrum disorder (ASD) and is thought to contribute to sensory hypersensitivities and difficulties in using regularities in the environment for behavior facilitation. In individuals with ASD, there are specific reductions in repetition suppression for face stimuli, which is associated with challenges in social communication. Altered functional connectivity and microstructural differences in related white matter tracts are also observed in ASD, indicating selective alterations in face processing.
JOURNAL OF NEUROSCIENCE
(2023)
Article
Audiology & Speech-Language Pathology
Anna Tendera, Matthew Rispoli, Ambikaipakan Sethilselvan, Heecheong Chon, Torrey M. Loucks
Summary: The phenomenon of repetition reduction can increase speech articulation rate in adults, but young children may not have the same speech motor flexibility. This study found that repetitions produced by 2;0-year-old children were faster than their original utterances, indicating the presence of a naturistic form of repetition reduction in children's speech.
LANGUAGE AND SPEECH
(2023)
Article
Behavioral Sciences
Satu Saalasti, Jussi Alho, Juha M. Lahnakoski, Mareike Bacha-Trams, Enrico Glerean, Iiro P. Jaaskelainen, Uri Hasson, Mikko Sams
Summary: This study used a data-driven approach to explore the neural mechanisms underlying comprehension of connected natural speech through lipreading. The results showed that the brain areas involved in lipreading, listening, and reading were largely overlapping, including the temporal, parietal, frontal cortices, precuneus, and cerebellum. However, lipreading showed less activity in higher-level linguistic processing compared to listening and reading. The lipreading test score and subjective comprehension of the lipread narrative were associated with activity in the temporal cortex.
BRAIN AND BEHAVIOR
(2023)
Article
Behavioral Sciences
Gunes Sager, Beyza Sungur Cetin, Yakup Cag, Zeynep Vatansever Pinar, Yasemin Akin
Summary: This study indicates that preschool-age children with GEFS+ have significant impairments in both articulation and auditory discrimination. Early diagnosis and treatment can prevent potential literacy problems and the development of dyslexia.
EPILEPSY & BEHAVIOR
(2022)
Article
Neurosciences
Mariel L. Schroeder, Arefeh Sherafati, Rachel L. Ulbrich, Muriah D. Wheelock, Alexandra M. Svoboda, Emma D. Klein, Tessa G. George, Kalyan Tripathy, Joseph P. Culver, Adam T. Eggebrecht
Summary: High-density diffuse optical tomography (HD-DOT) is a neuroimaging modality that allows high-fidelity mapping of human brain function in a silent and open scanning environment. This study assessed the application of HD-DOT in language tasks and found that it is sensitive to brain function underlying language comprehension and production. HD-DOT has potential for imaging naturalistic language processing and for broader applications.
Article
Chemistry, Multidisciplinary
Anna Lichnowska, Marcin Kozakiewicz
Summary: This study evaluated the influence of non-normative primary functions on consonant pronunciation in adults with facial skeletal deformities, and proposed a new type of speech therapy, orthognathic speech therapy. Surgical correction of malocclusion improved speech and primary functions, leading to better oral motor control and articulation of Polish consonants in adults.
APPLIED SCIENCES-BASEL
(2021)
Article
Neurosciences
Sara Guediche, Angela de Bruin, Cesar Caballero-Gaudes, Martijn Baart, Arthur G. Samuel
Summary: Spoken language comprehension is a fundamental cognitive skill, relying on prior linguistic knowledge and context. For bilinguals, the overlap of word forms across languages affects how they influence each other during auditory word recognition. Semantic information plays a crucial role in spoken word recognition.
Article
Psychology, Educational
Yi Weng, Yicheng Rong, Gang Peng
Summary: This study examines the developmental trajectory of Mandarin-speaking children in audiovisual speech perception. The findings show that 3-4-year-olds perform worse than older groups in identifying congruent stimuli, and there is a developmental shift in perceiving incongruent stimuli. With increasing auditory noise, the difference between children and adults widens in identifying congruent stimuli but narrows in perceiving incongruent ones, which supports the statistically optimal hypothesis.
Article
Psychology, Multidisciplinary
Hannah S. Sarvasy, Weicong Li, Jaydene Elvin, Paola Escudero
Summary: In many communities, speech to infants and small children has distinct features compared to speech to adults, which can also be observed in speech directed to foreigners. This study examines the vowel acoustics in the Nungon language of Papua New Guinea, specifically in child-directed speech, conversational speech, and monologues directed towards a non-native speaker. The findings show that Nungon child-directed speech lacks vowel hyper-articulation but displays other prosodic traits common to child-directed speech. Furthermore, the vowel patterns in Nungon foreigner-directed speech are significantly different from those in child-directed speech and conversational speech. This study contributes to the understanding of speech variation and its cultural implications in different linguistic communities.
