Article
Cell Biology
Yiyun Yao, Xingxing Chai, Chen Gong, Lifang Zou
Summary: WT1 functions as an oncogene and tumor suppressor in AML, with p53 playing a critical role in regulating WT1's function. P53 interacts with WT1 to modulate the expression of WT1's target genes. AML-derived p53 mutation can disrupt this interaction, leading to loss of modulation of WT1's target genes.
Article
Multidisciplinary Sciences
Damian E. Berardi, Althea Bock-Hughes, Alexander R. Terry, Lauren E. Drake, Grazyna Bozek, Kay F. Macleod
Summary: Hepatic steatosis is a major factor in the development of hepatocellular carcinoma (HCC). In this study, BNIP3, a mitochondrial cargo receptor, was identified as a suppressor of HCC that reduces lipid accumulation and inhibits tumor cell growth. Deletion of Bnip3 in a mouse model of HCC resulted in shorter tumor latency and increased tumor burden, accompanied by early lipid accumulation. Low BNIP3 expression in human HCC was also associated with increased lipid content and worse prognosis.
Article
Multidisciplinary Sciences
Jorg H. Stehle, Zhiyuan Sheng, Laura Hausmann, Philipp Bechstein, Oliver Weinmann, Juha Hernesniemi, Joseph S. Neimat, Martin E. Schwab, Ajmal Zemmar
Summary: Exercise-induced downregulation of Nogo-A in rats' motor cortex promotes neural plasticity and enhances motor learning, while the subsequent upregulation of Nogo-A is crucial for consolidating acquired motor skills. The timing of Nogo-A modulation plays a critical role in balancing learning and memory consolidation in the context of physical exercise.
Article
Oncology
Maria V. Yusenko, Abhiruchi Biyanee, Mattias K. Andersson, Silke Radetzki, Jens P. von Kries, Goran Stenman, Karl-Heinz Klempnauer
Summary: Studies on MYB in human malignancies have identified it as a potential drug target for AML and ACC. While transcription factors are often considered hard to target, recent developments have shown successful targeting of MYB with low molecular weight compounds. The use of proteasome inhibitors to suppress oncogenic MYB activity opens up new possibilities for therapeutic approaches in MYB-driven cancers.
Article
Pharmacology & Pharmacy
Jia Liu, Zhuojun Liu, Jing Zhang, Xiaofang Chen, Junge Chen, Linlin Sui, Jian Yu
Summary: In this study, the researchers found that Ibrutinib has a stronger cytotoxic effect on endothelial cells compared to Zanubrutinib, while Acalabrutinib has a very weak cytotoxic effect. Ibrutinib was also found to induce endothelial dysfunction through the stimulation of BMP4 expression. The findings suggest the potential use of Ibrutinib in the treatment of angiogenesis-dependent cancers.
Article
Oncology
Ding Wang, Xiaodong Wei, Xuyang Chen, Qian Wang, Jinghua Zhang, Dhan V. Kalvakolanu, Baofeng Guo, Ling Zhang
Summary: The study demonstrates that GRIM-19 inhibits CRC cell proliferation and induces apoptosis through posttranslational regulation of p53, while also enhancing the effect of oxaliplatin against CRC. Therefore, GRIM-19 plays a critical role in CRC development and may serve as a potential biomarker and therapeutic target for CRC.
EXPERIMENTAL CELL RESEARCH
(2021)
Article
Cell Biology
Guoliang Zhang, Yiqing He, Yiwen Liu, Yan Du, Cuixia Yang, Feng Gao
Summary: The study revealed that the deficiency of cross-linked HA induced breast cancer malignancy in a CAF-dependent manner, with CAFs restoring high levels of cross-linked HA and inhibiting malignancy through upregulating TSG6. These findings suggest that recovering HA cross-linking may be a potential therapeutic strategy.
