Article
Cardiac & Cardiovascular Systems
Hilmi Alnsasra, Gal Tsaban, Jean Marc Weinstein, Mhamad Nasasra, Tal Ovdat, Roy Beigel, Katia Orvin, Moti Haim
Summary: Among patients with AMI, women are more likely to have atrial fibrillation and HAVB, but lower rates of early ventricular tachyarrhythmia compared to men. Early and late VTAs, AF, and HAVB are associated with increased 30-day mortality, while only late VTA and AF are linked to post-30-day mortality.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2023)
Article
Biochemistry & Molecular Biology
Konstantinos D. Rizas, Luisa Freyer, Nikolay Sappler, Lukas von Stuelpnagel, Peter Spielbichler, Aresa Krasniqi, Michael Schreinlechner, Felix N. Wenner, Fabian Theurl, Amira Behroz, Elodie Eiffener, Mathias P. Klemm, Annika Schneidewind, Martin Zens, Theresa Dolejsi, Ulrich Mansmann, Steffen Massberg, Axel Bauer
Summary: The study compared the efficacy of digital smart devices in detecting atrial fibrillation (AF) and found that digital screening technology more than doubled the detection rate of treatment-relevant AF compared to usual care. This technology has the potential for broad applicability and further studies are needed to assess if digital screening for AF leads to better treatment outcomes.
Article
Medicine, General & Internal
Irene Hiniesto-Inigo, Laura M. Castro-Gonzalez, Valentina Corradi, Mark A. Skarsfeldt, Samira Yazdi, Siri Lundholm, Johan Nikesjo, Sergei Yu Noskov, Bo Hjorth Bentzen, D. Peter Tieleman, Sara I. Liin
Summary: In this study, the researchers investigated the potential modulation of the cardiac voltage-gated potassium channel KV7.1/KCNE1 by endocannabinoids. They found that certain endocannabinoids facilitate channel activation and have protective effects in Long QT Syndrome.
Review
Medicine, General & Internal
Alban Belkouche, Hermann Yao, Alain Putot, Frederic Chague, Luc Rochette, Nicolas Danchin, Laurent Fauchier, Marianne Zeller, Yves Cottin
Summary: This review highlights the complex relationship between atrial fibrillation and myocardial infarction, with AF being a common trigger for different types of MI. AF plays a crucial role in the pathogenesis of MI and requires specific management.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Biochemistry & Molecular Biology
Yang Gong, Tingting Yu, Wei Shuai, Tao Chen, Jingjing Zhang, He Huang
Summary: USP38 plays an important role in atrial inflammation, fibrosis, and AF susceptibility after MI. The TAK1/NF-kappa B signaling pathway is involved in this process. USP38-CKO attenuates atrial inflammation, fibrosis, and abnormal electrophysiologic properties, and reduces susceptibility to AF, while USP38-TG shows the opposite effect by overactivating the TAK1/NF-kappa B signaling pathway.
MOLECULAR MEDICINE
(2023)
Article
Biochemistry & Molecular Biology
Estefania Martinez-Barrios, Sergi Cesar, Jose Cruzalegui, Clara Hernandez, Elena Arbelo, Victoria Fiol, Josep Brugada, Ramon Brugada, Oscar Campuzano, Georgia Sarquella-Brugada
Summary: Sudden death is rare in the pediatric population, and in cases where the cause is inconclusive, sudden arrhythmic death syndrome is suggested as the main potential cause. However, the current challenges in genetic diagnosis include establishing the correct genotype-phenotype association and classifying variants of uncertain significance.
Review
Cell Biology
Laura Iop, Sabino Iliceto, Giovanni Civieri, Francesco Tona
Summary: Rhythm disturbances are life-threatening cardiovascular diseases that can be better understood through preclinical modeling of human pathophysiology, leading to effective strategies for prevention, diagnosis, and clinical management. In the vast array of rhythm disturbances, diseases of the conduction system have been extensively preclinically modeled.
Article
Medicine, General & Internal
Francesco Luzza, Rosalba De Sarro, Roberto Licordari, Pasquale Crea, Pietro Pugliatti, Giuseppe Certo, Lorenzo Pistelli, Francesca Campanella, Maria Claudia Lo Nigro, Matteo Casale, Michele Correale, Giuseppe Dattilo
Summary: QT interval varies with heart rate and needs to be corrected. Atrial fibrillation (AF) is associated with elevated heart rate and beat-to-beat variation. The study aims to find the best correlation between QTc in AF and restored sinus rhythm (SR) and determine the best correction formula and method for determining QTc in AF. The results show that Bazzett's formula is the least accurate in estimating QTc during AF.