FRONTIERS IN PSYCHOLOGY
(2022)
Article
Behavioral Sciences
Marjorie Dole, Coriandre Vilain, Celise Haldin, Monica Baciu, Emilie Cousin, Laurent Lamalle, Helene Loevenbruck, Anne Vilain, Jean-Luc Schwartz
Summary: This study shows that the human cortex exhibits a pattern of auditory-narrow motor-wide selectivity for speech sound representations, with temporal areas being more sensitive to acoustic variations and frontal areas being more tolerant of atypical stimuli.
Article
Behavioral Sciences
Kate E. Watkins, Gaelle S. L. Coullon, Holly Bridge
Summary: Individuals with congenital blindness offer a unique opportunity to examine cross-modal plasticity in the absence of visual stimulation. This study investigates the functional specialization of occipital cortex in six cases with anophthalmia, finding different patterns of activation compared to other blind populations.
Article
Radiology, Nuclear Medicine & Medical Imaging
Joshua Vic Chen, Gunvant Chaudhari, Christopher P. Hess, Orit A. Glenn, Leo P. Sugrue, Andreas M. Rauschecker, Yi Li
Summary: A convolutional neural network is developed to estimate the gestationally corrected age of neonates and infants based on brain myelination patterns on MRI scans. Attention map analysis reveals different myelination patterns at different gestational stages. The method demonstrates good performance on an external test set.
Article
Behavioral Sciences
Adam J. Parker, Zoe V. J. Woodhead, David P. Carey, Margriet A. Groen, Eva Gutierrez-Sigut, Jessica Hodgson, John Hudson, Emma M. Karlsson, Mairead MacSweeney, Heather Payne, Nuala Simpson, Paul A. Thompson, Kate E. Watkins, Ciara Egan, Jack H. Grant, Sophie Harte, Brad T. Hudson, Maria Sablik, Nicholas A. Badcock, Dorothy V. M. Bishop
Summary: Most people have strong left-brain lateralisation for language, but there can be variations in lateralisation within individuals. This study found that language lateralisation can fractionate into at least two factors within individuals, and these factors do not neatly correspond to language generation and comprehension.
Article
Multidisciplinary Sciences
Else Eising, Nazanin Mirza-Schreiber, Eveline L. de Zeeuw, Carol A. Wang, Dongnhu T. Truong, Andrea G. Allegrini, Chin Yang Shapland, Gu Zhu, Karen G. Wigg, Margot L. Gerritse, Barbara Molz, Gokberk Alagoz, Alessandro Gialluisi, Filippo Abbondanza, Kaili Rimfeld, Marjolein van Donkelaar, Zhijie Liao, Philip R. Jansen, Till F. M. Andlauer, Timothy C. Bates, Manon Bernard, Kirsten Blokland, Milene Bonte, Anders D. Borglum, Thomas Bourgeron, Daniel Brandeis, Fabiola Ceronihh, Valeria Csepe, Philip S. Dale, Peter F. de Jong, John C. DeFries, Jean-Francois Demonet, Ditte Demontis, Yu Feng, Scott D. Gordon, Sharon L. Guger, Marianna E. Hayiou-Thomas, Juan A. Hernandez-Cabrera, Jouke-Jan Hottenga, Charles Hulme, Juha Kere, Elizabeth N. Kerr, Tanner Koomar, Karin Landerl, Gabriel T. Leonard, Maureen W. Lovett, Heikki Lyytinen, Nicholas G. Martin, Angela Martinelli, Urs Maurer, Jacob J. Michaelson, Kristina Moll, Anthony P. Monaco, Angela T. Morgan, Markus M. Nothen, Zdenka Pausova, Craig E. Pennell, Bruce F. Pennington, Kaitlyn M. Price, Veera M. Rajagopal, Franck Ramus, Louis Richer, Nuala H. Simpson, Shelley D. Smith, Margaret J. Snowling, John Stein, Lisa J. Struguuu, Joel B. Talcott, Henning Tiemeier, Marc P. van der Schroeff, Ellen Verhoef, Kate E. Watkins, Margaret Wilkinson, Margaret J. Wright, Cathy L. Barr, Dorret Boomsma, Manuel Carreiras, Marie-Christine J. Franken, Jeffrey R. Gruen, Michelle Luciano, Bertram Muller-Myhsok, Dianne F. Newbury, Richard K. Olson, Silvia Paracchini, Tomas Paus, Robert Plomin, Sheena Reilly, Gerd Schulte-Korn, J. Bruce Tomblin, Elsjevan Bergen, Andrew J. O. Whitehouse, Erik G. Willcutt, Beate St Pourcain, Clyde Francks, Simon E. Fisher
Summary: The use of spoken and written language is a fundamental human capacity. Genetic variation influences individual differences in reading- and language-related skills, with a heritability estimate of 30 to 80%. This study conducted a genome-wide association study on samples of 13,633 to 33,959 participants and identified a significant association between a genetic locus and word reading. All five reading-/language-related traits showed robust SNP heritability.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2022)
Article
Biology
Saloni Krishnan, Gabriel J. Cler, Harriet J. Smith, Hanna E. Willis, Salomi S. Asaridou, Mairead P. Healy, Daniel Papp, Kate E. Watkins
Summary: This study used a novel imaging protocol to investigate microstructural neural differences in children with DLD, revealing lower MTsat values in certain brain regions and globally lower R1 values in DLD children, suggesting the presence of microstructural abnormalities.
