Article
Neurosciences
Magdalena Pereyra, Ana Belen de Landeta, Juliana Fatima Dalto, Cynthia Katche, Jorge H. Medina
Summary: The study shows that the activity of mTORC1 signaling pathway is crucial for the normal expression of aversive and non-aversive long-term memories during memory retrieval. Specifically, the de novo synthesis of GluA1 and GluA2 AMPAR subunits plays an important role in memory retrieval, with mTORC1 potentially regulating AMPAR trafficking during this process.
MOLECULAR NEUROBIOLOGY
(2021)
Article
Cell Biology
Rabia R. Khawaja, Amit Agarwal, Masahiro Fukaya, Hey-Kyeong Jeong, Scott Gross, Estibaliz Gonzalez-Fernandez, Jonathan Soboloff, Dwight E. Bergles, Shin H. Kang
Summary: Regulation of AMPAR GluA2 content in oligodendrocyte precursor cells affects cell proliferation and regenerative behavior, serving as a potential target for myelin repair.
Review
Neurosciences
Magdalena Pereyra, Jorge H. Medina
Summary: Retrieval is a highly regulated and dynamic phase in memory processing, where AMPA receptors play a crucial role in supporting transient memory trace reactivation. The dynamic movements and changes in receptor number and subunit composition of AMPAR during retrieval greatly impact memory recall through their differential regulations in plasticity processes.
FRONTIERS IN HUMAN NEUROSCIENCE
(2021)
Article
Clinical Neurology
Ian D. Coombs, Julie Ziobro, Volodymyr Krotov, Taryn-Leigh Surtees, Stuart G. Cull-Candy, Mark Farrant
Summary: In this study, a novel gain-of-function mutation in the GRIA2 gene was identified, leading to enhanced GluA2 A643V receptor activity. The results suggest that perampanel may have therapeutic efficacy for GRIA2 mutation-related disorders.
Article
Behavioral Sciences
Frank Raven, Iris W. Riemersma, Martha F. Olthuis, Ieva Rybakovaite, Elroy L. Meijer, Peter Meerlo, Eddy A. van der Zee, Robbert Havekes
Summary: Many organisms in the animal kingdom have the ability to form and retrieve memories. Synaptic plasticity is crucial for memory storage. Overactivating cofilin improves short-term memory formation.
FRONTIERS IN BEHAVIORAL NEUROSCIENCE
(2023)
Article
Biochemistry & Molecular Biology
Emmanuel Prikas, Esmeralda Paric, Prita R. Asih, Kristie Stefanoska, Holly Stefen, Thomas Fath, Anne Poljak, Arne Ittner
Summary: Microtubule-associated protein tau plays a central role in Alzheimer's disease and other tauopathies. This study used proximity-labelling proteomics to examine tau interactions in neurons and mouse brains. The results show that tau interacts with proteins involved in cytoskeletal regulation, synaptic vesicle regulation, and postsynaptic receptor regulation. These interactions are related to Parkinson's disease, Alzheimer's disease, and prion disease. Furthermore, the study demonstrates that tau interacts with N-ethylmaleimide sensitive fusion protein (NSF) and reduces its activity, leading to altered trafficking of AMPA-type glutamate receptors (AMPAR) and enhanced memory formation.
Article
Neurosciences
Elisabetta Gerace, Lorenzo Polenzani, Maurizio Magnani, Elisa Zianni, Gabriella Stocca, Fabrizio Gardoni, Domenico E. Pellegrini-Giampietro, Renato Corradetti
Summary: The chronic treatment with trazodone or paroxetine increases the expression of GluA2 AMPA receptor subunits in the hippocampus of rats, but does not lead to enhanced basal neurotransmission or the appearance of functional calcium-permeable AMPARs.
Article
Neurosciences
Shu-Ling Chiu, Chih-Ming Chen, Richard L. Huganir
Summary: The study revealed a novel function of ICA69 in AMPAR trafficking, synaptic plasticity, and animal cognition. ICA69 regulates the distribution and stability of PICK1 in neurons, which impacts AMPAR function in the brain. The genetic deletion of ICA69 selectively impairs NMDAR-dependent LTP and leads to behavioral deficits in spatial and associative learning and memory.
FRONTIERS IN MOLECULAR NEUROSCIENCE
(2023)
Article
Biochemistry & Molecular Biology
Mohammad Qneibi, Hanan Jumaa, Sosana Bdir, Nawaf Al-Maharik
Summary: This study investigates the effects of four novel 2,3-benzodiazepine derivatives on AMPA receptor subunits. The results show inhibitory activity of all four compounds against both homomeric and heteromeric subunits, with two compounds altering desensitization and deactivation rates. These findings contribute to a better understanding of AMPARs and potential 2,3-BDZ drugs.
Article
Neurosciences
Zengyan Zhu, Wenjuan Wang, Chao Gu, Mei Wang, Yinghui Yan
Summary: This study investigates the regulation of AMPARs GluA2 trafficking by M1 mAChRs and identifies the key proteins and signaling cascade involved. Experiments using primary hippocampal neurons and mice reveal that M1 mAChR activation promotes the endocytosis of GluA2 and reduces its postsynaptic localization. PICK1 is found to be crucial for M1 mAChR-mediated GluA2 endocytosis and downstream phosphorylation of GluA2-Ser880, and the interaction between PICK1 and GluA2 is essential for M1 mAChR-mediated postsynaptic expression of GluA2.
