Immune and inflammatory pathways in NASH

Dendritic cells limit fibroinflammatory injury in nonalcoholic steatohepatitis in mice

(2013) Justin R. Henning et al.   HEPATOLOGY

Nonalcoholic Fatty Liver Disease/Steatohepatitis: Epidemiology, Pathogenesis, Clinical Presentation and Treatment

(2012) Sandra Milic et al.   DIGESTIVE DISEASES

Sterile Inflammation in the Liver

(2012) Paul Kubes et al.   GASTROENTEROLOGY

NKT-associated hedgehog and osteopontin drive fibrogenesis in non-alcoholic fatty liver disease

(2012) Wing-Kin Syn et al.   GUT

Toll-like receptor 2 and palmitic acid cooperatively contribute to the development of nonalcoholic steatohepatitis through inflammasome activation in mice

(2012) Kouichi Miura et al.   HEPATOLOGY

Oxidized Mitochondrial DNA Activates the NLRP3 Inflammasome during Apoptosis

(2012) Kenichi Shimada et al.   IMMUNITY

Inflammasomes in liver diseases

(2012) Gyongyi Szabo et al.   JOURNAL OF HEPATOLOGY

Loss of toll-like receptor 3 function improves glucose tolerance and reduces liver steatosis in obese mice

(2012) Linda H. Wu et al.   METABOLISM-CLINICAL AND EXPERIMENTAL

High-mobility group box family of proteins: ligand and sensor for innate immunity

(2012) Hideyuki Yanai et al.   TRENDS IN IMMUNOLOGY

Microvesicular fat, inter cellular adhesion molecule-1 and regulatory T-lymphocytes are of importance for the inflammatory process in livers with non-alcoholic steatohepatitis

(2011) CECILIA SÖDERBERG et al.   APMIS

Effects of two Lactobacillus strains on lipid metabolism and intestinal microflora in rats fed a high-cholesterol diet

(2011) Ning Xie et al.   BMC Complementary and Alternative Medicine

Interleukin-17 exacerbates hepatic steatosis and inflammation in non-alcoholic fatty liver disease

(2011) Y. Tang et al.   CLINICAL AND EXPERIMENTAL IMMUNOLOGY

Role of oxidative stress in the pathogenesis of nonalcoholic steatohepatitis

(2011) Anabela P. Rolo et al.   FREE RADICAL BIOLOGY AND MEDICINE

Mitochondrial antiviral signaling protein defect links impaired antiviral response and liver injury in steatohepatitis in mice

(2011) Timea Csak et al.   HEPATOLOGY

Pathogen- or damage-associated molecular patterns during nonalcoholic fatty liver disease development

(2011) Anna Alisi et al.   HEPATOLOGY

Nuclear factor high-mobility group box1 mediating the activation of toll-like receptor 4 signaling in hepatocytes in the early stage of nonalcoholic fatty liver disease in mice

(2011) Liang Li et al.   HEPATOLOGY

Fatty acid and endotoxin activate inflammasomes in mouse hepatocytes that release danger signals to stimulate immune cells

(2011) Timea Csak et al.   HEPATOLOGY

Regulation of the Antimicrobial Response by NLR Proteins

(2011) Eran Elinav et al.   IMMUNITY

Inflammatory links between obesity and metabolic disease

(2011) Carey N. Lumeng et al.   JOURNAL OF CLINICAL INVESTIGATION

Lack of interleukin-1α or interleukin-1β inhibits transformation of steatosis to steatohepatitis and liver fibrosis in hypercholesterolemic mice

(2011) Yehuda Kamari et al.   JOURNAL OF HEPATOLOGY

Blockade of IL-6 signaling exacerbates liver injury and suppresses antiapoptotic gene expression in methionine choline-deficient diet-Fed db/db mice

(2011) Kanji Yamaguchi et al.   LABORATORY INVESTIGATION

Neutrophil to lymphocyte ratio: a new marker for predicting steatohepatitis and fibrosis in patients with nonalcoholic fatty liver disease

(2011) Naim Alkhouri et al.   LIVER INTERNATIONAL

Foxp3Expression in Liver Correlates with the Degree but Not the Cause of Inflammation

(2011) Matthaios Speletas et al.   MEDIATORS OF INFLAMMATION

Fatty acid–induced NLRP3-ASC inflammasome activation interferes with insulin signaling

(2011) Haitao Wen et al.   NATURE IMMUNOLOGY

The NLRP3 inflammasome instigates obesity-induced inflammation and insulin resistance

(2011) Bolormaa Vandanmagsar et al.   NATURE MEDICINE

Inflammasome is a central player in the induction of obesity and insulin resistance

(2011) R. Stienstra et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The Sterile Inflammatory Response

(2010) Kenneth L. Rock et al.   Annual Review of Immunology

Nonalcoholic Fatty Liver Disease: Pathology and Pathogenesis

(2010) Dina G. Tiniakos et al.   Annual Review of Pathology-Mechanisms of Disease

HMGB proteins: Interactions with DNA and chromatin

(2010) Michal Štros   Biochimica et Biophysica Acta-Gene Regulatory Mechanisms

Toll-like receptor-2 deficiency enhances non-alcoholic steatohepatitis

(2010) Chantal A Rivera et al.   BMC GASTROENTEROLOGY

The Inflammasomes

(2010) Kate Schroder et al.   CELL

Role of IL-17 and Th17 Cells in Liver Diseases

(2010) Linda Hammerich et al.   Clinical & Developmental Immunology

Toll-like receptor 2-deficient mice are protected from insulin resistance and beta cell dysfunction induced by a high-fat diet