Article
Clinical Neurology
C. B. N. Tran, P. Nedelec, D. A. Weiss, J. D. Rudie, L. Kini, L. P. Sugrue, O. A. Glenn, C. P. Hess, A. M. Rauschecker
Summary: This study aimed to develop a deep learning algorithm for automatically measuring intracranial and brain volumes of fetal brain MRIs across gestational ages. The algorithm was trained and tested on a dataset of 246 patients and performed well, with high accuracy and correlation with manual measurements. The results showed that deep learning techniques can quickly and accurately quantify intracranial and brain volumes on clinical fetal brain MRIs.
AMERICAN JOURNAL OF NEURORADIOLOGY
(2023)
Letter
Hematology
Andreas M. Rauschecker, Shirley S. Mo, Michael Randall, John Shen-Sampas, James L. Rubenstein
BRITISH JOURNAL OF HAEMATOLOGY
(2023)
Article
Neurosciences
Paul A. Thompson, Kate E. Watkins, Zoe V. J. Woodhead, Dorothy V. M. Bishop
Summary: This study investigates how to align the analysis of brain lateralization using fTCD data with the statistical methods commonly used in fMRI. The results show that using complex GAM method has the lowest measurement error and can more accurately identify cases of bilateral language. Additionally, the GAM-based approach can efficiently analyze more complex designs that include interactions between tasks.
HUMAN BRAIN MAPPING
(2023)
Article
Psychiatry
Kaitlyn M. Price, Karen G. Wigg, Else Eising, Yu Feng, Kirsten Blokland, Margaret Wilkinson, Elizabeth N. Kerr, Sharon L. Guger, Filippo Abbondanza, Andrea G. Allegrini, Till F. M. Andlauer, Timothy C. Bates, Manon Bernard, Milene Bonte, Dorret I. Boomsma, Thomas Bourgeron, Daniel Brandeis, Manuel Carreiras, Fabiola Ceroni, Valeria Csepe, Philip S. Dale, John C. DeFries, Peter F. de Jong, Jean Francois Demonet, Eveline L. de Zeeuw, Marie-Christine J. Franken, Clyde Francks, Margot Gerritse, Alessandro Gialluisi, Scott D. Gordon, Jeffrey R. Gruen, Marianna E. Hayiou-Thomas, Juan Hernandez-Cabrera, Jouke-Jan Hottenga, Charles Hulme, Philip R. Jansen, Juha Kere, Tanner Koomar, Karin Landerl, Gabriel T. Leonard, Zhijie Liao, Michelle Luciano, Heikki Lyytinen, Nicholas G. Martin, Angela Martinelli, Urs Maurer, Jacob J. Michaelson, Nazanin Mirza-Schreiber, Kristina Moll, Anthony P. Monaco, Angela T. Morgan, Bertram Mueller-Myhsok, Dianne F. Newbury, Markus M. Noethen, Richard K. Olson, Silvia Paracchini, Tomas Paus, Zdenka Pausova, Craig E. Pennell, Bruce F. Pennington, Robert J. Plomin, Franck Ramus, Sheena Reilly, Louis Richer, Kaili Rimfeld, Gerd Schulte-Korne, Chin Yang Shapland, Nuala H. Simpson, Shelley D. Smith, Margaret J. Snowling, Beate St Pourcain, John F. Stein, Joel B. Talcott, Henning Tiemeier, J. Bruce Tomblin, Dongnhu T. Truong, Elsje van Bergen, Marc P. van der Schroeff, Marjolein Van Donkelaar, Ellen Verhoef, Carol A. Wang, Kate E. Watkins, Andrew J. O. Whitehouse, Erik G. Willcutt, Margaret J. Wright, Gu Zhu, Simon E. Fisher, Maureen W. Lovett, Lisa J. Strug, Cathy L. Barr
Summary: Reading Disability (RD) is often associated with difficulties in language phonology. Genome-wide association studies have identified genetic loci related to neuronal migration, axon guidance, and autism spectrum disorder (ASD) that may be implicated in RD. This study contributes candidate loci to the genetics of word reading and suggests that alleles linked to ASD risk may also be involved in word reading.
