Article
Cell Biology
Yaoping Zhu, Tao Xiao, Yijia He, Xiaowei Hong, Ting Zhou, Mingjie Da, Sumeng Ge, Diya Xie, Zhiyong Wang
Summary: This study successfully identified lingual lymph nodes and described the presence of lymphatic drainage channels in the floor of the mouth using intraoperative near-infrared fluorescence imaging with indocyanine green absorbed into human serum albumin. The technique could assist in determining metastatic lymph nodes in tongue carcinoma patients.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2022)
Review
Oncology
Belinda Thompson, Katrina Gaitatzis, Xanne Janse de Jonge, Robbie Blackwell, Louise A. Koelmeyer
Summary: Recent research on manual lymphatic drainage (MLD) massage for lymphedema has shown conflicting results, with some studies reporting positive effects on symptoms and quality of life, while others finding no additional benefit. Additionally, studies have shown that MLD may reduce the incidence of lymphedema in at-risk patients, but there are also studies showing no such benefits. Further experimental studies are needed to determine the effectiveness of MLD in lymphedema treatment.
JOURNAL OF CANCER SURVIVORSHIP
(2021)
Article
Obstetrics & Gynecology
Kensuke Sakai, Masaru Nakamura, Wataru Yamagami, Tatsuyuki Chiyoda, Yusuke Kobayashi, Hiroshi Nishio, Shigenori Hayashi, Hiroyuki Nomura, Fumio Kataoka, Eiichiro Tominaga, Kouji Banno, Daisuke Aoki
Summary: The study compared the efficacy of drainage following pelvic lymph node dissection in laparoscopic versus laparotomy cases. Results showed that routine drainage may not be necessary, especially in cases involving laparoscopic surgery. The study found a significantly lower prevalence of lymphocyst in the laparoscopy group compared to the laparotomy group.
INTERNATIONAL JOURNAL OF GYNECOLOGY & OBSTETRICS
(2021)
Review
Surgery
Julia Roka-Palkovits, Miffy Chia-Yu Lin, Chieh-Han J. Tzou, Ines Tinhofer, Ming-Huei Cheng
Summary: Vascularized lymph node transfer with retrograde manual lymphatic drainage significantly improves the treatment outcomes for extremity lymphedema patients, with better results observed in distal recipient sites.
PLASTIC AND RECONSTRUCTIVE SURGERY
(2021)
Article
Health Care Sciences & Services
Bronwyn Overall, Kaori Langley, Janet Douglass
Summary: Manual lymph drainage (MLD) may offer a non-pharmaceutical approach to resolving long-COVID symptoms such as cough, breathlessness, and fatigue, with improvements observed after multiple treatments.
Article
Oncology
Nele Devoogdt, Sarah Thomis, An De Groef, An-Kathleen Heroes, Ines Nevelsteen, Nick Gebruers, Wiebren A. A. Tjalma, Jean-Paul Belgrado, Chris Monten, Marianne Hanssens, Tessa De Vrieze
Summary: This multicentre randomised controlled trial aimed to investigate the added value of fluoroscopy-guided manual lymph drainage (MLD) in decongestive lymphatic therapy (DLT) for superficial lymphatic architecture in patients with chronic mild to moderate breast cancer-related lymphoedema (BCRL). The trial found no significant differences between the groups in terms of changes in superficial lymphatic vessels, dermal backflow score, and superficial lymph nodes, indicating that MLD did not provide additional benefits to the other components of DLT for patients with BCRL.
Article
Medicine, General & Internal
Kuo-Yang Tsai, Su-Fen Liao, Kuan-Lin Chen, Hao-Wei Tang, Hsin-Ya Huang
Summary: This study compared the short-term effects of early interventions with rehabilitation exercise versus manual lymphatic drainage (MLD) and rehabilitation exercise in patients with oral cancer after surgery. The results showed that early intervention significantly improved pain, range of motion (ROM), and lymphedema in the patients. Moreover, the use of MLD intervention showed more improvement in neck lateral flexion and skin-to-bone distance in the jaw.
Article
Biotechnology & Applied Microbiology
Ahmet Hamdi Sakarya, Chi-Wei Huang, Chin-Yu Yang, Hui-Yi Hsiao, Frank Chun-Shin Chang, Jung-Ju Huang
Summary: The study demonstrates that vascularized lymph node transplantation (VLNT) is an effective treatment for lymphedema. VLNT reduces the volume of lymphedema by restoring lymphatic drainage function and reducing inflammation and fibrosis. It also promotes lymphangiogenesis and restores immune function locally and systemically.
