Predicting cardiac electrical response to sodium-channel blockade and Brugada syndrome using polygenic risk scores

SCN5A mutation type and topology are associated with the risk of ventricular arrhythmia by sodium channel blockers

(2018) Ahmad S. Amin et al.   INTERNATIONAL JOURNAL OF CARDIOLOGY

The Diagnostic Yield of Brugada Syndrome After Sudden Death With Normal Autopsy

(2018) Michael Papadakis et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

PR interval genome-wide association meta-analysis identifies 50 loci associated with atrial and atrioventricular electrical activity

(2018) Jessica van Setten et al.   Nature Communications

Value of the sodium-channel blocker challenge in Brugada syndrome

(2017) Dylan Therasse et al.   INTERNATIONAL JOURNAL OF CARDIOLOGY

2016 ESC Guidelines for the management of atrial fibrillation developed in collaboration with EACTS

(2016) Paulus Kirchhof et al.   EUROPACE

52 Genetic Loci Influencing Myocardial Mass

(2016) Pim van der Harst et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

Next-generation genotype imputation service and methods

(2016) Sayantan Das et al.   NATURE GENETICS

High prevalence of concealed Brugada syndrome in patients with atrioventricular nodal reentrant tachycardia

(2015) Can Hasdemir et al.   HEART RHYTHM

Sodium channel-inhibiting drugs and survival of breast, colon and prostate cancer: a population-based study

(2015) Caroline Fairhurst et al.   Scientific Reports

Severe cholestatic jaundice after a single administration of ajmaline; a case report and review of the literature

(2014) Benjamin H Mullish et al.   BMC GASTROENTEROLOGY

Sudden cardiac death is associated both with epilepsy and with use of antiepileptic medications

(2014) Abdennasser Bardai et al.   HEART

A common genetic variant within SCN10A modulates cardiac SCN5A expression

(2014) Malou van den Boogaard et al.   JOURNAL OF CLINICAL INVESTIGATION

Advantages and pitfalls in the application of mixed-model association methods

(2014) Jian Yang et al.   NATURE GENETICS

Genetic association study of QT interval highlights role for calcium signaling pathways in myocardial repolarization

(2014) Dan E Arking et al.   NATURE GENETICS

A rare loss-of-function SCN5A variant is associated with lidocaine-induced ventricular fibrillation

(2014) Q Xiong et al.   PHARMACOGENOMICS JOURNAL

Executive summary: HRS/EHRA/APHRS expert consensus statement on the diagnosis and management of patients with inherited primary arrhythmia syndromes

(2013) Silvia G. Priori et al.   EUROPACE

Sudden cardiac arrest associated with use of a non-cardiac drug that reduces cardiac excitability: evidence from bench, bedside, and community

(2013) Abdennasser Bardai et al.   EUROPEAN HEART JOURNAL

Life-threatening ventricular arrhythmias during ajmaline challenge in patients with Brugada syndrome: Incidence, clinical features, and prognosis

(2013) Giulio Conte et al.   HEART RHYTHM

Common variants at SCN5A-SCN10A and HEY2 are associated with Brugada syndrome, a rare disease with high risk of sudden cardiac death

(2013) Connie R Bezzina et al.   NATURE GENETICS

‘Intrahepatic cholestatic hepatitis following diagnostic ajmaline challenge’

(2012) Greg Mellor et al.   EUROPACE

Common Variation in the NOS1AP Gene Is Associated With Drug-Induced QT Prolongation and Ventricular Arrhythmia

(2012) Yalda Jamshidi et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

The safety of flecainide treatment of atrial fibrillation: long-term incidence of sudden cardiac death and proarrhythmic events

(2011) H. Almroth et al.   JOURNAL OF INTERNAL MEDICINE

Antidepressant medication use and future risk of cardiovascular disease: the Scottish Health Survey

(2010) Mark Hamer et al.   EUROPEAN HEART JOURNAL

Drugs and Brugada syndrome patients: Review of the literature, recommendations, and an up-to-date website (www.brugadadrugs.org)

(2009) Pieter G. Postema et al.   HEART RHYTHM