Microfluidic co-cultures with hydrogel-based ligand trap to study paracrine signals giving rise to cancer drug resistance

Using reconfigurable microfluidics to study the role of HGF in autocrine and paracrine signaling of hepatocytes

(2015) Dipali Patel et al.   Integrative Biology

Therapy-induced tumour secretomes promote resistance and tumour progression

(2015) Anna C. Obenauf et al.   NATURE

Sensitivity of Melanoma Cells to EGFR and FGFR Activation but Not Inhibition is Influenced by Oncogenic BRAF and NRAS Mutations

(2015) Tamás Garay et al.   PATHOLOGY & ONCOLOGY RESEARCH

Effects of FGF-2 and FGF receptor antagonists on MMP enzymes, aggrecan, and type II collagen in primary human OA chondrocytes

(2015) E Nummenmaa et al.   SCANDINAVIAN JOURNAL OF RHEUMATOLOGY

Photodegradable Hydrogels for Capture, Detection, and Release of Live Cells

(2014) Dong-Sik Shin et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

The role of MEK inhibitors in the treatment of metastatic melanoma

(2014) Antonio M. Grimaldi et al.   CURRENT OPINION IN ONCOLOGY

Reconfigurable microfluidics with integrated aptasensors for monitoring intercellular communication

(2014) Timothy Kwa et al.   LAB ON A CHIP

Efficient production and purification of extracellular domain of human FGFR-Fc fusion proteins from Chinese hamster ovary cells

(2014) Aleksandra Sokolowska-Wedzina et al.   PROTEIN EXPRESSION AND PURIFICATION

Treatment of BRAF-Mutant Melanoma: The Role of Vemurafenib and Other Therapies

(2013) S Jang et al.   CLINICAL PHARMACOLOGY & THERAPEUTICS

Stat3-Targeted Therapies Overcome the Acquired Resistance to Vemurafenib in Melanomas

(2013) Fang Liu et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

FGF Receptors: Cancer Biology and Therapeutics

(2013) Masaru Katoh et al.   MEDICINAL RESEARCH REVIEWS

Acquired Resistance and Clonal Evolution in Melanoma during BRAF Inhibitor Therapy

(2013) H. Shi et al.   Cancer Discovery

A mechanism of resistance to gefitinib mediated by cellular reprogramming and the acquisition of an FGF2-FGFR1 autocrine growth loop

(2013) K E Ware et al.   Oncogenesis

Second-Line Therapies in Hepatocellular Carcinoma: Emergence of Resistance to Sorafenib

(2012) A. Villanueva et al.   CLINICAL CANCER RESEARCH

Mechanisms of acquired resistance to targeted cancer therapies

(2012) Mark R Lackner et al.   Future Oncology

Tumour micro-environment elicits innate resistance to RAF inhibitors through HGF secretion

(2012) Ravid Straussman et al.   NATURE

Widespread potential for growth-factor-driven resistance to anticancer kinase inhibitors

(2012) Timothy R. Wilson et al.   NATURE

Survival in BRAF V600–Mutant Advanced Melanoma Treated with Vemurafenib

(2012) Jeffrey A. Sosman et al.   NEW ENGLAND JOURNAL OF MEDICINE

Improved Survival with MEK Inhibition in BRAF-Mutated Melanoma

(2012) Keith T. Flaherty et al.   NEW ENGLAND JOURNAL OF MEDICINE

MAP kinase signaling and inhibition in melanoma

(2012) R J Sullivan et al.   ONCOGENE

A versatile valve-enabled microfluidic cell co-culture platform and demonstration of its applications to neurobiology and cancer biology

(2011) Yandong Gao et al.   BIOMEDICAL MICRODEVICES

Improved Survival with Vemurafenib in Melanoma with BRAF V600E Mutation

(2011) Paul B. Chapman et al.   NEW ENGLAND JOURNAL OF MEDICINE

RG7204 (PLX4032), a Selective BRAFV600E Inhibitor, Displays Potent Antitumor Activity in Preclinical Melanoma Models

(2010) H. Yang et al.   CANCER RESEARCH

Co-culture of neurons and glia in a novel microfluidic platform

(2010) Devi Majumdar et al.   JOURNAL OF NEUROSCIENCE METHODS

Clinical efficacy of a RAF inhibitor needs broad target blockade in BRAF-mutant melanoma

(2010) Gideon Bollag et al.   NATURE

Tumor cell-specific bioluminescence platform to identify stroma-induced changes to anticancer drug activity

(2010) Douglas W McMillin et al.   NATURE MEDICINE

Inhibition of Mutated, Activated BRAF in Metastatic Melanoma

(2010) Keith T. Flaherty et al.   NEW ENGLAND JOURNAL OF MEDICINE

PLX4032, a potent inhibitor of the B-Raf V600E oncogene, selectively inhibits V600E-positive melanomas

(2010) John T. Lee et al.   Pigment Cell & Melanoma Research

Micropatterned co-cultures of T-lymphocytes and epithelial cells as a model of mucosal immune system

(2009) Gulnaz Stybayeva et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Directing hepatic differentiation of embryonic stem cells with protein microarray-based co-cultures

(2009) Ji Youn Lee et al.   Integrative Biology

Cellular observations enabled by microculture: paracrine signaling and population demographics

(2009) Maribella Domenech et al.   Integrative Biology