BIOENGINEERING & TRANSLATIONAL MEDICINE
(2022)
Article
Medicine, General & Internal
Jose Maria Pereira de Godoy, Livia Maria Pereira de Godoy, Henrique Jose Pereira de Godoy, Maria de Fatima Guerreiro Godoy
Summary: Manual lymphatic therapy (MLT) (Godoy method) is effective in reducing the development of lymphedema after breast cancer treatment.
CUREUS JOURNAL OF MEDICAL SCIENCE
(2022)
Article
Acoustics
Saskia Van Heumen, Jonas J. M. Riksen, Mithun Kuniyil Ajith Singh, Gijs Van Soest, Dalibor Vasilic
Summary: LED-based photoacoustic imaging (PAI) can visualize and differentiate lymphatic vessels and veins, even in the presence of dermal backflow (DBF). This technique can be used for pre-operative lymphatic vessel imaging in the planning of lymphovenous bypass surgery. Further development of the technique is needed to improve its usability in clinical settings.
Article
Oncology
H. Winters, H. J. P. Tielemans, S. Hummelink, N. J. Slater, D. J. O. Ulrich
Summary: In this study, it was found that vascularized lymph node transfer in combination with DIEP flap breast reconstruction can significantly improve lymphedema-related quality of life. Even without a decrease in volume difference, it can reduce the usage of compression garments and the need for physiotherapy.
Article
Oncology
Kyungsu Kim, Kook Nam Han, Byeong Hyeon Choi, Jiyun Rho, Jun Hee Lee, Jae Seon Eo, Chungyeul Kim, Beop-Min Kim, Ok Hwa Jeon, Hyun Koo Kim
Summary: The feasibility of using Indocyanine green (ICG) to detect metastatic lymph nodes and tumors was evaluated in both animal and clinical studies. ICG successfully detected metastatic lymph nodes and tumors. However, due to its low fluorescence, it may be challenging to detect tumors in vivo using ICG.
Article
Oncology
Yan Lin, Yan Yang, Xiaoyu Zhang, Wandi Li, Haoran Li, Dali Mu
Summary: This systematic review and meta-analysis evaluated the effectiveness of manual lymphatic drainage (MLD) on breast cancer-related lymphedema (BCRL) patients. The findings demonstrate that MLD significantly improves pain in BCRL patients, but does not have significant effects on volumetric changes of lymphedema and quality of life. The potential preventive effect of MLD on BCRL requires further discussion.
CLINICAL BREAST CANCER
(2022)
Article
Medicine, General & Internal
Jesus Baltasar Gonzalez Rubino, Maria Jesus Vinolo-Gil, Cristina Garcia Munoz, Rocio Martin-Valero
Summary: Breast cancer is the most common malignant tumor in women, and post-mastectomy lymphedema and axillary web syndrome are common surgical sequelae that affect patient functionality and treatment time.
Article
Surgery
Justin M. Broyles, Jeffrey M. Smith, Franklin C. Wong, Matthew M. Hanasono, Edward Chang, S. Cheenu Kappadath, Mark Schaverien
Summary: This study demonstrates the utility of SPECT/CT lymphoscintigraphy in presurgical planning for groin vascularized lymph node transplantation. It also evaluates the physiological lymphatic drainage to the superficial inguinal lymph nodes.
PLASTIC AND RECONSTRUCTIVE SURGERY
(2022)
Article
Computer Science, Interdisciplinary Applications
Banghe Zhu, Sunkuk Kwon, John C. Rasmussen, Maritoni Litorja, Eva M. Sevick-Muraca
IEEE TRANSACTIONS ON MEDICAL IMAGING
(2020)
Article
Surgery
John C. Rasmussen, Banghe Zhu, John R. Morrow, Melissa B. Aldrich, Aaron Sahihi, Stuart A. Harlin, Caroline E. Fife, Thomas F. O'Donnell, Eva M. Sevick-Muraca
Summary: Near-infrared fluorescence lymphatic imaging showed that lymphatic anatomy and contractile function deteriorate with the severity of venous insufficiency in comparison to normal health subjects. Lymphatic abnormalities in venous insufficiency resemble those in early cancer-acquired lymphedema.
JOURNAL OF VASCULAR SURGERY-VENOUS AND LYMPHATIC DISORDERS
(2021)
Review
Oncology
Melissa B. Aldrich, John C. Rasmussen, Caroline E. Fife, Simona F. Shaitelman, Eva M. Sevick-Muraca
Article
Immunology
Alexandre E. Malek, Caroline E. Fife, John C. Rasmussen, Ron J. Karni, John R. Morrow, Audrey Wanger, Eva M. Sevick-Muraca, Luis Ostrosky-Zeichner
Summary: Cutaneous tuberculosis caused by skin inoculation of Mycobacterium tuberculosis is rare but can occur in healthcare settings. This case report describes an unusual case of primary cutaneous tuberculosis of the thumb following a needlestick injury, with progression to necrotic granuloma, lymphatic dysfunction, and axillary web syndrome.