PSYCHOPHARMACOLOGY
(2023)
Article
Physics, Fluids & Plasmas
Paul C. Bressloff
Summary: In this paper, the relaxation to steady state of intracellular diffusion in a pair of cells with gap junction coupling is analyzed. The local accumulation time is calculated and it is found to be a monotonically increasing function of spatial position. Both static and dynamic gap junction models are considered.
Article
Chemistry, Medicinal
Horea Stefan Szedlacsek, David Bajusz, Rodica Aura Badea, Andreea Pop, Constantin Catalin Bica, Lilla Ravasz, Daniel Mittli, Dominik Matyas, Georgiana Necula-Petrareanu, Cristian V. A. Munteanu, Ildiko Papp, Gabor Juhasz, Lucian Hritcu, Gyorgy Miklos Keseru, Stefan Eugen Szedlacsek
Summary: Cognitive impairment and learning ability in the brain are directly tied to synaptic plasticity, with AMPAR internalization being linked to the activity of the STEP enzyme. Inhibitors designed to target this process have shown promise in restoring memory deficits and improving anxiety and depression symptoms.
JOURNAL OF MEDICINAL CHEMISTRY
(2022)
Review
Neurosciences
Changyong Guo, Yao-Ying Ma
Summary: Excitotoxicity is a key mechanism of cell loss in various diseases of the central and peripheral nervous systems. In addition to the previously established pathways, CP-AMPAR-mediated excitotoxicity is identified in multiple disease models. Specific manipulation of CP-AMPARs may be a more effective strategy to delay pathological changes with fewer side effects compared to blocking NMDARs.
FRONTIERS IN NEURAL CIRCUITS
(2021)
Article
Cell Biology
Haifeng Lu, Shujun Chen, Qianqian Nie, Qun Xue, Hua Fan, Yiqing Wang, Shenghao Fan, Juehua Zhu, Haitao Shen, Haiying Li, Qi Fang, Jianqiang Ni, Gang Chen
Summary: Syt3 is upregulated after ischemia/reperfusion injury and its overexpression negatively affects motor function recovery. Ischemia/reperfusion injury augments Syt3-GluA2 interactions, decreases GluA2 surface expression, and promotes the formation of Ca2+-permeable AMPA receptors (CP-AMPARs). Inhibiting the Syt3-GluA2 complex promotes neurological recovery and improves cognitive function.
Article
Pharmacology & Pharmacy
Mohamed Z. Habib, Esraa M. Elnahas, Yasmin M. Aboul-Ela, Mai A. Ebeid, Marwa Tarek, Doaa R. Sadek, Eman A. Negm, Dina A. Abdelhakam, Sawsan Aboul-Fotouh
Summary: Several reports suggest that calcium permeable AMPA glutamate receptors with RNA hypo-editing at the GluA2 Q/R site and excitotoxicity-mediated neuronal death play a role in the pathogenesis of neurological disorders including autism spectrum disorder (ASD). This study examined the effects of risperidone treatment on Adar2 expression, GluA2 editing, oxidative/nitrosative stress, and neuronal death in a rat model of ASD. The results showed that risperidone improved behavioral deficits and increased Adar2 expression and GluA2 editing, while reducing oxidative/nitrosative stress and neurodegeneration.
EUROPEAN JOURNAL OF PHARMACOLOGY
(2023)
Article
Neurosciences
Paola Virginia Migues, Lidong Liu, Georgina E. B. Archbold, Einaro O. Einarsson, Jacinda Wong, Kyra Bonasia, Seung Hyun Ko, Yu Tian Wang, Oliver Hardt
JOURNAL OF NEUROSCIENCE
(2016)
Review
Psychology
Oliver Hardt, Einar Oern Einarsson, Karim Nader
ANNUAL REVIEW OF PSYCHOLOGY
(2010)
Article
Neurosciences
Szu-Han Wang, Peter S. B. Finnie, Oliver Hardt, Karim Nader
Editorial Material
Psychology, Biological
Oliver Hardt, Almut Hupback, Lynn Nadel
LEARNING & BEHAVIOR
(2009)
Article
Neurosciences
Almut Hupbach, Oliver Hardt, Rebecca Gomez, Lynn Nadel
Article
Neurosciences
Oliver Hardt, Szu-Han Wang, Karim Nader
Review
Neurosciences
Karim Nader, Oliver Hardt
NATURE REVIEWS NEUROSCIENCE
(2009)
Review
Neurosciences
Lynn Nadel, Oliver Hardt
NEUROPSYCHOPHARMACOLOGY
(2011)
Article
Biology
Oliver Hardt, Karim Nader, Yu-Tian Wang
PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES
(2014)
Review
Behavioral Sciences
Oliver Hardt, Karim Nader, Lynn Nadel
TRENDS IN COGNITIVE SCIENCES
(2013)
Article
Neurosciences
Paola Virginia Migues, Jacinda Wong, Jeongho Lyu, Oliver Hardt
Article
Neurosciences
Bruno Jose Moraes, Oliver Hardt
Summary: Auditory fear conditioning in rats is a widely used method to study learning, memory, and emotional responding. This study explores the factors that could explain interindividual variability in fear expression, and identifies candidate predictors of fear generalization that may inform our understanding of anxiety-related disorders.
Article
Neurosciences
Daisy Arkell, Isabelle Groves, Emma R. Wood, Oliver Hardt
Summary: Reducing sensory experiences after learning can improve long-term memory retention, but the neurobiological mechanisms behind this effect are still unclear. Daily sensory experiences may interfere with processes that promote long-term memory retention, and this interference is not sleep-dependent.
Article
Neurosciences
Almut Hupbach, Rebecca Gomez, Oliver Hardt, Lynn Nadel