A novel monoclonal antibody to characterize pathogenic polymers in liver disease associated with α1-antitrypsin deficiency

Conformational Pathology of the Serpins: Themes, Variations, and Therapeutic Strategies

(2009) Bibek Gooptu et al.   Annual Review of Biochemistry

Probing Neuroserpin Polymerization and Interaction with Amyloid-β Peptides Using Single Molecule Fluorescence

(2009) Albert Chiou et al.   BIOPHYSICAL JOURNAL

Molecular characterization of the new defective Pbresciaalpha1-antitrypsin allele

(2009) Daniela Medicina et al.   HUMAN MUTATION

Endoplasmic Reticulum-associated Degradation (ERAD) and Autophagy Cooperate to Degrade Polymerogenic Mutant Serpins

(2009) Heike Kroeger et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Crystallographic and Cellular Characterisation of Two Mechanisms Stabilising the Native Fold of α1-Antitrypsin: Implications for Disease and Drug Design

(2009) Bibek Gooptu et al.   JOURNAL OF MOLECULAR BIOLOGY

The intracellular accumulation of polymeric neuroserpin explains the severity of the dementia FENIB

(2008) E. Miranda et al.   HUMAN MOLECULAR GENETICS

Crystal structure of a stable dimer reveals the molecular basis of serpin polymerization

(2008) Masayuki Yamasaki et al.   NATURE