OPEN FORUM INFECTIOUS DISEASES
(2021)
Meeting Abstract
Oncology
Melissa B. Aldrich, Meghan E. McWain, Wenyaw Chan, John C. Rasmussen, Sarah DeSnyder, Eva M. Sevick-Muraca, Simona F. Shaitelman
Meeting Abstract
Oncology
Wintana Balema, Janelle Morton, Richard Larson, Fred C. Velasquez, Eva Sevick-Muraca, Wendy A. Woodward
Meeting Abstract
Oncology
Anna R. Vang, Simona F. Shaitelman, Eva M. Sevick-Muraca, Chan Wen-yaw, John C. Rasmussen, Sarah D. DeSnyder, Melissa B. Aldrich
Editorial Material
Nanoscience & Nanotechnology
Eva M. Sevick-Muraca
NATURE NANOTECHNOLOGY
(2022)
Article
Oncology
Carolina Mantilla-Rojas, Fred C. Velasquez, Janelle E. Morton, Leticia C. Clemente, Edwin R. Parra, Carlos Torres-Cabala, Eva M. Sevick-Muraca
Summary: This study demonstrates that combining vaccination and checkpoint blockade immunotherapy delivered through the lymphatics can improve anti-tumor responses in non-immunogenic melanoma models. This method may potentially benefit more patients by directing immune responses within the regional lymph node environment.
Article
Oncology
Melissa B. Aldrich, John C. Rasmussen, Sarah M. DeSnyder, Wendy A. Woodward, Wenyaw Chan, Eva M. Sevick-Muraca, Elizabeth A. Mittendorf, Benjamin D. Smith, Michael C. Stauder, Eric A. Strom, George H. Perkins, Karen E. Hoffman, Melissa P. Mitchell, Carlos H. Barcenas, Lynn E. Isales, Simona F. Shaitelman
Summary: This study investigated the use of near-infrared fluorescence lymphatic imaging (NIRF-LI) surveillance to predict early onset of peripheral lymphatic dysfunction as a predictor of breast cancer-related lymphedema (BCRL). The results showed that dermal backflow can predict the development of BCRL months before arm swelling occurs, enabling early treatment to prevent edema and irreversible tissue changes.
BREAST CANCER RESEARCH AND TREATMENT
(2022)
Article
Endocrinology & Metabolism
John C. Rasmussen, Melissa B. Aldrich, Caroline E. Fife, Karen L. Herbst, Eva M. Sevick-Muraca
Summary: This study investigated the lymphatic vessel anatomy and function in early stages of lipedema using near-infrared fluorescence lymphatic imaging. The results showed that while lower extremity lymphatic vessels were dilated in lipedema patients, their propulsion rates exceeded those of the control group. In contrast, upper extremity lymphatics were normal and no dermal backflow was observed in patients with Stage I and II lipedema.
Article
Oncology
Anna R. Vang, Simona F. Shaitelman, John C. Rasmussen, Wenyaw Chan, Eva M. Sevick-Muraca, Melissa B. Aldrich
Summary: Breast cancer-related lymphedema (BCRL) occurs in approximately 40% of patients after axillary lymph node dissection (ALND), radiation therapy (RT), or chemotherapy. First-line palliative treatment involves the use of compression garments and specialized massage. Reparative microsurgeries are a second-line treatment, but both compression and surgical therapy are most effective in the early stages of LE development. Identifying patients at the highest risk for BCRL would allow for earlier and more effective treatment.
Article
Computer Science, Interdisciplinary Applications
Banghe Zhu, Jonathan Hendricks, Janelle E. Morton, John C. Rasmussen, Christopher Janssen, Manish N. Shah, Eva Marie Sevick-Muraca
Summary: This study used near-infrared fluorescence imaging to investigate the role of the lymphatics in clearing cerebrospinal fluid (CSF) from the brain. The results showed that trace doses of the fluorescent dye ICG can be used to monitor CSF dynamics and extracranial outflow. The techniques developed in this study could potentially be applied to infants and children with impaired CSF outflow due to intraventricular hemorrhage.
IEEE TRANSACTIONS ON MEDICAL IMAGING
(2023)
Article
Computer Science, Interdisciplinary Applications
Banghe Zhu, Eva M. Sevick-Muraca, Ryan D. Nguyen, Manish N. Shah
IEEE TRANSACTIONS ON MEDICAL IMAGING
(2020)
Article
Physiology
John C. Rasmussen, Sunkuk Kwon, Amanda Pinal, Alexander Bareis, Fred C. Velasquez, Christopher F. Janssen, John R. Morrow, Caroline E. Fife, Ron J. Karni, Eva M. Sevick-Muraca
PHYSIOLOGICAL REPORTS
(2020)