Review
Biochemistry & Molecular Biology
Ting Huang, Jingyi Zhou, Jianliu Wang
Summary: Intracellular calcium ions act as important regulators in cancer progression, with estrogen playing a role in inducing calcium increases and kinase cascades. Modulating calcium channels may offer a new approach for treating endometrial cancer.
INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES
(2022)
Article
Neurosciences
Alasdair J. Gibb
Summary: NMDA receptors, specifically the triheteromeric structure of GluN1/GluN2B/GluN2D receptors, play fundamental roles in synaptic physiology and have implications for pharmacological research. This study reviews the mechanism of action of drugs targeting allosteric antagonists at these receptors.
Review
Chemistry, Medicinal
Mingming Zhao, Ziyan Zhang, Zhiyu Pan, Sijia Ma, Meiying Chang, Jiao Fan, Shunxuan Xue, Yuejun Wang, Hua Qu, Yu Zhang
Summary: This meta-analysis of 12 randomized controlled trials demonstrates that N-/T-type calcium channel blockers are more effective than L-type calcium channel blockers in reducing urine albumin/protein excretion in patients with chronic kidney disease treated with renin-angiotensin system inhibitors, without affecting serum creatinine, glomerular filtration rate, and adverse effects.
Article
Pharmacology & Pharmacy
Yulia D. Stepanenko, Dmitry A. Sibarov, Natalia N. Shestakova, Sergei M. Antonov
Summary: N-methyl-D-aspartate receptors (NMDARs) are essential targets for the analgetic action of tricyclic antidepressants (TCAs). The study revealed that the action of TCAs on NMDARs is mainly through the open-channel block. However, at therapeutic blood concentrations, the action of TCAs on NMDARs is insufficient to cause open-channel block. The study also showed that desipramine (DES) demonstrates a profound Ca2+-dependent inhibition, while clomipramine (CLO) has weak effects on NMDARs.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Aparna Ann Mathew, Rajitha Panonnummal
Summary: Magnesium is an important intracellular cation that regulates various biological functions and has therapeutic benefits in treating diseases caused by its deficiency.
Article
Medicine, General & Internal
Maddalena Ardissino, Eric A. W. Slob, Skanda Rajasundaram, Rohin K. Reddy, Benjamin Woolf, Joanna Girling, Mark R. Johnson, Fu Siong Ng, Dipender Gill
Summary: This study investigates the effects of beta-blocker and calcium channel blocker antihypertensive drugs on maternal and foetal outcomes. The results suggest that beta-blocker use may lower birthweight, while calcium channel blocker use may reduce the risk of pre-eclampsia and eclampsia.
Article
Medicine, Research & Experimental
Na Li, Xiang Xu, Dan Liu, Jiaxin Gao, Ying Gao, Xufeng Wu, Huiming Sheng, Qun Li, Jun Mi
Summary: This study reveals that GPT2 promotes breast cancer metastasis through up-regulation of GABA activation of GABAAR-PKC-CREB signaling, suggesting it as a potential target for breast cancer therapy.
Review
Endocrinology & Metabolism
Michael M. Gezalian, Luigi Mangiacotti, Padmesh Rajput, Nicklaus Sparrow, Konrad Schlick, Shouri Lahiri
Summary: Adrenoceptor and calcium channel modulating medications have cerebrovascular-specific effects related to the unique characteristics of cerebrovascular anatomy, which differ from their systemic effects. Future research should consider lesion location when selecting vasoactive medications, aiming to improve neurological outcomes in acute neurological and systemic disorders.
JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM
(2021)
Article
Neurosciences
Wenling Chen, James A. McRoberts, Helena S. Ennes, Juan Carlos Marvizon
Summary: The study showed that the cAMP signaling pathway mediates substance P release in the dorsal horn through the activation of PKA on NMDA receptors, with Epac2 signaling through Raf-mitogen activated protein kinase pathway to increase Ca2+ channel activity. The release of substance P induced by cAMP decreases during pain hypersensitivity.