TRANSLATIONAL PSYCHIATRY
(2022)
Article
Clinical Neurology
N. Pham, V. Hill, A. Rauschecker, Y. Lui, S. Niogi, C. G. Fillipi, P. Chang, G. Zaharchuk, M. Wintermark
Summary: Clinical adoption of artificial intelligence-enabled imaging tool requires systematic, standardized, and objective evaluation based on scientific evidence. The proposed hierarchical evaluation system aims to establish an evidence-based framework for transparent reporting and understanding of the creation and efficacy of artificial intelligence tools. This proposal is a crucial step toward a formalized, clinically validated, and regulated deployment of artificial intelligence imaging applications.
AMERICAN JOURNAL OF NEURORADIOLOGY
(2023)
Review
Radiology, Nuclear Medicine & Medical Imaging
Brian Tsui, Evan Calabrese, Greg Zaharchuk, Andreas M. Rauschecker
Summary: This article reviews the clinical uses and risks of gadolinium contrast in neuroimaging, as well as the latest advances in machine learning methods for reducing or eliminating gadolinium contrast administration.
JOURNAL OF MAGNETIC RESONANCE IMAGING
(2023)
Article
Clinical Neurology
Hanna E. Willis, I. Betina Ip, Archie Watt, Jon Campbell, Saad Jbabdi, William T. Clarke, Matthew R. Cavanaugh, Krystel R. Huxlin, Kate E. Watkins, Marco Tamietto, Holly Bridge
Summary: The concentration of neurotransmitters GABA and glutamate in the hMT+ region strongly predicted blind-field visual detection abilities, indicating that they may serve as biomarkers for the quality of residual visual processing in the blind field. However, these neurotransmitter levels did not correlate with visually evoked blood oxygenation level-dependent signal changes in the motion-sensitive region, suggesting a unique relationship between neurotransmitter concentrations and blind-field perception.
Article
Computer Science, Artificial Intelligence
Jeffrey D. Rudie, Evan Calabrese, Rachit Saluja, David Weiss, John B. Colby, Soonmee Cha, Christopher P. Hess, Andreas M. Rauschecker, Leo P. Sugrue, Javier E. Villanueva-Meyer
Summary: Neural networks have demonstrated potential clinical value in the automated longitudinal assessment of posttreatment diffuse glioma. The segmentation and classification of longitudinal changes showed high accuracy.
RADIOLOGY-ARTIFICIAL INTELLIGENCE
(2022)
Article
Computer Science, Artificial Intelligence
Andreas M. Rauschecker, Tyler J. Gleason, Pierre Nedelec, Michael Tran Duong, David A. Weiss, Evan Calabrese, John B. Colby, Leo P. Sugrue, Jeffrey D. Rudie, Christopher P. Hess
Summary: This study assessed the performance of a brain MRI lesion segmentation algorithm trained at one institution and applied at another institution. It also explored the impact of multi-institutional training datasets on performance loss mitigation. The results showed that adding relevant training data from an external institution supported the successful application of the previously trained model to the external institution.
RADIOLOGY-ARTIFICIAL INTELLIGENCE
(2022)
Article
Computer Science, Artificial Intelligence
Gunvant R. Chaudhari, Tengxiao Liu, Timothy L. Chen, Gabby B. Joseph, Maya Vella, Yoo Jin Lee, Thienkhai H. Vu, Youngho Seo, Andreas M. Rauschecker, Charles E. McCulloch, Jae Ho Sohn
Summary: This study developed radiology-specific BERT models that can identify SR errors in radiology reports and suggest corrections.
RADIOLOGY-ARTIFICIAL INTELLIGENCE
(2022)