EUROPEAN JOURNAL OF CLINICAL INVESTIGATION
(2023)
Review
Biochemistry & Molecular Biology
Antonella Liantonio, Matteo Bertini, Antonietta Mele, Cristina Balla, Giorgia Dinoi, Rita Selvatici, Marco Mele, Annamaria De Luca, Francesca Gualandi, Paola Imbrici
Summary: Brugada syndrome is a challenging disease in terms of diagnosis, arrhythmia risk prediction, pathophysiology, and management. The identification of a polygenic origin and the potential role of common genetic variants have laid the foundation for using polygenic risk scores for individual risk prediction. The understanding of this syndrome is evolving towards considering it as a partly structural disease rather than solely an electrical disease.
Article
Cardiac & Cardiovascular Systems
Cheng Li, Haicheng Wang, Mohan Li, Xiangjun Qiu, Qunshan Wang, Jian Sun, Mei Yang, Xiangfei Feng, Shu Meng, Pengpai Zhang, Bo Liu, Wei Li, Mu Chen, Yan Zhao, Rui Zhang, Binfeng Mo, Yuling Zhu, Baohong Zhou, Min Chen, Xia Liu, Yuelin Zhao, Mingzhen Shen, Jinkang Huang, Li Luo, Hong Wu, Yi-Gang Li
Summary: This study investigated the prevalence of atrial fibrillation (AF) in the Chinese community population in 2019 and the association with other arrhythmias and myocardial ischemia (MI) events. The results showed a higher prevalence of AF in the Chinese community population than previously reported, and AF patients, especially elderly males, had a higher risk of developing myocardial infarction. Stricter measures should be taken to control the common risk factors of AF and coronary heart disease, and more attention should be paid to identifying fatal arrhythmias in this population.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2022)
Review
Medicine, General & Internal
Clara Bonanad, Sergio Garcia-Blas, Javier Torres Llergo, Rosa Fernandez-Olmo, Pablo Diez-Villanueva, Albert Ariza-Sole, Manuel Martinez-Selles, Sergio Raposeiras, Ana Ayesta, Vicente Bertomeu-Gonzalez, Francisco Tarazona Santabalbina, Lorenzo Facila, David Vivas, Ana Gabaldon-Perez, Vicente Bodi, Julio Nunez, Alberto Cordero
Summary: Our meta-analysis indicates that DOACs are more effective and safer than warfarin in patients with nonvalvular AF over the age of 80, showing statistical superiority in reducing stroke and all-cause mortality. Despite no significant reduction in major bleeding and gastrointestinal bleeding risk, DOACs were associated with a 43% decrease in intracranial bleeding risk compared to warfarin.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Multidisciplinary Sciences
Stephan Baldus, Jan Beyer-Westendorf, Helge Moellmann, Wolfgang Rottbauer, Elisabeth Beyerlein, Andreas Goette
Summary: ENCOURAGE-AF is a non-interventional study in Germany aiming to investigate the usage patterns and safety of edoxaban in patients with atrial fibrillation (AF) who have undergone percutaneous coronary intervention (PCI), as well as evaluating patients' quality of life and health resource utilization.
SCIENTIFIC REPORTS
(2023)
Article
Medicine, General & Internal
Bianca J. J. M. Brundel, Xun Ai, Mellanie True Hills, Myrthe F. Kuipers, Gregory Y. H. Lip, Natasja M. S. de Groot
Summary: Atrial fibrillation (AF) is the most common cardiac arrhythmia and is increasing in prevalence. Understanding the molecular mechanisms underlying AF is crucial for the development of personalized diagnostic tools and mechanism-based therapies. Co-creation with patients is essential for successful management of AF.
NATURE REVIEWS DISEASE PRIMERS
(2022)
Article
Genetics & Heredity
Jia Chen, Hong Li, Sicheng Guo, Zhe Yang, Shaoping Sun, JunJie Zeng, Hongjuan Gou, Yechang Chen, Feng Wang, Yanping Lin, Kun Huang, Hong Yue, Yuting Ma, Yubi Lin
Summary: Brugada syndrome (Brs) and long QT syndrome (LQTs) are common inherited arrhythmia syndromes caused by mutations that may affect the function of cardiac ion channels.
ORPHANET JOURNAL OF RARE DISEASES
(2022)
Article
Medicine, General & Internal
Amalia Ioanna Moula, Iris Parrini, Cecilia Tetta, Fabiana Luca, Gianmarco Parise, Carmelo Massimiliano Rao, Emanuela Mauro, Orlando Parise, Francesco Matteucci, Michele Massimo Gulizia, Mark La Meir, Sandro Gelsomino
Summary: Atrial fibrillation (AF) is the most common arrhythmia, with its incidence increasing with age and comorbidities. Obstructive sleep apnea (OSA) is a chronic sleep disorder more commonly found in older men. Previous studies have shown a link between OSA and AF, although the prevalence of OSA in AF patients remains unknown due to underdiagnosis. This meta-analysis investigated the association between OSA and AF, using data from 54,271 patients. A strong link was found between these two disorders, with the incidence of AF being 88% higher in patients with OSA. Age and hypertension were found to independently strengthen this association, indicating that treating OSA may help reduce AF recurrence. Further research is needed to confirm these findings.