CELL DEATH & DISEASE
(2021)
Article
Immunology
Cecilia Abreu, Claudia Ortega, Natalia Olivero-Deibe, Federico Carrion, Aracelly Gaete-Argel, Fernando Valiente-Echeverria, Ricardo Soto-Rifo, Rafaela Milan Bonotto, Alessandro Marcello, Sergio Pantano
Summary: To combat emerging SARS-CoV-2 variants, a customizable pentameric scaffold was created based on a mammalian protein, capable of neutralizing Spike proteins from multiple viral particles simultaneously. With just two modules targeting the Spike's RBD domain, it outperforms human antibodies from vaccinated individuals and blocks virus entry. This multibody can be easily produced and contributes to therapeutic development and preparedness against evolving pathogens.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Cell Biology
Long Liao, Yan He, Shu-Jun Li, Xiao-Mei Yu, Zhi-Chao Liu, Yi-Yao Liang, Han Yang, Jing Yang, Guo-Geng Zhang, Chun-Miao Deng, Xian Wei, Yi-Dong Zhu, Tao-Yang Xu, Can-Can Zheng, Chao Cheng, Ang Li, Zhi-Gang Li, Jin-Bao Liu, Bin Li
Summary: Posttranslational modifications, such as lysine acylation, are highly complex in proteomes, particularly in cancer metastases. This study identified N-acetyltransferase 10 (NAT10) as a substrate for lysine 2-hydroxyisobutyrylation (Khib) modification, which plays a crucial role in promoting metastasis through the stabilization of NAT10 protein and enhancement of NAT10- USP39 interaction. Furthermore, a lead compound inhibiting NAT10 Khib modification showed promising anti-metastatic efficacy in vivo. These findings elucidate the link between lysine acylation and RNA modifications, providing new insights into epigenetic regulation in cancer and suggesting NAT10 Khib modification as a potential therapeutic target for metastasis.
Article
Cell Biology
Yanan Li, Shujing Li, Xiaoxia Shi, Zhiqiang Xin, Yuxi Yang, Binggong Zhao, Yvlin Li, Linlin Lv, Ping Ren, Huijian Wu
Summary: KLF12 gene plays a role in promoting proliferation and inhibiting apoptosis in breast cancer. It affects the stability and acetylation of p53 protein and transcription of p21 gene, suggesting its importance as a prognostic marker and therapeutic target in breast cancer.
CELL DEATH & DISEASE
(2023)
Article
Biochemistry & Molecular Biology
Viktoria K. Ilic, Olga Egorova, Ernest Tsang, Milena Gatto, Yi Wen, Yong Zhao, Yi Sheng
Summary: The proto-oncogene MDM2 is frequently amplified in many human cancers and its overexpression is associated with poor prognosis. MDM2 shows oncogenic activity by negatively regulating tumor suppressor p53 and proteins involved in DNA repair, cell cycle control, and apoptosis pathways. Inhibition of MDM2 activity has been pursued as an attractive direction for anti-cancer therapeutics. This study identified a biflavonoid compound Hinokiflavone as a promising candidate compound targeting MDM2. Hinokiflavone was shown to bind the MDM2-MDMX RING domain and inhibit MDM2-mediated ubiquitination in vitro. Hinokiflavone treatment downregulated MDM2 and MDMX and induced apoptosis in various cancer cell lines. Hinokiflavone demonstrated tumor-suppressive activity that is both p53-dependent and -independent.
Article
Cell Biology
Abhiruchi Biyanee, Maria Yusenko, Karl-Heinz Klempnauer
Summary: Recent studies have identified transcription factor MYB as a potential drug target for acute myeloid leukemia and adenoid cystic carcinoma. While transcription factors are traditionally considered undruggable, researchers have successfully targeted MYB using low-molecular-weight compounds. In this study, protein kinase inhibitors bosutinib, PD180970, and PD161570 were identified as MYB-inhibitory agents and shown to interfere with the activity of MYB, induce differentiation and cell death in AML cells, and dampen the effects of MYB activation. These findings suggest that targeting MYB function may play a role in the pharmacological impact of these inhibitors on leukemic cells.
Article
Multidisciplinary Sciences
Annie Vincent, Frederic Dessauge, Florence Gondret, Benedicte Lebret, Nathalie Le Floc'h, Isabelle Louveau, Louis Lefaucheur
Summary: The study found that pigs have muscle-type specific metabolic adaptations to poor hygiene conditions, with different muscle fibers reacting differently and possibly related to strategies to fuel the activated immune system.
SCIENTIFIC REPORTS
(2022)
Article
Multidisciplinary Sciences
Gillian Kearney, David Grau, Damaris Nieves Torres, Seung Min Shin, Sang H. Lee
Summary: Overexpression of the S-SCAM gene is associated with schizophrenia and leads to male-specific impairments in synaptic plasticity and working memory. Reductions in synaptic levels of Axin1 and GSK3 beta are implicated in the mechanisms underlying these sex-specific deficits.
SCIENTIFIC REPORTS
(2022)
Article
Endocrinology & Metabolism
Andre Sarmento-Cabral, Mercedes del Rio-Moreno, Mari C. Vazquez-Borrego, Mariyah Mahmood, Elena Gutierrez-Casado, Natalie Pelke, Grace Guzman, Papasani Subbaiah, Jose Cordoba-Chacon, Shoshana Yakar, Rhonda D. Kineman
Summary: The study found that knocking down GHR in adult hepatocytes leads to non-alcoholic fatty liver disease, with no significant changes observed in female mice but with symptoms of steatosis, hepatocyte ballooning, and inflammation present in male mice.
JOURNAL OF ENDOCRINOLOGY
(2021)