Article
Biochemistry & Molecular Biology
Jide Tian, Blake Middleton, Victoria Seunghee Lee, Hye Won Park, Zhixuan Zhang, Bokyoung Kim, Catherine Lowe, Nancy Nguyen, Haoyuan Liu, Ryan S. Beyer, Hannah W. Chao, Ryan Chen, Davis Mai, Karen Anne O'Laco, Min Song, Daniel L. Kaufman
Summary: The expression of gamma-aminobutyric acid receptors in immune cells may have therapeutic potential in diseases like T1D, multiple sclerosis, rheumatoid arthritis, and COVID-19. Specific modulation of GABA(B)-Rs with agonists like lesogaberan shows promise in restoring normoglycemia and improving T1D remission rates in mouse models. The analysis of gene expression databases suggests a common feature of GABA receptors and production/secretion-related genes in immune cells.
Review
Cell Biology
Maggie L. Kalev-Zylinska, Marie-Christine Morel-Kopp, Christopher M. Ward, James Hearn, Justin R. Hamilton, Anna Y. Bogdanova
Summary: Ionotropic glutamate receptors, including AMPAR, KAR, and NMDAR, play distinct roles in platelet function, with AMPAR and KAR amplifying platelet function and thrombus formation, and the contribution of NMDAR being less well defined.
Correction
Medicine, General & Internal
Kiyotsugu Iede, Terumasa Yamada, Masami Ueda, Yujiro Tsuda, Shinsuke Nakashima, Katsuya Ohta, Tsukasa Tanida, Jin Matsuyama, Masakazu Ikenaga, Shusei Tominaga
Summary: This study retrospectively analyzed the baseline differences between patients with advanced pancreatic cancer (APC) with and without hypertension. It found that patients with hypertension had a significantly longer overall survival. Therefore, hypertension may affect the prognosis of patients with advanced pancreatic cancer.
Correction
Medicine, General & Internal
Kiyotsugu Iede, Terumasa Yamada, Masami Ueda, Yujiro Tsuda, Shinsuke Nakashima, Katsuya Ohta, Tsukasa Tanida, Jin Matsuyama, Masakazu Ikenaga, Shusei Tominaga
Summary: This study retrospectively analyzed the efficacy of antihypertensive drugs in patients with advanced pancreatic cancer and found that hypertensive patients had longer survival and significant differences in baseline characteristics compared to non-hypertensive patients. This suggests that antihypertensive drugs may lack antitumor activity.
Article
Medicine, General & Internal
Kiyotsugu Iede, Terumasa Yamada, Masami Ueda, Yujiro Tsuda, Shinsuke Nakashima, Katsuya Ohta, Tsukasa Tanida, Jin Matsuyama, Masakazu Ikenaga, Shusei Tominaga
Summary: This study retrospectively investigated the baseline differences between hypertensive (HT) and non-hypertensive (non-HT) patients with advanced pancreatic cancer (APC). It found significant differences in characteristics between the two groups, suggesting a major selection bias. Although no significant difference was found in treatment response, HT patients had significantly longer overall survival. The use of antihypertensive drugs was not identified as an independent prognostic factor.
Article
Pharmacology & Pharmacy
Mariana Peluci Garcia Mendes, Duana Carvalho dos Santos, Marcio Junior S. Rezende, Luana Caroline Assis Ferreira, Flavia Karine Rigo, Celio Jose de Castro Junior, Marcus Vinicius Gomez
Summary: The study found that recombinant Ph alpha 1 beta toxin and pregabalin had a certain therapeutic effect on reserpine-induced mechanical and thermal hyperalgesia, but diclofenac was ineffective. These drugs did not affect the depressive-like behavioral effect induced by reserpine.