JOURNAL OF CLINICAL MEDICINE
(2022)
Editorial Material
Cardiac & Cardiovascular Systems
Ahmad S. Amin, Arthur A. M. Wilde
EUROPEAN HEART JOURNAL
(2016)
Letter
Cardiac & Cardiovascular Systems
Ahmad S. Amin, Yigal M. Pinto, Michael J. Ackerman, Arthur A. M. Wilde
CIRCULATION-CARDIOVASCULAR GENETICS
(2016)
Article
Cardiac & Cardiovascular Systems
Yuka Mizusawa, Hiroshi Morita, Arnon Adler, Ofer Havakuk, Aurelie Thollet, Philippe Maury, Dao W. Wang, Kui Hong, Estelle Gandjbakhch, Frederic Sacher, Dan Hu, Ahmad S. Amin, Najim Lahrouchi, Hanno L. Tan, Charles Antzelevitch, Vincent Probst, Sami Viskin, Arthur A. M. Wilde
Letter
Cardiac & Cardiovascular Systems
Ahmad S. Amin, Yigal M. Pinto, Michael J. Ackerman, Arthur A. M. Wilde
CIRCULATION-CARDIOVASCULAR GENETICS
(2016)
Article
Cardiac & Cardiovascular Systems
Arthur A. M. Wilde, Ahmad Amin
INTERNATIONAL JOURNAL OF CARDIOLOGY
(2017)
Article
Cardiac & Cardiovascular Systems
Maarten M. G. van den Hoogenhof, Abdelaziz Beqqali, Ahmad S. Amin, Ingeborg van der Made, Simona Aufiero, Mohsin A. F. Khan, Cees A. Schumacher, Joeri A. Jansweijer, Karin Y. van Spaendonck-Zwarts, Carol Ann Remme, Johannes Backs, Arie O. Verkerk, Antonius Baartscheer, Yigal M. Pinto, Esther E. Creemers
Editorial Material
Cardiac & Cardiovascular Systems
Ahmad S. Amin, Arthur A. M. Wilde
Article
Cardiac & Cardiovascular Systems
Ahmad S. Amin, Yolan J. Reckman, Elena Arbelo, Anne M. Spanjaart, Pieter G. Postema, Rafik Tadros, Michael W. Tanck, Maarten P. Van den Berg, Arthur A. M. Wilde, Hanno L. Tan
INTERNATIONAL JOURNAL OF CARDIOLOGY
(2018)
Letter
Cardiac & Cardiovascular Systems
Ahmad S. Amin, Arthur A. M. Wilde, Hanno L. Tan
INTERNATIONAL JOURNAL OF CARDIOLOGY
(2018)
Article
Cardiac & Cardiovascular Systems
Rafik Tadros, Hanno L. Tan, Sulayman el Mathari, Jan A. Kors, Pieter G. Postema, Najim Lahrouchi, Leander Beekman, Milena Radivojkov-Blagojevic, Ahmad S. Amin, Thomas Meitinger, Michael W. Tanck, Arthur A. Wilde, Connie R. Bezzina
EUROPEAN HEART JOURNAL
(2019)
Article
Cardiac & Cardiovascular Systems
Caroline Bruikman, Maurice W. J. de Ronde, Ahmed Amin, Sonja Levy, Pien Lof, Ursula de Ruijter, G. Kees Hovingh, Hanno L. Tan, Sara-Joan Pinto-Sietsma
Article
Cardiac & Cardiovascular Systems
Arnon Adler, Valeria Novelli, Ahmad S. Amin, Emanuela Abiusi, Melanie Care, Eline A. Nannenberg, Harriet Feilotter, Simona Amenta, Daniela Mazza, Hennie Bikker, Amy C. Sturm, John Garcia, Michael J. Ackerman, Raymond E. Hershberger, Marco V. Perez, Wojciech Zareba, James S. Ware, Arthur A. M. Wilde, Michael H. Gollob
Review
Cardiac & Cardiovascular Systems
Arie O. Verkerk, Ahmad S. Amin, Carol Ann Remme
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2018)
Review
Cardiac & Cardiovascular Systems
Arthur A. M. Wilde, Ahmad S. Amin
JACC-CLINICAL ELECTROPHYSIOLOGY
(2018)
Review
Cardiac & Cardiovascular Systems
Ahmad S. Amin, Arthur A. M. Wilde
PROGRESS IN PEDIATRIC CARDIOLOGY
(2017)