(2010) J. A. Ehses et al.   DIABETOLOGIA

Interleukin-6-deficient mice develop hepatic inflammation and systemic insulin resistance

(2010) V. B. Matthews et al.   DIABETOLOGIA

Anti-inflammatory effects of excessive weight loss: potent suppression of adipose interleukin 6 and tumour necrosis factor   expression

(2010) A. R. Moschen et al.   GUT

Accumulation of natural killer T cells in progressive nonalcoholic fatty liver disease

(2010) Wing-Kin Syn et al.   HEPATOLOGY

Evolution of inflammation in nonalcoholic fatty liver disease: The multiple parallel hits hypothesis

(2010) Herbert Tilg et al.   HEPATOLOGY

T-helper 17 cell: A distinctive cell in liver diseases

(2010) Chao Ye et al.   HEPATOLOGY RESEARCH

Th17 cells: The emerging reciprocal partner of regulatory T cells in the liver

(2010) Li ZHAO et al.   Journal of Digestive Diseases

Blockade of interleukin-6 signaling enhances hepatic steatosis but improves liver injury in methionine choline-deficient diet-fed mice

(2010) Kanji Yamaguchi et al.   LABORATORY INVESTIGATION

Autophagy proteins regulate innate immune responses by inhibiting the release of mitochondrial DNA mediated by the NALP3 inflammasome

(2010) Kiichi Nakahira et al.   NATURE IMMUNOLOGY

The role of pattern-recognition receptors in innate immunity: update on Toll-like receptors

(2010) Taro Kawai et al.   NATURE IMMUNOLOGY

Natural Killer Cells in Obesity: Impaired Function and Increased Susceptibility to the Effects of Cigarette Smoke

(2010) Donal O'Shea et al.   PLoS One

Metabolic Syndrome and Altered Gut Microbiota in Mice Lacking Toll-Like Receptor 5

(2010) M. Vijay-Kumar et al.   SCIENCE

Increased Hepatic Myeloperoxidase Activity in Obese Subjects with Nonalcoholic Steatohepatitis

(2009) Sander S. Rensen et al.   AMERICAN JOURNAL OF PATHOLOGY

The Inflammasomes: Guardians of the Body

(2009) Fabio Martinon et al.   Annual Review of Immunology

Depletion of Liver Kupffer Cells Prevents the Development of Diet-Induced Hepatic Steatosis and Insulin Resistance

(2009) W. Huang et al.   DIABETES

VSL#3 probiotic treatment attenuates fibrosis without changes in steatohepatitis in a diet-induced nonalcoholic steatohepatitis model in mice

(2009) Arumugam Velayudham et al.   HEPATOLOGY

Increased intestinal permeability and tight junction alterations in nonalcoholic fatty liver disease

(2009) Luca Miele et al.   HEPATOLOGY

Kupffer cell and interleukin-12-dependent loss of natural killer T cells in hepatosteatosis

(2009) Michael Kremer et al.   HEPATOLOGY

Toll-like receptor 4 is involved in the development of fructose-induced hepatic steatosis in mice

(2009) Astrid Spruss et al.   HEPATOLOGY

Kupffer cells in non-alcoholic fatty liver disease: The emerging view

(2009) György Baffy   JOURNAL OF HEPATOLOGY

HMGB1 loves company

(2009) Marco E. Bianchi   JOURNAL OF LEUKOCYTE BIOLOGY

Metabolic syndrome, non-alcoholic fatty liver disease and hepatitis C virus: impact on disease progression and treatment response

(2009) Zobair M. Younossi et al.   LIVER INTERNATIONAL

The role of interleukins in insulin resistance and type 2 diabetes mellitus

(2009) Bruno Fève et al.   Nature Reviews Endocrinology

Neutrophil Activation in Morbid Obesity, Chronic Activation of Acute Inflammation

(2009) Jeroen Nijhuis et al.   Obesity

High Fat Feeding Induces Hepatic Fatty Acid Elongation in Mice

(2009) Maaike H. Oosterveer et al.   PLoS One

Attenuation of inflammation and cellular stress-related pathways maintains insulin sensitivity in obese type I interleukin-1 receptor knockout mice on a high-fat diet

(2009) Baukje de Roos et al.   PROTEOMICS

Alternative M2 Activation of Kupffer Cells by PPARδ Ameliorates Obesity-Induced Insulin Resistance

(2008) Justin I. Odegaard et al.   Cell Metabolism

Immune regulation by invariant NKT cells in autoimmunity

(2008) Francesca Ronchi   Frontiers in Bioscience-Landmark

Bacterial DNA in patients with cirrhosis and noninfected ascites mimics the soluble immune response established in patients with spontaneous bacterial peritonitis

(2008) Rubén Francés et al.   HEPATOLOGY

Nonalcoholic fatty liver disease and nonalcoholic steatohepatitis: Selected practical issues in their evaluation and management

(2008) Raj Vuppalanchi et al.   HEPATOLOGY

Probiotics improve high fat diet-induced hepatic steatosis and insulin resistance by increasing hepatic NKT cells

(2008) Xiong Ma et al.   JOURNAL OF HEPATOLOGY

Relationship of Porphyromonas gingivalis with glycemic level in patients with type 2 diabetes following periodontal treatment

(2008) N. Makiura et al.   Oral microbiology and immunology