Article
Neurosciences
Paola Virginia Migues, Lidong Liu, Georgina E. B. Archbold, Einaro O. Einarsson, Jacinda Wong, Kyra Bonasia, Seung Hyun Ko, Yu Tian Wang, Oliver Hardt
JOURNAL OF NEUROSCIENCE
(2016)
Article
Neurosciences
Ayano Fujinaka, Ruoshi Li, Masanobu Hayashi, Deependra Kumar, Gopakumar Changarathil, Keisuke Naito, Kousuke Miki, Taihei Nishiyama, Michael Lazarus, Takeshi Sakurai, Nohjin Kee, Satomi Nakajima, Szu-Han Wang, Masanori Sakaguchi
Article
Geriatrics & Gerontology
Alexandra Gros, Szu-Han Wang
NEUROBIOLOGY OF AGING
(2018)
Article
Biochemistry & Molecular Biology
Peter S. B. Finnie, Karine Gamache, Maria Protopoulos, Elizabeth Sinclair, Andrew G. Baker, Szu-Han Wang, Karim Nader
Article
Neurosciences
Paola Virginia Migues, Oliver Hardt, Peter Finnie, Yu Tian Wang, Karim Nader
Article
Neurosciences
Szu-Han Wang
Article
Neurosciences
Paola Virginia Migues, Jacinda Wong, Jeongho Lyu, Oliver Hardt
Article
Neurosciences
Deependra Kumar, Iyo Koyanagi, Alvaro Carrier-Ruiz, Pablo Vergara, Sakthivel Srinivasan, Yuki Sugaya, Masatoshi Kasuya, Tzong-Shiue Yu, Kaspar E. Vogt, Masafumi Muratani, Takaaki Ohnishi, Sima Singh, Catia M. Teixeira, Yoan Cherasse, Toshie Naoi, Szu-Han Wang, Pimpimon Nondhalee, Boran A. H. Osman, Naoko Kaneko, Kazunobu Sawamoto, Steven G. Kernie, Takeshi Sakurai, Thomas J. McHugh, Masanobu Kano, Masashi Yanagisawa, Masanori Sakaguchi
Article
Geriatrics & Gerontology
Alexandra Gros, Amos W. H. Lim, Victoria Hohendorf, Nicole White, Michael Eckert, Thomas John McHugh, Szu-Han Wang
Summary: The study found that in young rats, neuronal assemblies activated by memory encoding were also partially activated by novelty, especially in the distal CA1 and proximal CA3 subregions. In early aging, both encoding- and novelty-triggered neuronal populations were significantly reduced, with a more profound effect in encoding neurons.
FRONTIERS IN AGING NEUROSCIENCE
(2022)
Article
Neurosciences
Szu-Han Wang
Summary: This review explores key findings on memory reconsolidation, focusing on the impact of memory strength and reactivation procedures. Interfering with reconsolidation of fear memory can aid in treating PTSD, while hippocampal-dependent spatial memories are crucial in boosting cognitive functions and everyday memory.
BRAIN RESEARCH BULLETIN
(2022)
Article
Multidisciplinary Sciences
Tabitha Broadbelt, Menekse Mutlu-Smith, Daniel Carnicero-Senabre, Takaomi C. Saido, Takashi Saito, Szu-Han Wang
Summary: This study investigated the impact of early amyloid pathology on peri-learning novelty in memory promotion. The results showed that novelty facilitated intermediate-term memory in wild-type mice, but not in App(NL-G-F/NL-G-F) mice. This effect occurred before the spatial memory impairment observed in the ADMP task. Other memory tests remained intact.
SCIENTIFIC REPORTS
(2022)
Article
Neurosciences
Bruno Jose Moraes, Oliver Hardt
Summary: Auditory fear conditioning in rats is a widely used method to study learning, memory, and emotional responding. This study explores the factors that could explain interindividual variability in fear expression, and identifies candidate predictors of fear generalization that may inform our understanding of anxiety-related disorders.
Article
Neurosciences
Daisy Arkell, Isabelle Groves, Emma R. Wood, Oliver Hardt
Summary: Reducing sensory experiences after learning can improve long-term memory retention, but the neurobiological mechanisms behind this effect are still unclear. Daily sensory experiences may interfere with processes that promote long-term memory retention, and this interference is not sleep-dependent.
Proceedings Paper
Mathematics, Interdisciplinary Applications
Alexander E. Brownlee, Suk-Jun Kim, Szu-Han Wang, Stella Chan, Jamie A. Lawson
PROCEEDINGS OF THE 2019 GENETIC AND EVOLUTIONARY COMPUTATION CONFERENCE COMPANION (GECCCO'19 COMPANION)
(2019)
Article
Neuroimaging
Maria C. Valdes Hernandez, Rupert Clark, Szu-Han Wang, Federica Guazzo, Clara Calia, Vivek Pattan, John Starr, Sergio Della Sala, Mario Alfredo Parra
NEUROIMAGE-CLINICAL
(2020)